Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting
... and titled "Molecular Control of RNA Alternative splicing
by sigma RNA, a Marker for Carcinomas" showed that antisense inhibition of Malat-1 altered the splicing
of multiple mRNAs. Altering splicing
results in the production of different variations ...
Seneca Valley High School Student Receives Science Award From MedImmune
... Li for her project
entitled "Discovering New splicing
Forms in von Willebrand Factor to
Understand ... and understanding the application of alternative splicing
individuals. VWD is an inherited bleeding ... was expected to have around 22
to 23 alternative splicing
forms. With ...
In vivo visualization of alternative splicing
... developmentally regulated alternative mRNA splicing
in a living organism. Dr. Hidehito Kuroyanagi and ... University engineered a transgenic alternative splicing
reporter system to monitor the developmentally regulated switching of let-2 alternative splicing
in live C. elegans worms. ...
VIRxSYS Publishes New Study on RNA Therapy
... was only expressed in liver cells, and not in other cells, which could have triggered an immune response. The technology used to perform the albumin splicing
process is owned by VIRxSYS and is known as spliceosomal mediated RNA trans- splicing, or SMaRT(TM). VIRxSYS now has 39 publications in top tier ...
ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics
... on the Agilent
Technologies and Affymetrix microarray platforms, now expand our product
offering and enable researchers to leverage alternative splicing
in the rat model system.
"ExonHit continues to grow its catalog of arrays for it genomics
services. This most recent addition will expand ...
Jivan Awarded US Patent #7,340,349 for Splice Array Analysis
... for DNA microarrays to detect alternative splicing," said Subha
Srinivasan, PhD, CEO of JIVAN. "Powerful data analysis is critical to the
adoption of splicing
arrays, the next generation of expression arrays."
The '349 Patent fits in JIVAN's broader strategy of providing a
complete solution for splice ...
The GeneZoo or the GeneJungle?
contiguous to the poly-A tail to perform the clustering, splicing
is not a
significant factor. We could choose to ignore splice ... is more rigorous,
and we rely instead on there being little splicing
near the 3
Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect
... appear to occur in mammalian cells since siRNA made
against one splice form of a particular gene does not silence other
variants (Tom Tuschl, personal communication, March 2002).
Within the cell, siRNA becomes associated with an RNA-induced
New Tools for Small RNA Analysis
... play critical roles in a
variety of cellular processes, from regulation of mRNA
translation, pre-mRNA splicing
or transcription to chromosome
maintenance and gene imprinting. In addition, two novel
classes of small ...
Efficient Cellular Fractionation for RNA
and Protein Isolation
... nuclear intronic sequences.
Figure 2. Analysis
of Fibronectin pre-mRNA Splicing. The mutually exclusive alternative splicing
of fibronectin exon EIIIb was analyzed by RT-PCR (35 cycles) using total
(T), cytoplasmic (C), and nuclear (N) RNA isolated ...
Gene Expression Arrays:
Highly Sensitive Detection of Expression Patterns
with Improved Tools for Target Amplification
To investigate the bias of these amplification methods, we used yeast
as a model eukaryotic organism due to its low level of splicing
The experiments included two different cell populations grown in rich
and minimal media.