FASgen Diagnostics, LLC Announces Production and Investment Agreement With Tetracore, Inc.
... antibodies. The tests measure the
over-expression of the enzyme fatty acid synthase
(FAS), which is found in
virtually all solid tumor cancers. FASgen's ... Hopkins who have been studying the role of over
expression of fatty acid synthase
in cancer. That work has been underway
for more than 15 years. FASgen ...
Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France
... organization for the
pharmaceutical and biotechnology industries. In these in vitro studies,
Celadrin(R) was shown to inhibit the thromboxane synthase
prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2) as substrates.
Thromboxane is a very strong facilitator of inflammation and local ...
New approach may render disease-causing staph harmless
... in Staph. He also knew that many compounds already had been developed to block the human enzyme.
I thought there was a good chance that squalene synthase
inhibitors developed early on as cholesterol lowering agents might also work on this other pathway, he said. Current cholesterol-lowering drugs like ...
ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
... agent 5-FU.
In comparison to leucovorin, CoFactor creates more stable binding of the
active form of 5-FU to the target enzyme, thymidylate synthase
CoFactor bypasses the metabolic pathway required by leucovorin to deliver
the active form of folate, allowing 5-FU to work more effectively. ...
Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System
... of enolpyruval-shikimate-3-phosphate
(EPSPS), which is required for the production of ... target enzyme 5-enolpyruvylshikimate 3-phosphate synthase
in atomic details. Proc Natl Acad Sci ... the 5-enolpyruvylshikimate-3-phosphate
active site. Journal of Biological Chemistry ...
Oragene and DNA sequencing with ABI PRISM
... Primer design
PCR primers for the human Thymidylate synthase
(TYMS) gene were designed
based on the publicly available DNA ... 5 samples correctly aligned to
the original human Thymidylate synthase
gene sequence. Figure 1 shows
a representative ABI PRISM ...
RNA Interference and Gene Silencing: History and Overview
... Lemieux C, and Jorgensen R. (1990)
Introduction of a chalcone synthase
gene into Petunia results in
reversible co-suppression of ... Cluster PD, English J, Que Q, and Napoli
CA. (1996) Chalcone synthase
cosuppression phenotypes in petunia
flowers: comparison of ...
A DELFIA Assay for Inhibition of PARP
... increase apoptosis in cancer cells, prevent infiltration of neutrofils and subsequent inflammation, and to suppress the production of nitric oxide synthase
in macrophages 3,4 . In response to low to moderate levels of DNA damage, PARP is activated and NAD levels in the cells decrease. Experiments with ...
RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs
... compound would slow or eliminate tumor growth.
* Based on the observation that fatty
(FASE) is over-expressed in human epithelial
cells, De Schrijver et al (5) considered the gene to be an
Setting up a kinase profiler with IMAP
7. B. Thors, H. Halldorsson, G. Thorgeirsson.
Thrombin and histamine stimulate endothelial
Ser1177 via an AMPK mediated pathway
independent of PI3K-Akt. FEBS Lett 2004
Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray
Ion Trap Mass Spectrometry
... vary depending on the specific site of
the oxidation: MetSO at the Nterminal end of CaM had an effect on CaM-dependent
nitric oxide synthase
(type-I) whereas MetSO near the C-terminus affected
CaM-dependent cyclic phosphodiesterase. 2,3 For a range of biochemical