Chromosome in Biological Technology

It's Not Just the Sun: deCODE Discovers Sequence Variants Affecting Susceptibility to Skin Cancer

... One of these, in the keratin 5 (KRT5) gene on chromosome 12, leads to a subtle but potentially damaging ... greater risk. Another of the SNPs is located on chromosome 9p21, the same region of the genome that deCODE ... to demonstrate that a third risk variant, on chromosome 7q32, confers greater risk if inherited from the ...

Chromosome breakpoints contribute to genetic variation

... contrary to decades of evolutionary thought chromosome regions that are prone to breakage when new ... cow genome . "Our results demonstrate that chromosome breakage in evolution is non-random and that the ... more susceptible to breakage, Lewin said. (The chromosome analysis was facilitated by Evolution Highway, a ...

deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes

... letter variations in the human genome (SNPs) on chromosome 9p21 linked to increased risk of heart attack and aortic aneurysm, SNPs on chromosome 4q25 conferring risk of AF and stroke, and ... who carry two copies of the at-risk SNPs on chromosome 9p21 are at an approximately 60% greater than ...

Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack

... Sweden, Australia, and South Korea. A SNP on chromosome 2q12 was associated with increased risk ... disease, and our own discoveries on chromosome 9p21 and in the leukotriene pathway have helped ... and senior author on the study. The SNP on chromosome 12q24 associated with heart attack risk is in ...

deCODE genetics Announces Third Quarter 2008 Financial Results

... of the first variant, a version of a SNP on chromosome 8q24, putting them at a 50% higher risk of ... two copies of a common version of another SNP on chromosome 3 were found to be at a 40% higher risk of the ... and sunburn. These SNPs, both located on chromosome 1, may therefore provide new insight into an ...

deCODE genetics Announces Second Quarter 2008 Financial Results

... The SNPs are located in the LOXL1 gene on chromosome 15, and confer respectively 26-fold and 8-fold ... deCODE's analysis of known variants located on chromosome 10q26 and accounting for approximately 16% of ... near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an ...

deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer

... of two common single-letter variants (SNPs) on chromosome 5 of the human genome that are associated with ... cancers overall. The paper, 'Common variants on chromosome 5p12 confer susceptibility to ... that a fourth known set of variants, located on chromosome 10q26 and accounting for approximately 16% of ...

Venter Institute Scientists Create First Synthetic Bacterial Genome

... the synthetic version of the M. genitalium chromosome began first by resequencing the native M. ... genome of more than 580,000 base pairs. The final chromosome was again sequenced in order to validate the ... to transplant a fully synthetic bacterial chromosome into a living organism and "boot up" the cell. ...

Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease

... general population. The signature is found in the LRRK2 gene located on chromosome 12. The work was led by Elizabeth Corder, PhD, Scientific director at ... general population. The signature is found in the LRRK2 gene located on chromosome 12. The work was led by Elizabeth H. Corder , PhD, Scientific Director at ...

deCODE genetics Announces First Quarter 2009 Financial Results

... 2 diabetes (T2D). The markers include SNPs discovered by deCODE on chromosome 9p21 linked to increased risk of heart attack and types of aneurysm, on chromosome 4q25 conferring risk of AF and stroke, and in the TCF7L2 gene linked ...

deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis

... are known to be involved in bone and skeletal development. The SNPs on chromosome 17 are adjacent to the SOST gene, which encodes sclerostin, a protein involved in the formation of bone. And the SNP on chromosome 18 lies close to the TNFRSF11A gene that has been implicated in Paget's ...

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

... homologous recombination (a process that cells naturally use to repair chromosome damage). Realizing how robustly yeast performed, the team ... is still working on experiments to install a fully synthetic bacterial chromosome into a recipient cell and thus "boot up" a synthetic chromosome. ...

Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy

... (ARIC) study, demonstrating that measuring the genetic risk factor on chromosome 9p21 detected by the deCODE MI(TM) test complements traditional risk ... deCODE discovered single-letter variations in the human genome (SNPs) on chromosome 9p21 that increase risk of heart attack, and launched its deCODE MI(TM) ...

deCODE genetics Announces First Quarter 2008 Financial Results

... receptor-positive (ER+) breast cancer. The latest SNPs are on chromosome 5p12, and although these variants confer modest risk, they are so ... paper also reveals that a fourth known set of variants, located on chromosome 10q26 and accounting for approximately 16% of breast cancers, appear ...

deCODE genetics Announces Third Quarter 2007 Financial Results

... myocardial infarction (MI), or heart attack. The SNPs are located on chromosome 9 and were discovered by deCODE earlier this year. As described in the ... subtype of glaucoma. The SNPs are located in the LOXL1 gene on chromosome 15, and confer respectively 26-fold and 8-fold increases in risk of ...

deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis

... and decreased bone mineral density (BMD). About 60% of the population carry two copies of a single-letter variation in the human genome (SNP) on chromosome 21, putting them at roughly 65% greater likelihood of developing kidney stones than those who carry no copies. This single variant may thus account ...

Fallopian tubes offer new stem cell source

... stem cells could be easily isolated and expanded in vitro, and are able to differentiate into muscle, fat, cartilage and bone cell lines. The cells' chromosome complement showed no abnormalities, suggesting chromosomal stability. Jazedje comments, "In addition to providing an additional potential source for ...

Telik Reports Preclinical Results at AACR Annual Meeting

... of Action of Orally Active Aurora Kinase/ VEGFR Inhibitors; Abstract # 1764 Aurora kinases are Ser/Thr kinases that play an important role in chromosome alignment, segregation and cytokinesis during mitosis. Over-expression of Aurora kinases has been demonstrated in both solid tumors and leukemia and ...

Beyond associations: Colorectal cancer culprit found

... led by Dr. Richard Houlston of The Institute of Cancer Research in the United Kingdom have delved into the biology underlying common variants on chromosome 18 that his group recently found to be associated with colorectal cancer in a GWAS. They sequenced the region of DNA surrounding these markers in a ...

New cow genome sequence released

... synteny map increases the number of syntenic breakpoints by approximately 30%. Salzberg's team also pinpointed a portion of the Bos taurus Y chromosome for the first time. "Until the assembly is truly finished - a state that no mammalian genome, including human, has yet reached - we will continue ...

deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor

... of a total of more than 16,000 patients and healthy subjects from Iceland, Austria, Germany and the United States. It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other. This makes the finding ...

A Scientific Milestone: Sex of Dolphin at SeaWorld San Diego Determined Prior to Conception

... XY Inc. SeaWorld and Busch Gardens Reproductive Research Center modified the technology to separate dolphin sperm that carry a female-producing X chromosome from sperm that carry a male-producing Y chromosome. Following separation into female and male populations, sperm are frozen and stored for future ...

deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke

... CEO of deCODE, a board-certified neurologist and neuropathologist. About deCODE AF(TM) and this study In 2007, deCODE discovered two SNPs on chromosome 4q25 that double the risk of atrial fibrillation, and later that year launched deCODE AF(TM) to enable doctors to detect these SNPs in their ....

JCI table of contents: April 22, 2008

... protein, AD is classified as a tauopathy. Other tauopathies include the neurodegenerative disease frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Although the tau protein in individuals with AD is not mutated, mice carrying the mutated forms of tau found in individuals with ...

A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease

... increasing the effectiveness of smoking cessation efforts, and of predicting risk of lung cancer and PAD. The SNP, rs1051730, is located on chromosome 15q24 in a nicotine acetylcholine receptor called CHRNA3. The paper, 'A variant associated with nicotine dependence, lung cancer and peripheral ...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

... complex. This complex enters the nucleus incorporating into the chromosomal DNA creating a stable molecule. The gene sequence is integrated in the chromosome and is copied along with the DNA during ongoing cell division. About Lentigen Corporation Lentigen Corporation is a privately owned biotechnology ...

DMetrix and the Armed Forces Radiobiology Research Institute Announce Cooperative Research and Development Agreement

... announced today that they have entered into a cooperative research and development agreement to improve the speed and accuracy of detecting dicentric chromosome aberrations for radiation dose assessment. The agreement will integrate DMetrix's EX-40(R) high-throughput array microscope imaging system into ...

DNA Testing Systems Inks Agreement with DNAPrint Genomics

... said Yates, "and probably want to keep it that way." In addition to biogeographical DNA tests, the company also sells traditional paternity, Y chromosome (male) and mitochondrial (female-passed DNA) tests. For more information, visit DNA Testing at http://www.dnaconsultants.com or call toll free ...

deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women

... variants in the sequence of the human genome (SNPs) that regulate one of the principle motors of evolution. Versions of the two SNPs, located on chromosome 4p16, have a genome-wide impact on the rate of recombination -- the reshuffling of the genome that occurs in the formation of eggs and sperm. ...

Discovery of new cause of mental retardation simplifies search for treatments

... brains memory center. A new mechanism opens possibilities The VIB scientists research is showing for the first time that the duplication of a chromosome region − whereby proteins are produced in too high a concentration − can lead to mental retardation. This is totally new information in ...

Susan G. Komen for the Cure Announces Recipients of 2007 Komen Brinker Award for Scientific Distinction

... He is credited with the development and implementation of many important technologies, including high-speed sorting; flow karyotyping; the first chromosome painting probes; development of interphase fluorescent in situ hybridization (FISH); and the first demonstration using FISH showing ERBB2 ...

Basic Scientist Mark Roth Wins MacArthur Fellowship

... to be recognized by such a wonderful organization," said Roth, who has pursued a variety of research avenues, including studies on gene regulation, chromosome structure and function, autoimmune disease and, most recently, induced metabolic hibernation. "The creative work I've been able to do has depended ...

New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human

... of this vague and poorly written initiative, but there's one that's immediately clear. If you're one of the thousands of Missourians with a chromosome abnormality, this initiative declares you not to be human and enshrines that definition into our constitution. I find that deeply troubling, and I ...

Rice Centromere, Supposedly Quiet Genetic Domain, Surprises

... has exposed a supposedly barren region of a rice chromosome known as the centromere. The work, published in ... long-term goal of creating an artificial chromosome for plants, says Jiang. Such a tool, now ... says Jiang, because the centromere of rice chromosome 8 lacks the vast tracts of repetitive non-coding ...

Medical College receives $11 million grant to study high blood pressure

... the impact that genes within specific regions of chromosome 13 have on salt-sensitive high blood pressure and ... how genes, all within four discrete areas of chromosome 13, impact salt-sensitive hypertension and kidney ... A second project will study one region of chromosome 13 to identify the gene or genes that offer ...

SNPs Powerful Tools for Association Studies

... to analyze SNP alleles only on a single chromosome in the laboratory (except for the X and Y ... Vega, 2002 and 2003) and on a collection of other chromosome segments (Gabriel, 2002) indicate that LD ... ethnic groups. For example, sample data from chromosome 22 demonstrate that LD blocks in Caucasians ...

Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies

... Down syndrome is caused by an extra copy of chromosome 21 (trisomy 21), and Edwards syndrome is caused by an extra copy of chromosome 18 (trisomy 18). It is extremely important to ... research. CMA uses CGH with bacterial artificial chromosome (BAC) or phage-derived ...

Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae

... analysis leading to a direct determination of chromosome copy number based on densitometric ... of cells per strain; 2) variability in chromosome length observed for otherwise ... indicate directly the number of copies of each chromosome requires further development. Minimal ...

Map and Link Human Genetic Disorders with SSLP Analysis

... as one of a number of polymorphic markers in chromosome 1p21. The markers were analyzed to generate haplotypes across the region of chromosome 1 containing COL11A1. Analysis of ... pedigree. Haplotype analysis, using markers in chromosome 6p21.3, also excluded COL11A2 as a candidate for ...