mediated in Biological Technology

Pharmacyclics to Present at the 8th Annual Needham and Company Life Sciences Conference

... innovative small molecule drugs for the treatment of immune mediated disease and cancer, today announced that Glenn Rice, President and COO ... innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the company is to create a profitable ...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... support the evaluation of BCX-4208 in the treatment of not only T-cell mediated diseases, but also B-cell mediated diseases. Corporate Developments Stanley ...

Pharmacyclics, Inc. Rights Offering Oversubscribed

... is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the company is to create a profitable business by generating income from products it develops, licenses and ...

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

... is an inflammatory disease initiated by T cells in the donor graft that recognize histocompatibility and other tissue antigens of the host, and is mediated by a variety of effector cells and inflammatory cytokines. GVHD presents in both acute and chronic forms. The symptoms of cGVHD typically present at ...

Novavax Announces Selection of a Respiratory Syncytial Virus Vaccine Candidate for Advanced Preclinical Studies

... of the native virus. The particle nature of the vaccine holds the promise for inducing a broad set of immune responses including antibody and cell mediated immune responses to prevent infection of the respiratory tract and attack respiratory cells that may already be infected with RSV. The ...

Pharmacyclics Announces Subscription Price for Rights Offering

... is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the Company is to create a profitable business by generating income from products it develops, licenses and ...

Bion Announces Approval of New U.S. Patent that Broadens Protection for the Company's Livestock Waste Environmental Treatment Processes

... Inc. (OTC Bulletin Board: BNET) announced today that it was notified that its U.S. Patent application 11/592,513 entitled "Low Oxygen Biologically mediated Nutrient Removal" has been approved. The patent application was made on November 6, 2006; upon publication and issuance, the patent will be ...

Centocor Ortho Biotech Inc. Awarded $1.67 Billion Patent Jury Verdict from Abbott Laboratories

... intellectual property rights for our immunology therapies, as they offer significant advances in treatment for patients with a number of immune mediated inflammatory diseases," Taylor added. About Centocor Ortho Biotech Inc. Centocor Ortho Biotech Inc. redefines the standard of care in ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... human blood monocyte cells to become dendritic cells that secrete the IL-12 cytokine. The dendritic cells that result initiate a protective cell mediated and antibody immune response. These results were obtained for L.E.A.P.S. vaccines against herpes simplex and HIV. The L.E.A.P.S. technology ...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

... that are resistant to cytarabine due to deficient expression of hENT1 on the cells. The enhanced cytotoxic activity of elacytarabine is thought to be mediated through increased cellular uptake, decreased deactivation and prolonged exposure to the active metabolite ara-C triphosphate (ara-CTP) within the ...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

... leukemia. EHA Abstract #1398. Harasym T, Lim W, Tardi P, et al. Leukemia cell-selective uptake of cytarabine (Cyt) and daunorubicin (Daun) mediated by CPX-351 liposome injection in the bone marrow compartment. EHA Abstract #383 ...

Ratcliff Promotes Jorge Burbano to Senior Associate; Tess Kavanagh and Tony Keung to Associate

... from the University of New Mexico in 1990. With more than 13 years of experience, architect Tess Kavanagh is assisting with the design of the mediated Learning Center at De Anza College in Cupertino, California. She recently completed work on the new Student Services Center for Golden Gate ...

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

... muscle from further damage, alter the deterioration of cellular energetics, and improve global cardiac function. Importantly, ARAs' effects are not mediated by conversion of the drug to adenosine or by any direct activity at the adenosine receptors. Rather, ARAs have been shown to increase endogenous ...

Pharmacyclics Files Registration Statement for Rights Offering

... is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the company is to create a profitable business by generating income from products it develops, licenses and ...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

... activity observed in highly refractory CLL patients, preclinical studies were performed on CLL cells to determine the mechanism(s) of direct TRU-016 mediated apoptosis. These studies demonstrate TRU-016-mediated apoptosis in CLL cells occurs via a distinct mechanism of apoptosis compared with many other ...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

... human blood monocyte cells to become dendritic cells that secrete the IL-12 cytokine. The dendritic cells that result initiate a protective cell mediated and antibody immune response. These results were obtained for L.E.A.P.S. vaccines against HSV and HIV. The use of the L.E.A.P.S. vaccine technology ...

VIRxSYS Publishes New Study on RNA Therapy

... could have triggered an immune response. The technology used to perform the albumin splicing process is owned by VIRxSYS and is known as spliceosomal mediated RNA trans- splicing, or SMaRT(TM). VIRxSYS now has 39 publications in top tier journals showing the effectiveness of SMaRT(TM) in a broad variety of ...

Novexel Strengthens its Scientific Advisory Board With the Appointment of Dr. Karen Bush

... scientific career in anti-infective research and development spans over three decades and she is a recognised authority in the study of resistance mediated by beta-lactamases. During her career, Dr. Bush has held the position of Distinguished Research Fellow at Johnson & Johnson, Director of ...

NOVAVAX Announces Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate Directed Against the Fusion (F) Protein

... group; responses with VLPs alone were higher than responses observed with either live or inactivated RSV immunization. The VLPs induced strong cell mediated immune responses with activation of CD8+ cytotoxic T-lymphocytes against the F protein, which are important for protection because they kill cells ...

ChanTest Acquires Applied Cell Sciences

... scientists pioneered the HERG assay essential to assess this risk. On the discovery side, the central nervous system's 'fight-or-flight' reaction is mediated by cardiac GPCR beta-receptors activating cardiac calcium channels, thereby increasing cardiac pumping. Drugs may affect function of the heart via ...

Bert W. O'Malley, M.D., Recipient of the 2008 National Medal for Science, Joins Bionovo's Scientific Advisory Board

... of estrogen and progesterone on implantation of a fertilized egg, pregnancy maintenance, and prenatal embryonic development, and for the hormone mediated embryonic and pubertal growth of breast, uterine, ovarian, prostate, and brain tissues under normal and cancer conditions. In 1992, the O'Malley lab ...

Cordex Pharma Presents 'New Frontiers in Cardiovascular Medicines' on January 29

... was promoted to full Professor. Dr. Stamler's work has centered on elucidating the fundamental physiological regulatory roles of nitric oxide mediated by S-nitrosylation, a ubiquitous protein modification. The ramifications of his work extend to all major classes of proteins: ion channels, ...

Lytix Closes USD 10.4 Million Funding Round

... In vivo studies in syngeneic mice demonstrate a potential for a rapid induction of tumour necrosis, and a complete and stable tumour response mediated by the immune-system. Both LTX-109 and LTX-315 will enter the clinical phases during the latter half of 2009." In order to capitalise on the ...

Cornerstone Therapeutics Provides Update on Integration Activities and Issues 2008 Revenue Guidance

... parties. As a result of this review, the Company has initiated a process to seek potential licensees for certain technologies, including the alpha 7 mediated anti-inflammatory pathway program. The Company completed a restructuring of former Critical Therapeutics officers and employees that resulted ...

Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009

... that prevent cell-to-cell transmission of virus down the respiratory tract, potentially reducing the severity of influenza disease; and cell mediated immune responses to M1 may lead to destruction of cells already infected. Further, the vaccine is made in cell culture rather than eggs, which ...

ProtoKinetix Receives Independent Confirmation of AAGP Anti-Inflammatory Action

... Senior, President and CEO of ProtoKinetix, said, "The control of inflammation is of vital importance to the treatment of a number of immune complex mediated diseases. AAGP(TM) continues to demonstrate its potential to become a major contributor in the successful treatment of a wide range of health ...

Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing

... of the claims in U.S. Patent Nos. 7,425,546 and 7,429,570, both entitled, "Methods of optimizing drug therapeutic efficacy for treatment of immune- mediated gastrointestinal disorders." "We are pleased that the USPTO has acknowledged the validity of these patents and approved their issuance," said ...

Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

... mission is to advance RNAi technology by using its proprietary multi-targeted siRNA cocktail design together with the company's nanoparticle- mediated siRNA delivery vehicles in the rapid delivery of novel therapeutics. The company is dedicated to becoming the leader in the field of RNAi technology ...

Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate

... that prevent cell-to-cell transmission of virus down the respiratory tract, potentially reducing the severity of influenza disease; and cell mediated immune responses to M1 may lead to destruction of cells already infected. Further, the vaccine is made in cell culture rather than eggs, which ...

Bion Announces Approval of New U.S. Patent for Phosphorus Removal Process for Livestock Waste Environmental Treatment

... Inc. (OTC Bulletin Board: BNET) announced today that it was notified that its U.S. Patent application 11/106,751 entitled "Low Oxygen Biologically mediated Nutrient Removal" has been approved. The patent application was made on April 15, 2005; upon publication and issuance, the patent will be officially ...

Oncolytics Biotech Inc. Announces 2008 Second Quarter Results

... myeloma. The results demonstrated that up to 70% of multiple myeloma cell lines tested showed reovirus sensitivity and reovirus induced cell death mediated through apoptosis. The investigators concluded that this preclinical data supports initiating a Phase I purging trial using reovirus against multiple ...

Global Probiotics Council Announces First Awardees for New Young Investigator Grant for Probiotics Research

... of Pediatric Gastroenterology at the University of North Carolina at Chapel Hill, was selected for his research proposal, "Antimicrobial Peptide mediated Alterations of the Gut Microbiome in Nod 2/IL-10 Deficient Mice." This research will focus on a very important mechanistic process that could help ...

Pharmacyclics Announces It Received Nasdaq Notice of Compliance

... compliance with the Rule. About Pharmacyclics Pharmacyclics is a pharmaceutical company developing innovative products to treat cancer and immune mediated diseases. The company is leveraging its small-molecule drug development expertise to build a pipeline in oncology and other diseases based on a wide ...

Alba Therapeutics Announces the Enrollment and Randomization of the First Patient in the Phase IIb Clinical Trial for Larazotide Acetate (AT-1001) for the Treatment of Active Celiac Disease

... visit the http://www.clinicaltrials.gov web site and search for Alba Therapeutics. About Celiac Disease Celiac disease is a lifelong T-cell mediated auto-immune disorder, which occurs in individuals who are genetically susceptible and is characterized by small intestinal inflammation, injury and ...

Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research

... Feldman and Maini's work has tremendous potential to transform research and human health, and it has shed new light on how we study crippling immune mediated inflammatory disorders." In addition to winning the 2008 Dr. Paul Janssen Award for Biomedical Research, Feldmann and Maini have been widely ...

Genetic Immunity To Present at the Rodman & Renshaw 5th Annual Global Healthcare Conference

... encoded antigens. DermaPrep is the topical administration device that delivers NanoComp into a patient's lymph node dendritic cells to induce T cell mediated immune responses that can treat a broad spectrum of diseases. These two components together make up the DermaVir Patch. The plasmid DNA within ...

LifeNet Health Chief Scientific Officer Wins Award

... commercial potential and/or social benefit. Dr. Wolfinbarger was awarded the Excellence in Innovation award for a patent on Bioreactor mediated Recellularization of Natural and Tissue Engineered Vascular Grafts. "We are honored to have Dr. Wolfinbarger leading our research efforts at ...

deCODE genetics Announces First Quarter 2008 Financial Results

... bleeding time. In clinical studies to date, DG041 has been shown to dramatically inhibit platelet aggregation as well as platelet activation mediated specifically through vasodilator-stimulated phosphoprotein (VASP), a biomarker useful for measuring platelet activity. These effects have ...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

... not been successfully treated with conventional therapeutics. The product being developed by the Company may represent a novel treatment for Ras mediated cancers which can be used as an alternative to existing cytotoxic or cytostatic therapies, as an adjuvant therapy to conventional chemotherapy, ...

JCI table of contents: April 22, 2008

... adiponectin reduced permeability to albumin and albuminuria, respectively. Further studies revealed that the effects of adiponectin on podocytes were mediated by AMPK activation and a subsequent reduction in Nox4 levels. The authors therefore suggested that targeting the adiponectin-AMPK-Nox4 pathway might ...