Lymphocytes in Biological Technology

JCI table of contents: Dec. 3, 2007

... and rheumatoid arthritis (RA) are caused when immune cells known as lymphocytes attack our own body tissues. Depletion of the B cell subset of lymphocytes using an antibody specific for the protein CD20 has been shown to be ...

R-Tech Ueno Notifies R&D Items

... type present in the vascular endothelium and the free type present in the serum. The former serves as a molecule adherent to white blood cells and lymphocytes and is involved in inflammation while the latter detoxifies amine in the living body by its amine oxidase activity. In other words, VAP-1 is a ...

Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance

... "The carbon nanotube AFM probes from C|D|I reveal the most accurate surface morphology, especially for cellular samples such as rat basophilic lymphocytes cells," states Dr. G. Y. Liu, University of California, Davis. "All observations reflect upon the superior geometry of these CCHAR probes, ...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

... nausea, vomiting, stomatitis, constipation, fatigue, fever and chills. Laboratory abnormalities included reduction in various blood cells such as lymphocytes and neutrophils comparable to what is typically observed with docetaxel monotherapy. The overall response rate according to RECIST [version ...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

... of mild fever, chills and creatinine levels (a laboratory measure for reduced kidney function) and a moderate to significant decrease in circulating lymphocytes in the blood (another laboratory measure) without any increase in infection rate compared to the docetaxel arm. The investigators concluded that the ...

Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate

... influenza virus and prevent spread throughout the cells of the respiratory tract -- and the matrix 1 or "M1" virus that stimulates cytotoxic T lymphocytes to kill cells that may already be infected. This three-pronged approach may offer an advantage over existing vaccines which contain mostly HA with ...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... system. Fragments of these proteins, such as chemoattractant complement fragment C5a, work to recruit immune system cells including neutrophils and lymphocytes to the site of inflammation. The C5a receptor is highly expressed on innate immune cells, making it an attractive target for small molecule ...

Micromet to Present Six Posters on Progress of BiTE Antibodies at the Annual Meeting of American Association for Cancer Research

... April 21, 2009, 8:00 AM in Hall B-F, poster section 12. Aigner, M. et al. (2009). Effective in vitro lysis of human melanoma cell lines by T lymphocytes redirected with a MCSP/CD3-bispecific single-chain antibody construct is independent of the expression of tumor-associated antigens gp100, MART-1, ...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

... and BAFF signaling pathways - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1340 -- Memory T lymphocytes expressing the inducible costimulator (icos) are required to maintain the secondary lymphoid tissue architecture in non human primates - ...

Medarex Reports Phase 1/2 Clinical Data of MDX-060 in Lymphoma at American Association for Cancer Research Meeting

... mild to moderate in severity. About Anti-CD30 Antibody Therapy MDX-060 is a fully human antibody that targets CD30, a marker found on activated lymphocytes that is present on malignant cells of Hodgkin's disease (HD) as well as other CD30-expressing cancers. Medarex is currently conducting an ongoing ...

National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment

... by the accumulation of functionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue, and other organs. Two types of lymphocytes are present in the blood, B cells and T cells. About 95 percent of CLL cases involve cancerous B cells. Because these B cells have a longer than ...

Revotar Reports First Positive Clinical Results From Phase IIa Study in COPD

... we were surprised to see that analysis of induced sputum prior to and after Bimosiamose treatment of 9 days showed that both relative and absolute lymphocytes count decreased significantly. In addition, sputum IL-8 was significantly decreased. The latter is supposed to correlate with the severity of the ...

Medical College of Wisconsin ties breast cancer to inflammation

... the expression of different genes in tissues and lymphocytes a form of white blood cells in lymph glands ... increases in several types of caspases in the lymphocytes from breast cancer patients. These results ... women without breast cancer. They also examined lymphocytes from the same patients and compared them ...

Th1 and Th2 Balance, Regulation, and Involvement in Disease

... immunity and allergic type responses. T lymphocytes are a major source of cytokines. These cells bear ... of cell surface molecules known as CD4 and CD8. T lymphocytes expressing CD4 are also known as helper T cells, ... grafts in experimental models, and regulatory T lymphocytes (Tr1/Treg cells) are now being implicated in ...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

... 8. Ulmer, A.J., Flad, H., Rietschel, T. and Mattern, T. (2000) Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS). Toxicology 152 (1-3):37-45 9. Spectral Diagnostics Inc. Endotoxin Activity Assay. www.spectraldx.com ...

BD IMag Human Regulatory T Lymphocyte Separation Set for Isolation of Treg Cells

... monocytes, B cells, and CD8 T cells to enrich for the CD4 T lymphocytes. Then, the CD25 + CD4 + Treg cells are isolated from the enriched CD4 T lymphocytes by positive selection. This Enrichment Set has been optimized for use with the BD IMagnet, and it contains sufficient reagents to label 10 9 PBMC. ...

Detection of Mutations in the CYP21 Gene Using the DCode System

... Samples DNA from healthy individuals and patients with 21-hydroxylase deficiency was isolated from peripheral blood lymphocytes using the salting-out method by Miller et al. 11 Polymerase Chain Reaction (PCR) For amplification of CYP21 and ...

Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis

... Materials and Methods Tumor biopsies were obtained during postoperative resection, and peripheral blood lymphocytes for controls were obtained from normal volunteers. Total RNA was isolated from cryopreserved specimens and 50-100 ng of RNA was ...

Amplification of Epstein-Barr Virus Exon C with Difficult Primers Using Eppendorf Mastercycler gradient

... gradient of 20C (48C to 68C) at a constant MgCl2 concentration of 2 mM. Template EBV DNA was extracted from B95.8 marmoset lymphocytes cell line. PCR was carried out in 50 l reactions with the following final concentration of each component: 200 M of each dNTP, ...

pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins

... interest are difficult or virtually impossible to transfect using current transfection methods. In particular, primary human cell lines and lymphocytes are best transduced using viral delivery systems. The most popular and user-friendly of these are the retroviral vectors. 4,5 Infection with ...