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fragments in Biological Technology

aTyr Pharma to Present at ChinaBio(R) Investor Forum in Hong Kong

... a novel platform of naturally occurring protein fragments that can be developed into biologic agents for ... are identifying a broad platform of protein fragments derived from human aminoacyl tRNA synthetases. ... of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent ...

Dr. James Cai Joins aTyr Pharma to Drive Clinical Development in Asia

... discovering novel, naturally occurring protein fragments that can be developed into biologic agents for ... are identifying a broad platform of protein fragments derived from human aminoacyl tRNA synthetases. ... of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent ...

Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

... antibody that triggers immune responses, antibody fragments consist of only the naturally occurring ... for these novel biologics. "While antibody fragments are an appealing new therapy class, limitations ... optimizing highly-stable, single-chain antibody fragments (scFv) without any phage display." ...

ESBATech's Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops

... has achieved high concentrations of its antibody fragments in all segments of the eye with topical delivery ... therapeutic concentrations of ESBATech's antibody fragments were observed in the anterior chamber (front of ... targets for topical ophthalmic use. Antibody fragments have a number of advantages over whole ...

Venter Institute Scientists Create First Synthetic Bacterial Genome

... of the native genome, the team specially designed fragments of chemically synthesized DNA to build ... The next step involved combining three 24kb fragments together to create 8 assembled blocks, each about ... two 1/8th fragments together to produce large fragments approximately 144,000 base pairs or 1/4th of the ...

String of fullerene pearls

... force microscope, the tiny structures look like fragments of nanoscopic pearl necklaces. In reality, the ... lined up like pearls. The researchers found fragments containing up to 35 pearls under the atomic force ... electron systems. This property could make these fragments interesting as a new starting material for more ...

New drugs faster from natural compounds: A UC San Diego breakthrough

... this fact. These algorithms make sense of the flood of tiny peptide fragments that are generated by machines called mass spectrometers that blast ... authors present new algorithms that computers use to piece these peptide fragments back together in order to determine the chemical structure of a cyclic ....

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

... the whole bacterial genome, Mycoplasma genitalium, in one step from 25 fragments of DNA. Lead author Daniel G. Gibson, Ph.D. and his team published their ... smaller, overlapping segments of DNA. For this study the team used DNA fragments that ranged in size from about 17,000 base pairs to 35,000 base pairs. ...

Beaumont Doctor's Invention Improves Cataract Surgery Outcomes

... before or during cataract surgery, thereby preventing the movement of lens fragments into the back of the eye. Each year, approximately 10 million people ... not ideal for various reasons. A net can block the needed removal of lens fragments while the extremely small diameter of a probe makes it a challenge for ...

Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinson's Research Award for Work on PD-implicated Protein LRRK2

... that bind to LRRK2. FBLD is a proven drug discovery approach where fragments of drugs are screened for ability to bind to a target. fragments will be visualized bound to LRRK2 and evolved into compounds that block ...

New molecular imaging techniques may lead to advances in disease treatment

... Annual Meeting. The new technique, which involves engineering antibody fragments to act as reporter genesor markers that signal cells of interest for PET ... new research, Weber and his team explored using cell surfacebound antibody fragments as reporter genes. These engineered antibody fragments, developed by the ...

Researchers bring new meaning to the term 'computer bug'

... in the fewest number of flips. In this experiment, the researchers used fragments of DNA as the pancakes. They added genes from a different type of ... that made the bacteria resistant to an antibiotic, but only when the DNA fragments had been flipped into the correct order. The time required to reach the ...

Antibody Engineering Company F-Star Buys Back Royalty Obligations

... the introduction of additional binding sites into antibodies and antibody fragments by engineering the non-CDR loops of constant or variable domains. Using Modular Antibody Technology, antibody fragments with antibody functionality and long half-life but much smaller size ...

Antibody Engineering Company f-Star Opens Second Research Site in Cambridge, UK

... the introduction of additional binding sites into antibodies and antibody fragments by engineering the non-CDR loops of constant or variable domains. Using Modular Antibody Technology, antibody fragments with antibody functionality and long half-life but much smaller size ...

Antibody Engineering Company f-Star Appoints Geert Mudde as Chief Scientific Officer

... the introduction of additional binding sites into antibodies and antibody fragments by engineering the non-CDR loops of constant or variable domains. Using Modular Antibody Technology, antibody fragments with antibody functionality and long half-life but much smaller size ...

Intellect Neurosciences, Inc. to Present Data on Alzheimer's Vaccine at 13th International Congress of Immunology Conference

... from potentially harmful human beta-amyloid T-cell epitopes. The short fragments of beta-amyloid used in RECALL-VAX(TM) ensure that only the toxin, and not ... is targeted by the antibodies, and because of their short length, the fragments are incapable of provoking an autoimmune response. About Alzheimer's ...

Synthetech Reports First Quarter Fiscal 2010 Results

... in organic synthesis, biocatalysis and chiral technologies. We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments and proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical industry. Synthetech produces advanced ...

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... Dr. Lindquist and her team tested whether yeast could make cyclic peptides that would save them from alpha-synuclein's toxicity. Cyclic peptides are fragments of protein that connect end-to-end to form a circle. Although cyclic peptides are synthetic, they resemble structures that are found in natural ...

Fallopian tubes offer new stem cell source

... regenerative medicine, these findings might contribute to reproductive science as a whole." Jazedje concludes, "Moreover, the use of human tissue fragments that are usually discarded in surgical procedures does not pose ethical problems." ...

DNA gripped in nanopores

... Molecular biologists, including the cool dudes from CSI, use gel electrophoresis to separate DNA fragments from each other in order to analyze the DNA. A team of researchers under the leadership of Vici winner Serge Lemay, has now shown for the first time ...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... properties." The complement system comprises a set of proteins that regulate certain types of inflammatory responses by the immune system. fragments of these proteins, such as chemoattractant complement fragment C5a, work to recruit immune system cells including neutrophils and lymphocytes to the ...

New cow genome sequence released

... access journal Genome Biology . The research team led by Steven Salzberg developed special-purpose software to assemble 35 million DNA sequence fragments into the 30 chromosomes that make up the Bos taurus genome. The algorithms use paired-end sequence information, mapping data, and synteny with the ...

Scientists publish complete genetic blueprint of key biofuels crop

... Researchers used the whole genome "shotgun" method of sequencing first pioneered in the Human Genome Project. In this method, short random DNA fragments are partially sequenced and then analyzed by powerful supercomputers to reconstruct the original genome sequence. The repetitive sections and the ...

Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection

... oligonucleotide approach, it aims to block the pathways leading to the formation of blood vessels in the cornea. This approach uses short DNA fragments that specifically target and block the production of a protein that is required for the formation and growth of new blood vessels. GS 101 eye drops ...

EUPROBIO 2008 Presentation to Highlight Latest Immune Research

... groundbreaking research. The abstract is based on a recent study focusing on Del-Immune V(R), a new immunomodulator containing DNA and peptoglycan fragments of lactobacillus rhamnosus V. The study, which confirms that this formulation enhances immune function, was conducted in the Ukraine by several ...

Tips on how to build a better home for biological parts

... systems starting from BioBricks, the parts documented in the Registry of Standard Biological Parts. The BioBrick is an emerging standard for DNA fragments that facilitates the assembly of biological parts into more complex devices and systems by using a standardized fabrication process. The entire ...

ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications

... generate product candidates against targets of clinical relevance. ESBATech is focused on delivering high concentrations of its therapeutic antibody fragments to the targeted sites, in combination with extremely low systemic load, in order to achieve low risk of systemic drug reactions using topical and ...

Tips on how to build a better home for biological parts

... systems starting from BioBricks, the parts documented in the Registry of Standard Biological Parts. The BioBrick is an emerging standard for DNA fragments that facilitates the assembly of biological parts into more complex devices and systems by using a standardized fabrication process. The entire ...

Pressure BioSciences, Inc. Announces the Market Release of its PCT-Enhanced Trypsin Digestion Application for Proteomics

... are often analyzed using a sophisticated laboratory method called mass spectrometry, which requires that proteins first be broken down into smaller fragments called peptides. This process is often accomplished by placing the protein in a test tube with the enzyme trypsin, and incubating the mixture ...

Roskamp Institute Wins Grant for Lung Cancer Research

... technology." The peer-reviewed grant given to Roskamp for the "Treatment of Lung Adenocarcinoma and Metastasis by Anti-angiogenic fragments of Abeta" project commences on July 1, 2008, and the life of the grant will be overseen by a grant manager of the James & Esther King Biomedical ...

Rentschler Biotechnologie Announces Cooperation with Boehringer Ingelheim

... manufacturing sites deliver biopharmaceutical products like therapeutic proteins, fusion proteins, protein scaffolds, monoclonal antibodies, antibody fragments and plasmid DNA. The Biberach site is specialized in highly efficient mammalian cell culture systems with yields well above industry standard in ...

Viventia Biotech to Explore Strategic Alternatives - Reports Positive Pivotal Phase III Interim Efficacy Data

... are designed to be safer and more beneficial for cancer patients. These products are fusion proteins comprised of human/humanized monoclonal antibody fragments specific to cancer cell markers, conjugated to highly potent cytotoxic proteins. Viventia's three lead products target EpCAM, which has recently ...

What To Do When a Holiday Guest Shows Up With a Pet

... can be serious hazards, and chocolate can be toxic to an animal. -- Make sure guests don't feed the pet food scraps. Small bones or fragments may lodge in the animal's throat, stomach or intestinal tract. If you choose to refuse a guest pet, consider these options: -- Call your ...

Antibody Engineering Company f-star Raises EUR 3.0 Million in a Second Closing of its Series A Financing Round From Novo A/S

... antibody fragments based on its Modular Antibody Technology, which allows the introduction of additional binding sites into antibodies and antibody fragments by engineering the non-CDR loops of constant or variable domains. Using Modular Antibody Technology allows for the creation of antibody ...

Massive reanalysis of genome data solves case of the lethal genes

... industrial-scale shotgun DNA sequencing strategy typically involves sheering the organisms DNA into manageable fragments, and then inserting these fragments into a disarmed strain of E. coli, which is used as an enrichment cultureto grow up vast amounts of the target DNA. The team led by Rubin showed that ...

Intellect Neurosciences, Inc. Obtains Validation of European Patent for Alzheimer's Vaccine in 19 Countries

... replaced with a safe T-cell epitope, such as bacterial Tetanus Toxoid, against which most people have been vaccinated. Moreover, by using only short fragments of the amyloid-beta toxin too small to contain T-cell epitopes, the immune response is more specific than when larger pieces are used, ensuring ...

Court bars patent protection for certain gene fragments

... were useful. Most notably whether the gene fragments have a specific and substantial use, as required ... the decision bars patent protection for gene fragments that do not have a "specific and substantial" ... experiments, they were intending to use the gene fragments they found as a tool in more efficiently ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... may differ from person to person. DNA fragments can be cut from those sequences using restriction enzymes. fragments from various samples can be analyzed to ... vivo). ligase An enzyme that causes fragments of DNA or RNA to link together; used ...

New Insights Into DNA Decontamination

... independent of the size and sequence of the DNA fragments since the destruction is based on a chemical ... of 100,000 nicks per minute is present, all DNA fragments will be destroyed, independent of their size. Smaller fragments will disappear before the larger ones. Applying ...
Other Contents
(Date:4/18/2014)... Seeds that sprout as soon as they,re planted may be ... be more careful. In the wild, a plant whose seeds ... risk disaster. More than just an insurance policy against late ... dormancy has long-term advantages too: Plants whose seeds put ... more species, finds in a team of researchers working at ...
(Date:4/17/2014)... under clinical trials to treat tuberculosis could be the ... against various bacteria, fungal infections and parasites, yet evade ... chemists and collaborators. , Led by U. of I. ... ways the drug SQ109 attacks the tuberculosis bacterium, how ... from yeast to malaria and how targeting multiple ...
(Date:4/17/2014)... Foundation has been named awardee of a three-year ... Defense Spinal Cord Injury Research Program. Gail Forrest, ... double-blinded, controlled, multi-site clinical trial, which will test ... spinal cord injury. Dr. Forrest is assistant director ... Foundation. Two additional sites will participate - the ...
Breaking Biology News(10 mins):Plants with dormant seeds give rise to more species 2Multitarget TB drug could treat other diseases, evade resistance 2Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2
(Date:4/18/2014)... psychologists have made a brain-related discovery that could ... , This discovery opens up the possibility that ... a specific brain activity that the researchers have ... Journal of Neuroscience has just published ... an associate professor of psychology and his doctoral ...
(Date:4/17/2014)... chronic inflammation in non-cancerous prostate tissue may have nearly ... those with no inflammation, according to results of a ... Kimmel Cancer Center. , The link between persistent inflammation ... high-grade prostate cancer those with a Gleason score ... the most aggressive and rapidly growing prostate cancers. , ...
(Date:4/17/2014)... Experimental Biology and Medicine a multidisciplinary research ... Kenis in the Institute of Genomic Biology (IGB) ... Urbana-Champaign describe their recent work on subcellular redox ... cell functions including energy metabolism, signaling, and transcriptional ... normal cellular behavior, redox status has been recognized ...
(Date:4/17/2014)... has created a new technology for modifying human ... the body and selectively target cancer and other ... that monitor and modify human physiology is a ... existing technology enabled bioengineers to build such devices ... in a customized fashion. , "The project addressed ...
(Date:4/17/2014)... April 17, 2014-- Colic affects about one in five ... numerous pediatric visits during the first several months after ... symptoms was showing promise; however, the April 1, 2014 ... Sung, Valerie) reported on a study, "Probiotics and Infant ... L reuteri for infant colic did not ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
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