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Ribosome in Biological Technology

Molecular sleuths track evolution through the ribosome

... of Illinois, reveals that key regions of the ribosome differ between bacteria and archaea, microbes ... of nucleotides that spell out the RNA of the ribosome in bacteria and archaea. These "molecular ... are really linked to one another." The ribosome has two subunits, each made up of RNA and ...

DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies

... ribosomes of many pathogenic bacteria are still unknown. Thus, the ribosome represents an important target for structural prediction and future drug ... structure accuracy. With this NIH project, DNA Software is modeling ribosome structure and function and aims to predict the 3D structures of complete ...

PTC Therapeutics Receives $2.6 Million in Government Grants

... Nonsense mutations create a premature stop signal in the mRNA causing the ribosome to terminate translation before a full-length protein is generated. This ... to be truncated and non-functioning. Ataluren is designed to allow the ribosome to continue translation of the mRNA, overriding the premature stop signal ...

Stem Cell Sciences Licenses Stem Cell Technology to Leading Provider of Genetically Modified Models for Pharmaceutical Research

... research and development activities. Under the terms of the licence, SCS will receive US$750,000 over six years plus royalties. SCS' IRES (Internal ribosome Entry Site) technology enables researchers to monitor the activity of a particular gene of interest in living cells or tissues without blocking the ...

Rib-X Pharmaceuticals, Inc. Announces Formation of Clinical Advisory Board

... resistant Gram positive bacteria and MRSA. Both radezolid and delafloxacin are currently in Phase 2 clinical trials. For more information on the ribosome and the Rib-X mission, please visit the Company website at http://www.rib-x.com . ...

Rib-X Pharmaceuticals to Present at Cambridge Healthtech Institute's 2nd Annual Challenge of Antibacterial Development Conference

... towards identifying a new chemical class of antibiotics active against multi-drug resistant Gram-negative bacteria. For more information on the ribosome and the Rib-X mission, please visit the Company website at http://www.rib-x.com . ...

Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741

... is directed towards identifying a new chemical class of agents active against multi-drug resistant hospital infections. For more information on the ribosome and the Rib-X mission, please visit the Company website at http://www.rib-x.com . ...

Researchers outline structure of largest nonvirus particle ever crystallized

... vaults offer a human-friendly nanocontainer, like a molecular-level C-5A transport jet, with a cargo hold large enough to encompass a whole ribosome with its hundreds of proteins and nucleic acids, or enough drugs to control a cell," Eisenberg said. The construction of the draft atomic model ...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

... more than one gene coding for 16S rRNA to increase the rate of ribosome production in the cell. Normally the genes have the same sequence ... have different sequences that, when transcribed, yield a ribosome with a slightly altered structure. ...

New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter

... stop codons are followed by the coding region of an internal ribosome entry site (IRES) for reentry of the ribosome and protein production of the downstream hrGFP gene. In these ...

Determination of the Chloramphenicol residues in milk and milk products using LC/MS/MS

... medicine because of its broad range of activity and its low cost. Chloramphenicol is primarily bacteriostatic. CAP binds to the 50S subunit of the ribosome and inhibits bacterial protein synthesis. It has a wide spectrum of activity against gram-positive and gram-negative cocci and bacilli, including ...

Translate More Protein with Higher Biological Activity

... a labeled amino acid (optional) and a DNA template that contains your gene of interest, a T7 promoter, ribosome binding site, and T7 terminator. The DNA template can be easily constructed by inserting your gene of ...

Increase Protein Activity and Yield

... only a labeled amino acid (optional) and a DNA template that contains your gene of interest, a T7 promoter, ribosome binding site, and T7 terminator. The DNA template can be easily constructed by inserting your gene of ...

TransMessenger Transfection Reagent Handbook

... a relevant DNA template or added post-transcriptionally using a poly-A polymerase. An IRES is a specific sequence which helps the ribosome to access the mRNA, thereby enhancing translation. However in some cell types, RNA species containing an IRES will not be ...

Mammalian and Bacterial Expression in One Vector

... distinguishing feature of the pDual vector is the tandemly arranged bacterial Shine-Dalgarno 1 and mammalian Kozak 2 consensus sequence. Each ribosome binding site is positioned at its optimal distance from the initiation codon of the target gene, which ensures efficient translation of mRNA ...

High-Titer Retroviral Vectors for Gene Delivery

... (ORF) for the neomycin-resistance (neo) gene is positioned downstream of the MCS, using the encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES). Expression of neo from the second ORF in a dicistronic message is advantageous in that G418-selection (i.e., selection ...

Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells

... both receptors are expressed from a single mRNA transcribed from the CMV promoter. We accomplished this by placing the internal ribosome entry site (IRES) from encephalomyocarditis virus (EMCV) upstream of the second (RXR) open reading frame (ORF), which ...
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