Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients

... monitoring cardiac transplant patients with the urine NGAL assay on Abbott's ARCHITECT immunoassay ... drug combinations and monitored with the urine NGAL assay within twelve hours of administration. The study concluded that urine NGAL monitoring may be able to assist in the ...

International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"

... obviates the need for analysis of 24-hour urine samples and eliminates the associated ... of AL amyloidosis, in which case a 24-hour urine sample should be run in addition to the ... paraprotein and it is present in the blood and/or urine in about 99% of cases. Normal antibody levels are ...

Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure

... elicited a statistically significant increase in urine output during infusion at both dose levels ... of CD-NP, there was an increase in hourly urine output of 48 mL/hr (p=0.01) compared to the ... CD-NP resulted in an increase in the hourly urine output of 93 mL/hr (p<0.01) compared to the ...

HemoCue Receives First FDA CLIA Waiver in Diagnostics Industry for Quantitative Point-of-Care Test for Microalbuminuria, a Kidney and Cardiovascular Disease Risk Marker

... test that accurately measures albumin in urine is expected to have a positive impact on ... of microalbuminuria. Unlike semiquantitative urine "dipstick" methods, which indicate if a patient's ... Foundation (NKF), physicians should assess urine albumin excretion annually in patients with type ...

Arizona Pain Society and Dr. Robert Barkin, Rush University Medical Center, Present Program on Comprehensive Urine Drug Testing Sponsored by Dominion Diagnostics

... program entitled "A Comprehensive Review of urine Drug Testing: Which Test, Which Patient and ... Barkin's instructional program on comprehensive urine drug testing followed an introductory segment on ... advanced, state-of-the-art clinical quantitative urine drug testing and monitoring for Pain Management, ...

GenVault Partnership with Genome Quebec Brings $3.3 Million Sale of Dynamic Archive Product

... a database of health-related data, and blood and urine specimens. It will be made available for ... include: biological data obtained from blood and urine samples (DNA, blood sugar levels, lipids ... data. Its biobank will contain DNA and blood and urine samples. Access to CARTaGENE will be granted to ...

AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

AEterna Zentaris Opens Extended Study for Cetrorelix in Benign Prostatic Hyperplasia

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs

... ducts of the kidney by binding to vasopressin 2 receptors, decreasing urine volume. Clinical data indicate that VA106483 is generally well tolerated ... an effective anti-diuretic that increases urine concentration and reduces urine output. Vantia's initial indication for VA106483 is nocturia. A ...

AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... in the kidney. Decreasing SGLT2 levels promotes glucose excretion in the urine and reduces blood sugar levels, making it an attractive target for the ... on human subjects who have mutations in the SGLT2 gene and have increased urine glucose levels but are otherwise asymptomatic. ISIS-SGLT2Rx effectively ...

Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure

... frequently in the management of heart failure patients. The average total urine volume during the 24-hour infusions of CD-NP at 3, 10 and 20 ng/kg/min was ... in which patients received standard doses of furosemide, the average total urine volume was 2,217 ml. "Worsening renal function is an independent ...

AEterna Zentaris Completes Patient Recruitment for Second Efficacy Trial of its Phase 3 Program with Cetrorelix in Benign Prostatic Hyperplasia

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

Gen-Probe Reports Strong Financial Results for First Quarter 2008, Raises Full-Year Guidance

... prostate cancer marker PCA3. In the first article, "PCA3: A Molecular urine Assay for Predicting Prostate Biopsy Outcome" (Volume 179, Issue 4, ... and number of prior biopsies. In the second article, "PCA3 Molecular urine Assay Correlates With Prostate Cancer Tumor Volume: Implication in ...

AEterna Zentaris Completes Patient Recruitment for First Phase 3 Efficacy Trial with Cetrorelix in Benign Prostatic Hyperplasia

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia

... to urinate, waking at night to urinate (nocturia), difficulty starting a urine stream (hesitancy and straining), decreased strength of the urine stream (weak flow), feeling that the bladder is not completely empty, an ...

PLC Systems to Present at the ROTH Conference

... This therapy is based on the theory that creating and maintaining a high urine output is beneficial to patients undergoing imaging procedures where ... design of the RenalGuard System is intended to ensure that a high urine flow is maintained before, during and after these procedures. This should ...

Acrongenomics on Track to Acquire Molecular Vision

... Laboratories. The results of comparative trial measuring creatinine in urine will be presented comparing the Molecular Vision device with the Siemens ... unit capable of measuring creatinine and vitamin C simultaneously in urine with the same level of accuracy and sensitivity to a pathology laboratory ...

Inverness - Chemogen Establish Exclusive License for TB Antibodies

... antibodies for the detection of Lipoarabinomannan (LAM) antigen in urine as an aid in the diagnosis of current mycobacterial infection (including ... a rapid point of care assay that will reliably and rapidly detect LAM in urine samples, using its proprietary lateral flow technology. About Inverness ...

Avitar's Notes Significance of New On-Site Oral Fluid Drug Testing Laws

... devices are cheaper, faster and easier to use than urinalysis. Traditional urine testing typically takes several days to obtain results, and requires ... provides initial results within 5-15 minutes at a fraction of the cost of urine lab tests. Any non-negative on-site test results can also be confirmed in ...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

... and tolerability, kidney GL-3 as measured in urine, and an assessment of renal function (including glomerular filtration rate (GFR) and 24-hour urine protein). Additionally, the FDA and Amicus reached agreement on an improved methodology for the histological evaluation of GL-3 in the kidney ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... dose-related decreases in blood pressure, increases in plasma cGMP (cyclic guanosine monophosphate), a natural messenger nucleotide, and increases in urine volume and sodium excretion. There were no serious or severe adverse events. PL-3994 incorporates a novel and proprietary amino acid mimetic ...

Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer

... is based on the discovery that circulating nanovesicles called exosomes contain unique genetic markers that can be reliably harvested from blood and urine and used diagnostically. For more information, visit www.exosomedx.com . ...

UCSF researchers help crack parasite genome, identify drug leads

... infects humans via the skin, taking approximately 6 weeks to reach adulthood and reproduce. For disease transmission, those eggs must be evacuated in urine or feces into fresh water, where the next parasitic stage seeks out a snail host to continue the life cycle. "It's a wonderfully evolved ...

Stanford researchers find a quicker, cheaper way to sort isotopes

... Zare said. Doctors and pharmacologists can use isotopic analysis to measure the targeting precision of a specific drug by testing samples of urine and breath to see if the right organs have properly metabolized it. Also, climatologists can learn more about the ancient earth by studying carbon ...

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

... core technology is based on discoveries by Harvard and Massachusetts General Hospital researchers that circulating nanovesicles in blood and urine called exosomes contain unique genetic markers that can be reliably harvested for personalized medicine cancer diagnostics. For more information, ...

Vancouver General Hospital is the First Canadian Institution to Implement Copan WASP(R): Walk-Away Specimen Processor

... the first instrument of its kind to use a single universal platform to automatically plant and streak most bacteriology specimens, including swabs, urine and fecal samples, regardless of the specimen's container style or specimen type. (Photo: ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... of cancer-related mutations where critical mutations are present at a very low percentage compared to normal DNA. Examples would be in blood and urine or where the tissue collected contains mostly normal cells. This would allow clinicians to use less intrusive methods for genetic analysis or allow ...

Corgenix to Exhibit AspirinWorks(R) Test at ACC.09

... platelet tests, which require freshly drawn blood that must be evaluated within at least four hours, the AspirinWorks Test is performed on a random urine sample that can be obtained in any doctor's office or patient service center, making the test convenient for both physician and patient. ...

Noridian Medicare Now Covers Renessa(R) Treatment for Incontinence in Women

... who suffer from the debilitating effects of SUI," she continued. Female Stress Urinary Incontinence SUI is the involuntary leakage of urine associated with laughing, coughing, sneezing and recreational activities. The condition is caused by a variety of factors, most commonly childbirth, ...

Watson's GELNIQUE(TM) (oxybutynin chloride) Gel 10% Approved by FDA for the Treatment of Overactive Bladder

... GELNIQUE was superior to placebo at relieving OAB symptoms, including a reduction in incontinence episodes and urinary frequency, and an increase in urine void volume. The treatment was well tolerated in the study with a low incidence of adverse events and no treatment-related serious adverse events. ...

UCF professor develops vaccine to protect against black plague bioterror attack

... freeze-dried plant cells to five-week-old diabetic mice for eight weeks. By the end of this study, the diabetic mice had normal blood and urine sugar levels, and their cells were producing normal levels of insulin. Daniell figured the same approach might work with a vaccine. He genetically ...

Winning University of Melbourne Ph.D. research boosts the search for sensitive sensors

... or explosives in the air or liquid. They could even result in more sensitive pathology, detecting minute amounts of drugs or hormonal changes in urine tests. Dr Gomez's PhD at the University of Melbourne examined the optical properties of nano-cystals of cadmium selenide, an element commonly used ...

Morria Biopharmaceuticals Plc Announces Positive Clinical Results for MRX-4 in its Phase II Clinical Study in Allergic Rhinitis Patients

... followed by an intranasal dose of allergen on the morning of the seventh day with a clinical follow-up and scoring over the next 24 hours. Blood, urine and pharmacokinetics (PK) analyses were also conducted. MRX-4 efficacy was assessed by its reduction of six clinical categories: rhinorrhea, nasal ...

Corgenix to Exhibit AspirinWorks(R) Test, Discuss New CHARISMA Trial Results at AHA 2008 Meeting

... functional platelet tests, which require freshly drawn blood that must be evaluated within at least four hours, the AspirinWorks Test only requires a urine sample that can be obtained in any doctor's office or patient service center, making the test convenient for both physician and patient. Physicians ...

FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children

... mild and temporary. Side effects may include headaches, muscle pain, joint stiffness, weakness, high blood sugar (hyperglycemia), sugar in your urine (glucosuria), swollen hands and feet due to fluid retention, and redness and itching in the area you inject. If you have any of these symptoms, ...

Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008

... higher urinary recovery than observed for colistin. Accordingly, and in contrast to colistin and polymyxin B, the NAB compounds are excreted into urine to a significant extent. This indicates that the reuptake of the NAB compounds in the proximal tubuli of the kidneys is less intense than that of ...

FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

... and developed by Astellas Pharma Inc. headquartered in Tokyo, Japan, Vaprisol is a drug that blocks the activity of AVP, resulting in increased urine output without loss of valuable electrolytes such as sodium and potassium. This effect, known as "aquaresis," helps to increase serum sodium levels ...

PLC Systems Expects Common Stock To Be Delisted From American Stock Exchange

... replacement capability, is intended to minimize the risk of over- or under-hydration during medical procedures where creating and maintaining high urine outputs is deemed beneficial to patients. Headquartered in Franklin, Massachusetts, PLC pioneered the CO2 Heart Laser System, which cardiac ...

UCF professor develops vaccine to protect against black plague bioterror attack

... freeze-dried plant cells to five-week-old diabetic mice for eight weeks. By the end of this study, the diabetic mice had normal blood and urine sugar levels, and their cells were producing normal levels of insulin. Daniell figured the same approach might work with a vaccine. He genetically ...