Binding in Biological Technology

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... technologies. "The determination of ligand binding affinity has been used to delineate the ligand binding site of GPCRs through a site-directed mutagenesis ... unique. It has aided the determination of ligand binding affinities without the use of radioactivity and ...

Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth

... the potent anti-tumor activity of a BiTE antibody binding to carcinoembryonic antigen (CEA) and to CD3 on T ... can be blocked by soluble CEA and prevented from binding to CEA on the surface of cancer cells, thereby ... T cells lack the appropriate receptors for binding antibodies. Previous attempts have shown the ...

Fitting pieces for biosensors

... identify and bind certain target molecules. These binding abilities allow, for instance, tracing, detecting ... an in vitro method, researchers select the best binding partners for the target molecule from a huge pool ... the enrichment of those which exhibit best binding and detecting abilities to the given target. The ...

International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"

... England, January 28 /PRNewswire/ -- The binding Site Limited ("The binding Site" or the "Company"), a privately-owned ... is a unique assay, developed and marketed by The binding Site, used for the diagnosis and monitoring of ...

The Binding Site Announces Trading Update for Year Ended September 30th 2008

... up 26%, Freelite(TM) Sales up More Than 50% The binding Site Limited ("The binding Site" or the "Company"), a privately-owned ... year, strongly outperforming their market as The binding Site gained market share and increased its level ...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

... a change in 3-D structure of the protein receptor binding site. The biochemical and structural modifications induced in the protein binding site provide for superior anti-HCV efficacy using ... a change in 3-D structure of the protein receptor binding site. The biochemical and structural ...

SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres

... and Benefits include: -- Highest free-biotin binding capacity > 12 nmol/mg -- Highest biotin-oligonucleotide binding capacity > 2.5 nmol/mg -- Highest biotin-IgG binding capacity > 1.7 nmol/mg (250 ug) -- Higher ...

Kosan Presents Preclinical Data on Novel Third-Generation Hsp90 Inhibitors at AACR

... a high degree of target specificity, strong binding affinity and potency, a long lifetime in ... and its derivatives, which bind to the ATP binding site in the N-terminal domain. Kosan's lead Hsp90 ... degree of specificity of tanespimycin for the ATP binding pocket of Hsp90 yet do not rely upon activation ...

Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France

... research from radio tracer label data and ligand binding assays supporting the hypothesis that ... In addition, Dr. Hesslink presented in vitro and binding assay studies conducted by a world leading ... action on thromboxane production, receptor binding assays were carried out on the thromboxane A2 ...

DNA technique yields 3-D crystalline organization of nanoparticles

... research, we know that highly selective DNA binding can be used to program nanoparticle ... together to link the nanoparticles. This first binding is necessary, but not sufficient, to produce the ... to unbind, reshuffle, and find more stable binding arrangements." The team also experimented with ...

DNA is blueprint, contractor and construction worker for new structures

... of DNA attached to another gold nanoparticle. The binding of the two single strands of linker DNA to each other completes the double helix, tightly binding the particles to each other. Each gold ... attached to its surface so the nanoparticle is binding in many directions, resulting in a ...

Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech

... breast cancer. r84 is distinctive because it selectively blocks VEGF from binding to VEGF receptor 2 (VEGFR2), while non-selective agents such as Avastin block binding to both VEGFR2 and VEGF receptor 1 (VEGFR1). Selective anti-VEGF agents ...

High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu

... sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... L.E.A.P.S. technology. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and ... containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently ...

Australia: Face Mask That Kills Swine Flu Readied for Australian Pandemic Fight

... sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks ...

Clinical Data on Peregrine's Bavituximab Cancer Program to Be Discussed in Two Presentations at 2009 ASCO Annual Meeting

... of tumors, creating a specific target for anti-cancer treatments. By binding to PS, bavituximab is believed to help mobilize the body's immune system ... effect and dampen the body's normal immune response to cancer. By binding to and blocking PS, bavituximab is believed to boost the body's ability to ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

... L.E.A.P.S. technology. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and ... containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

... specific vaccine. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and ... containing the antigenic disease epitope linked to an Immune / T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently ...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

... the B-cell antigen receptor, and HLA-DR, an HLA Class II molecule. Target binding by the SCORPION molecule has an affinity similar to Trubion's Small ... SMIP(TM) therapeutics -- single-chain polypeptides comprising one binding domain, one hinge domain and one effector domain -- SCORPION therapeutics ...

Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting

... platinum (dach-Pt) release kinetics, ex-vivo and in vivo plasma protein binding and evaluation of red blood cell (RBC) partitioning of ProLindac, a novel ... reported in the 2009 AACR poster provides in vitro and ex-vivo data on the binding of ProLindac to blood components, and suggests a mechanistic rationale for ...

AACR 100th Annual Meeting Highlights Superior Ability of InNexus' DXL-Modified Anti-CD20 Antibody to Attach and Kill NHL With Safety Comparable to Approved Antibody Therapies in Preclinical Studies

... These "self-binding" interactions were seen to effectively increase the binding strength between the antibody and the target antigen, as determined ... and " Oxidative Modification Of An Anti-CD20 Antibody Imparts Autophilic binding Kinetics ", (AACR# 1230). Posters and company representatives will also ...

Researchers develop new way to see single RNA molecules inside living cells

... location of RNA inside a single cell and the interaction between RNA and binding proteins," said Philip Santangelo, an assistant professor in the Wallace ... RNA-protein co-localization, which is the joining of RNA molecules and RNA binding proteins in a single cell. "We observed substantial transient ...

Brown chemists create more efficient palladium fuel cell catalysts

... acid fuel cell. The researchers then did something new: They used weak binding amino ligands to keep the palladium nanoparticles separate and at the same ... important step, Mazumder emphasized, because previous attempts to remove binding ingredients have caused the particles to lose their rigid sizes and clump ...

New research identifies faster detection of viruses

... the viruses by using micro-sized cantilevers to directly detect viruses binding to membrane proteins. Micro-cantilevers, which look like springboards ... was submerged in a T5 containing fluid, the researchers detected the virus binding to FhuA by measuring shifts in the vibrational frequency of the ...

Hong Kong Biotech Company, Filligent, Announces CE Certification of Its Revolutionary, Anti-Infective Medical Face Mask, the BioMask

... sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks ...

Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling

... Officer, Patrick Baeuerle. Micromet is developing two antibodies binding to EpCAM. MT110, an EpCAM-specific BiTE antibody, is being tested in a ... a phase 1 clinical trial with adecatumumab, a human monoclonal antibody binding to EpCAM, investigating its use in combination with docetaxel for patients ...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

... demonstrated that CKEY2 disrupts PF4-RANTES heteromer formation by binding preferentially to RANTES. In vitro assays demonstrated that CKEY2 ... receptors for MIF. Identification of structural motifs for high affinity binding of MIF to its target receptors ( Weber et al., PNAS, 2008 ) enables ...

Genmab A/S: Ofatumumab Pivotal CLL Data to be Presented at ASH

... Mabs Allows for Calcium Influx Which Induces Streamers. Poster I-683 - binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab ... that targets a distinct membrane proximal, small loop epitope (specific binding site) of the CD20 molecule on the surface of B-cells. Ofatumumab is being ...

deCODE genetics Announces Third Quarter 2008 Financial Results

... suggest that the observed side effects were closely correlated with the binding of these molecules in the PDE4 enzymatic active site competitively with ... Those structures allowed the deCODE chemistry team to identify a novel binding site for allosteric modulators in the PDE4 regulatory domain. In animal ...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... agent, doxorubicin. The design of this product allows for the specific binding and selective uptake of the cytotoxic conjugate by LHRH-receptor-positive ... these receptors, results in its accumulation in the malignant tissue. This binding is followed by internalization and retention of the cytotoxic ...

Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants

... recombinant human insulin-like growth factor (rhIGF-I) and its predominant binding protein IGFBP-3 (rhIGFBP-3), increased serum IGF-I levels into the normal ... human insulin-like growth factor-I (rhIGF-I) and its predominant binding protein IGFBP-3 (rhIGFBP-3). The drug, approved in the United States in ...

Sonus Pharmaceuticals and OncoGenex Technologies complete business combination; OncoGenex Pharmaceuticals to commence trading on NASDAQ Capital Market today

... aims to reduce the production of both Insulin-Like Growth Factor binding Protein -2 and Insulin-Like Growth Factor binding Protein -5 with a single product to enhance treatment sensitivity and ...

Research helps understand factors that influence efficiency of organic-based devices

... every vendor's indium tin oxide is somewhat different. Then he modeled the binding of a self-assembled monolayer of phosphonic acid to the indium tin oxide ... at the University of Arizona, they were able to characterize the main binding modes of the phosphonic acid molecules on indium tin oxide. This work has ...

Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests

... Rosetta Genomics has Signed a binding Term Sheet to Acquire Parkway Clinical Laboratories Inc., a Company ... diagnostics and therapeutics, announced today that it has signed a binding term sheet to acquire Parkway Clinical Laboratories Inc. ("Parkway"), a ...

Sonus Pharmaceuticals and OncoGenex Technologies to Merge

... aims to reduce the production of both Insulin-Like Growth Factor binding Protein -2 and Insulin-Like Growth Factor binding Protein -5 with a single product to enhance treatment sensitivity and ...

Sidec AB Expands Into New Offices

... interaction in situ and in vitro for a rapid localization of antibody binding epitopes and validation of molecular mode of action. With Sidec's ... the most promising therapeutic antibody and to locate the antibody binding epitope. The company's new location is Torshamnsgatan 30A, SE-164 40 ...

MIT explains spread of 1918 flu

... human upper respiratory tract. Two mutations dramatically change the HA binding affinity to receptors found in the human upper airways, said Ram ... as a model system to investigate the biochemical basis for hemagglutinin binding to glycans, which leads to viral transmission. They compared the virus ...

Immune system protein starves 'staph' bacteria

... zinc. The findings, reported Feb. 15 in Science, support the notion that binding metals to starve bacteria is a viable therapeutic option for treating ... that calprotectin inhibits staph growth and that it does this by binding chelating nutrient metals, specifically manganese and zinc. It ...

AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers

... uptake of the cytotoxic conjugate by LHRH-receptor-positive tumors. The binding of AEZS-108 to cancerous cells that express these receptors results in its accumulation in the malignant tissue. This binding is followed by internalization and retention of the cytotoxic drug, ...

Schering-Plough Announces Sugammadex New Drug Application Filed in Japan

... Welfare (MHLW) seeking marketing approval for its novel selective relaxant binding agent (SRBA), sugammadex. Sugammadex is specifically designed to rapidly ... 19, 2007. About Sugammadex Sugammadex is a novel selective relaxant binding agent (SRBA) under development by Organon, a part of Schering-Plough ...