Innate in Biological Technology

Inimex Pharmaceuticals begins First Clinical Study of an Innate Defense Regulator

... is pleased to announce that its novel innate Defense Regulator (IDR) IMX942 was administered ... is the first of a new class of drugs known as innate Defense Regulators, which modulate innate defenses to improve survival, reduce bacterial ...

Implicit Licenses Clinical Stage Antibody Program From Lilly

... of human CD14, an essential component of the innate inflammatory response to bacterial infection. CD14 triggers activation of the innate immune response to bacterial components ... (TLR) pathway. Lung inflammation in response to innate immune activation through the TLR pathway is a ...

Opsona Therapeutics Closes EUR18M Funding

... by targeting inflammatory diseases through the innate immune system, with our ultimate aim being to ... and small molecule products which modulate the innate immune system, which is the key trigger in ... technology and approaches towards the clinic. The innate immune system represents a new frontier in ...

CorMatrix(R) Announces FDA 510(k) for Novel Biomaterial Implant for Intracardiac Repair

... biomaterial technologies that harness the body's innate ability to repair damaged cardiovascular tissue, ... migrate and integrate, stimulating the body's innate wound-healing mechanisms to repair tissue at the ... biomaterial devices that harness the body's innate ability to repair damaged cardiovascular ...

Oncolytics Biotech Inc. Announces Journal of Immunology Publication on Reovirus Activation of Dendritic Cells

... Human Dendritic Cells to Promote innate Antitumor Immunity." The researchers studied ... cells (DC), key regulators of both innate and adaptive immune responses. The data ... activates human DC, which in turn stimulate innate killing of cancer cells by natural killer (NK) ...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

... several patents. Dr. Stahl's laboratory investigates the role of the innate immune system in mediating inflammation, tissue injury and organ failure ... His research findings have changed the way scientists think about the innate immune system in disease. About Catalyst Biosciences Catalyst ...

Oncolytics Biotech Inc. Announces 2008 Second Quarter Results

... reovirus to activate human dendritic cells ("DC"), key regulators of both innate and adaptive immune responses. The data demonstrated that reovirus directly activates human DC, which in turn stimulate innate killing of cancer cells by natural killer ("NK") and T cells, suggesting a ...

New strategies against bird flu

... in multiple lung injuries and directly links oxidative stress to innate immunity. They also report for the first time a common molecular disease ... as danger-signals by the receptor TLR4. Subsequently, the bodys innate immune system is activated. This defense machinery in turn leads to a ...

A single VSOP can do a 'proton' magic!

... finding may help to design new medications for enhancing the activities of innate immunity. They report this work in Proceeding National Academy of ... finding may help to design new medications for promoting activities of innate immunity or prevention of abnormal state of immunity such as asthma", said ...

MacroChem Announces Michael Zasloff, M.D., Ph.D. Joins Company's Scientific Advisory Board

... laboratory to patient care. Dr. Zasloff has been a pioneer in the field of innate immunity. His studies have helped elucidate the pathophysiology of chronic ... the recipient of numerous awards. His current studies focus on the role of innate immunity in the setting of human small intestinal transplantation, and the ...

MIT: Leveraging learning for artificial respiration

... CAMBRIDGE, MA- MIT researchers have found that the body's innate ability to adapt to recurring stimuli could be leveraged to design more ... patients on mechanical ventilation. Nonassociative learning, or our innate ability to adapt to recurring stimuli, is the focus of work to be ...

Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference

... Kornman will be discussing multiple ways in which genetic variations in innate immunity may influence drug responses, and be relevant to drug ... of rheumatoid arthritis. "Because of the critical role played by innate immunity in so many diseases, the potential for genetic variation to ...

MIT: Leveraging learning for artificial respiration

... CAMBRIDGE, MA- MIT researchers have found that the body's innate ability to adapt to recurring stimuli could be leveraged to design more ... patients on mechanical ventilation. Nonassociative learning, or our innate ability to adapt to recurring stimuli, is the focus of work to be ...

Junying Yu, Leading Stem Cell Researcher, Joins Cellular Dynamics International

... cells additionally enable the creation of stem cells from any individual. However in the original method, because the inserted genes are not an innate part of the cell's DNA and are integrated directly into the genome via a viral vector, concerns have arisen over the potential risks associated with ...

Cequent Names F. Stephen Laroux, Ph.D., Director, Immunology and Inflammatory Diseases

... completed a post-doctoral fellowship at Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School where he conducted research focused on innate immune responses to bacteria as well as the role of the immune system in chronic disease. Prior to his tenure at BIDMC, Dr. Laroux conducted research ...

Celsense, Inc Receives NIH Grant to Translate Cell Imaging Technology for Clinical Use

... data from pre-clinical studies using human cells show that the Cell Sense reagent is highly biocompatible inside cells and does not affect their innate function. A clinical-grade version of the Cell Sense reagent has been formulated by Celsense, Inc. and is currently being subjected to mandatory in ...

Roche Venture Fund, Enterprise Ireland Commit EUR3.3 M to Opsona Series B Financing

... "Opsona's scientific founder, Professor Luke O'Neill of Trinity College Dublin , is world renowned for his expertise in Toll-like receptors and innate immunity." Commenting on today's announcement John O'Dea, Head of Lifesciences in the High Potential Start Up department in Enterprise Ireland ...

GenomeQuest, Inc. Announces Digital Gene Expression Solution Within Its Sequence Data Management Platform

... an integrated gene viewer, drill downs on individual alignments, and clickable, queryable gene and annotation databases. But they also get the innate ability to use and share previous experiments as the annotation for future experiments." The Digital Gene Expression Workflow is fully ...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... C5a, work to recruit immune system cells including neutrophils and lymphocytes to the site of inflammation. The C5a receptor is highly expressed on innate immune cells, making it an attractive target for small molecule therapeutics. Given architectural similarities between the C5a receptor and ...

NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains

... tract. Finally, the structure of the HA and NA proteins and the way in which they are embedded in lipids on the surface of the VLP may activate the innate immune system providing protection against both the H1N1 and H5N1 strains," said Dr. Heaton. Although cross protection against influenza ...

Orcrist Bio Inc. Receives Approval from European Competent Authority to Initiate its Planned Phase I, Open-label, Single-ascending-dose, Safety Study of HYC750

... be harvested and applied toward treating chemotherapy-related blood cell depletion. Orcrist is actively looking to add to its pipeline exploring the innate properties of HYC750 and its effects on stem cells, as well as through in-licensing opportunities of other products with clear market potential. ORC ...

TechniKrom's Biopharmaceutical Equipment Operations to be Integrated With Asahi Kasei Medical

... by providing the biopharmaceutical industry with an expanded, integrated toolset to both lower the cost of drug manufacturing and achieve the highest innate drug product quality. "In addition to our existing products and services that we will continue to offer, we are extremely excited about the lineup of ...

Orcrist Bio Inc. Files with European Competent Authority for a Phase I, Open-label, Single-ascending-dose, Safety Study of HYC750

... and applied toward treating chemotherapy-related white blood cell depletion. Orcrist is actively looking to add to its pipeline exploring the innate properties of HYC750 and its effects on stem cells, as well as through in-licensing opportunities of other products with clear market potential. ORC ...

Novavax and Vivalis Sign a Research License Agreement to Use the EB66(R) Cell Line for the Production of Virus Like Particle Based Vaccines

... Plough or Virbac and has already been licensed to 4 companies for the production of proteins including Sanofi-Aventis, CSL limited and innate Pharma. With a portfolio of 23 licenses (10 research licenses and 13 commercial licenses), the EB66(R) cell line is becoming a new standard cell ...

Gene against bacterial attack unravelled

... Humans have an innate defence system against deadly bacteria. However, how the step from gene to anti-bacterial effect occurs in the body is not yet known. To date, B. ...

Tengion to Present at the Piper Jaffray 20th Annual Healthcare Conference

... uses biocompatible materials and a patient's own (autologous) cells to create neo-organs or neo-tissues that are designed to catalyze the body's innate ability to regenerate. Tengion's product candidates may ultimately address the most critical problems facing organ and tissue failure patients, ...

Tengion Announces Second Closing of Series C Financing

... biocompatible materials and a patient's own (autologous) cells to create a functional neo-organ or neo-tissue that is designed to catalyze the body's innate ability to regenerate. Tengion's product candidates may ultimately address the most critical problems facing organ and tissue failure patients, ...

Frost & Sullivan Presents CorMatrix Cardiovascular Inc. with 2008 Healthcare Innovation Award for the Treatment of Cardiovascular Disease

... held company based in Atlanta, Georgia, is dedicated to developing and delivering innovative biomaterial devices that harness the body's own innate ability to regenerate damaged heart tissue. For more information visit http://www.cormatrix.com . ...

CorMatrix Announces Pre-Clinical Data Suggesting Next Generation ECM Technology(TM) Can Improve Cardiac Function

... held company based in Atlanta, Georgia, is dedicated to developing and delivering innovative biomaterial devices that harness the body's own innate ability to regenerate damaged heart tissue. For more information visit http://www.cormatrix.com . ...

Japanese Cancer Association and Debiopharm Honour Japanese Research

... kinase called the apoptosis signal-regulating kinase 1 (ASK1). ASK1 controls cellular responses to stress and therefore plays a key role in cancer, innate immunity and wound-induced inflammation. The research work conducted by Professor Mano, from the Functional Genomics Division at Jichi Medical ...

DermTech and Rady Children's Hospital-San Diego, Initiate Study to Understand Effects of Vitamin D as a Treatment for Atopic Dermatitis in Children and Young Adults

... of life and there are limited therapeutic options. In "normal skin", anti-microbial peptides (AMP) such as cathelicidin (hCAP18/LL37) help regulate innate immunity by directly killing microbes including Gram-positive and Gram-negative bacteria, as well as fungi and certain viruses. Patients with atopic ...

CorMatrix Cardiovascular to Present Data on Its Next Generation ECM Technology(TM) at Annual Transcatheter Cardiovascular Therapeutics (TCT) Conference in Washington, D.C.

... held company based in Atlanta, Georgia, is dedicated to developing and delivering innovative biomaterial devices that harness the body's own innate ability to regenerate damaged heart tissue. For more information visit http://www.cormatrix.com . ...

UTSA/UTHSCSA publish results on bio-threat agent

... mortality rate. "We have found that mast cells, historically associated with allergic conditions and asthma, may also be involved in priming innate and adaptive immunity against tularemia," said Bernard Arulanandam, UTSA College of Sciences immunologist and associate professor of biology. "Our ...

UTSA/UTHSCSA publish results on bio-threat agent

... mortality rate. "We have found that mast cells, historically associated with allergic conditions and asthma, may also be involved in priming innate and adaptive immunity against tularemia," said Bernard Arulanandam, UTSA College of Sciences immunologist and associate professor of biology. "Our ...

Pittsburgh Region Middle School Students Participate in Hands-on Tissue Engineering Summer Camp

... revolutionary technologies that offer incredible hope to people with compromised tissue function. The challenge for is to help humans tap into their innate ability to regenerate damaged, diseased or compromised body parts -- Much like the Starfish and salamander! This requires a team approach and the ...

UTSA/UTHSCSA publish results on bio-threat agent

... mortality rate. "We have found that mast cells, historically associated with allergic conditions and asthma, may also be involved in priming innate and adaptive immunity against tularemia," said Bernard Arulanandam, UTSA College of Sciences immunologist and associate professor of biology. "Our ...

BioMS Medical Provides Update On Pipeline Products

... and applied toward treating chemotherapy-related white blood cell depletion. Orcrist is actively looking to add to its pipeline exploring the innate properties of HYC750 and its effects on stem cells, as well as through in-licensing opportunities of other products with clear market potential. ...

MedImmune Fortifies Strategic Scientific Portfolio Management and International Leadership With New Executive Appointments

... seek to build out the organization globally," said David M. Mott, chief executive officer and president. "Jacqui, Lorin, Beth, E-J and Reg have the innate talent, industry experience and drive for results that will contribute to MedImmune's continued leadership in biologics." Based at MedImmune's ...

Peregrine Pharmaceuticals Announces Four Upcoming Presentations at the American Association for Cancer Research 2008 Annual Meeting

... for Monday, April 14, 2008 at 2:10 pm. -- "Antibody targeting of phosphatidylserine produces a cytokine microenvironment that enhances innate anti-tumor immune responses" (Abstract #4079, Immunoconjugates, Peptides, and Protein Therapeutics Session) - Poster session scheduled for ...

5AM Ventures Announces Expansion of Investment Team: Names Richard Ulevitch Venture Partner; Promotes Kevin Forrest and Andrew McMillan to Principal

... For nearly three decades, Dr. Ulevitch's pioneering research has contributed to the identification and understanding of the basic mechanisms of human innate immune response to infection. His discoveries have and are currently being translated into drug development in the areas of acute and chronic ...