Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus
... (defined by an improvement in SELENA SLEDAI score
of 4 points or greater, no BILAG worsening, and ... experiencing one new BILAG A organ domain score
(which would indicate a severe flare of lupus ... or more than one new BILAG B organ domain score
(which would indicate a moderate flare of disease ...
Boston Scientific Welcomes Launch of Syntax Score Website
... Scientific Program in Barcelona.
The SYNTAX score
was developed in connection with the SYNTAX ... informed treatment decisions.
The SYNTAX score
was used in the trial to characterize coronary ... frequency, complexity and location; it assigned a score
to each patient. Higher SYNTAX Scores indicate ...
Genomic Health Announces Positive Preliminary Results from QUASAR Validation Study of Oncotype DX(R) Colon Cancer Assay
... to make the Onco type DX colon cancer Recurrence score
available to physicians and patients in early ... make the Onco type DX colon cancer Recurrence score
available to physicians and patients in early ... Health logo, Oncotype, Oncotype DX and Recurrence score
are trademarks or registered trademarks of ...
Frost & Sullivan Lauds Carl Zeiss Meditec for Dominating the OCT Market for Ophthalmic Applications
... overall Frost & Sullivan Competitive Metrics score
in the recently completed Strategic Analysis of ... segment of the Analysis."
With an overall score
of 10.22, Carl Zeiss Meditec received tier I ... 'growth strategy,' and 'leveragable assets'. The score
break-up is 2.67 for 'market positioning and ...
Physicians in Europe Rate Novartis #1 on Service Delivery, While Merck Earns Top Honors in the US
... in any other market.
"In the US, companies score
well on rep attributes -- such as knowledge, ... In the US, for example, the average TRI*M(TM) score
-- a measure of relationship strength -- fell ... their scores tumble. Though the UK's TRI*M(TM) score
overall remains fairly low, individual companies ...
Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay
... designed to generate both a prognostic Recurrence score
and predictive Treatment Score. Researchers will evaluate the association of the Recurrence score
with recurrence in stage II colon cancer patients ... also evaluate the association of the Treatment score
with the magnitude of chemotherapy benefit in ...
Phase 3 Data Demonstrate Efficacy and Tolerability of Paliperidone Palmitate, an Investigational Long-Acting Therapy for the Treatment of Schizophrenia
... of the trial was change in PANSS(c) total score
from baseline to endpoint.
The results ... primary endpoint was the change in PANSS total score
from baseline to endpoint. Non-inferiority was ... in the least square adjusted mean change in PANSS score
was -2.6 points, with a 95% confidence interval ...
Genomic Health Announces Publication of a Study Demonstrating the Oncotype DX(R) Breast Cancer Assay Influences Chemotherapy Treatment Recommendation in 44 Percent of Patients Evaluated
... three risk categories based on the Recurrence score
Researchers compared treatment recommendations made utilizing the
result to recommendations made based on the 2007 ... alone based on their Oncotype DX Recurrence score
less than 18. Conversely, and notably, four ...
One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study
... as measured by good or
moderate Disease Activity score
28 (DAS 28) response. At week 24, 64
percent and ... to placebo patients
worsening by a mean of 0.01 score
(P < 0.001). At one year, the mean
improvements ... Maastricht Ankylosing
Spondylitis Enthesitis score
(MASES), respectively. In patients ...
FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania
... Depression Rating Scale) total score
compared to placebo
at week 8. In the study, ... than placebo. The mean change in MADRS total score
baseline to Week 8 was -17.4 for SEROQUEL XR ... in YMRS(**) (Young Mania Rating Scale)
compared to placebo at week 3. The study showed ...
FDA Approves GlaxoSmithKline's AVODART(R) in Combination with Tamsulosin for the Treatment of Symptomatic Enlarged Prostate
... was the change in International Prostate
(IPSS) from baseline at Month 24 for combination ... to 125 mL and International
Prostate Symptom score
(IPSS) greater than or equal to 12] ...
* The International Prostate Symptom score
(IPSS) is a symptom index for enlarged ...
Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity
dosage levels of 100 mg/kg. A deltaT/deltaC score
of 31% was demonstrated,
where T is equal to the ... 7-1037 group than in the control group.
The 31% score
achieved with ANAVEX 7-1037 is far better (lower) than the
42% deltaT/deltaC score
standard set by the U.S. National Cancer ...
U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD)
... symptoms. A reduction in MADRS Total score
improvement in depressive symptoms. ... placebo plus ADT in reducing the mean SDS Total score
study. In these studies, adjunctive ... Rating Scale (HAMD17), minimal HAMD17 score
of 14, and a Clinical Global Impressions ...
SAPHRIS(R) (asenapine) Meets Primary Endpoint in Long-Term Extension Study in Patients With Predominant, Persistent Negative Symptoms of Schizophrenia
... repeated measures (MMRM), least square mean changes in the NSA-16 total score
were -15.8 for SAPHRIS vs. -11.0 for olanzapine (P=0.015). Full results ... demonstrated statistically significantly greater change in NSA-16 total score
from the core study baseline after one year of treatment, the primary ...
New Report Just Published: World Prostate Cancer Therapeutics Market Report
... Ultrasound II-26
Staging of Prostate Cancer II-26
and Grading of Prostate Cancer II-27
TNM Staging II-27
BioSyntech Reports Positive Results from Pivotal Trial for BST-CarGel(R) Cartilage Repair Device
... between treatment groups at p(less than)0.05. First, the Overall ICRS II score
was significantly better for the BST-CarGel group than for the ... important parameter within the ICRS II scoring system, the ICRS II Overall score
assimilates all the parameters listed in the grading system to generate an ...
AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule
... stability of voiding symptoms based on the International Prostate Symptom score
(IPSS). Patients are then randomly allocated to cetrorelix or placebo in a ... will be followed-up for safety, International Prostate Symptom score
(IPSS) and quality of life during the extended treatment, providing ...
AEterna Zentaris Opens Extended Study for Cetrorelix in Benign Prostatic Hyperplasia
... study will be followed-up for safety, International Prostate Symptom score
(IPSS) and quality of life during the extended treatment, providing ... stability of voiding symptoms based on the International Prostate Symptom score
(IPSS). Patients are then randomly allocated to cetrorelix or placebo in a ...
Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C
... from a study of 214 healthy volunteers. The diagnostic performance score
for Hepascore by AUROC(1) was 0.81 for significant fibrosis, 0.83 for ... a test's overall performance based on sensitivity and specificity, with a score
up to 1.0. The closer a test scores to 1.0, the more accurate its ...
Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients
... was defined as the rate of response (defined as a decrease in CDAI score
greater than or equal to 100 points from baseline) at week 6. Remission was defined as a CDAI score
of less than or equal to 150 points. After the induction period, 62 ...
Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union
... health related quality of
life (HRQoL) as measured by the QOLIE-31 score
during a one year open label
extension of the above 3 studies. ESL is ... a statistically significant improvement from baseline in the
overall MADRS score
(p<0.0001) and individual domains of the MADRS scale
Traditional Risk Factors Often Miss Heart Disease Warning Signs
... a series of clinical studies showing that the traditional Framingham risk score
doesn't always do a good job of estimating that risk, especially among ... III guidelines.
The authors concluded that, "The Framingham risk score
underestimates cardiovascular risk in individuals with a family history of ...
Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601
... analog scale for pain intensity
(VASPI), a modified Neuropathy Impairment score
-- Lower Limbs (NIS-LL)
scoring system as well as total neuropathy score
(TNS) to assess signs and
symptoms of the condition. In addition, data ...
Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures
... self-care, usual activities of daily living, pain, and
depression. The score
is expressed as a health utility score, 1
representing perfect health and ... 45 years (0.78 vs.
0.74 and 0.65, respectively). The mean health utility score
0.76 for women with wrist fractures to 0.64 for women with ...
Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes
... In the Telecare arm of the study, 50.6%
of patients reached an A1C score
of less than or equal to 7%, whereas in
the standard blood glucose monitoring arm, 54.6% of patients similarly
achieved an A1C score
of less than or equal to 7%.
About the ELEONOR Study
ELEONOR was an ...
Landmark SYNTAX Trial Reports Comparable Safety Outcomes for Complex Patients Treated With TAXUS(R) Express2(TM) Stents or Bypass Surgery
... defining a new measure
for anatomical complexity - the SYNTAX score
- which seeks to provide
guidance to physicians on optimal treatment options for this high-risk
group of patients. The SYNTAX score
characterizes vasculature based on
lesion frequency, complexity and ...
Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia
... standard 400 mg/day dose in a 2:1 ratio. Patients were
stratified by Sokal score
for evaluation. Sokal score
is a clinical measure
that is used to identify those at highest risk for ...
Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis
... with some patients achieving remission as measured by Disease Activity score
(DAS28). Findings from two multicenter, randomized, double-blind, ... clinically relevant improvement in physical function (improvement in HAQ score
of at least 0.25 from baseline), compared with 39 percent of patients ...
Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores
... or a semi-quantitative result, RT-PCR by Oncotype DX
generates a specific score
across a continuous range of expression which
allows physicians to factor ... Health, the Genomic Health logo, Oncotype, Oncotype DX
and Recurrence score
are trademarks or registered trademarks of Genomic
Health, Inc. All other ...
Vermillion Biomarker Panel Potential Aid in the Diagnosis of Peripheral Artery Disease
... combinations of protein markers to create a
distinct biomarker panel score
to stratify individuals according to their
risk of having PAD. However, ... Drug Administration (FDA)."
The study was conducted to develop an index score
based on a
combination of proposed biomarkers for PAD, including two based ...
JADO Reports Clinical Proof of Concept With Raft Modulator in Atopic Dermatitis
... through a highly significant improvement in TIS (Three
Item Severity) score
after three week treatment. Both TF002 and
hydrocortisone achieved an improvement of the TIS score
of more than 1.5
which was defined as being clinical efficacious. This ...
Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness
... they did not
achieve, therefore zero is the lowest possible overall score
and 10 the
highest. Data for the public health indicators were collected ... funding for
public health programs for FY 2005-06 to FY 2006-07?
10 out of 10: Illinois, Kentucky, Nebraska, New Jersey, ...
Recent Study Confirms Alimentary Health's Bifantis(R) Demonstrates Efficacy in the Treatment of Irritable Bowel Syndrome
... infantis 35624
resulted in significant improvement in the composite score
pain/discomfort, bloating/distention and bowel movement ... incomplete evacuation,
straining, passage of gas and a composite score
pain/discomfort, bloating/distention, and bowel movement ...
Genomic Health Announces Second Quarter 2009 Financial Results and Business Progress
... disclaims any obligation to update these forward-looking statements.
NOTE: The Genomic Health logo, Oncotype, Oncotype DX and Recurrence score
are trademarks or registered trademarks of Genomic Health, Inc. All other trademarks and service marks are the property of their respective owners. ...
Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease
... scores than those previously reported were observed at each assessment time point (Day 45, 90 and 104). At Day 45 the improvement in ADAS-cog score
was 4.18 (p=0.0004), while at Day 90 the difference was 4.73 (p=0.001). Of interest, a significant difference in cognitive test scores of 3.27 was ...
Brazil's Scientific Research On The Rise, Thomson Reuters Study Finds
... below the overall world average for scientific impact, Brazil has been steadily rising towards parity since the late 1980s. It has moved from a score
that was at 44 percent of the world average during the 1985-1989 time period to 63 percent of the world mark during 2004-2008. In recent years, ...
Study Showed VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Significant Efficacy at 14 Hours After Administration in Adults with ADHD in an Adult Simulated Workplace Environment
... to placebo. The key secondary efficacy measure was to assess the duration of efficacy of VYVANSE compared to placebo using PERMP; the PERMP total score
is the sum of the number of math problems attempted (PERMP-A) plus the number of math problems answered correctly (PERMP-C) in a 10-minute session. ...
Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma
... chemotherapy treatments. More than 70% of the patients on both arms were considered intermediate to high risk by the International Prognostic Index score
(>=2). The median prior doxorubicin equivalent dose was approximately 300 mg/m2, the dose that is associated with six cycles of CHOP ...
ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week
... phase of the study is the attainment of a clinical response defined as a decrease from baseline in the Crohn's Disease Activity Index (CDAI) score
of at least 70 points.
ChemoCentryx, Inc., is a clinical-stage biopharmaceutical company focused on discovering, ...
Ocera Therapeutics Presents Data on AST-120 in Patients With Hepatic Encephalopathy at the European Association for the Study of Liver Disease Annual Meeting
... 150 patients with MHE. Patients will be evaluated on neurocognitive improvement at the end of the study, defined as the change in the global summary score
of the RBANS or Repeatable Battery for the Assessment of Neuropsychological Status.
"The ASTUTE trial will use a battery of neuropsychometric ...