Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting
Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution
The use of DOXIL may lead to cardiac toxicity. Myocardial ... be reduced in patients with impaired hepatic function
has resulted in severe side effects. Do not substitute for doxorubicin HCl ...
Shire begins the year with a strong performance
... 577.2 581.5
(1) Following substitution
of the convertible bond to Shire plc in 2008,
the Company no longer receives a tax deduction on its convertible bond
interest, and the interest add ...
Spherix Announces 2008 Financial Results
... showed that mice fed sucrose became obese, hyperglycemic; and hyperlipidemic; and atherosclerosis was increased in these mice as well. Equivalent substitution
of D-tagatose did not result in the same extent of these conditions and showed that D-tagatose did not promote substantial weight gain. The fat ...
Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia
... impairment of attention, vigilance, information processing or declarative memory as measured by the Leeds Psychomotor Battery, Digit Symbol substitution
Test or Word Pair Associates Test. Pharmacokinetic analyses revealed dose-related increases in exposure to ITI-007 and two metabolites with ...
BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
... dynamics will likely come from the recent introduction of generic calcium acetate from Roxane Laboratories, as very few Nephrologists oppose the substitution
of a generic for Fresenius Medical Care's PhosLo. Another recent market shift came with the introduction of Genzyme's Renvela in Q108. Although the ...
EcoSphere(R) Biolatex(TM) Secures Funding from Granholm and Invest Michigan!
... platform provides EcoSphere biolatex products as replacements for petroleum-based paper and paperboard coating binders such as SB and SA Latex. At substitution
levels up to 50 percent, the biolatex products are comparable or superior to traditional petroleum-based alternatives and can be specifically ...
New nanocluster to boost thin films for semiconductors
... for large-area applications.
The key to a "bottom-up" production of possibly the first heterometallic gallium-indium hydroxide nanocluster was the substitution
of nitroso-butylamine as an additive in place of nitrosobenzene.
The substitute was identified during a comprehensive screening of potential ...
GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology
... which is found in all major
human populations It is a naturally occurring variant of human IFN alpha
17, which incorporates an innovative amino acid substitution
provides a novel positive charge together with a change in 3-D structure of
the protein receptor binding site. The biochemical and ...
Shire Delivers Strong Quarter: Driven by $243m of New Product Sales (+164% YOY Growth). Revenue Guidance Upgrade.
... three months to June 30, 2008 was 4% lower than the corresponding
period in 2007 principally due to a permanent tax benefit arising on the
of the Company's convertible bond on the Scheme of
Arrangement in May 2008.
Equity in earnings of equity method investees
Net losses of equity ...
Shire to Introduce a New UK Listed Holding Company
... election, will be deemed to have elected to receive their
dividends from a company resident for tax purposes in the UK (i.e. Shire).
under Shire's Convertible Bonds
In connection with the Scheme, Shire Limited will be substituted in
place of Shire, with effect from immediately ...
GPhA Annual Meeting Focuses on Industry Opportunities and Challenges for 2008
... -- Enacting legislation to promote e-prescribing to increase patient safety. -- Stopping state "carve out" legislation that bars generic substitution
for various therapeutic classes of medicines. Carve outs cost states millions of dollars.
GPhA represents the manufacturers and ...
Rochester Medical Reports 31% Increase in Branded Sales Resulting in 9% Overall Sales Growth for the First Quarter
... provided by other companies. Non-GAAP Net Income has
limitations as an analytical tool and should not be considered in isolation
or as a substitution
for analysis of our results as reported under GAAP.
Reconciliations of Net Income and Non-GAAP Net Income are presented at
the end of this press ...
FDA Approves INTELENCE(TM) (etravirine) for HIV Combination Therapy
... Agents and Chemotherapy (ICAAC) in September 2007.
DUET-1 and -2 Resistance
-- The presence of K103N, which was the most prevalent NNRTI substitution
in DUET-1 and -2 studies at baseline, did not affect the response in the INTELENCE arm. -- The presence at baseline of the substitutions ...
Dragon Announces R&D Achievement in Biotech Manufacturing Process
... industries during China's 10th Five-year Plan period.
Currently, project team members are already in the critical stage of raw
test, bacteria selection test and fermentation
process optimization. This press release contains forward looking statements, including but
Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA
... use in patients who were not already taking opioids
around-the-clock (opioid nontolerant); improper dosing of the medication;
and/or improper substitution
of FENTORA for other fentanyl-based
medications. The letter has been sent to physicians, pharmacists, managed care
organizations, and other ...
Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
... on the subjective perception
of sleep quality. The following morning there was no subjective perception of any
residual sedation. The Digit Symbol substitution
Test (DSST) showed a small
but clinically insignificant change tested the next day 9 h after dosing. The PSG analysis also showed that EVT 201 did ...
SemBioSys updates Apo AI development program
naturally removes plaque from arteries. Apo AI Milano is a natural variant
of native human Apo AI characterized by a single amino acid substitution
its primary structure. In an epidemiological study, Apo AI Milano appears
to confer enhanced resistance to atherosclerosis, suggesting that it ...
Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon
Allelic Discrimination Kits
G to A
that results in Val to Ile change at position 64 ... enzyme
G to A
that results in Arg to Gln change at position 506 ...
C to T
at nucleotide position 677 that results in an Ala ...
Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A
... proteins at relatively moderate acrylamide
concentrations. Thus, substitution
of tricine for glycine as the
trailing ion, 7 results in low ... weight proteins using the Mini Prep Cell.
In this system, the substitution
of tricine for glycine in the running
buffer and the use of a ...
Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using
an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier
produces a fragment structure that does not contain the substitution
The fragment ion should have ... of formation
produces a fragment structure that does contain the substitution
if the fragment ion has a m/z value of M in the drug ...
Fluorescence-Based Single-Tube Assays to Rapidly Detect Human Gene Mutations
... in the coagulation factor II (prothrombin)
gene. The mutation, a G to A substitution
at nucleotide position 20210, is
associated with elevated plasma ... beacon allelic discrimination kit ff ,
is used to detect a G to A substitution
at the nucleotide position 845 of the
HFE gene. 8 This mutation, which ...
Brilliant Core Reagent Kits for QPCR and QRT-PCR
... Allelic Discrimination kit,
which detects a common G-to-A substitution
that may delay or accelerate
the onset of AIDS in humans (Figure
3). We detected this substitution
by amplifying human genomic DNA
in the presence of two ...
The Generic Drug Industry in Illinois
... the money in this category goes into the pharmacys hands and is a more attractive margin than what Big Pharma might pay (hence the pharmacist generic substitution
of the product). The pharmacist makes more money and the patient is satisfied because medication is costing substantially less.
While Big Pharma ...
Health Care Costs Continue Double-Digit Pace, But May Start Moderating in 2004
... evaluating new strategies to help contain costs. For next year, companies are implementing higher copayments, coinsurance models, mandated low-cost substitution
provisions for certain therapeutic classes and generic incentives.
Contracting with plans that offer specialized or disease management programs. ...
An Easy-to-Use Research Fermentor/Bioreactor
... is a versatile tool
capable of achieving high yields from a wide variety of
anchorage-dependent or suspension cultures. The system
allows easy substitution
of control modules and
interchangeable vessels and impellers. Optional data logging
and control software make this a powerful research tool. ...
A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
... surfaces that may introduce RNases onto glove surfaces.
Do not use reagents not supplied with the Paradise Reagent System. substitution
of reagents or kit components may adversely affect yields or introduce RNases.
Use only new plasticware that is certified nucleic ...
Quantitative Analysis of GFP in Plant Extracts Using the VersaFluor Fluorometer System
... improved expression characteristics for eukaryotes, or altered spectral
properties. One form, GFP-S65T incorporates a threonine amino acid substitution
in place of serine at position 65, which results in red-shifted fluorescence
characteristics. 1 This form is one that has been ...
Protein Truncation Tests Using the DCode System
deletion, the final protein product would lack only 58 amino acids. Genomic
sequencing analysis revealed a homozygous G to A substitution
at the last
nucleotide of exon 26 (nt 3576). This mutation is referred to as 3576
G > A (c1135del174nt).
Sample 10 ...
Trouble-shooting: Misincorporation or low fidelity
... is optimal
pH of reaction buffer can be lowered to 5-6
changes decreased by 60 fold and
frame-shift changes decreased by 11 fold with a 3 unit pH decrease
Production of Full-Length, Biologically Active MEK1WT and MEK1CA
... other protein kinases, such as raf. 4-6 The recombinant
human MEKs produced in E. coli are not very active because E. coli
lacks MEK activators. substitution
of the two phosphoacceptors (Ser-218 and
Ser-222) in MEK1 WT with glutamic acid, in combination with an
internal deletion (from amino acid 32 to ...