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Substitution in Biological Technology

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution The use of DOXIL may lead to cardiac toxicity. Myocardial ... be reduced in patients with impaired hepatic function Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl ...

Shire begins the year with a strong performance

... 577.2 581.5 ________ ________ (1) Following substitution of the convertible bond to Shire plc in 2008, the Company no longer receives a tax deduction on its convertible bond interest, and the interest add ...

Spherix Announces 2008 Financial Results

... showed that mice fed sucrose became obese, hyperglycemic; and hyperlipidemic; and atherosclerosis was increased in these mice as well. Equivalent substitution of D-tagatose did not result in the same extent of these conditions and showed that D-tagatose did not promote substantial weight gain. The fat ...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... impairment of attention, vigilance, information processing or declarative memory as measured by the Leeds Psychomotor Battery, Digit Symbol substitution Test or Word Pair Associates Test. Pharmacokinetic analyses revealed dose-related increases in exposure to ITI-007 and two metabolites with ...

BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

... dynamics will likely come from the recent introduction of generic calcium acetate from Roxane Laboratories, as very few Nephrologists oppose the substitution of a generic for Fresenius Medical Care's PhosLo. Another recent market shift came with the introduction of Genzyme's Renvela in Q108. Although the ...

EcoSphere(R) Biolatex(TM) Secures Funding from Granholm and Invest Michigan!

... platform provides EcoSphere biolatex products as replacements for petroleum-based paper and paperboard coating binders such as SB and SA Latex. At substitution levels up to 50 percent, the biolatex products are comparable or superior to traditional petroleum-based alternatives and can be specifically ...

New nanocluster to boost thin films for semiconductors

... for large-area applications. The key to a "bottom-up" production of possibly the first heterometallic gallium-indium hydroxide nanocluster was the substitution of nitroso-butylamine as an additive in place of nitrosobenzene. The substitute was identified during a comprehensive screening of potential ...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

... which is found in all major human populations It is a naturally occurring variant of human IFN alpha 17, which incorporates an innovative amino acid substitution G45R that provides a novel positive charge together with a change in 3-D structure of the protein receptor binding site. The biochemical and ...

Shire Delivers Strong Quarter: Driven by $243m of New Product Sales (+164% YOY Growth). Revenue Guidance Upgrade.

... three months to June 30, 2008 was 4% lower than the corresponding period in 2007 principally due to a permanent tax benefit arising on the debtor substitution of the Company's convertible bond on the Scheme of Arrangement in May 2008. Equity in earnings of equity method investees Net losses of equity ...

Shire to Introduce a New UK Listed Holding Company

... election, will be deemed to have elected to receive their dividends from a company resident for tax purposes in the UK (i.e. Shire). Issuer substitution under Shire's Convertible Bonds In connection with the Scheme, Shire Limited will be substituted in place of Shire, with effect from immediately ...

GPhA Annual Meeting Focuses on Industry Opportunities and Challenges for 2008

... -- Enacting legislation to promote e-prescribing to increase patient safety. -- Stopping state "carve out" legislation that bars generic substitution for various therapeutic classes of medicines. Carve outs cost states millions of dollars. GPhA represents the manufacturers and ...

Rochester Medical Reports 31% Increase in Branded Sales Resulting in 9% Overall Sales Growth for the First Quarter

... provided by other companies. Non-GAAP Net Income has limitations as an analytical tool and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income are presented at the end of this press ...

FDA Approves INTELENCE(TM) (etravirine) for HIV Combination Therapy

... Agents and Chemotherapy (ICAAC) in September 2007. DUET-1 and -2 Resistance -- The presence of K103N, which was the most prevalent NNRTI substitution in DUET-1 and -2 studies at baseline, did not affect the response in the INTELENCE arm. -- The presence at baseline of the substitutions ...

Dragon Announces R&D Achievement in Biotech Manufacturing Process

... industries during China's 10th Five-year Plan period. Currently, project team members are already in the critical stage of raw materials substitution test, bacteria selection test and fermentation process optimization. This press release contains forward looking statements, including but not ...

Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA

... use in patients who were not already taking opioids around-the-clock (opioid nontolerant); improper dosing of the medication; and/or improper substitution of FENTORA for other fentanyl-based medications. The letter has been sent to physicians, pharmacists, managed care organizations, and other ...

Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201

... on the subjective perception of sleep quality. The following morning there was no subjective perception of any residual sedation. The Digit Symbol substitution Test (DSST) showed a small but clinically insignificant change tested the next day 9 h after dosing. The PSG analysis also showed that EVT 201 did ...

SemBioSys updates Apo AI development program

... which naturally removes plaque from arteries. Apo AI Milano is a natural variant of native human Apo AI characterized by a single amino acid substitution in its primary structure. In an epidemiological study, Apo AI Milano appears to confer enhanced resistance to atherosclerosis, suggesting that it ...

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

... G to A substitution that results in Val to Ile change at position 64 ... enzyme G to A substitution that results in Arg to Gln change at position 506 ... C to T substitution at nucleotide position 677 that results in an Ala ...

Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A

... proteins at relatively moderate acrylamide concentrations. Thus, substitution of tricine for glycine as the trailing ion, 7 results in low ... weight proteins using the Mini Prep Cell. In this system, the substitution of tricine for glycine in the running buffer and the use of a ...

Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier Software Package

... formation produces a fragment structure that does not contain the substitution site. The fragment ion should have ... of formation produces a fragment structure that does contain the substitution site (i.e. if the fragment ion has a m/z value of M in the drug ...

Fluorescence-Based Single-Tube Assays to Rapidly Detect Human Gene Mutations

... in the coagulation factor II (prothrombin) gene. The mutation, a G to A substitution at nucleotide position 20210, is associated with elevated plasma ... beacon allelic discrimination kit ff , is used to detect a G to A substitution at the nucleotide position 845 of the HFE gene. 8 This mutation, which ...

Brilliant Core Reagent Kits for QPCR and QRT-PCR

... Allelic Discrimination kit, which detects a common G-to-A substitution that may delay or accelerate the onset of AIDS in humans (Figure 3). We detected this substitution by amplifying human genomic DNA in the presence of two ...

The Generic Drug Industry in Illinois

... the money in this category goes into the pharmacys hands and is a more attractive margin than what Big Pharma might pay (hence the pharmacist generic substitution of the product). The pharmacist makes more money and the patient is satisfied because medication is costing substantially less. While Big Pharma ...

Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004

... evaluating new strategies to help contain costs. For next year, companies are implementing higher copayments, coinsurance models, mandated low-cost substitution provisions for certain therapeutic classes and generic incentives. Contracting with plans that offer specialized or disease management programs. ...

An Easy-to-Use Research Fermentor/Bioreactor

... is a versatile tool capable of achieving high yields from a wide variety of anchorage-dependent or suspension cultures. The system allows easy substitution of control modules and interchangeable vessels and impellers. Optional data logging and control software make this a powerful research tool. ...

A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays

... surfaces that may introduce RNases onto glove surfaces. Do not use reagents not supplied with the Paradise Reagent System. substitution of reagents or kit components may adversely affect yields or introduce RNases. Use only new plasticware that is certified nucleic ...

Quantitative Analysis of GFP in Plant Extracts Using the VersaFluor Fluorometer System

... improved expression characteristics for eukaryotes, or altered spectral properties. One form, GFP-S65T incorporates a threonine amino acid substitution in place of serine at position 65, which results in red-shifted fluorescence characteristics. 1 This form is one that has been ...

Protein Truncation Tests Using the DCode System

... deletion, the final protein product would lack only 58 amino acids. Genomic sequencing analysis revealed a homozygous G to A substitution at the last nucleotide of exon 26 (nt 3576). This mutation is referred to as 3576 G > A (c1135del174nt). Sample 10 ...

Trouble-shooting: Misincorporation or low fidelity

... is optimal Suggestions: pH of reaction buffer can be lowered to 5-6 Base substitution changes decreased by 60 fold and frame-shift changes decreased by 11 fold with a 3 unit pH decrease ...

Production of Full-Length, Biologically Active MEK1WT and MEK1CA

... other protein kinases, such as raf. 4-6 The recombinant human MEKs produced in E. coli are not very active because E. coli lacks MEK activators. substitution of the two phosphoacceptors (Ser-218 and Ser-222) in MEK1 WT with glutamic acid, in combination with an internal deletion (from amino acid 32 to ...
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Breaking Biology News(10 mins):Scientists wield plant viruses against deadly human disease 2Scientists wield plant viruses against deadly human disease 3First-of-a-kind Solution for Utilizing Photon Upconversion 2Biodiversity in the Mediterranean is threatened by alien species 2
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