fibrosis

Fluorescence-Based Single-Tube Assays to Rapidly Detect Human Gene Mutations

...ns:One is a three-base-pair deletion in the cystic fibrosis transmembraneconductance regulator (CFTR) gene, an...ee-base-pair deletion, within exon 10 of thecystic fibrosis transmembrane conductance regulator (CFTR) gene, accounts forapproximately 70% of all mutant CF alle...

The use of the Mastercycler gradient for single-cell PCR and preimplantation diagnosis

...polymerase-chain-reaction assay for cystic fibrosis allele DF508 in single cell. Lancet, 339, 1190-1192. Sermon, K., Lissens, W., Joris, H., Desmyttere, S., Devroey, P., Van Steirteghem, A. and Liebaers, I. (1997) Clinical application of preimplantation diagnosis for myotonic dy...

Heteroduplex Analysis Using the DCode System

...be used to analyze mutations in the cystic fibrosis gene. Method The test s...ype and mutant DNA samples from the cystic fibrosis gene exons 7 and 10. The heterozygous mutations from exon 7 were 1154insTC, two base inserti...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

...ce in the lung, and thus may play a role in cystic fibrosis and other airway disorders. Novel ligands targeting P2Y-receptors represent potential therapeutic agents and the ability to screen such compounds reliably and reproducibly has been demonstrated using FlexStation 8 . Using Z-factor analysis ...

Third Wave reports net loss of $18.9M for 2006

... and Drug Administration for approval of a cystic fibrosis molecular test. President and chief executive Kevin Conroy said the expense of HPV clinical trials and other litigation will cause operating expenses to increase in 2007....

Healthcare slow to adopt genetic advances

... this period, detecting a predisposition to cystic fibrosis and other single-allele diseases - an allele is a member of a pair of genes that occupy a specific position on a chromosome - has been the domain of genetic counselors and medical geneticists. Tonellato, who recently addressed a bioinformatics semi...

EraGen set to highlight diagnostic products at BIO

...son and Bayer Health Care in the area of cystic fibrosis and [with] Promega Corp . in the life sciences market," Reynolds said. "There are many products on the horizon for EraGen." EraGen also has worked with the BloodCenter of Wisconsin and AmeriPath to develop the molecular diagnostic tests it has...

EraGen gets $250,000 state loan to revamp manufacturing facility

...p it upgrade its manufacturing facility for cystic fibrosis tests. EraGen's $1 million improvement plan is ex...ribution deal with Bayer HealthCare for its cystic fibrosis tests. That deal was announced last week. "One of the major drivers for obtaining and applying fo...

EraGen cystic fibrosis test to be distributed worldwide through Bayer

...orldwide distribution agreement for its new cystic fibrosis assay, MultiCode PLx, to the Diagnostics Division ...or the past several years, and the specific cystic fibrosis application as it applies to the Bayer agreement has been in development for the past year. "We've ...

Third Wave boosts numbers in latest report

...d capabilities for a variety of conditions cystic fibrosis transmembrane conductance regulator (CFTR), hepatitis C virus (HCV) and human papillomavirus (HPV), among others. "We met those milestones," Puisis said during a company conference call on Wednesday. "The combination of our commitment to building str...

Third Wave to seek FDA clearences after expanding pipeline

...obably be driven primarily by its genetics, cystic fibrosis and hepatitis C genotyping reagents. It plans to seek FDA clearance for certain coagulation tests next year. Milwaukee-headquartered analyst firm R.W.Baird kept its neutral rating of the companys stock, saying in a report that Third Wave is making p...

Wisconsin publicly traded biomedical companies report gains this quarter

...ovide analyte-specific reagents for testing cystic fibrosis mutations. To further combat cystic fibrosis, Third Wave will be combining their Invader chemistry technology with the healthcare firm 3M to create a microfluidic platform, scheduled for completion in 2005. Merge eFilm: $2.2 million, increased by ex...

Third Wave releases reagents for Hepatitis C testing

...mpany announced the release of reagents for cystic fibrosis tests....

Third Wave strikes deal with Kaiser Permanente on cystic fibrosis reagents

...es has announced the launch of its Invader cystic fibrosis genotyping analyte-specific reagents. In conjunct...evelop individual assays for each of the 25 cystic fibrosis genetic mutations recommended for screening by the American College of Medical Genetics and the Amer...

Wisconsin-based Third Wave reports increased revenue for 2003, fourth quarter

...ew products. The company plans to release a cystic fibrosis diagnostic for high-volume customers, launch a HCV genotyping assay, establish clinical trials program for an HCV viral load prototype assay, release a prenatal chromosomal analysis product, release a HPV detection product and introduce various CYP45...

Scientific Protein Laboratories Acquired by New York firm

...h is used to treat pancreatic deficiency of cystic fibrosis and a variety of digestive disorders. We look forward to working with the Arsenal Capital team to invest in our existing businesses as well as pursue new opportunities within the carbohydrate and natural protein product areas, said David Strunce, p...

Armed Forces Institute of Pathology Adopts Third Wave's Invader Screen

...ecific reagents* (ASRs) exclusively for its cystic fibrosis (CF) genetic screening. AFIP, the central reference laboratory for the Army, Navy, Air Force, Public Health Service and Department of Veterans Affairs, will use Invader to screen select U.S. military personnel for genetic mutations associated with C...