Markers in Biological Technology

OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial

... Reductions in circulating tumor cells and tumor markers both suggest single-agent activity warranting ... than 5 CTCs at baseline. Reduction in tumor markers defined as declines of PSA levels in prostate ... in patients with prostate and ovarian cancer, markers that strongly suggest single agent anti-cancer ...

deCODE genetics Announces First Quarter 2009 Financial Results

... application for one of our major genetic risk markers also underscores the wisdom of our approach ... worldwide licenses to deCODE's genetic markers for increased risk of major cardiovascular ... fibrillation (AF) and type 2 diabetes (T2D). The markers include SNPs discovered by deCODE on ...

deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes

... worldwide licenses to deCODE's genetic markers for increased risk of major cardiovascular and ... (AF) and type 2 diabetes (T2D). These markers can be incorporated into laboratory tests ... risk of these diseases. The deCODE markers include single letter variations in the human ...

Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH

... Chief Executive Officer of Alexion. Blood markers of Thrombin Generation and Inflammation ... Results in Rapid and Sustained Decreases in markers of Thrombin Generation and Inflammation in ... laboratory tests to track levels of blood markers in order to determine the effect of Soliris ...

Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA

... the "Black Hole" and "Cryohalo" are markers for the Efficacy of Ultrasound-guided ... termed "black hole" and "cryohalo" serve as markers for successful ablation, giving us a noninvasive ... (CEMRI), the "Black Hole" and "Cryohalo" are markers for the Efficacy of Ultrasound (US)-guided ...

LabCorp(R) and Vanda Pharmaceuticals Collaborate to Offer Genetic Tests

... a series of diagnostic tests for genetic markers identified by Vanda in the course of its ... Vanda has identified a series of pharmacogenetic markers during its development of Fanapta(TM), and the ... commercialization partner for tests for genetic markers of the Fanapta(TM) program. "Working with ...

Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study

... CMM for Professional Services in Finding Genetic markers That May Improve Treatment GRAND RAPIDS, Mich., ... Polymorphisms (SNPs), serve as signposts or markers in the genome. Associating these SNP markers with diseases in different individuals provides ...

Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease

... Alzheimer's disease demonstrates an interaction between two genetic markers that strongly influence the therapeutic response in patients. Dr. Samuel ... product on Day 104. In addition, analyses of a number of genotypic markers judged to be relevant to the physiological background of Alzheimer's ...

Clarient Completes Second Tranche of Private Placement of Convertible Preferred Stock With Oak Investment Partners

... The Company is also developing new, proprietary "companion" diagnostic markers for therapeutics in breast, prostate, lung and colon cancers, and ... Company's ability to fund development of new diagnostic tests and novel markers and the amount of resources the Company determines to apply to novel ...

OncoGenex Pharmaceuticals Announces Release of Two ASCO Abstracts: Impact of OGX-011 on Survival in Randomized Phase 2 Trial and Phase 1 Safety Data for OGX-427

... treatment effect, have been observed at all dose levels. Changes in tumor markers (i.e declines of PSA, CA-125) have also been observed. Reductions in CTCs and tumor markers both suggest single-agent activity. The abstract represents preliminary ...

Beyond associations: Colorectal cancer culprit found

... of cancer-related deaths in the United States. Several common genetic markers have been found to be associated with the disease, but finding the ... cancer in a GWAS. They sequenced the region of DNA surrounding these markers in a large group of colorectal cancer cases and controls, identifying all ...

Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation

... The Company is also developing new, proprietary "companion" diagnostic markers for therapeutics in breast, prostate, lung and colon cancers, and ... Company's ability to fund development of new diagnostic tests and novel markers and the amount of resources the Company determines to apply to novel ...

Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies

... seven and 35 weeks of pregnancy. Amniotic fluid (AF) cells that had markers similar to bone marrow stem cells (termed AFKL cells) were then isolated for use in experiments, as these cell markers were indicative of progenitor cells (cells that have the capacity to ...

Clarient Reports Strong Revenue Increase for Fourth Quarter and Full-Year 2008

... The Company is also developing new, proprietary "companion" diagnostic markers for therapeutics in breast, prostate, lung and colon cancers, and ... Company's ability to fund development of new diagnostic tests and novel markers and the amount of resources the Company determines to apply to novel ...

Mosquito genes linked to insecticide resistance may be new target in fight against malaria

... should have low risk for toxicity in humans. This report of genetic markers that can be used to predict insecticide resistance in laboratory ... evaluation of wild mosquito populations. "Routine use of these molecular markers for resistance will provide early warning of future control problems due ...

Anthera Completes Enrollment and Dosing of Varespladib Cardiovascular Trial

... is designed to assess the impact of oral varespladib on known biological markers of cardiovascular risk. Anthera plans to enroll between 500-700 patients ... A2 (sPLA2), has demonstrated marked improvements in independent markers of cardiovascular risk including a near complete suppression of the target ...

Orexigen(R) Therapeutics Announces First of Four Phase 3 Trials of Contrave(R) Meets Co-Primary and Key Secondary Endpoints

... endpoints, showing a significant reduction in body weight, improvements in markers of cardiovascular risk and reductions in selected food craving measures. ... over placebo included HDL, triglycerides, waist circumference and hsCRP, markers of cardiovascular risk. Contrave patients also demonstrated improvements ...

Axial Biotech Launches Genetic Test for Adolescent Idiopathic Scoliosis (AIS)

... over several years because of the lack of precise clinical indicators or markers that can identify the likelihood of severe curve progression. This lack of ... a genome wide association study that identified a panel of 53 genetic markers associated with severe curve progression. This scoliosis research involved ...

CISBIO Bioassays Launches Chromoa(TM) Chromogranin A ELISA Kit

... neuroendocrine form. CGA-RIACT has long been part of CISBIO'S tumor markers detection portfolio and its analytical and clinical performance has been ... manufactures and markets diagnostic assays for the quantification of tumor markers and other biomarkers in clinical biology. In addition, CISBIO is a global ...

DNA Study Unlocks Mystery to Diverse Traits in Dogs

... Center for Pet Nutrition in the United Kingdom, studied simple genetic markers known as Single Nucleotide Polymorphisms, or SNPs, to find places in the ... new frontiers in canine genomic science, discovering important genetic markers that will help identify breed mixes. These major scientific advances can ...

Gen-Probe Launches Cash Tender Offer to Acquire Belgian Molecular Diagnostics Company Innogenetics

... Add Complementary Products, Technologies and markers - - Combined Entity Anticipated to be World's Largest Standalone ... provide access to a number of complementary products, technologies and markers that are generating revenue today or that we believe could be ...

/C O R R E C T I O N -- Rosetta Genomics Ltd/

... other neuroendocrine tumors. - Identified specific microRNAs that are markers to differentiate between primary liver and brain tumors and metastases to ... other neuroendocrine tumors. - Identified specific microRNAs that are markers to differentiate between primary liver and brain tumors and metastases to ...

Immune Tolerance Institute Appoints Aaron B. Kantor Ph.D. Chief Scientific Officer

... a range of bioanalytical technologies to the discovery of biological markers for human diseases," said Dr. Matis. "His extensive record of ... At PPD, his work centered on the broad effort to discover biological markers for human diseases using bioanalytical methods including cytometry, ...

DNA Testing Systems Inks Agreement with DNAPrint Genomics

... in 1997 to commercialize the biogeographical, and proprietary, genetic markers developed from the work of Mark Shriver, a biogenetics professor at ... ancestry test from DNAPrint. EuroDNA 2.0 uses discoveries in genetic markers and human migration to determine an individual's proportion of ancestry in ...

Acrongenomics on Track to Acquire Molecular Vision

... rights to the use of the product in the fields of Kidney Function, Cardiac markers and Sexually Transmitted Diseases. Molecular Vision continues to develop ... device in less than 5 minutes. Work is underway on developing cardiac markers with preliminary data demonstrating that myoglobin at 100ng/ml can be ...

REMICADE(R) Becomes First Anti-TNF Biologic Therapy to Treat One Million Patients Worldwide

... in patients who have severe axial symptoms, elevated serological markers of inflammatory activity and who have responded inadequately to ... of AS in patients who have severe axial symptoms, elevated serological markers of inflammatory activity and who have responded inadequately to ...

Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio

... areas related to drug transport and distribution. In turn, these genetic markers should play a significant role in better understanding drug response in ... tests will gain wide acceptance in the market; the extent to which genetic markers (haplotypes) are predictive of clinical outcomes and drug efficacy and ...

OncoGenex Reports Second Quarter 2009 Financial Results

... tumor cells at all doses evaluated as well as evidence of reduction in tumor markers. Reductions in circulating tumor cells and tumor markers both suggest single-agent activity warranting further clinical investigation. - The Company reached an agreement with the U.S. Food and ...

iCardiac Expands Sales and Marketing Team

... to the manual evaluation of ECGs in Thorough QT studies. In addition, iCardiac provides Beyond QT, a suite of advanced ECG-based cardiac safety markers that have been accepted and used as secondary end-points by the regulators, and deliver a more accurate assessment of the cardiac safety profile of ...

ImmuneRegen BioSciences Confirms Homspera's Therapeutic Anti-Influenza Effect on Pandemic H1N1 Influenza Virus After Oral Administration

... of influenza infection, resulting in shortened duration and more rapid resolution of the hyperthermia associated with infection. Immune markers of infection remain to be assessed, but this pilot study apparently reveals that the ability of Homspera to attenuate symptoms of influenza virus ...

iCardiac Processes Volume of Data Equivalent to One Thousand Traditional Thorough QT Studies

... to the manual evaluation of ECGs in Thorough QT studies. In addition, iCardiac provides Beyond QT, a suite of advanced ECG-based cardiac safety markers that have been accepted as secondary end-points by the regulators, and deliver a more accurate assessment of the cardiac safety profile of drugs in ...

Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer

... and metabolic disease. The company's core technology is based on the discovery that circulating nanovesicles called exosomes contain unique genetic markers that can be reliably harvested from blood and urine and used diagnostically. For more information, visit www.exosomedx.com . ...

Axial Biotech Enters Partnership with the University of Utah to Utilize the Utah Population Database to Develop Personalized Diagnostic Tests for Spine Disorders

... passed on from family member to family member, the University's proprietary datasets further accelerate our ability to identify and validate genetic markers that can be used to develop diagnostic tests that allow for a more personalized and a more accurate approach to spine care." About Axial ...

DermTech and Stiefel Laboratories, Inc. to Further Evaluate EGIR(TM) Technology

... it has entered into the second part of a feasibility study using DermTech's advanced EGIR(TM) technology to help Stiefel identify specific genetic markers involved in acne. The two companies will now move forward with a proof-of-concept study to assess the use of the technology to understand the ...

iCardiac Selected by Top 10 Pharmaceutical Company

... to the manual evaluation of ECGs in Thorough QT studies. In addition, iCardiac provides Beyond QT, a suite of advanced ECG-based cardiac safety markers that have been accepted as secondary end-points by the regulators, and deliver a more accurate assessment of the cardiac safety profile of drugs in ...

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

... by Harvard and Massachusetts General Hospital researchers that circulating nanovesicles in blood and urine called exosomes contain unique genetic markers that can be reliably harvested for personalized medicine cancer diagnostics. For more information, visit www.exosomedx.com . ...

iCardiac Selected for Multiple Cardiac Safety Studies

... to the manual evaluation of ECGs in Thorough QT studies. In addition, iCardiac provides Beyond QT, a suite of advanced ECG-based cardiac safety markers that have been accepted as secondary end-points by the regulators, and deliver a more accurate assessment of the cardiac safety profile of drugs in ...

Orexigen(R) Therapeutics Presents Additional NB-302 Contrave(R) Data at American Diabetes Association (ADA) 69th Scientific Sessions

... endpoints and measures of cardiometabolic risk. "NB-302 results show that Contrave initiates and sustains weight loss and can improve predictive markers for heart disease such as waist circumference, triglycerides, HDL-cholesterol and hsCRP," said Eduardo Dunayevich, Chief Medical Officer, Orexigen ...

Clarient to Present at Noble Financial's 5th Annual Equity Conference on Tuesday, June 9th

... testing and diagnostic services available both onsite and over the web. The Company is also developing new, proprietary "companion" diagnostic markers for therapeutics in breast, prostate, lung and colon cancers, and leukemia/lymphoma. Clarient is a Safeguard Scientifics, Inc. partner company. ....

Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation

... Discovery of a significant number of biomarker candidates in academia and industry has created the need to verify and validate these markers in large-scale projects to determine the most promising for clinical development. Caprion specializes in large-scale studies of biomarkers as a ...