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Silencing in Biological Technology

Nobel Laureates to Speak at Keystone Symposia RNA Silencing Conference

... School will present on "Complexity of RNA silencing in C. elegans." Both scientists shared the 2006 ... the world working in different branches of RNA silencing to share their findings and facilitate a deeper ... complexity of small RNA-related phenomena. RNA silencing pathways control an ever-expanding range of ...

Lentigen Licenses Fundamental Lentiviral Vector Technology Patent From the University of Cambridge

... vehicles for stable delivery of genes or gene silencing sequences (e.g. RNAi) into cells. Gene delivery ... The LV genomic RNA comprising the gene or gene silencing sequence is then converted to DNA and permanently ... extraordinary high efficiency. The gene or gene silencing sequence is then expressed in the cells, ...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

... of normal cell survival and aberrant gene silencing in cancer cells. Inhibition of sirtuins allows ... emerged as a key contributor to the epigenetic silencing of genes that drive tumorigenesis," said Stephen ... reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and ...

Altogen Biosystems Launches New Nanoparticle-based In Vivo Transfection Reagent

... as generation of stably-transformed cell lines in 28-days, as well as gene silencing and RNAi services (http://www.altogen.com/support.htm ). About Altogen ... pharmaceutical services, including generation of stable cell lines, gene silencing and RNA Interference (RNAi) services, assay development, library ...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA

... targets small interfering RNA (siRNA), likely within the RNA-induced silencing complex (RISC) of the RNA interference (RNAi) mechanism. The paper is ... at New York Medical College and Alfacell. The study demonstrated that silencing the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene (an abundant ...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

... to the target cell membrane. The LV RNA containing the gene or gene silencing sequence is then incorporated into the cell via reverse transcription ... vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, ...

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

... research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, ... of the structure and function of small interfering RNA including their silencing properties and complex interplay with the targeted sequences inside ...

Sirnaomics Received Multiple Government Fundings For Its Multi-Targeted siRNA Therapeutics Programs

... research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, ... of the structure and function of small interfering RNA including their silencing properties and complex interplay with the targeted sequences inside ...

Benitec MOU With CalbaTech, Inc.

... a license agreement with Benitec, an Australian corporation. Gene silencing Gene silencing is about controlling the flow of genetic information. Our genome operates ...

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

... important biological phenomenon and as a versatile, powerful tool for biomedical research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving ...

University of Lodz Invests in the Unique Cellaxess(R)HT System for Research on Multidrug Resistance Genes in Cancer

... high transfection efficiency and viability in biologically relevant cell types. Cellaxess(R)HT will allow us to undertake ambitious expression and silencing screening projects that would have been both economically and practically unfeasible with conventional instrumentation." Purchase of the ...

Roche Madison Moves to New Facility

... of a major new class of medicines, known as RNAi therapeutics, is on the horizon. RNAi therapeutics targets the cause of diseases by potently silencing specific messenger RNAs (mRNAs), thereby preventing disease-causing proteins from being made. RNAi therapeutics has the potential to treat disease ...

Sigma-Aldrich Streamlines Access to Advanced Stem Cell Research Portfolio and Opens Stem Cell Biology Community Through New Web Portal

... technologies for stem cell research includes the industry's most highly-validated shRNA library, the MISSION(R) RNAi portfolio, which enables gene silencing across a wide range of cellular targets. The site also features the CompoZrTM zinc finger nuclease (ZFN) reagent platform which enables researchers, ...

Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement

... and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing Lentiviral vector-based products across a broad spectrum of ...

Intradigm Announces Issuance of Key Patent Related to Enhancing Efficacy and Potency of RNAi Therapeutics

... Professor of Biochemistry & Molecular Pharmacology at University of Massachusetts Medical School , generally claims methods of enhancing the RNA silencing activity of an RNAi agent through certain structural modifications in various cell types, including mammalian. The issued claims not only focus on ...

Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

... important biological phenomenon and as a versatile, powerful tool for biomedical research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving ...

Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008

... targets for siRNA therapeutic development. A third poster, submitted by Hagit Ashush, is titled "Tandem and RNAstar molecules for simultaneous silencing several genes," and evaluates the potential of complex dsRNA structures targeting two ("tandem") or three ("RNAstar") different genes in vitro. The ...

Lentigen Corporation Announces Relocation to New Facility

... and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of ...

Lentigen Appoints Jim Meade as Vice President of Corporate Development

... and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of ...

Lentigen Corporation Receives Four Research Grants From the National Institutes of Health

... vaccine and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of ...

OPKO Health Announces Issuance of U.S. Patent Covering the Use and Administration of Certain Anti-VEGF siRNA's, Including Its Phase III Compound Bevasiranib

... . About OPKO Health, Inc. Miami-based OPKO is a specialty healthcare company. Its lead investigational drug, the pioneering gene silencing agent bevasiranib, has entered a pivotal Phase III trial after successfully completing Phase II trials for wet age-related macular degeneration and ...

Lentigen to Move Headquarters and Manufacturing to Gaithersburg

... vaccine and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of ...

EMEA Accepts for Review Vidaza(R) Marketing Authorization Application for Higher-Risk Myelodysplastic Syndromes

... gene expression. Epigenetic changes can silence gene expression and, unlike DNA mutations, may be reversed by targeting the mechanisms involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and ...

Progen Expands Drug Development Pipeline Through Acquisition of CellGate

... technologies in the areas of epigenetics and polyamines that will form the foundation for new compound development. Epigenetics, or the silencing of cancer related gene expression, is becoming a well-defined target in oncology and Progen is excited to be entering this new frontier of cancer ...

Lentigen Appoints Tim Ravenscroft as Chief Executive Officer

... and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing Lentiviral vector-based products across a broad spectrum of ...

Amarin Provides Business Update and Announces Implementation of Reverse Stock Split

... regimen, as compared with current first line treatment. The acquisition also provides Amarin with access to a platform messenger RNA (mRNA) silencing technology which targets the cholinergic pathway, and a promising preclinical program in neurodegeneration and inflammation. Amarin also ...

VIRxSYS and Lentigen Announce Litigation Settlement

... a wide range of applications in biotechnology and medicine. Lentiviral vectors are highly adapted delivery vehicles that can transport genes or gene silencing sequences into cells with high efficiency and stability. Lentigen is positioning itself to become the leading provider of lentiviral vector products ...

Cell Genesys Announces Sale of Lentiviral Gene Delivery Technology for $12 Million

... a wide range of applications in biotechnology and medicine. Lentiviral vectors are highly adapted delivery vehicles that can transport genes or gene silencing sequences into cells with high efficiency and stability. Lentigen is positioning itself to become the leading company for the development of ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... initial consideration is $15 million, plus up to $17 million in contingent payments. Ester's core assets include (i) a platform messenger RNA (mRNA) silencing technology which targets the cholinergic pathway; (ii) EN101, a Phase II compound with promising efficacy data for the treatment of myasthenia gravis ...

OPKO Health Acquires Rights to Clinical Stage Compound for Dry Eye

... often ineffective. About OPKO Health, Inc. Miami-based OPKO is a specialty healthcare company. Its lead investigational drug, the pioneering gene silencing agent bevasiranib, has entered a pivotal Phase III trial after successfully completing Phase II trials for wet age-related macular degeneration and ...

Biotech Hall of Fame Inductees Announced

... Z. Fire and Craig C. Mello Co-recipients of the 2006 Nobel Prize in Physiology or Medicine for their discovery of RNA interference -- gene silencing by double-stranded RNA. RNA interference occurs in plants, animals, and humans. It is of great importance for the regulation of gene ...

Isis Awarded $1.5 Million NIH Grant to Improve Chemical Properties of RNAi-Based Therapeutics

... (mRNA) for degradation. The most common RNAi agents are double-stranded RNAs, which ultimately associate with proteins to form an RNA-induced silencing complex (RISC). The antisense RNA within active RISC binds to its mRNA target, which is then cleaved and degraded by the RNase enzyme in the complex. ...

Team demos safety of RNA therapy

... not have the same toxic effects as large doses of shRNA because it does not interfere with the microRNA pathway. Further, they achieved 80 percent silencing of target genes in mice and hamster liver cells. Using chemically synthesized siRNA, you can deliver sufficient siRNA to achieve therapeutically ...

Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes

... of gene expression. Epigenetic changes can silence gene expression and, unlike DNA mutations, may be reversed by targeting the enzymes involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation have been demonstrated in vitro and ...

Mirus Bio Awarded Grants & Contracts of Over $5 Million

... systemic delivery of small interfering RNA (siRNA), a molecule that triggers a natural cellular process called RNA interference. By selectively silencing the expression of a gene, one can prevent the production of disease-causing proteins. DPCs are comprised of proprietary polymers, masking agents and ...

Fluorescently Labeling Long dsRNA with the Silencer siRNA Labeling Kit

... In general, we obtain a maximum silencing effect with a final concentration of 10 nM ... Figure 1A shows that the same powerful silencing effect was obtained with both labeled ... Pab 1, was not affected (Figure 1A). The specific silencing of hrp48 and U2AF 50 proteins was ...

RNA Interference and Gene Silencing: History and Overview

... May 20, 2002 Post-transcriptional gene silencing (PTGS), which was initially considered a ... and has roles in viral defense and transposon silencing mechanisms. Perhaps most exciting, ... ). But what causes this gene silencing effect? Although ...

Your Data: Silencing of a Pro-apoptotic Transcription Factor Using Synthetic siRNA

... One of the RNA silencing products available from Ambion is ... siRNA mediated gene silencing studies were carried out to assess the ... neural stem cell differentiation. silencing of Gadd153, a pro-apoptotic transcription factor, ...

Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect

... or Cy3 was demonstrated to have no effect on silencing efficiency, but allowed visualization ... labeled siRNA, the time course of gene silencing was examined at both the mRNA and protein level. ... 10 days post transfection. The initiation of the silencing effect was found to correlate well ...
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