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libraries in Biological Technology

Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells

... LentiPlex(TM) Pooled Human and Murine shRNA libraries ( http://www.sigma-aldrich.com/lentiplex ). ... (TRC), the MISSION LentiPlex Pooled shRNA libraries enable rapid, genome-wide RNAi screening at the ... commercial source for access to TRC shRNA libraries in lentiviral format. The MISSION ...

Sigma-Aldrich Signs Agreement With CPC Scientific for the Distribution of PEPscreen(R) Custom Peptide Libraries

... offer Sigma-Aldrich's PEPscreen(R) custom peptide libraries ( http://www.sigma.com/pepscreen ) to ... which are ideal for producing custom peptide libraries applicable to peptide based drug discovery. ... "The addition of PEPscreen custom peptide libraries to our portfolio benefits our customers by ...

Sigma-Aldrich Joins Phase 2 of The RNAi Consortium to Validate shRNA Libraries

... and utilize its collection of validated shRNA libraries to develop new and improved RNAi screening strategies. Design and development of TRC libraries is led by the Broad Institute of MIT and Harvard. ... for researchers to access TRC and TRCII shRNA libraries in the plasmid DNA and lentiviral formats. All of ...

Open Biosystems' Open Access RNAi Program Adopted by University of Copenhagen and University of Queensland

... Biosystems' lentiviral shRNAmir human and mouse libraries developed in collaboration with Dr. Greg Hannon ... research programs." "The lentiviral shRNAmir libraries are important tools for our high throughput ... include shRNAmir lentiviral and retroviral libraries targeting the entire human and mouse genomes, the ...

Open Biosystems' Open Access RNAi Program Adopted by Harvard Medical School and University of North Carolina

... include shRNAmir lentiviral and retroviral libraries targeting the entire human and mouse genomes, The RNAi Consortium human and mouse lentiviral shRNA libraries and RNAi libraries targeting Drosophila, C. elegans and Arabidopsis ...

Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services

... leads to a selection of compounds that can be compiled into target libraries based upon the identified SARs and molecular designs. Target compounds ... to delivery of custom packaged chemical building blocks and screening libraries ready for testing. "ChemNavigator is well-recognized for its fast ...

METTLER TOLEDO Introduces an Affordable Reaction Block for Solid Phase Peptide Synthesis (SPPS)

... Columbia, MD (PRWEB) June 21, 2009 -- Peptide libraries are widely investigated and routinely screened for their drug-like ... for solid phase peptide synthesis enabling the synthesis of arrays and libraries from 6 to 96 peptides and is a viable alternative to traditional ...

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

... system - by enabling kinetic characterization and screening of fragment libraries that include compounds in the 150 to 300 dalton range. "Fragment-based ... our new analysis software capabilities, enable rapid screening of fragment libraries in a microplate format." ForteBio's Octet biosensors are configured ...

HiveMind Marketing to Enhance Search Results for Chemistry Solutions Leader ChemBridge

... Corp., a leader in discovery chemistry services and screening compound libraries for pharma, biotech and research institutions. ChemBridge will retain ... Corp., a leader in discovery chemistry services and screening compound libraries for pharma, biotech and research institutions. ChemBridge will retain ...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... the development of its proposed SURVEYOR Endonuclease Adaptor-ligated libraries (SEAL) technology. A cost-effective and high throughput enabling ... About SEAL SURVEYOR Endonuclease Adaptor-ligated libraries (SEAL) is a cost-effective and high throughput enabling technology for ...

Sigma-Aldrich Welcomes Memorial Sloan-Kettering Cancer Center to the RNAi Partnership Program

... for which we are fully equipped. Access to Sigma-Aldrich's MISSION shRNA libraries will greatly enhance our current gene scanning capabilities and will ... followed by licensing agreements with MIT to make and sell the shRNA libraries developed by TRC and, subsequently, the introduction of Sigma-Aldrich's ...

Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008

... facilitates siRNA therapeutic development. "Construction of Complex RNAi libraries for Positive and Negative Phenotypic Selection of Target Genes," a poster ... development of Quark's BiFAR target discovery platform, these complex libraries can provide a high throughput tool to help identify targets for siRNA ...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... announced that it is developing SURVEYOR Endonuclease Adaptor-ligated libraries (SEAL). A cost-effective and high throughput enabling technology for whole ... current methods." About SEAL SURVEYOR Endonuclease Adaptor-ligated libraries (SEAL) is a cost-effective and high throughput enabling technology for ...

SimBioSys Utilizes Revolutionary Hardware Technology to Open New Frontiers in Molecular Modeling

... processor configuration. With this improvement in performance, much larger libraries of chemical compounds can be screened in a comparable time, or ... Virtual screening is the evaluation of very large libraries of compounds using algorithms and computer programs to filter massive ...

Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library

... technology for the synthesis of diverse genetic libraries. Diverse genetic libraries are essential in the screening for new and improved therapeutic proteins ... Sloning uses Slonomics™ to synthesize customised mutant libraries for its customers from the biopharmaceutical, industrial biotech, ...

Viventia Biotech to Explore Strategic Alternatives - Reports Positive Pivotal Phase III Interim Efficacy Data

... Fusogenics(TM) platform generates fully human monoclonal antibody libraries by leveraging the natural immune response of cancer patients and ... Combining both binding and functionality, Viventia's Fusogenic(TM) libraries are designed for rapid, high-content screening, focused on the ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

... mechanism. In addition, more potent structures may be possible, so the cyclic peptides' known structure can be used as a starting point for more libraries which may produce even more effective versions. Lindquist also says the technique is not limited to just yeast or just Parkinson's disease. ...

EUCODIS Bioscience Signs Research Agreement With Genencor

... of commercial enzymes and for industrial partners - our technology of in vivo recombination has reliably shown its capacity to generate high-quality libraries of active enzymes with significant improvement of the desired activities in a single cycle of recombination." About EUCODIS Bioscience ...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... into a wider range of tests. Dr. Caroline Shamu, director of the ICCB-Longwood Screening Facility, which provides high-throughput screens of RNAi libraries for Harvard Medical School researchers, said, "We are looking forward to screening the MISSION esiRNA library at ICCB-Longwood." esiRNA are ...

ChemAxon Launches Marvin and JChem Version 5.2; Web Services, native .NET API, Homology Groups, 3D Alignment and Structural Frameworks

... homology groups and repeating units. Our Markush project works toward robust support for Chemical IP, including identification of overlap of Markush libraries without enumeration. Developments of core search features include a new chemical hashed fingerprint to improve search performance and added ...

Zinc oxide gives green shine to new photoconductors

... for their materials to be used for solar energy, Stupp says, they must build entire "macroscopic libraries" of these books. And, like the books, the libraries must be highly ordered. "Right now our library is a little disordered, but we are working on optimizing our materials for use in solar energy ...

New Brain Fitness Survey Reinforces Importance of Brain Awareness Week

... (5%) -   "Lack of information and products available to people - perhaps a drive to get the products and information in public libraries would help." Note: The full results and analysis of the complete survey will be included in the upcoming SharpBrains market report, The ...

Pharmexa and Affitech to Combine Operations to Create a New Antibody Therapeutics Company

... Martin Welschof, CEO of Affitech, also commented: "Affitech has developed a fully integrated antibody discovery platform consisting of human antibody libraries with high functionality, based on phagemid display technology plus several screening technologies with high degree of versatility. Through ...

Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

... in stem cell research and drug discovery technologies. In September 2008, Burnham was awarded a prestigious six-year , $98 million Molecular libraries Probe Production Centers Network (MLPCN) grant from the National Institutes of Health, and is one of four comprehensive small-molecule screening and ...

SENOMYX ANNOUNCES THIRD QUARTER 2008 FINANCIAL RESULTS

... is the primary receptor responsible for human salt taste. Senomyx developed new screening assays based on SNMX-29, and screening of the Company's libraries is ongoing. The recent discovery of sodium chloride (table salt) enhancers that are active in the assays is a significant step forward. In ...

RainDance Technologies Delivers RDT 1000, Sequence Enrichment Solution to The Genome Center at Washington University School of Medicine in St. Louis

... RainDance's Early Access Partner program, RainDance will provide its new RDT 1000 and expert training to the GC, along with customized PCR primer libraries to selectively amplify loci of interest for their research initiatives. Elaine Mardis, Ph.D., Co-Director of The Genome Center, said GC researchers ...

RainDance Technologies Delivers RDT 1000, Sequence Enrichment Solution to JCVI

... delivers its RDT 1000 and expert training to selected premier organizations in genomic research. RainDance will also provide customized PCR primer libraries designed to selectively amplify loci of interest for research initiatives at JCVI. "The program provides an opportunity for some of the world's ...

Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline

... early-stage drug discovery by bringing together specialists from around the world for the systematic exploration of vast, private molecular libraries in search of new TB treatments. Headquartered in Seattle, The Lilly TB Drug Discovery Initiative includes representatives of government agencies, ...

The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline

... early-stage drug discovery by bringing together specialists from around the world for the systematic exploration of vast, private molecular libraries in search of new TB treatments. Headquartered in Seattle, The Lilly TB Drug Discovery Initiative includes representatives of government agencies, ...

David Hsia, Ph.D. Joins Kinex Pharmaceuticals' Board of Directors

... About Kinex Pharmaceuticals Kinex is a drug discovery and development company that is focused on the use of its platform technology and compound libraries to identify and develop peptide-competitive kinase inhibitors. The Company's clinical compound KX2-391 is a selective Src kinase inhibitor that is ...

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

... intellectual property position, will continue to advance the development of its MASP-2 program. Affitech will apply its expansive human antibody libraries and proprietary antibody discovery and screening technologies, including its AffiScreen(TM) platform and engineering methods, to generate fully ...

Transgenomic Reports Second Quarter 2008 Results

... businesses. One example of our novel research efforts is our recently announced SEAL technology, or SURVEYOR(R) Endonuclease Adaptor-ligated libraries (SEAL). This cost-effective and high-throughput enabling technology for whole genome analysis evolved from our highly sensitive SURVEYOR Nuclease ...

Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinson's Research Award for Work on PD-implicated Protein LRRK2

... Scientific Advisory Board. "The fragment-based screening method has the potential to identify and develop novel compounds not present in the libraries of large pharmaceutical companies. It also is more likely to identify small ligands with a better chance of good penetration into the brain, making ...

Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery

... that can often provide valuable insight into complex disease models. Pharmacopeia's screening platform is based on its ECLiPS (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from ...

GEN Reports on Novel Hit-to-Lead Drug Discovery Strategies

... can often provide valuable insight into complex disease models. Pharmacopeia's screening platform is based on its ECLiPS(R) (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from ...

Nuevolution Announces Research and Development Collaboration with Merck & Co. Inc.

... fragment-based drug screening at an unprecedented scale. Nuevolution will screen multiple multi-million member diverse fragment based screening libraries for hit identification. Through the design, synthesis and screening of target focused Chemetics(R) follow-up libraries, the parties will also work ...

Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals

... and hit-to-lead optimization by exploration of ultra large chemistry space through the screening of multiple fragment-based small molecule libraries of more than 100 million compounds per library. The validated targets have been identified through Lexicon's Genome5000TM program where the company ...

Canadian Centre for DNA Barcoding to Participate in Microchip Biotechnologies Early Access Program for Microchip-Based DNA Sample Preparation and Cycle Sequencing

... CCDB is moving towards the activation of the International Barcode of Life Project (iBOL). This 5 year/ $150M project aims at building DNA barcode libraries for 5M specimens from 0.5M socio-economically important species. More details can be found on: http://www.dnabarcoding.ca, ....

NIH collaborates with EPA to improve the safety testing of chemicals

... for the testing of thousands to hundreds of thousands of chemicals a day to determine their possible toxic effect. NCGC is part of a larger Molecular libraries Imaging Program within the NIH Roadmap for Medical Research. It was designed to advance research on molecules from which most medicines marketed ...

Xenome Receives a Syndicated US$10 Million Equity Investment from Queensland BioCapital Fund, Amylin Pharmaceuticals and Innovis Investment Partners

... has generated a unique expertise in peptide chemistry to translate the evolutionary advantages inherent in venom peptides into highly bioactive libraries of molecules that are of interest to global biotechnology and pharmaceutical companies. http://www.xenome.com About QBF Queensland BioCapital ...
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