Messenger in Biological Technology

Novel compound may treat acute diarrhea

... decreases the formation of ever-present cellular messenger molecules, cyclic guanosine monophosphate and ... with the identification of a link between the messenger molecules and a bacterial strain of diarrhea ... for increasing the production of intracellular messenger molecules. These molecules contribute to the ...

Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research

... rare for researchers to identify a molecular messenger in test tube studies, demonstrate its ... Maini investigated the role of cytokines, protein messenger molecules that drive inflammation, and found that ... clinical applicability of our discovery that a messenger molecule, TNF, was an effective target for ...

Genetic pathway critical to disease, aging found

... part of a complex that controls the expression of messenger RNA, all-important molecules that carry genetic ... for adding a critical biochemical tail onto messenger RNA. The tail, in kite-like fashion, is necessary for the stability of the messenger RNA molecules, can turn them on and off, and thus ...

New yeast trick for eating favorite food: Details in Nature paper

... the glucose network actively shuts down the galactose network by degrading messenger RNA that would otherwise go on to form the enzymes needed to metabolize ... mechanism in which jumps in glucose increase the degradation rate of messenger RNA that are crucial for the functioning of the galactose metabolic ...

AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy

... parts of the gene being used. At the cellular level, a molecule called messenger RNA (mRNA) reads off (transcribes) the protein instructions from the gene. ... instructions to the ribosomes in the cell where the protein is assembled. messenger RNA is not a transcript of the complete gene sequence, but only of the ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... hypertension. PL-3994 produced dose-related decreases in blood pressure, increases in plasma cGMP (cyclic guanosine monophosphate), a natural messenger nucleotide, and increases in urine volume and sodium excretion. There were no serious or severe adverse events. PL-3994 incorporates a novel ...

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

... genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in basic research, drug discovery and clinical settings. The ...

SenesTech Announces New Vice President of Business Development

... Inc., Director of ILINC Communications, Inc., and President for RideAmerica Transportation Group, Parcelway Couriers Systems, Inc., Dynamex, and U.S. messenger Service of Chicago, San Francisco. "George's experience will be a valuable asset as he takes us to the world stage," said Everett Hale, CEO. ...

Roche Madison Moves to New Facility

... new class of medicines, known as RNAi therapeutics, is on the horizon. RNAi therapeutics targets the cause of diseases by potently silencing specific messenger RNAs (mRNAs), thereby preventing disease-causing proteins from being made. RNAi therapeutics has the potential to treat disease and help patients in ...

Researchers develop new way to see single RNA molecules inside living cells

... whether they could visualize individual RNA molecules using the probes. To do this, they simultaneously delivered probes designed to target a human messenger RNA (mRNA) sequence region and a probe designed with no target in the human genome. They were able to image unbound probes of both types as well as ...

Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting

... an amplified nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger RNAs (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes targeting these ...

Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

... genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in many basic research, drug discovery and clinical settings. ...

Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research

... transformed the treatment of people diagnosed with chronic inflammatory conditions. Feldmann and Maini investigated the role of cytokines, protein messenger molecules that drive inflammation, and found that a single cytokine, TNF-alpha, was responsible for the debilitating symptoms of inflammatory ....

Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure

... safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a pre-specified reduction in systemic ...

Gen-Probe Launches in Europe CE-Marked APTIMA(R) HPV Assay for Detection of Human Papillomavirus

... an amplified nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger RNAs (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes that targeting these ...

Gen-Probe Reports Strong Financial Results for First Quarter 2008, Raises Full-Year Guidance

... is designed to detect 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay is designed to detect two messenger RNAs (mRNAs), E6 and E7, which are produced in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe expects to ...

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

... genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene functions in basic research, drug discovery and clinical settings. ...

Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure

... safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a prespecified reduction in systemic blood ...

Egenix Licenses Harvard Anti-Cancer Platform

... of translation initiation licensed by Egenix from Harvard Medical School target the eIF4F and ternary complexes, the two critical regulators of messenger RNA translation into protein. The company's management believes that small molecules for the inhibition of translation initiation are at the ...

Amarin Provides Business Update and Announces Implementation of Reverse Stock Split

... side effect profile and dosing regimen, as compared with current first line treatment. The acquisition also provides Amarin with access to a platform messenger RNA (mRNA) silencing technology which targets the cholinergic pathway, and a promising preclinical program in neurodegeneration and inflammation. ...

Sirnaomics Received Multiple Government Fundings For Its Multi-Targeted siRNA Therapeutics Programs

... genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in many basic research, drug discovery and clinical settings. ...

DermTech Is Issued U.S. Patent for the Early Detection, Staging and Monitoring of Melanoma

... melanoma. The patent also claims the use of evaluating additional biomarkers based upon differences in gene expression such that a change in these messenger RNAs is indicative of late-stage melanoma. The ability to detect, stage and monitor disease is critical for improved clinical outcomes. "DermTech ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... close tomorrow. The initial consideration is $15 million, plus up to $17 million in contingent payments. Ester's core assets include (i) a platform messenger RNA (mRNA) silencing technology which targets the cholinergic pathway; (ii) EN101, a Phase II compound with promising efficacy data for the treatment ...

Isis Awarded $1.5 Million NIH Grant to Improve Chemical Properties of RNAi-Based Therapeutics

... grant funds the discovery of RNAi-based drugs. About RNAi RNAi is an antisense mechanism that involves using RNA to target a specific messenger RNA sequence (mRNA) for degradation. The most common RNAi agents are double-stranded RNAs, which ultimately associate with proteins to form an ...

Mechanism for the in-vivo transport of siRNA

... its activity instead of reinforcing it as had been assumed. A few years later it was found that the mechanism is based on the degradation of messenger RNA in the cells. Finally, in the late nineties the Nobel prizewinners Andrew Fire and Craig Mello established the technique of RNA interference, in ...

Benitec MOU With CalbaTech, Inc.

... for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery. These instructions are conveyed by messenger RNA (mRNA). In 1998 it was discovered that a certain mechanism can degrade mRNA from a specific gene. This mechanism is RNA interference. It is ...

Getting Started with MicroRNA Research

... or stability of target messenger RNAs. Each microRNA is believed to regulate ... levels of regulatory miRNAs than on the levels of messenger RNAs that encode the proteins [3]. ... single-stranded RNA molecules target specific messenger RNA transcripts and prevent protein ...

Three mainstream technologies you should not ignore

... of my clients, an international insurance company, uses Microsoft Instant messenger to conduct daily business. Why? Because instant messaging equals instant ... it's behind the competition. Get an AOL, MSN, Jabber, ICQ or Yahoo instant messenger account. Better yet, get all of them and configure a single program to ...

HTRF IP-One Assay Performed on the PHERAstar and RUBYstar Plate Readers

... mentioned, IP3, though, being the top choice as a secondary messenger for the Gq signaling pathway, nevertheless does not possess the ... Gq-coupled receptors via the quantification of a new secondary messenger for this pathway, IP1. The messengers stability opens the ...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

... the neurotransmitter to its receptor alters the production of the second messenger adenosine 3', 5' cyclic monophosphate (cAMP), through the enzyme adenylyl ... In addition, the use of this technology does not stop at second messenger assessment, but can be applied to all RIA applications as well as ...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

... selective isolation by laser capture microdissection while preserving messenger RNA (mRNA). Polymerase chain reaction showed a differential expression ... Witzemann V, Sakmann B. Imprinting of acetylcholine receptor messenger RNA accumulation in mammalian neuromuscular synapses. Nature. ...

miRNA Expression in White Blood Cells

... by pairing with the 3' untranslated region of messenger RNAs and acting as translational repressors. The ... have been optimized to recover long (>500 nt) messenger RNAs, while ignoring smaller molecules. As a result, ...

Instant messaging comes to groups

... Today, Palo Alto-based start-up Five Across introduced a new instant messenger system, called InterComm. At first blush, another IM system may seem redundant, silly and unnecessary. After all, AOL, MSN, and Yahoo already capture ...

Will mobile phones go back to school?

... I were a lifeline," you're in luck. AOL and Buena Vista Television are adding an "interactive element" to the TV show by allowing AOL and AOL Instant messenger users to become lifelines. To do this, add the "MillionaireIM" screen name to your Buddy List. When a contestant asks for the "Ask the Audience" ...

Tech Digest: what's moving in the Midwest

... system. The software is also designed to support back-end monitoring and alarms that are sent through e-mail, mobile phones, pagers, or online messenger systems. It utilizes GigE and 100Mbps links, giving it a direct connection to the customer via fiber optics. Bret Kindness, vice president of ...

Google delves deep within your computer with new desktop tool

... advertising. It not only finds files fast but can peer into the entirety of the contents of Outlook and Outlook Express e-mails, AOL Instant messenger cached chats, regular and secure Web pages youve viewed in Internet Explorer, text files, Word documents, PowerPoint files and Excel files. Now when ...

Gender hormones may lend to social disorder therapies

... To the scientists' surprise, a similar result took place when they treated the females with a mimic of the neurotransmitter dopamine, a chemical messenger in the brain that regulates emotions and feelings of pleasure. The UW-Madison study results imply that many factors, beyond steroid receptors and ...

Promega and Benitec settle contract case

... Benitec had previously granted an exclusive license to Promega in 2003 for use of its ddRNAi technology, a method of blocking certain genes in messenger RNA. In addition to its use for pure research on which genes form specific phenotypes and react to certain diseases and treatments, there is also ...

UW researcher named top innovator

... each other to form "biofilms" which are a main cause of infection. Bacteria promote that growth through a technique called quorum sensing, sending messenger molecules to fellow cells. In her research, Blackwell has screened hundreds of those molecules to attempt a "hijack" of the bacteria's ...