Complement in Biological Technology

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... potent inflammatory mediator and component of the complement system, which is associated with the onset of ... with such excellent properties." The complement system comprises a set of proteins that regulate ... of these proteins, such as chemoattractant complement fragment C5a, work to recruit immune system cells ...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

... and clotting disorders, inflammation, the complement system, and immunology," said Dr. Ed Madison, ... current research focuses on the role of specific complement components and pathways involved in diabetes, ... several clinical trials and a recently approved complement inhibitor for clinical use. His research ...

Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH

... -- Soliris(R) (eculizumab), a terminal complement inhibitor developed by Alexion Pharmaceuticals, ... the small percentage of patients with PNH in whom complement inhibition is not consistently maintained ... (1) Hillmen P, Muus P et al. Effect of the complement inhibitor eculizumab on thromboembolism in ...

Potentia Pharmaceuticals Appoints Johanna M. Seddon, M.D. and Janet Stoltz Sunness, M.D. to Scientific Advisory Board

... so-called "dry" form of the disease. About the complement System and POT-4 complement activation is an inflammatory process involving ... attack complex (MAC). Activation of the complement system is an important part of the body's ...

Potentia Pharmaceuticals' Drug Candidate for Age-Related Macular Degeneration Shows Positive Safety Profile in Phase I Clinical Trial

... continue this trial." About POT-4 POT-4 is a complement inhibitor, which shuts down the ... so- called "dry" form of the disease. About the complement System and POT-4 complement activation is an inflammatory process involving ...

Potentia Pharmaceuticals to Present ASaP Phase I Clinical Trial Data for POT-4 at the American Academy of Ophthalmology Annual Meeting

... POT-4 is the first complement inhibitor to be tested in AMD patients ... said, "POT-4 is the first of several complement inhibitors that will ultimately be tested in macular degeneration. The role of complement in this disease was established in 2005 as the ...

Alexion's Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product

... Recognizes Scientific Accomplishment in complement Inhibition and Impact of Soliris on Patients ... blood disorder. Soliris is a first-in-class complement inhibitor that selectively blocks the formation ... proteins that ordinarily prevent terminal complement from causing the red blood cell destruction ...

Volcano Corp Announces First Human Use of the Volcano Optical Coherence Tomography (OCT) Imaging Catheter

... in Rotterdam, Netherlands. Volcano OCT will complement its existing line of IVUS imaging catheters and ... the leader in intravascular imaging, both to complement everyday PCI technique, and to further ... of new clinical applications and opportunities to complement our existing product line. We are delighted to be ...

Alexion Acquires All Rights to OMRF Patents Related to Soliris(R)

... by OMRF in the 1980s relating to the treatment of complement system mediated disorders, to which Alexion has ... antibodies capable of blocking the body's complement system. One result of these Alexion programs was ... during 2007. Soliris(R) (eculizumab) is a complement inhibitor product developed and marketed by ...

Taligen Therapeutics Secures Series B Financing

... products to control the alternative pathway of complement activation. With this additional funding, we ... on modulation and control of the complement system. The complement system is believed to be a ... component in the initiation of inflammation. complement system activation is characteristic of many ...

Optherion, Inc. Completes $37 Million Start Up Financing

... Diseases Associated with Alternative complement System NEW HAVEN, Conn., Oct. 9 /PRNewswire/ -- ... other chronic diseases related to the alternative complement system. Optherion was founded following ... discoveries published in 2005 linking the role of complement Factor H (CFH) ...

Arius Features Preclinical Data on Antibody Candidates at Two Conferences

... Marriott. At the XIth European Meeting on complement in Human Disease held in Cardiff, Wales on ... in regulating cell lysis mediated by the complement system, is a potent therapeutic in various in ... a monoclonal antibody targeting CD59, enhances complement activity and exhibits potent in vivo efficacy in ...

Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services

... services. "The addition of dissolution testing is the perfect complement to our portfolio of services," said Steven Richter, Ph.D., President and ... used to measure a drug's rate of release from its dosage form. It is a complement to other analytical assays -- potency and related substances (Microtest ...

Optherion Announces Presentation at ARVO 2009 Annual Meeting

... Degeneration (AMD) and other chronic diseases involving the alternative complement system, announced today that it will be reporting data from its ... Degeneration (AMD) and other chronic diseases involving the alternative complement system. Optherion's proprietary technologies are based on landmark ...

Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services

... services. "The addition of dissolution testing is the perfect complement to our portfolio of services," said Steven Richter, Ph. D., President and ... used to measure a drug's rate of release from its dosage form. It is a complement to other analytical assays - potency and related substances (Microtest ...

Waters Corporation Continues to Meet Today's Challenges for Improved Laboratory Operations with New Products at Pittcon 2009

... expanded its award-winning UPLC product portfolio and will have its entire complement of UPLC products on display during Pittcon 2009, March 8 - 13 in Chicago. ... is introducing the PATROL UPLC Process Analyzer for at-line analysis to complement the on-line version introduced at Pittcon 2008. For more information: ...

InCode BioPharmaceutics Appoints New President and CEO

... 20 /PRNewswire/ -- InCode BioPharmaceutics, Inc., an emerging company in complement depletion, announced that it has appointed Kevin L. Stark, Ph.D. as ... on the selective interruption of the complement cascade. Activation of the complement cascade has been implicated in the pathogenesis of many inflammatory ...

MyHeritage And Family Tree DNA Partner To Help People Trace Family History Using DNA

... of genealogic DNA information in the world. This provides the perfect complement to MyHeritage's current research tools, giving our members another way to ... resource when researching family history online, which is a perfect complement for our DNA research. Our DNA research can show two people that they are ...

GenVault Corporation Launches GenTegra(TM) DNA

... provide smart, environmentally and financially sustainable solutions which complement and enhance existing cryostorage systems. For more information on ... leverage the rapidly growing genomics industry. As a scalable and reliable complement to traditional freezers and DNA purification systems, the company's dry ...

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

... target, is involved in the activation of the complement system. The complement system plays a role in the inflammatory response and becomes activated as ... appears to be unique to, and required for the function of, a principal complement activation pathway, known as the lectin pathway. Importantly, inhibition ...

Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests

... compliance will provide us with strong commercial infrastructure that will complement our advanced R&D capabilities." The acquisition is expected to allow ... and growth strategy. The 5,000 square foot laboratory will complement two additional CLIA-certified labs in New York and California, Columbia ...

Galderma Completes Acquisition of CollaGenex

... Pharma S.A. "CollaGenex's oral rosacea therapy will be an important complement to Galderma's topical products, and the two company's development ... improve therapy and meet unmet needs." CollaGenex's innovative products complement and enhance Galderma's portfolio for rosacea. Launched by CollaGenex in ...

NicOx Initiates Two Large ABPM Studies for Naproxcinod in Hypertensive Patients with Osteoarthritis

... used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). These data should complement the promising results of a 2-week ABPM study for naproxcinod in healthy ... in November 2007 (see press release of November 7, 2007). They will also complement the Office Blood Pressure Measurements (OBPMs) being collected in each of ...

ARIUS announces fourth quarter and year-end fiscal 2007 financial results

... Cancer Stem Cell Program, our Trop-2 Signal Transduction Program, our CD59 complement Inhibitor Program and our CD9 Cancer Stem Cell Program. The majority of ... and the filing of a Phase I IND application in late 2008. CD59 complement Inhibitor Program - Announced positive findings demonstrating highly ...

New nanoparticle vaccine is more effective but less expensive

... something foreign, and so a low-level, generic immune reaction known as complement is triggered. This results in a particularly potent immune response ... nanoparticles for a while, says Hubbell. Our ideas -- to activate complement as a danger signal, and to exploit the slow interstitial flow towards the ...

Genmab Announces Encouraging Preclinical Data for ofatumumab

... today that ofatumumab (HuMax-CD20(R)) appeared more effective at inducing complement dependent cytotoxicity (CDC), an immune system killing mechanism, than ... will be presented in an oral presentation at the XIth European Meeting on complement in Human Disease, in Cardiff, United Kingdom on September 9, 2007. About ...

The Foundation for National Institutes of Health Announces Unprecedented Product Donation by sanofi-aventis in the U.S.

... efforts of the NIH. As a non-profit, 501(c)(3) corporation, the Foundation raises private-sector funds for a broad portfolio of unique programs that complement and enhance NIH priorities and activities. The Foundation's Web site address is http://www.fnih.org . The NIH - The Nation's Medical ...

Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement to Commercialize Intermezzo(R) in the United States

... aid market. This agreement is part of Purdue's plan to diversify our product portfolio and broaden our commercial focus into therapeutic areas that complement our leadership position in pain management." Mr. Stewart added, "We are confident that prescribers will find Intermezzo ((R)) to be a valuable ...

Kendle Realigns C-Suite Leadership to Drive Increased Innovation, Productivity and Organizational Efficiency

... our future growth and meet the strategic outsourcing needs of our customers." The creation of the CAO role and the appointment of Mr. Bergen complement other recent moves by Kendle to strengthen its executive leadership team. In conjunction with the appointment of Mr. Bergen, Kendle today announced ...

Human Genome Sciences Announces Proposed Public Offering of Common Stock

... The Company may also use a portion of the proceeds for the potential acquisition of, or investment in, companies, products or technologies that complement our business. While the Company evaluates company, product, technology and similar opportunities from time to time, the Company currently has no ...

Alexandria Real Estate Equities, Inc. Signs Biopharmaceutical Company, Lilly, as Anchor New York City Tenant at the Alexandria Center for Science and Technology

... in multiple tumor types. Committed to building an oncology powerhouse, Eli Lilly and Company acquired ImClone Systems in November 2008 as a complement to its internal cancer research unit, Lilly Oncology. Locating translational research and development at the Alexandria Center provides ImClone ...

Magellan Diagnostic Businesses to Feature Automated Systems and Diagnostic Tests at Clinical Lab Expo

... and experience. The DSX and DS2 are open systems with full walk-away automation and precise liquid-handling capabilities. They execute the entire complement of analytical steps required for virtually any ELISA immunoassay: adding samples and reagents, washing, incubation, and detection, delivering all you ...

UCSF researchers help crack parasite genome, identify drug leads

... a decade to achieve, researchers said. Three UCSF researchers contributed to that research by identifying and characterizing the parasite's complement of proteolytic enzymes, known as the "degradome," which in many other biomedical contexts has provided valuable drug targets. Findings are published ...

Health Robotics Expands and Diversifies Global Channel Strategies With Joint-Ventures & Direct Operations

... BOZEN, Italy, July 13 /PRNewswire/ -- Health Robotics today announced that it has decided to complement its successful indirect channel strategies with direct investments in local infrastructure at a few territories where a couple of Health Robotics' ...

BioNeutral's Ygiene(TM) Hospital Grade Antimicrobial Demonstrates a 99.9997% Kill Rate Against Clostridium Difficile Spores (C.diff) in Independent Lab Pre-testing Phase

... breakthrough. The fact that it is also environmentally friendly makes it a groundbreaking event." To complement its internal Ygiene(TM) research and development efforts, BioNeutral frequently uses highly recognized independent laboratories such as ATS Labs of ...

Shanghai ChemPartner and Agios Expand Integrated Drug Discovery Research Collaboration

... the strength and breadth of our integrated drug discovery and development capabilities and this is a wonderful opportunity to share expertise and complement strengths." "Due to the rapid success and progression of our pipeline and platform, Agios has experienced a need for significant resource ...

King and Pain Therapeutics Announce REMOXY(R) NDA Update

... through the development, including through in-licensing arrangements and acquisitions, of novel branded prescription pharmaceutical products that complement the Company's focus in specialty-driven markets, particularly neuroscience, hospital care. King's wholly-owned subsidiary, Alpharma, Inc., is also a ...

OmniComm Systems Announces Acquisition of EDC Business of eResearchTechnology

... was the first prong of executing on this strategy. ERT has served several markets, including the governmental sector and Fortune 500 sponsors, that complement our focus on biotech and medical device clinical trial sponsors." Dr. Michael McKelvey, ERT's President and CEO, commented "We have been ...

ForteBio Launches Two Revolutionary High-Throughput, Label-Free Instruments: The Octet(R) RED384 and the Octet QK384

... more expensive than the new Octet 384 series instruments." The new systems support two 384- or 96-well plate positions and enable a full complement of samples to be run in one plate, while the second plate holds buffers, diluents and controls. The system is also capable of regeneration and ...

Fallopian tubes offer new stem cell source

... could be easily isolated and expanded in vitro, and are able to differentiate into muscle, fat, cartilage and bone cell lines. The cells' chromosome complement showed no abnormalities, suggesting chromosomal stability. Jazedje comments, "In addition to providing an additional potential source for ...