Glycosylation in Biological Technology

GlycoVaxyn AG Raises CHF 25 Million in Financing Led by Edmond de Rothschild Investment Partners

... has built a broad portfolio of novel conjugate vaccines against common severe bacterial infections based on its unique, proprietary in-vivo glycosylation platform. With this platform, the company can develop and produce immunogenic glycoproteins in a simplified biological process that circumvents many ...

Sigma-Aldrich Launches Breakthrough Genome-Editing Tools

... of new drug compounds. For biopharmaceutical manufacturers, ZFNs will enable the creation of cell lines with improved growth characteristics, altered glycosylation properties, and other traits resulting in higher yields. Through its exclusive partnership with Sangamo BioSciences, Inc. (Nasdaq: SGMO ), the ...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

... and Ion Trap-ETD Poster T345 -- Automated LC-MALDI Analysis of Glycopeptides from Glycoprotein Digests using DHB as Matrix Poster T348 -- glycosylation Profiling of Immunoglobulin G (IgG) Subclasses Poster T384 Metabolomics -- Detailed Investigation of the Fragmentation of ...

GenTel to distribute cancer research tool

... protein after its synthesis, in a process called glycosylation . Changes in the glycosylation of proteins are associated with many types of ... uses antibody microarrays to profile changes in glycosylation of proteins captured on the surface of a chip. ...

GenTel licenses next generation cancer research

... and is an important determinant of protein function. Changes in glycosylation are thought to play roles in certain disease processes. GenTel's ... per year worldwide, Negm said. Although nobody has an exact number on the glycosylation segment of that market, Negm believes that GenTel's first-to-market ...

ZyStor receives first funding and buys theraputics for rare diseases

... on its treatment for Gauchers disease. One patients treatment for a year runs $160,000. The technology ZyStor bought from Symbiontics is called glycosylation independent lysosomal targeting. It is meant to make enzyme-replacement therapies more effective. Replacement enzymes need to attach to target cells ...

Milwaukee area biotech ZyStor seeks more funding

... are delivered to critical tissues, and patients must have large intravenous doses on a frequent basis. GILT complex ZyStor's response, glycosylation Independent Lysosomal Targeting or GILT, has proven effective in animal testing. With this technology, a peptide tag replaces a chemical component ...

ZyStor seeks to raise $15M for clinical trials

... into patients are delivered to critical tissues, and patients must have large intravenous doses on a frequent basis. With ZyStor's therapy, called glycosylation Independent Lysosomal Targeting or GILT, a peptide tag replaces a chemical component found on some of the enzyme's carbohydrates. The tag is embedded ...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

... of the proteins being produced. Many eukaryotic proteins can be produced in E. coli but are produced in a nonfunctional, unfinished form, since glycosylation or post-translational modifications do not occur. Therefore, researchers have recently turned to eukaryotic yeast and ...