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Polymorphic in Biological Technology

BioNanomatrix Awarded New NIH Grant for Development of Nanoscale Platform for Single-Molecule DNA Mapping and Haplotype Applications

... designed to accommodate massively parallel analyses of individual DNA molecules to permit standardized, high-throughput mapping of sequence motifs or polymorphic sites along the DNA. Such capabilities could transform biological analyses, permitting highly sensitive detection of genetic information for ...

ARCA biopharma Appoints James Carr as Vice President of Marketing

... at Buffalo School of Pharmacy. He earned a Doctor of Pharmacy degree from the University of Minnesota and conducted post-graduate work in the area of polymorphic drug metabolism of beta-blockers, also at the University of Minnesota. About ARCA biopharma ARCA biopharma, Inc. is a privately held company ...

Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales

... MPH and MBA degrees from Illinois Benedictine College, and a BS in Mechanical Engineering from Iowa State University. About Haptoglobin The polymorphic haptoglobin (Hp) protein is derived from two alleles, 1 and 2, existing at the Hp genetic locus. Three phenotypes linked to the three genotypes, Hp ...

Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes

... cardiovascular events in patients with Hp 2-2 taking Vitamin E, as the primary endpoints had been met. About Haptoglobin 2-2 The Hp protein is polymorphic in humans, occurring with two alleles, 1 and 2, existing at the Hp genetic locus. Three phenotypes linked to the three genotypes, Hp 1-1, Hp 1-2 and ...

Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor

... Genetics will be conducting various clinical studies, which shall be fully funded by Alticor. Studies will look to correlate single nucleotide polymorphic (SNPs) gene variations to the risk of osteoporosis or cardiovascular disease in Asian populations. Other studies will seek to identify genetic ...

Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems

... can rapidly and accurately identify common and polymorphic peaks among large numbers of samples. Genotyping ... in GeneMapper software for easy identification of polymorphic peaks (red arrow) and common peaks (black arrow). For example, in the data shown in Figure 4, a polymorphic peak can be easily identified in the P1 sample ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... larger ones. This two-pronged approach may be used in developing polymorphic markers when available universal primers are inadequate. Using ... genetics surveys and genetic mapping require numerous polymorphic DNA markers. Denaturing gel electrophoresis, in its various ...

Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis

... ethidium bromide staining, we were able to easily identify 5% polymorphic RNA, and even as little as 1% was detectable. ... FasIII cDNAs with DraI results in an 368 bp fragment when the polymorphic codon is expressed, while this enzyme does not cut the wild ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... teristics of life. DNA fingerprinting Sequences of nucleic acids in specific areas (loci) on a DNA molecule are polymorphic , meaning that the genes in those locations may differ from person to person. DNA fragments can be cut from those sequences using ...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

... shock. LPS causes a very strong stimulation of different cells of the immune system, such as monocytes, macrophages, B cells, polymorphic nuclear- and endothelial vascular cells. LPS is biologically effective even in lowest concentrations (lower pg/ml ...

Practical Applications of HyperDSC in a Pharmaceutical Laboratory

... pharmaceutical analysis. As demonstrated HyperDSC increases the sensitivity of DSC analysis, separates transitions and allows better evaluation of polymorphic materials. The analysis time is very short and permits you to increase your sample throughput or to use this technique as a screening tool for new ...

The Gradient Feature: Use in Optimization of Allelic Discrimination Assays, Rev B

... assays. Most of these homogeneous assays for mutation detection combine amplification of the DNA sequence that spans the target polymorphic nucleotide with the use of allele-specific oligonucleotide (ASO) probes (Wallace et al. 1979). In addition to appropriate probe ...

Real-Time PCR/Melt-Curve Analysis: SNP Detection With FRET, Rev A

... reverse primer that is incorporated into the amplified PCR product. A sequencespecific 6-FAM-labeled probe, with the polymorphic nucleotide placed in the middle, hybridizes next to the Cy5 fluorophore in the PCR product. FRET occurs from FAM to Cy5 with ...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

... for sequencing. Our study offers the first example of the potential use of DGGE for large scale population surveys of highly polymorphic DNA loci. In our laboratory, each technician runs 160 fish per day on DGGE (8 gels) using two DCode systems (80 fish each for ...

PCR principles

... analysis of organisms in which genomic sequences are largely unknown [e.g. Differential Display, Random Amplified polymorphic DNA (RAPD)]. ...

Fully automated DNA purification and efficient multiplex PCR for analysis of microsatellite loci

... Corinna Kppers, Gaby Schulte, Silke Zobel, and Dirk Lffert QIAGEN GmbH, Hilden, Germany Microsatellites highly polymorphic DNA markers comprised of nucleotides that are repeated in tandem arrays and distributed throughout the genome are a useful tool ...

Map and Link Human Genetic Disorders with SSLP Analysis

... genome. Use the CastAway System for Mapping Studies Employing polymorphic markers in a mapping study relies upon the method used to separate the ... alleles and provides more time to test additional markers. Methods polymorphic markers were analyzed by PCR amplification of genomic DNA in ...
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