crystallography in Biological Technology

Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria

... that can be used to create a picture of the molecule; however, X-ray crystallography could not be used to characterize the chlorosomes in green bacteria ... in their compositions had prevented scientists from using X-ray crystallography to characterize the internal structure." To get around this problem, ...

Zenobia Therapeutics, Inc. Begins Operations as a Fragment-Based Lead Discovery Company

... Corporation, where she built a diverse team of protein biochemistry, X-ray crystallography and drug discovery experts. Before that, Dr. Nienaber was the Senior Director of Lead Discovery and crystallography at SGX Pharmaceuticals, where she oversaw strategic drug discovery and ...

Lilly to Acquire SGX Pharmaceuticals

... structures of key Lilly drug targets utilizing SGX's proprietary x-ray crystallography technology. The ongoing collaboration also provides Lilly with access to ... SGX-CAT, which is a state-of-the-art synchrotron facility enabling X-ray crystallography and protein structure determination built by SGX at the Advanced Photon ...

CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform

... CRELUX will continue to provide customers with crystallization and x-ray crystallography services. CRELUX will support ProQinase by performing crystallization ... CRELUX. “The combination of CRELUX’s expertise in protein crystallography and ProQinase’s know-how in kinase cloning and expression makes the ...

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

... an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address ...

Jubilant to Work With Endo Pharmaceuticals on Drug Development

... of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modelling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan.For more information visit: ...

Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals

... Director of Chemistry at Syntonix. About Zenobia Zenobia provides a commercial fragment library and access to their structural biology, crystallography and fragment-based lead discovery expertise through partnerships, consulting and collaborations. Zenobia's internal programs combine fragment-based ...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

Jubilant and BioLeap Announce New Partnership in Drug Discovery

... of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modeling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan. About Jubilant Organosys ...

BioCryst to Present at the J.P. Morgan 27th Annual Healthcare Conference

... . The presentation will be archived for ninety days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

... 7, 2008, 6:00 p.m. - 8:00 p.m. Pacific Time; Hall A About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

deCODE genetics Announces Third Quarter 2008 Financial Results

... past few months we have continued to bring forward new products for treating and preventing common diseases. Utilizing the expertise of our protein crystallography and medicinal chemistry units we have filed an IND on an exciting new PDE4 modulator for Alzheimer's disease that has the potential to avoid some of ...

Carna Biosciences Signs Distribution Agreement with Shanghai Universal Biotech Company

... The products and services provided by Carna include kinase proteins, assay development services, kinase profiling and screening services, and crystallography products and services. About SUBC Shanghai Universal Biotech Company (http://www.univ-bio.com ), founded in December 2004, is a Chinese ...

New Dual Wavelength X-ray Diffractometer From Oxford Diffraction, Now a Part of Varian, Inc., Allows Increased Throughput for Challenging Single Crystal Analyses

... and proteins at high resolution. Applications include chemistry, geology, physics, structural biology and pharmaceutical research. The trend in crystallography is towards the ability to analyze smaller, poorer crystal samples and to increase the speed of sample throughput. The significant improvement in the ...

Evotec Expands Collaboration With InterMune

... lead series have been identified for further optimization. Evotec also provides medicinal chemistry, secondary screening, protein production, X-ray crystallography and ADMET. The financial terms include a technology access fee for access to Evotec's fragment-based drug discovery platform, EVOlutionTM, plus ...

New approach may render disease-causing staph harmless

... enzymes it targets are so similar. Andrew Wang and his colleagues at Academia Sinica and the National Taiwan University, both in Taipei, used X-ray crystallography to determine the structure of the enzyme and how it interacts with the inhibitors. Our structural studies pinpointed how these drug candidates ...

Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome

... evaluation in a Phase 1b clinical trial in healthy volunteers. Employing high-throughput screening of its proprietary chemical libraries, x-ray crystallography and medicinal chemistry, Lexicon scientists discovered and optimized a series of orally-administered, peripherally-acting small molecule inhibitors ...

Bruker Participates in Dutch Funded Super Microscope Project

... and several companies, as specialists in electron microscopy, X-ray crystallography and drug design. The Cyttron project is headed by Professor J. P. Abrahams from Leiden University , located the Netherlands. The X-ray crystallography R&D competency within Bruker AXS as well as the complementary nature of ...

Protein-crystal companies join forces for better imaging process

... place it ahead of the pack. "Together with the Bruker Proteum x-ray crystallography system, this constitutes a powerful yet affordable high-throughput ... and imaging system for protein crystallization to be offered to the crystallography community. By providing high throughput protein crystallization ...

Bruker AXS unveils new X-ray detector

... The new systems were unveiled at the 2005 International Union of crystallography meeting in Florence, Italy. Axiom 200, a new digital imaging detector ... problems that adjust the data quality, making it more accurate for crystallography tests such as protein screening and ligand-binding studies, according to ...

Ambion Custom

... Kit. 5X MEGAscript Kit Enables Efficient crystallography Dr. Barbara Golden's laboratory (Purdue University) used ... mg purified group I intron from bacteriophage Twort--for crystallography (Figure 1). The superior performance of this kit led to ...

UW-Madison awarded $20 million grant for protein research

... to develop these maps the team has worked with gene cloning, purifying and crystallizing proteins and using nuclear magnetic resonance and x-ray crystallography to determine structures. The center will be building off this experience in Phase II, which is focused on using the Phase I methods to quickly map ...

Frantz Group brings Web conferencing in-house

... volume restrictions or delays. Bruker announces Smart Breeze Madison, Wis . -- Bruker AXS Inc . has launched Smart Breeeze, a compact X-ray crystallography system that features Bruker AXS' latest addition to its X-ray detectors, the air-cooled Smart Breeze 4K CCD detector, as well as a compact goniometer ...

Double-Affinity Purification of GST-His Tagged Proteins Using Vivapure 8-to-96 Well Cobalt-Chelate Kit

... system enables to scale up the yields to several mg without necessity to modify the basic protocol to reach amounts sufficient for robot-driven crystallography screening. Figure 2. Workflow of the double-affinity purification The GST-HIS fusion protein was first purified by ...