Lipids in Biological Technology

Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies

... is the study of nucleic acids, proteins, and lipids from the same biological sample. Very few ... and fractionation of nucleic acids, proteins, and lipids from a wide variety of cells and tissues; that ... nucleic acids; that nucleic acids, proteins, and lipids can be partitioned separately in a single step ...

The Omega-3 Industry Leader, Croda Health Care, selects Neptune Technologies' Ingredients for New Essentially Brand

... Society for the Study of Fatty Acids and lipids for optimum foetal development. Essentially ... offer enhanced potency, purity and efficacy for specific conditions. The lipids are concentrated and purified to pharmaceutical grade requirements using ...

Phosphagenics Reports Superior Pre-clinical Cholesterol Results from APA-01 and Atorvastatin Combination

... and the statin atorvastatin (Lipitor(TM)) significantly reduced serum lipids and inflammatory proteins involved in the development of atherosclerosis. ... process initially involving endothelial dysfunction and accumulation of lipids on the linings of blood vessel. Atherosclerotic lesions develop as a ...

Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria

... pulmonary liposome technology prolongs the release of amikacin in the lungs while minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micron), neutral liposomes that enable penetration of the biofilm and are highly ...

Synthetic Genomics Inc. and ExxonMobil Research and Engineering Company Sign Exclusive, Multi-Year Agreement to Develop Next Generation Biofuels Using Photosynthetic Algae

... and harvested in a process that can be expensive and time consuming. One of SGI's achievements has been in engineering algal strains that produce lipids in a continuous process that is currently more efficient and cost-effective. "This investment is an important addition to ExxonMobil's ...

NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains

... prevents spread of the virus down the respiratory tract. Finally, the structure of the HA and NA proteins and the way in which they are embedded in lipids on the surface of the VLP may activate the innate immune system providing protection against both the H1N1 and H5N1 strains," said Dr. Heaton. ...

VAP Test Demonstrates Value of Fish Oil in Reducing Heart Risk for Super Bowl Champs

... or stroke. "We are now entering a new era of cardiac risk assessment," the study stated. "Newer specialized blood tests can fractionate blood lipids into many component molecules in order to better assess which lipid subfraction may possess a greater risk for causing disease." The VAP Test, ...

The Pittsburgh Life Sciences Greenhouse Starts 2009 With Investment Momentum

... based on its proprietary "pro-lipid" technology. Pro-lipid technology stimulates the body's own skin cells to produce the full complement of skin lipids necessary to maintain the optimum barrier function of the skin. The Company's products are being developed for the OTC and Rx skin care markets. The ...

New label-free method tracks molecules and drugs in live cells

... cells," says Xie, professor of chemistry and chemical biology in Harvard's Faculty of Arts and Sciences. "We've already used the technology to map lipids in a live cell, and to measure diffusion of medications in living tissue. These are just two early examples of how SRS microscopy may impact cell ...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

... potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally active GPR119 agonist ...

Lilly to Take Charge to Earnings Related to Pending Federal and State Investigations of Past Practices

... testing. Patients who develop symptoms of hyperglycemia during treatment should undergo fasting blood glucose testing. Undesirable alterations in lipids have been observed with olanzapine use. Clinical monitoring, including baseline and follow-up lipid evaluations in patients using olanzapine, is ...

ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting

... in patients; these increases were generally mild and reversible, with no evidence of hepatic injuries. Laboratory changes, including increases in lipids (total cholesterol, LDL, HDL, triglycerides) and decreases in neutrophils and platelets, were seen in patients without association with ...

Novavax Announces Closing of $18 Million Registered Direct Offering

... (VLP) technology. The Company creates VLPs by genetically engineering three-dimensional, nanostructures, which incorporate immunologically important lipids and recombinant proteins. Novavax's VLPs resemble a virus but lack the genetic material that would cause infection. Using the Company's proprietary ...

Novavax Announces Pricing of $18 Million Financing of Common Stock and Warrants

... (VLP) technology. The Company creates VLPs by genetically engineering three-dimensional, nanostructures, which incorporate immunologically important lipids and recombinant proteins. Novavax' VLPs resemble a virus by lack the genetic material that would cause infection. Using the Company's proprietary VLP ...

90 billion tons of microbial organisms live in the deep biosphere

... to Bacteria, Archaea represent a distinct domain in the three-domain system of life. Both groups can be identified by fat-like molecules, so-called lipids that make up their cell membranes. To date, estimations of the deep biosphere biomass range from about 60 to 300 billion tons of carbon. Says Prof. ...

Novavax to Join Russell 3000 Index

... (VLP) technology. The Company creates VLPs by genetically engineering three-dimensional, nanostructures, which incorporate immunologically important lipids and recombinant proteins. Novavax' VLPs resemble a virus by lack the genetic material that would cause infection. Using the Company's proprietary ...

BRISTOL-MYERS SQUIBB SELECTS ISIS DRUG TARGETING PCSK9 AS DEVELOPMENT CANDIDATE FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE

... to drug," said Brett Monia, Ph.D., Vice President of Antisense Drug Discovery of Isis. "PCSK9 is a new and exciting target for the management of lipids both to prevent and treat cardiovascular disease. Furthermore, our antisense technology is uniquely suited to provide viable clinical drug candidates ...

Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients

... next-generation liposomal drug products for inhalation. ARIKACE is a form of the antibiotic amikacin, which is enclosed in nanocapsules of lipids called liposomes. The study evaluated the ability of the ARIKACE liposomes to pass through patient mucus (sputum) ex vivo and to penetrate the ...

Inverness Medical Innovations to Close Cholestech, HemoSense and BioStar Facilities

... by Inverness in September 2007 and manufactures and distributes the Cholestech LDX system, a point-of- care monitor of blood cholesterol and related lipids used to test patients at risk of, or suffering from, heart disease and related conditions will move to Inverness Biosite facility in San ...

Cellular construction methods emulated

... the aqueous medium. The Dutch team imitated this concept by using two types of self-aggregating compounds: surfactants and gelators. Like the lipids in natural membranes, surfactants have a hydrophilic segment and a hydrophobic segment and aggregate into structures such as membrane-like double ...

FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder

... serum total cholesterol, LDL (low density lipoprotein) cholesterol, and triglycerides were observed in clinical studies. Measurement of serum lipids should be considered during PRISTIQ treatment. -- Symptoms associated with discontinuation of PRISTIQ have been reported. Patients should be ...

MIT researcher addresses biomedical engineering challenges

... combat a variety of diseases. Anderson, Langer and graduate student Michael Goldberg have also been working on the design of chemicals similar to lipids in the body, called lipidoids that could be used to deliver drugs including siRNA to specific tissues in the body and release them in a controlled ...

Abbott Receives FDA Approval for SIMCOR(R) (Niaspan(R) / simvastatin), a Novel Combination Medicine for Comprehensive Cholesterol Management

... with diet, SIMCOR can help patients with lipid disorders reach their treatment goals by addressing more than just bad cholesterol, targeting multiple lipids with one pill. The FDA's approval was based on SIMCOR safety and efficacy trial data from more than 640 patients with mixed dyslipidemia and type ...

Neptune Technologies receives GRAS notification in the United States

... pharmaceutical market by licensing rights are ongoing. About Cholesterol Important risk factors for cardiovascular disease are abnormal levels of lipids such as triglycerides and cholesterol. Increased levels of low density lipoprotein (LDL - "bad cholesterol") and decreased levels of high density ...

Arena Pharmaceuticals Initiates Second and Third Pivotal Trials Evaluating Lorcaserin for the Treatment of Obesity

... with a 5% or greater weight reduction from baseline at week 52 will be the primary efficacy endpoint. Secondary endpoints include changes in serum lipids and HbA1c and, in the BLOOM-DM trial, other indicators of glycemic control will also be evaluated. In both of these additional studies, all patients ...

Juvaris BioTherapeutics Announces Six Scientific Presentations at Infectious Diseases Society of America (IDSA) Meeting October 6, 2007

... in 2003 to develop an immunotherapeutic product platform for the treatment of infectious diseases and cancers using lipid-DNA complexes. Cationic lipids are formulated with non-coding DNA (plasmid) to create the JuvImmune Immunostimulant, a lipid-DNA complex, which as a single product will have ...

Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases

... Vice President, Isis Pharmaceuticals. "Both ISIS 325568 and ISIS 377131 have broad and exciting therapeutic profiles that include lowering of blood lipids and body fat, in addition to significant glucose-lowering effects. These drugs have demonstrated robust effects in extremely diabetic and ...

New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition

... Update. Dallas, Tex: American Heart Association, 2007. Page e164. (2) American Heart Association. 2007 High Blood Cholesterol and Other lipids Statistical Update. Dallas, Tex: American Heart Association, 2007. Page 2. (3) IMS National Prescription Data, June 22, 2007. ...

GenVault Partnership with Genome Quebec Brings $3.3 Million Sale of Dynamic Archive Product

... age will be recruited. Data collected from participants will include: biological data obtained from blood and urine samples (DNA, blood sugar levels, lipids measurements etc), physiological measurements and their answers to a health and lifestyle questionnaire. "Placement of these systems, especially at ...

FREE FAT CELL ASSAY

... in incorporation of radioactivity into the lipid pool. Extraction of the lipids from the cells has traditionally been performed using a toluene-based ... 1 mL Hepes buffer. Results Extraction of only the lipids is crucial for the interpretation of the insulin action, and the results ...

Medical College researchers win federal grants

... serious complications. With this grant, Pritchard and Hillery will study the interactions between inflammation, HDL function, and pro-inflammatory lipids in an effort to identify downstream "partners" that team up with the sickling red cells to impair dilation of blood vessels. Their findings could ...

QBI Life Sciences snags $130,000 NIH grant

... together with fellow Madison life sciences firm GWC Technologies . QBI will contribute its PreserveX Polymeric Micelles, which extract proteins and lipids and immobilizes them in SPRi sensors, while GWC will add its SpotReady SPRi biosensor chips to analyze multiple levels of the components and their ...

The Bio-Rad Silver Stain, Rev E

... Bio-Rad Laboratories, bulletin 1200 17. Dzandu JK et al., Detection of erythrocyte membrane proteins, sialoglycoproteins, and lipids in the same polyacrylamide gel using a double-staining technique, Proc Natl Acad Sci USA 81, 17331737 (1984) 18. Dzandu JK et ....

Fractionation of Bovicola ovis Homogenates Using the Mini Whole Gel Eluter

... shown in Figure 1B, lane b. Results and Discussion Louse homogenate preparations are often rich in lipids and do not separate well on SDS-PAGE gels (Figure 1A, lane a). Individual proteins are poorly resolved and their extraction ...

EndoFree Plasmid Kits

... which can lead to misinterpretation of transfection results. These responses include induced synthesis of proteins and lipids such as IL-1 and prostaglandin. Overall, endotoxins represent a non-controllable variable in transfection experiment ...

Effectene Transfection Reagent

... efficiencies. The enhancer first condenses the DNA molecules and Effectene Reagent subsequently coats them with cationic lipids (see figure " Model of Effectene Principle "), providing a particularly efficient way of transferring DNA into eukaryotic cells. ...

Luminol-enhanced Assay for Superoxide Anion (O2 face="Symbol" )

... of superoxide anion. Superoxide anion is subsequently released into the extracellular environment where it can oxidize luminol and available lipids and proteins. This oxidation results in chemiluminescence, a release of photons (light), which can be measured by a luminometer. Figure 1 illustrates ...