Interfering in Biological Technology

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

... represent a unique approach for truly realizing the advantages of small interfering RNA (siRNA)-based drugs to treat various critical human diseases. ... role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing ...

Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

... represent a unique approach for truly realizing the advantages of small interfering RNA (siRNA)-based drugs to treat various critical human diseases. ... role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing ...

Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent

... 10/633,630, "Interfering RNA Molecules," which covers stabilized, small interfering RNA (siRNA) molecules with defined positional modifications. The claims ... for patent application No. 2003260370 entitled "Further novel forms of interfering RNA molecules." The European equivalent of the US and Australian patent ...

M. D. Anderson Automates Laboratory Workflow with Stone Bond Technologies : EE-LIMS™ from Stone Bond Technologies Will Document Activities within the Laboratory Workflow at the siRNA Facility, Increasing Throughput, While Reducing Risks

... The newly established Small interfering Ribonucleic Acid (siRNA) Facility at M. D. Anderson Cancer Center has been ... As one of the newest fields in the study of nucleic acids, small interfering RNA has shown considerable potential in laboratory studies to change how ...

Intradigm Licenses Key Next Generation RNA Interference (RNAi) Intellectual Property From University of Massachusetts Medical School

... in Emerging RNAi Industry through Addition of Important and Novel Small interfering RNA (siRNA) Structural IP PALO ALTO, Calif., April 9, 2008 /PRNewswire/ ... (IP) covering certain efficacy-enhancing structural elements of small interfering RNA (siRNA) from the University of Massachusetts Medical School. The ...

Sirnaomics Received Multiple Government Fundings For Its Multi-Targeted siRNA Therapeutics Programs

... represent the unique approach for truly realizing advantages of small interfering RNA (siRNA)-based drugs, to treat various critical human diseases. ... role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing ...

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

... and Asthma -- 20050008617 Compositions and Methods for Delivery of Short interfering RNA and Short Hairpin RNA -- WO2004028471 Influenza Therapeutic -- ... that can be used to turn off the production of a protein by using small interfering RNAs (siRNAs). siRNAs are double-stranded RNA molecules that are able to ...

Team demos safety of RNA therapy

... he said. Researchers were concerned that a second type of RNA, small interfering RNA (siRNA), would induce the same toxicity. In the current study, the ... siRNA to achieve therapeutically valuable gene silencing, without interfering with the cell's endogenous microRNA, said David Bumcrot, a director of ...

Unexpectedly long-range effects in advanced magnetic devices

... memory or sensor devices will find interesting new scientific issues for investigation in optimizing how closely they can be packed without interfering with each other. ...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

... production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. About Helix BioPharma Corp. Helix BioPharma Corp. is a biopharmaceutical company specializing in ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... tunicate, Ecteinascidia turbinate ("sea squirt"). The compound is now produced synthetically. Trabectedin binds to the minor groove of DNA, interfering with cell division and genetic transcription processes and DNA repair machinery. Trabectedin is currently in Phase 3 development in ovarian cancer ...

PCI Biotech-led Consortium Awarded EUR1.1 m Eurostars Grant for siRNA

... comprises three companies PCI Biotech, SpectraCure and siRNAsense and the project is entitled "Photochemical Internalisation for delivery of short interfering RNA (siRNA) - towards safe and specific cancer therapy". Competition was extremely fierce. All projects were assessed by carefully selected ...

Intradigm Receives Notice of Allowance for Key RNA Interference (RNAi) Patent Covering Potent siRNA Sequence

... States Patent and Trademark Office (USPTO) has issued the company a notice of allowance for a patent covering various aspects of a potent small interfering RNA (siRNA) sequence. The allowed subject matter covers a specific double-stranded siRNA sequence that is directed against the angiogenic pathway ...

Synvista Therapeutics Announces Progress in Phase 2 Clinical Trial Program for Alagebrium

... could provide proof of efficacy and a partial basis for drug approval." About Alagebrium Alagebrium is Synvista's clinical candidate for interfering with A.G.E.-related sclerosis and fibrosis of the heart, kidney and other tissues leading to heart failure, diabetic nephropathy and other disorders. ...

CJP Declares the Dates of 3rd Global Jatropha Hi-Tech Agricultural Training Programme

... our dependence on fossil fuel Jatropha can bring significant environmental benefits. It can replace jet fuel and diesel from petroleum without interfering with food crops or leading to the clearing of forests. The good thing about Jatropha is that we're producing a tree shrub that lives for a long time ...

Osteotech's Next Generation Grafting Material, MagniFuse(TM) Bone Graft, a Breakthrough in Bone Regeneration; MagniFuse(TM) Bone Graft seeks to redefine the standard of care in the U.S. bone graft substitute market estimated to be in excess of $1.2 billio

... from a biodegradable suture material and is designed for effective cellular in-growth and complete resorption within three to six months, while not interfering with bone regeneration. The polymer mesh provides a controlled environment for proximate allograft interaction eliminating issues with graft site ...

Altogen Biosystems Launches New Nanoparticle-based In Vivo Transfection Reagent

... introduce DNA and RNA molecules into cells and tissues. This technique makes it possible to cross the cellular barriers and deliver a gene or a small interfering RNA (siRNA) into the cells for research or therapeutic purposes. The company has previously developed lipid- and polymer-based in vivo transfection ...

Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.

... currently working to harness RNAi for use against HIV and other viruses and they have developed novel strategies for cell-specific targeting of small interfering RNAs to confer in vivo protection from viral disease. In related work, Dr. Lieberman's laboratory is also working in the emerging field of miRNAs by ...

Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System

... worldwide since 2001 and is reinvesting most of its revenues in research and development. Transfection consists in introducing a gene or a small interfering RNA into cells. This technique makes it possible to cross the cellular barriers and deliver such biomolecules into the cells for research or ...

Sun Pharmaceutical Sends Second Letter to Taro Pharmaceutical Regarding Taro's Irish Subsidiary

... turn -- we have no alternative means of alerting other shareholders to the unseemly circumstances of the proposed sale. We have no intention of interfering with Taro's business. Indeed, this would be contrary to our own interests. We do, however, seek full disclosure of the facts relating to the proposed ...

Senesco Technologies Reports Third Quarter Fiscal 2008 Financial Results

... important industry conferences, the Keystone Islet and Beta Cell Symposium, and the Upper Midwest Islet Club's Annual Meeting. Using a small interfering RNA (siRNA) against Senesco's Factor 5A technology, the data showed what Senesco believes to be a variety of promising results regarding ...

Synvista Therapeutics Announces Initiation of the BREAK Study of Alagebrium for Diastolic Heart Failure

... forward to seeing the results of the BREAK study before the end of next year." About Alagebrium Alagebrium is Synvista's clinical candidate for interfering with A.G.E.- related sclerosis and fibrosis of the heart, kidney and other tissues leading to heart failure, diabetic nephropathy and other ....

OPKO Health Announces Issuance of U.S. Patent Covering the Use and Administration of Certain Anti-VEGF siRNA's, Including Its Phase III Compound Bevasiranib

... it has been issued a key patent by the United States Patent and Trademark Office (USPTO) for methods related to the use and administration of small interfering RNAs (siRNAs) for targeting vascular endothelial growth factor (VEGF), including OPKO's siRNA drug candidate, bevasiranib, which is currently in a ...

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

... powerful tool for biomedical research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi ...

Cellular construction methods emulated

... new angle. As they report in the journal Angewandte Chemie, they allow surfactants and gelators to form aggregates. These aggregates coexist without interfering with each other and thus make versatile, highly complex structures with separate compartments. Cells contain various components, such as channels, ...

MIT researcher addresses biomedical engineering challenges

... Such new polymers, Langer says, might eventually lead to new treatments for some kinds of cancer. And they may also enable the delivery of small interfering RNA segments (siRNAs), whose discovery led to a Nobel Prize in 2006. These may be used to combat a variety of diseases. Anderson, Langer and ...

New research shows that iPods do not interfere with cardiac pacemakers

... 10 mm from an iPod. The peak magnetic field strength was 0.2 millionths of a Tesla, a value hundreds of times lower than the levels capable of interfering with a pacemaker. In addition, Bassens team attempted to detect any voltages these fields might produce within the protective "can" of a ....

Faster X-ray interferometers due to single-photon interference

... which made their use in practice more difficult, could now be increased by a factor of 100 by exploiting the temporal correlation of singly interfering X-ray photons. X-ray interferometers can measure lengths in the mm range with sub-nm resolution, whereby the almost perfect crystal grid of ...

Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers

... as well as with newer targeted therapies in preclinical experimental tumors models. Brostallicin binds covalently to DNA within the DNA minor groove interfering with DNA division and leading to tumor cell death. More than 200 patients have been treated with brostallicin in single-agent and combination ....

World's most complex silicon phased-array chip developed at UC-San Diego

... nearby satellites. And with amplitude and phase control, you can synthesize deep nulls in the antenna pattern so as to greatly reduce the effect of interfering signals from neighboring transmitters. ...

Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers

... Potential to halt cancer cell growth without interfering with insulin may address limitations of current IGF inhibitors SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. ...

Mechanism for the in-vivo transport of siRNA

... in the attempt to transfer the strategy used by Mello and Fire to vertebrates. In particular the administration of small RNAs, known as siRNAs (small interfering RNAs), in animals proved difficult. Although it was possible to administer siRNAs successfully by using various methods such as high-pressure ...

Mirus Bio Awarded Grants & Contracts of Over $5 Million

... in nucleic acid delivery technologies." Dynamic PolyConjugates(TM) (DPC) are an enabling platform for the targeted, systemic delivery of small interfering RNA (siRNA), a molecule that triggers a natural cellular process called RNA interference. By selectively silencing the expression of a gene, one can ...

RNA Interference and Gene Silencing: History and Overview

... siRNAs - Small interfering RNAs. Current models of PTGS indicate that these ... is digested into 21-23 nucleotide small interfering RNAs (siRNAs), which have also been ... PD. (2001) ATP requirements and small interfering RNA structure in the RNA interference ...

siRNA transfection optimization with the Agilent 2100 bioanalyzer

... requiring the transfection of small interfering RNA (siRNA) into a cell, the presence of having ... dsRNA into double stranded small interfering RNA (siRNA). In vitro studies in Drosophila ... Materials and Methods Short interfering RNA preparation Cy5 labeled ...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

... Recent developments in RNA interference (RNAi) and small interfering RNA (siRNA) techniques for specifically modulating gene expression in a ... 2333–2340 (2003). 5. Luo, B. et al. Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc. Natl. Acad. ...

More siRNA Vectors for RNA Interference

... Small interfering RNAs (siRNAs) are short, double-stranded RNA molecules that ... Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296 , 550-553. ...

Optimize Transfection of siRNAs for RNAi

... is Critical The ability of small interfering RNAs (siRNAs) to silence gene expression is proving to be ... of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Science 114 : 45574565. 4. ...

Get the miRNA OutPlant Applications

... Quantitative recovery of small RNA such as small interfering RNA (siRNA) and microRNA (miRNA) requires optimized ... compounds can cross-link with RNA, potentially interfering with quantitation and downstream applications such as ...