Telik Reports Preclinical Results at AACR Annual Meeting
... Active Aurora Kinase/ VEGFR Inhibitors; Abstract # 1764
Aurora kinases are Ser/Thr kinases that play an important role in chromosome alignment, segregation
and cytokinesis during mitosis. Over-expression of Aurora kinases has been demonstrated in both solid tumors and leukemia and is considered to be ...
EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial
... multiple preclinical models, including
MKC-1 has been shown to inhibit mitotic spindle formation, prevent
in the M-phase (mitosis) of the cell cycle, and
induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR signaling
pathways, which may occur ...
CBDM.T, The Market and Business Intelligence Company Reviews The Biomanufacturing Market
... 10 to 15%. Pharmaceutical biomanufacturing could account for more than 20% of the global contract manufacturing market in 2012. If we analyze the segregation
of production capacity between CMOs (Contract Manufacturing Organisations) and product development companies, the "build versus buy" ...
Auditors paying more attention to IT woes
... involved access to programs and data (includes segregation
31 percent were related to ... faithfully executing these procedures. Inadequate segregation
of duties, both within IT and the business, was ... these findings was wide: change control, backup, segregation
of duties, etc.
Vendors and SAS-70
Out of ...
Managing SOX in the age of SOA
... to financial applications that have been exposed as Web services.
Segregation of roles is a core technique of internal controls ... authorization, it may be impossible to establish clear role segregation
in an SOA. If the "user" of a Web service-based financial application is ...
Companies still neglect network security
... be thinking about it in terms of an ice storm in Wisconsin. Is it going to happen? Yeah."
Running the gauntlet
Practices such as establishing segregation
of duties, identifying what employees can have access to sensitive information, and controlling what can be copied onto a USB flash drive should be ...
Technology helps but the best way to reduce Sarbox cost is with people
Wrong skill sets for position.
Excessive staff turnover.
Floored by 404
These challenges are nothing new. However, they are coming to the forefront largely due to ...
Testing Compressed Air Lines for Microbiological Contamination
... design the facility whereby the air compressor is segregated from the area where the product is assembled for logical hygienic reasons. However, this segregation
may lead to a false sense of security because it is possible that the environmental air source that feeds into the compressor may contain biological ...
SNPs Powerful Tools for Association Studies
... and the putative disease allele. Under such circumstances, only a higher density map, such as a SNP map, will be able to follow the recombination and segregation
of alleles (also seeChoosing SNPs for an Association Study below). This density is defined by the observed average size of co-inheritance blocks, ...
Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module
... of genotoxic compounds and analysis of micronuclei formation resulting from DNA strand breakage (clastogens) or interference with chromosome segregation
(aneugens) is an important component of toxicology screening of new drug candidates. Manual scoring of micronucleus assays is time consuming and ...