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Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

...cence patterns that may be associated with bad prognosis. To illustrate the approach, Figure 4 shows immunofluorescent staining of cryostat sections of an SCC tumor (Figures 4B, E, H, K, and N) and urothelium with field disease (Figures 4C, F, I, L, and O) obtained from ...

A heavenly tax cut: Act 255 stimulates economic growth

...mes, legislators like me can focus too much on the bad things happening in our state. We spend a lot of time talking about our oppressive tax burden, out of control spending by state government, a regulatory scheme that stifles business development and an economy that is growing more slowly than the rest...

Corporate Social Responsibility - Burden, sham, or golden opportunity?

...eparate sustainability reports. Is CSR a good or bad thing? Does it represent an opportunity to recognize the many ways that business and society are interdependent and to help make the world better while creating economic growth? Or does it place unfair and unrealistic obligations on corporations? Or ...

Who is minding the Innovation Gap?

...dirt, while there are legions of examples in which bad management have doomed otherwise promising ideas t...a great management team is highly desirable (and a bad management team certainly to be abhorred), not all ideas traversing the innovation gap require a pha...

Media-savvy workers: New front in the War for Talent

...ide of work can be put to good use on the job. The bad news is few organizations yet recognize or are doing anything to engage and leverage the skills of media-savvy workers. Research recently conducted by a team of researchers and thought leaders brought together by QuestG suggests that the emergenc...

Promega Corporation: Wisconsin's quiet innovator

...of good news in terms of sophisticated science and bad news in terms of funding and technology transfer. Madison is interesting, he said. The seeds of invention are here. The university is just incredible. The science the university puts out can generate biotech-sales capability. The problem stems from ...

Symantec: Cyber fraudsters look for low-hanging fruit

...munities. Think of it as social networking for the bad guys. This is where commodities such as people's i...ctivity? Cole : Yeah, but there is good news and bad news in this report. The bad news is that, absolutely, the criminals are coordinated. Absolutely, th...

Chicago-Milwaukee "mega-metro" infrastructure improvements are critical

...option to stay at home on days when the weather is bad or when some other issue pops up. There are also... a home office are pretty cut and dried. It's too bad we do not have Verizon up here because they have packages today that offer 50Mbps. You need fiber...

Here's why Wisconsin's stem cell patents are being challenged

...on by the U.S. Patent and Trademark Office looks bad if you're watching this drama play out at home - but Wisconsin has yet to have its day in court. The Patent Office announced two weeks ago it has rejected three patents filed by Dr. James Thomson, the world-famous UW scientist who discovered how to ...

Proposed telecom bill would have Katrina impact

... the model for remote offices corporate-wide. Too bad your community does not have that type of package ...ead of Chicago as far as population back then. Too bad its politicians made the wrong decisions. In 35 years, Chicago surpassed St. Louis, which is now abo...

Early Stage, Step 9: Raising capital in the securities landscape

...y do the laws not indicate whether it is a good or bad investment, but there is no assurance you can resell the security to anyone. In other words, when individuals invest in small new companies, they better understand that their money is illiquid, that it is not going to be repaid anytime soon. This i...

A Midwest life-science odyssey comes full circle

... of Beloit's population hailed from this area. Not bad for a small Wisconsin town in the middle of farmland (and bloody cold in the winter). I think we made Midwest history with a Frank Zappa and the Mothers of Invention concert my freshmen year, when it seemed half of Wisconsin and Chicago descen...

UW System must remove barriers to innovation

...heir education at UW-Milwaukee. Good money after bad leadership I agree with the Governor that we nee...em, but dumping piles of new money into it rewards bad behavior. New money should have a list of contingencies; set goals to meet on a set timetable. The G...

Healthcare of business: Universal coverage plan includes new business taxes

...mer presented a study in which 10 vice stocks (the bad guys such as tobacco, gambling, and alcohol stocks...'s flamboyant presentation - were compelling. The bad guys gave an equal-weighted return of 35.7 percent over the past year as compared to the good guys, ...

Data centers: Buyers beware of over-hyped facilities

...: Impressive ink and unfortunately deserved. Too bad for them. I'm not Rain Man Without belaboring the points raised by the readers, I did not get a good impression of what PEAK 10 claimed they had in terms of facilities, and I would be very suspect of what they list in their marketing materials a...

The 10 biggest events shaping biotech in 2006

...of new stem cell-based research and therapies. Not bad considering that Wisconsin was the forerunner of much of this research, and holds a number of key patents. The promise of stem cell-based therapy is still early but exciting, and it may change the course of therapy as we know it. Biofuels The exp...

Real pulse of the economy? Check real estate foreclosures

..., it seems like there are pockets of both good and bad economies within the overall economy, so the future is dependent on where you're at within the job market. Reality in foreclosures From a recent edition of the Small Business Times , the headline read, Foreclosures skyrocketed in 2006 in the Mid...

The Apple iPhone: A call to competitors

...o charge a premium for their coffee, no matter how bad it is. Try to find a restaurant with coffee under a dollar today. You can't. Some are charging $1.95 on stuff that you could use for an oil change. Coffee is coffee, but when you add some premium label, everyone else raises their price because they s...

Intellectual Property: Are you an infringer?

...sonal culpability. The district court did not find bad faith or fraud or culpable intent on the part of [the officer-owner]. The court erred in imposing liability, although the corporate veil was not pierced. (Hoover Group, Inc. vs. Custom Metalcraft, Inc., Fed. Cir. 1996) The concepts of contributory...

New book touts educational power of computer games

...ood for kids," Shaffer stated. "However, there are bad games out there, just as there are bad books. So adults who care about what children learn have to educate themselves about games - and, mo...

Two-week notices: People are still concerned

...professional when you go, they cannot say anything bad about you other than you opted not to give two wee... waste your time, your energy, or your emotions on bad ones. CARLINI-ISM: Two-week notices are, at best, only for those employers that earn them. Copyr...

The press vs. Google: Copyright cases to watch

...n the books against the risk of making law that is bad for future disputes or negotiations. Just the facts? A fundamental principle of copyright law is that it protects an author's original expression but not any facts or ideas divorced from that expression. Facts and ideas inhabit the public domain...

DNASTAR catches second wave of sequencing

...The early 1980s was an era where it was considered bad form - even a social stigma - for an academician like Blattner to start a business. The dominant perception was that research and development was a big company function. We were among the first five or 10 [technology] companies getting off the grou...

Midwest gaining stature in nanotech research

... as Massachusetts, New York, and Pennsylvania. The bad news is that the number one state, California, is far ahead of the other states. Illinois moved up from 3rd place to second place this year, passing over Massachusetts by a nose! In the prior month's edition, Small Times ranked the states in term...

Securities compliance is part of raising capital

...ss will likely save money and reduce the risk of a bad offering in the long run. Previous articles by Matt Storms Matt Storms: Raising capital through placement agents Due diligence and corporate clean-up Matt Storms: The mechanics of raising capital for your business Sarbanes-Oxley f...

Early-stage quality brings investment, Meier says

...sideration is that 2005 was viewed as an unusually bad year for venture investment in Wisconsin, even as national venture investment continued to rally. Last year, people were saying, `Why on Earth is there so little being invested in Wisconsin? This is ridiculous,' Esser said. Now we're getting back ...

Wisconsin identity theft law: A cheap plastic sword

...re a business, Wisconsin's law isn't necessarily a bad thing. In fact, it's probably a good thing. There's been a national clamor by consumers for protections from identity theft. What better way to quiet the masses than with new legislation that appears to be a strong weapon to combat identity theft, bu...

The misguided talent war

...e issue then is not whether meritocracy is good or bad but how to do it right. What should the logic of meritocracy be - that the most talented receive the lion's share of rewards or that all performers are rewarded commensurate with their contribution? There is no doubt that top talent is important, but...

Early-stage executives hear from investors

... expect much faster returns, Meier said it's not a bad idea for any technology company to start thinking about sales long before the product goes to market. If nothing else, talking to potential future customers will sharpen the sense of product validation. "Before you even start your business," Meier s...

Midwest colleges strong contenders for NIH funds

...rsity of St. Louis and University of Michigan; not bad when you consider that there are more than 1,000 research institutions that win NIH money annually The Midwest also had another nine universities in the top 50 institutions winning NIH funding during 2005, for a total of 11 institutions in the top ...

Treo 700w solves my smart phone woes

...r enough to make modifications that corrected this bad design. In fact, Palm has modified Windows Mobile 5 in several places to make basic tasks much less obscure than they are in Microsoft's native implementation. For example, in the text message application, Palm added a menu item to look up recipient...

IT worker shortage linked to tech enrollment drop

...Solutions . "There is a decline, but it is not as bad as it may seem." Dakwar said. "It looks like IT is coming back. Every indication shows that IT is growing. The only unfortunate part is we don't see the students yet." To attract more students, Dakwar and his colleagues are developing virtual server...

Safe Internet requires total network security, prof. says

...nt from the standpoint that it also means that the bad guys are getting much more organized and focused in their activities," Barford stated. So while there have been issues of worms, viruses, and spy ware for years, Barford predicts they are going to grow more acute in the near future, which suggests t...

NIH '05 funding: Midwest has two states in Top 10

...are in these results? Well, there is good news and bad news. The Midwest had two states in the top 10 l...ase - not spectacular but by no means shabby! The bad news was that if you add up all of the results of the six Midwestern states, the total funding was a...

Compliance at HP - Pretexting paranoia

...s because people see the company as getting rid of bad leadership. My advice to Larry is "Wake up and sme...all actions taken under the investigation. I feel bad for the employees of HP and their new super-star CEO, Mark Hurd, who have been working so hard to re...

Am I spoiled if I expect well-designed mobile devices?

...ngness to forgive poor design only propagates more bad design. More technology consumers need to become more spoiled if our technology-rich lives are going to become less complex. So, yes, Sherry, I am spoiled. And while I'm delighted that you are pleased with your mobile device choice, I can't share y...

Madison is flourishing while Marinette is dying

..., Mississippi, and Alabama. If Madison has such a bad business climate, why are there so many cranes in the skyline? You can build more than an office here, you can build a career here. You can play professional golf (see Steve Stricker, Jerry Kelly, Andy North, and Sheri Steinhauer), work on state leg...

Business leaders can learn from historical insights

...siness and higher-education environments. It's too bad that many people in those higher-level positions are not familiar with his observations: "The purpose of education is to replace an empty mind with an open one." "People who matter are most aware that everyone else does, too." "Never hire someo...

Opportunities rise from travel chaos

...tier will help fellow travelers make the best of a bad situation. This weekend, I take off for my first international travel since the new rules were imposed last week. Ill report from the road, and I ask you do the same. How are you making business travel tenable? What are you doing to transport your t...

Medical College researcher working to make genetic-based medicine a reality

... response to the drugs, which patients will have a bad response, who will likely have no response, and who will experience side effects. Project timetable Stephens, who earned his doctor of medicine degree from the University of South Dakota , believes five years is a realistic time frame for the ...

Fiber-optic infrastructure spurring city economic development

... 1 gigabit or bust by 2010 and saying that isn't a bad benchmark to adopt. They definitely aren't understanding the market. In fact, they are probably putting this country in jeopardy from a global competitiveness standpoint. Put the bandwidth out there and people will use it. Economic development and ...

No word on NASDAQ extension for Merge

...de," Pedlar said. Dunham characterized the recent bad news as "non-cash-effecting" items and said the company has sufficient liquidity with $60 million in cash on hand....

Elimination of phone tax tempered by paperwork

...ing a 41-month period between 2003 and 2006. The bad news is that neither the Internal Revenue Service nor telephone companies will be required to calculate the taxes paid by business consumers. Companies or their tax preparers will have to pore through phone bills dating back to March 1, 2003, to fi...

Some great insights into the current Mergers & Acquisitions Market

...here you wind up finding out later that this was a bad match. While this sounds so basic, it isn't. All in all, the panels provided some practical insights for finding successes and failures that armed everyone with some valuable concepts to integrate into their strategies. The Awards Dinner Conclud...

Work-life imbalance - A global problem getting worse

...ress coming to grips with this issue. Things are bad all over According to the authors, the main culprit for the growing gap between work and life is globalization and the "productivity" pressures it's causing that are undermining progressive policies and a focus on equity in the workplace. "The glob...

Security goes beyond technology into common-sense practices

... priority of CIOs and CTOs a couple years ago. Too bad they don't guard against a lack of common sense. Security goes beyond installing technology and software. It is a strategic issue and should be part of the overall policies and procedures of an organization. You would think with Sarbanes-Oxley focus...

Keyword advertisers win some, lose some

...ce." Perhaps the court was swayed by other claimed bad acts of the competitor, including displaying the EDINA REALTY trademark on its site in white font on a white background. That case has now settled. In direct contrast is the other recent ruling, issued from the Southern District of New York in Mer...

A (modern) Tale of Two Cities: Milwaukee and Madison inch together

...ze one city in favor of the other, or which reward bad behavior in one city while punishing good policy in the other. Still, it was a night when Barrett made it to the forum on time despite a flat tire on I-94 and Cieslewicz needed to skip part of a pivotal City Council meeting. Better yet, theyve pled...

California group says ruling weakens WARF's stem cell patent

...Cohn said. "This company [Xenon] made a very, very bad tactical decision by trying to get out of, or trying to ignore the contract they made with us. They are now paying for it dearly." Dr. Simon Pimstone, president and CEO of Xenon, could not be reached for comment. California dreamin'? The FTCR's ...

Two DEMO alumni make big product splashes

...6% with overall growth at 111% year over year. Not bad for a company and an OS that some were ready to write off to the onslaught of Microsoft smart phones. My suspicion: Windows-based smart phones and other devices may do well as the choice of the enterprise volume buyer, but when individuals make a sid...

Managing the nightmare of identity theft

... rate of inflation, a strict standard could make a bad situation worse, he said. "I assure you the cost ...all criminal culpability centers on knowledge of a bad act. "If you know people's credit card bills are being run up, and you don't do anything about it, y...

A missing link in innovation

...e economy can not be an excuse for why business is bad and why it is good. We need to keep growing and innovation is how we grow." Despite all the attention, 96% of innovation initiatives fail . Even a small increase in success rate can be a major advantage for a business. S.C. Johnson and their fam...

In public attitudes about taxes and spending, Wisconsin is Jekyll and Hyde

...the Senate, where many senators may believe it's a bad idea to alter the Constitution to control spending and taxes. Wisconsin has a representative democracy, skeptical senators argue, and voters elect legislators to make tough tax and spending decisions for them. If those voters don't like decisions mad...

Consultant says beware hidden costs of bad IT projects

...hands indicated that most in the audience have had bad project experiences. Throughout the seminar, they were advised to implement an IT governance model with the aid of assessment frameworks like COBIT (why to remediate) and ITIL (how to remediate), and program tools like Project Office. Balon, who has ...

Notion of bandwidth spedometers for DSL, cable sparks controversy

...r. There were even some people who said it's took bad if you can't figure it out yourself. My reply to that comment was: "I don't need to be a master electrician to plug in a toaster. Why should I have to know all these 'techie issues' to use the network?" If everything is always so good, having a netwo...

Renew your domain name!

...fense, there are many who register domain names in bad faith, i.e., with the intent to wrongly profit fro...k and a dictionary word has registered the name in bad faith, this is often evident from the fact that the particular combination of registered "dictionary...

Critics say tax limits could handcuff tech investment

...s not only decimated the schools, it has been very bad for business," Leistikow said. "I think there will be a lot of opposition to the amendment with or without this [AP] study, and there will be opposition from the business community because it would really put economic development in the crosshairs." ...

The world's leading biotech companies

...ts actually grew 18% for the top 25 companies. Not bad for an industry that invests an unprecedented amount of money in R&D to develop new products! Now I have to admit we only listed the top 25 companies out of a worldwide total of close to 4500 biotech companies, so this is not the complete picture. M...

Midwest plays small role in VC investment, angel groups to the rescue

...nd have more than doubled in the last 3 years; the bad news is that this segment is minuscule, representing less than 4 percent of total VC money. If you also add in the early stage money, which represents about 16 percent of total VC money, the two categories, just about reach 20 percent of total VC in...

2005 was a tough year for U.S. biotech financing

...billion in 2005 was down 7 percent. This result is bad news for the 1200+ privately held biotech companies in the U.S. that depend mostly on VC financing. Assuming the number of 1200 companies, the average raise-up per company was less than $3 million in 2005, versus about $37 million/company for publicl...