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Ribonuclease in Biological Technology

Alfacell Provides ONCONASE(R) NDA Submission Update

... as of January 1, 2009. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

... in this disease. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Reports Fiscal Fourth Quarter and Full Year 2008 Financial Results

... clinical development program." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA

... that failed prior chemotherapy." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Hires Advisors to Advance Strategic Alternatives

... has approved a specific transaction. About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Reports Financial Results for Third Quarter of Fiscal 2008

... site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Announces Retirement of Chief Executive Officer

... foundation she has built for us." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Reports Financial Results for Second Quarter of Fiscal 2008

... site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell Announces ONCONASE(R) Purchase and Supply Agreement with Scientific Protein Laboratories

... and straight through to commercial launch. About ONCONASE(R) ONCONASE is a first-in-class product candidate from Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells ...

Alfacell to Host Webinar on RNA Interference-Like Mechanics of RNase Therapeutics on Nov. 29

... will Include World-Renowned RNase and RNA Researchers SOMERSET, N.J., Oct. 25 /PRNewswire-FirstCall/ -- The RNA interference- like mechanics of ribonuclease (RNase) therapeutics will be the focus of scientific presentations in a Nov. 29 Webinar hosted by Alfacell Corporation (Nasdaq: ACEL ). Moderated ...

Nuclease Protection Assays: The Basics

... Nuclease protection assays (NPAs), including both ribonuclease protection assays (RPAs) and S1 ... flexibility. The most common type of NPA, the ribonuclease protection assay, requires ... Inhibition of ribonuclease activity ...

Combat RNase Contamination in the Lab

... Trace amounts of ribonuclease (RNase) contamination can ... Figure 1. SUPERaseIn vs. Placental ribonuclease Inhibitor (RI). A 32 P-labeled RNA probe was ... RNase inhibitor is placental ribonuclease inhibitor (RI), sold ...

Detecting miRNA & siRNA

... RNA probe were removed by a brief ribonuclease digestion. Protected target RNA fragments were ... a reagent that simultaneously inactivates the ribonuclease and precipitates the nucleic acid. The ... hybridization assay based on ribonuclease protection can sensitively and ...

Northern Analysis: The Basics

... disruption Inhibition of ribonuclease activity Deproteinization ... Zap , a nontoxic ribonuclease decontamination solution for equipment and work ...

Measuring RNase Activity A Real-time Kinetic Analysis

... the removal of contaminating RNA from DNA preparations and ribonuclease protection assays (RPA). Ambion sells an RPA grade RNase A ... B (1960) Spectrophotometric assay of bovine pancreatic ribonuclease by the use of cytidine 2',3'-phosphate. Biochem. J. 74 ...

Detecting Attomole Amounts of Small RNA

... and excess RNA probe is then removed by a rapid ribonuclease digestion step. The hybridized, protected RNA ... patented single step technology for simultaneous ribonuclease inactivation and nucleic acid precipitation. RNA ...

Americas Third Coast nurtures biotechnology

... RNA is essential for life, ribonucleases can be toxic to cells, especially rapidly proliferating cancer cells. However, cells also contain natural ribonuclease inhibitors (RI), which bind ribonucleases to prevent cell destruction. The Evade technology genetically modifies selected ribonucleases to prevent ...

Quintessence Biosciences forms cancer therapeutic advisory board

... T. Raines, Ph.D., professor of biochemistry and chemistry at UW-Madison, co-founder of Quintessence Biosciences, Inc. and inventor of the EVade ribonuclease technology Paul M. Sondel, M.D., Ph.D., professor in the departments of pediatrics, human oncology and genetics at the University of Wisconsin ...

Quintessence cancer treatment chosen for clinical studies

... drug application in late 2007, with human clinical trials expected to begin in early 2008. The company is developing new drugs based on its EVade ribonuclease technologies. In pre-clinical disease models, the QB139 compound demonstrated safe tumor-growth inhibition in vivo (inside the body) against ...

Quintessence Biosciences advances cancer drug

... cancer. As the company's lead cancer drug, QBI-139 represents the first in a series of oncology products advancing from the company's EVade ribonuclease development program. The AACR meeting provides Quintessence with an opportunity to report information on its emerging drug candidates, and perhaps ...

RNA Interference and Gene Silencing: History and Overview

... & Development 12 :225-232. Bernstein E, Caudy AA, Hammond SA, and Hannon GJ. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 :363-366. Nykanen A, Haley B, and Zamore PD. (2001) ATP ...

Recombinant HIV Reverse Transcriptase

... times. Reactions were performed using the manufacturer-supplied reaction buffer in the presence of * 32 -P dUTP and 0.5 U/l ribonuclease inhibitor. The percentage cDNA conversion was determined by measuring the amount of cDNA made via scintillation counting. ...

Getting Started with MicroRNA Research

... structure that likely forms around the miRNA sequence of the pri-miRNA acts as a signal for digestion by a double-stranded (ds) ribonuclease (Drosha) to produce the precursor miRNA (Pre-miRNA). (3) Exportin-5 mediates nuclear export of pre-miRNAs. (4) A ...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

... as parts of longer RNA molecules [7] that are processed in the nucleus into hairpin RNAs of 70-100 nucleotides by the dsRNA-specific ribonuclease Drosha [8] (Figure 1). The hairpin RNAs are transported to the cytoplasm and digested by a second, double-strand specific ...

Designing Controls for siRNA Experiments

... synthetase catalyzes the synthesis of 2'-5' polyadenylic acid, which activates the nonspecific ribonuclease RNase L. Another way is to monitor activation of the dsRNA-dependent protein kinase, PKR, which is involved in ...

Improve RNA Isolation for Array Analysis and More

... are difficult to disrupt (e.g. muscle, fibrous plant tissue, yeast, bacteria), or samples that are high in ribonuclease or other contaminants (e.g. spleen, pancreas, plant and neural tissues). RiboPure is the method of choice ...

RNase Protection Assay (RPA) Using DIG-Labeled RNA Probes

... The ribonuclease protection assay (RPA) is a highly sensitive and specific method for the detection and quantitation of mRNA species. The assay was made ...

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

... against these surface markers can differentially label immature erythrocytes. 9,10 When fixed blood cells are treated with ribonuclease and antitransferrin receptor antibody (FITC-conjugate), and then stained with propidium iodide, normochromatic erythrocytes (NCEs) ...
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