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Proliferation in Biological Technology

Data for Oncothyreon's PX-12 and PX-866 presented at AACR Annual Meeting

... of these cells with PX-866 blocked their proliferation and inhibited tumor growth, demonstrating not ... cancer cells have been linked to the aggressive proliferation of solid tumors, including colon, lung, and ... and cervical cancers, where it leads to increased proliferation and inhibition of apoptosis (programmed cell ...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... glioma, colon, ovarian, prostate and melanoma, where it leads to increased proliferation and inhibition of apoptosis (programmed cell death). PX-866 has been shown ... provides control over a number of transcription factors affecting cell proliferation and death through the mechanism of redox regulation. An initial Phase 1 ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... AMG 479, a novel IGF-1R antibody, inhibits endometrial cancer cell proliferation through disruption of the P13K/Akt and MAPK pathways Overview: ... the effect of a novel antibody to the IGF-1R (AMG 479) on cell proliferation and expression of key targets involved in IGF-1R signaling in ...

Spectrum Pharmaceuticals and Cell Therapeutics to Jointly Market ZEVALIN, a Proprietary, Marketed Oncology Drug

... NHL. Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a ... Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a ...

Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy

... of breast tumor sections under a microscope, could not describe the proliferation ability of 30 to 60 % of tumors. By contrast, the Genomic Grade index could capture proliferation in most tumors and showed superior prognostic and classification value ...

Exelixis Submits XL139 Diligence Report to Bristol-Myers Squibb

... pathway. Hedgehog plays a critical role in regulating cell growth, proliferation and differentiation in normal development. The pathway is deregulated in ... that hedgehog signaling may play a key role in cancer stem cell (CSC) proliferation and the resistance of CSCs to chemotherapeutics and radiotherapy. "One ...

Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells

... prominent cancer cell signaling pathways as essential for the efficient proliferation and self-renewal of human embryonic stem cells (hESCs). The findings were ... implication that key cancer pathways are associated with human stem cell proliferation and self-renewal is yet another exciting outgrowth from the extensive stem ...

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

... cancer stem cell frequency, thereby delaying the re-growth or recurrence of tumors, anti-DLL4 therapy was shown to reduce tumor growth and tumor cell proliferation and disrupt tumor angiogenesis. Moreover, OMP-21M18 displayed additive activity in reducing tumor volume when combined with traditional ....

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

... repair and lower the overall level of protein required. Growth Factor Gene Portfolio Growth factor proteins stimulate cellular proliferation and cellular differentiation. Growth factors regulate a variety of cellular processes, as well as other signaling molecules, which play key roles in ...

Sunesis Reports Financial Results for the Second Quarter 2009

... ovarian cancer. About Acute Myeloid Leukemia AML is a rapidly progressing cancer of the blood characterized by the uncontrolled proliferation of immature blast cells in the bone marrow. The Leukemia and Lymphoma Society estimates that over 13,000 new cases of AML were diagnosed and ...

Cardium Provides Update on Phase 2b Excellarate Clinical Study and Plans for Additional Tissue Repair Applications

... a patient's own cells directly at the wound site is believed to stimulate angiogenesis and granulation tissue formation through the recruitment and proliferation of cells such as monocytes, fibroblasts and endothelial cells. These cell types are critical for the effective stimulation of a variety of wound ...

Global Prescription Drugs Market to Cross $897 Billion by 2015, According to New Report by Global Industry Analysts, Inc.

... slowing down growth in the global prescription drugs market include economic downturn, increasing number of drugs going off patent, increasing proliferation of generics, falling drug costs, and fewer new drug approvals. On the positive side, the market is experiencing increased demand for biologics, ...

Gene Network Sciences Announces Broad Cancer Collaboration With UCSF and Initial Results

... utilized REFS(TM) to discover and validate novel mediators of the cell cycle transition, which is a critical determinant of the rate of cancer cell proliferation and tumor growth. These results were presented by UCSF researcher Dr. Rina Gendelman, a post-doctoral fellow in Dr. W. Michael Korn's laboratory, at ...

Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis

... is implicated in a large proportion of human cancers including breast, glioma, colon, ovarian, prostate and melanoma, where it leads to increased proliferation and inhibition of apoptosis (programmed cell death). PX-866 has been shown to induce prolonged inhibition of tumor PI-3 kinase signaling following ...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

... mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell proliferation and function. Fate Therapeutics is developing these small molecule and biologic SCMs to modulate the activity of adult stem cells to stimulate ...

Bayer and Onyx Announce Nexavar Data Presentations at 45th American Society of Clinical Oncology Annual Meeting

... and tumor vasculature. In preclinical studies, Nexavar has been shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included Raf kinase, VEGFR-1, VEGFR-2, ...

Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor

... a phase I clinical study with its selective PLK-1 small molecule inhibitor for the treatment of cancer. PLK-1 is a mitotic kinase required for the proliferation of cancer cells. This new compound is orally bioavailable, highly efficient and well tolerated in preclinical models of cancer after repeated dosing. ...

Cell Biosciences Launches Next-Generation Protein Characterization System

... in the fields of cancer research, stem cell biology, and diabetes. Our products enable researchers to uncover fundamental mechanisms controlling cell proliferation and cell death, to accelerate the development of new therapeutics, and to help identify new prognostic and diagnostic disease biomarkers. Cell ...

Cell Biosciences Announces Publication in Nature Medicine

... in the fields of cancer research, stem cell biology, and diabetes. Our products enable researchers to uncover fundamental mechanisms controlling cell proliferation and cell death, to accelerate the development of new therapeutics, and to help identify new prognostic and diagnostic disease biomarkers. Cell ...

Cell Biosciences Closes $10 Million Series C Financing

... the fields of cancer research, stem cell biology, and diabetes. Our products enable researchers to uncover fundamental mechanisms controlling cell proliferation and cell death, to accelerate the development of new therapeutics, and to help identify new prognostic and diagnostic disease biomarkers. Cell ...

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results

... ovarian cancer. About Acute Myeloid Leukemia AML is a rapidly progressing cancer of the blood characterized by the uncontrolled proliferation of immature blast cells in the bone marrow. The Leukemia and Lymphoma Society estimates that over 13,000 new cases of AML were diagnosed and ...

Agencies Unite to Launch Donor Network Alliance: First-Ever Web-Based Collective of Egg Donor Candidates

... of Chicago. "DNA is needed as the fertility field grows in size and complexity," said Robin von Halle, president of ARR. "This has resulted in a proliferation of agencies that recruit egg donors, which makes weighing agency and donor choices more costly, confusing and time consuming for intended parents." ...

Cell Therapeutics Exercises Its Option to Sell Interest in Zevalin Joint Venture to Spectrum Pharmaceuticals for $18 Million

... can visit www.zevalin.com for more information. About Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a system of vessels that drains fluid from the body. NHL can be broadly ...

FDA Approves Clinical Studies of a Novel Anti-Cancer Drug Developed by Italian Researchers

... to conduct for the first time clinical trials of a novel antitumoral agent. The drug blocks Cdc7, a protein that is responsible for the uncontrolled proliferation of cancer cells. The preclinical data, recently published on the prestigious journal Nature Chemical Biology ( ...

EAU Technologies Receives Patent for Empowered Water(TM)

... to clean, disinfect and nourish in large industries such as agriculture and food processing. EAU has solutions for existing bacteria, virus and mold proliferation threats. EAU continues to add innovative and efficacious products that offer a systemic approach to pathogen elimination in food processing plants ...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

... ovarian cancer. About Acute Myeloid Leukemia AML is a rapidly progressing cancer of the blood characterized by the uncontrolled proliferation of immature blast cells in the bone marrow. The Leukemia and Lymphoma Society estimates that over 13,000 new cases of AML were diagnosed and ...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

... About AML AML (acute myeloblastic leukemia ) is a cancer of the myeloid line of white blood cells, characterized by the rapid proliferation of abnormal cells which accumulate in the bone marrow and interfere with the production of normal blood cells. AML is a potentially curable disease; ...

Portola Data on Its Novel Syk Inhibitors and Novel Universal Factor Xa Inhibitor Antidote to be Presented at 2008 American Society of Hematology (ASH) Meeting

... on the ASH website at http://www.hematology.org . Syk Inhibitor Program "Specific Inhibition of Syk is Sufficient to Disrupt proliferation and Survival of Non-Hodgkin's Lymphoma Cell Lines without Concomitant Inhibition of JAK" (abstract # 1794) Saturday, December 6, 5:30 PM ...

FDA Accepts Cell Therapeutics' Zevalin sBLA and Grants Priority Review

... http://www.zevalin.com for more information. About Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a system of vessels that drains fluid from the body. NHL can be broadly ...

Solar power game-changer: 'Near perfect' absorption of sunlight, from all angles

... and thus unharvestable. From an economic and efficiency perspective, this unharvested light is wasted potential and a major barrier hampering the proliferation and widespread adoption of solar power. After a silicon surface was treated with Lin's new nanoengineered reflective coating, however, the ...

Abbott's XIENCE V(TM) Drug Eluting Stent Wins Prestigious Chicago Innovation Award

... and supplied to Boston Scientific as part of a distribution agreement between the two companies. Everolimus, developed by Novartis Pharma AG, is a proliferation signal inhibitor, or mTOR inhibitor, licensed to Abbott by Novartis for use on its drug eluting stents. Everolimus has been shown to inhibit ...

High-Dose Zevalin(R) With Tandem Stem Cell Infusion Produces 87 Percent Overall Survival in Relapsed/Refractory or High Risk Non-Hodgkin's Lymphoma

... can visit http://www.zevalin.com for more information. About Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a system of vessels that drains fluid from the body. NHL can be ...

CorMatrix Cardiovascular to Present Data on Its Next Generation ECM Technology(TM) at Annual Transcatheter Cardiovascular Therapeutics (TCT) Conference in Washington, D.C.

... D.C. next week. The presentation entitled "Cell Therapy Devices and Concepts: Acellular Matrix Emulsion Injections to Induce Myofibroblast proliferation and Angiogenesis" will take place on Monday, October 13th at 1:35 p.m. EDT in room 145AB as part of the Innovative Devices and Futuristic ...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

... Inflammatory Protein 1 alpha), MCP-1 (Monocyte Chemoattractant Protein-1), IP-10 (Inducible Protein 10) and PGE-2 (Prostaglandin E-2). Cell proliferation assay (XTT reduction) demonstrated that these effects were not caused by cytotoxicity. The anti-inflammatory efficacy was comparable or better than ...

Cell Therapeutics Submits Supplemental Biologics License Application for Zevalin Use in First-Line Consolidation Therapy

... can visit http://www.zevalin.com for more information. About Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a system of vessels that drains fluid from the body. NHL can be ...

FDA Meeting Provides Green Light for Cell Therapeutics Submission of Supplemental Filing for Zevalin(R) Label Expansion

... can visit http://www.zevalin.com for more information. About Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is caused by the abnormal proliferation of white blood cells and normally spreads through the lymphatic system, a system of vessels that drains fluid from the body. NHL can be ...

Old and new therapies combine to tackle atherosclerosis

... with atherosclerosis often take statins to lower cholesterol. Statins also decrease atherosclerotic plaque progression by modestly inhibiting proliferation of new vessels (neovessels) within plaques. These neovessels provide increased blood and oxygen to cells in actively developing plaques. Because of ...

Germicidal UVC Lights Improve Clinical Pregnancy Rates for IVF Lab, New Study Finds

... "UVC energy will destroy 90 -- 99% of airborne microbial contaminants. By targeting the DNA and RNA of microorganisms, UVC degrades and abates the proliferation of airborne and surface embryotoxic organics. Of equal significance to the developing embryo is the suggested impact of UVC irradiation on the ...

Repair Stem Cell Institute Announces Industry's First Standards of Excellence for Global Stem Cell Treatment Centers to Protect Patients from Less-than-Competent Therapeutics

... DALLAS, Aug. 12 /PRNewswire/ -- To protect potential patients from being unwitting victims in the proliferation of less than competent therapeutics, the Repair Stem Cell Institute LLC (RSCI) ( http://www.RepairStemCells.org ) and its Scientific Advisory Board ...

SuperGen Reports 2008 Second Quarter Financial Results

... in MOLM-13 (AML) and MV-4-11 (AML) xenograft models. -- SGI-1252, the Company's JAK2 kinase inhibitor, inhibits tumor cell proliferation in vivo (abstract #741). In an oral presentation titled "SGI-1252: A Potent Small Molecule JAK2 Inhibitor," Dr. Steven Warner, Manager ...
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(Date:9/2/2014)... -- A team of University of Maryland physicists ... other scientists say make possible new nanostructures and ... energy and quantum computing advances to new sensor ... of Nature Communications the Maryland scientists, ... for hybrid nanostructures that uses a connector, or ...
(Date:9/2/2014)... a new study that could ultimately lead to many ... Scripps Research Institute (TSRI) have adapted a chemical approach ... molecules that can treat a form of muscular dystrophy. ... and a disease-causing defect as a catalyst to synthesize ... Matthew Disney.,"Because the treatment is synthesized only in diseased ...
(Date:9/2/2014)... COLUMBUS, Ohio New research suggests that professional baseball pitchers ... or more days in a single season because of injury ... their lower back and pelvis. , In the study, 347 ... with more tilt in their pelvis as they raised a ... likely to miss at least 30 days cumulative, not ...
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(Date:9/2/2014)... 2014 Today, Therapy Changes ... for Me?” The guide outlines common questions an individual ... addition to common types of groups an individual can ... from the interventions of the therapist, but also from ... group members,” says Rochelle Perper, Ph.D. and founder of ...
(Date:9/2/2014)... September 02, 2014 The exciting information ... top-industry professionals Carey Lewis and Bob Wiley. ... seeking those who have the desire to illuminate entertainment ... callback, performers could be invited to join the ... Charlotte, NC – Saturday, Sept. 6, Charlotte Convention Center, ...
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(Date:9/2/2014)... CA (PRWEB) September 02, 2014 On ... on its website titled “Why You Should Wash Your ... 80 percent of the global population breathes air considered ... particles of pollution lodge in the skin’s pores destroying ... natural barrier to free radicals that may cause cell ...
(Date:9/2/2014)... in California, the percentage undergoing a double mastectomy increased ... not associated with a lower risk of death than ... the September 3 issue of JAMA . The ... one breast was associated with a higher risk of ... , Randomized trials have demonstrated similar survival for patients ...
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