Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy

... Additional work described at the meeting focused on the use of Monogram's phenotypic and genotypic technology to identify specific markers of HIV resistance to ... HIV infection. Determining a patient's HIV profile at the molecular and phenotypic level, and the effect of therapy on that profile, is not only an ...

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

... found that the Quest Diagnostics HIV-1 Coreceptor Tropism laboratory developed test demonstrated 74 percent agreement with Trofile(TM), the leading phenotypic tropism test available from Monogram Biosciences, and 74 percent agreement with SensiTrop(TM) II, a genotypic tropism test previously available from ...

Prometheus Research Signs 3-Year Contract With Simons Foundation to Expand HTSQL Informatics System for Autism Research

... The SFARI database, known as SFARI Base, is a new resource for autism research that provides the scientific community access to genetic and phenotypic information on 2000 families. "Researchers need flexible, adaptive, and secure informatics systems that empower them to uncover critical data ...

Amnis Launches New ImageStreamX Imaging Flow Cytometer

... Officer. "No other cell analysis platform gives you as much information in a single experiment or allows you to combine detailed functional and phenotypic studies," added Ortyn. "The modularity of the new ImageStreamX allows it to fit into a much wider range of budgets, while its performance ...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... School , which has invested in a human genome-wide esiRNA library, is using esiRNA to help identify the human genes that enable HIV propagation. "The phenotypic results from the initial tests of MISSION esiRNA using our assay for finding HIV dependency factors demonstrated very effective knockdown over a wide ...

Cardiff University Becomes a GeneGo Center of Excellence

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Children's Memorial Research Center, Chicago Becomes a Member of GeneGo's MetaMiner Stem Cell Partnership Program

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

VisualSonics to Sell Mauna Kea Technologies' Cellvizio(R) LAB on a Worldwide Basis to Animal Imaging Market

... to conduct research in cardiovascular, cancer, and developmental biology areas. The technology supports applications that include genetic research, phenotypic studies and drug development. VisualSonics platforms combine high-resolution, real time in vivo imaging at reasonable cost with ease-of-use and ...

Van Andel Institute Joins the MetaMiner Oncology Partnership Program

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

GeneGo Announces Systems Tox Relationship With Entelos

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Millipore Launches an Interactive Biological Pathway Tool Using GeneGo's Manually Curated Pathway Maps

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Queensland Facility for Advanced Bioinformatics (QFAB) Becomes a GeneGo Center of Excellence for the Asia Pacific Region

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

23andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases

... enrollment in the 23andMe Personal Genome Service(TM). Researchers then will be able to study the genetic information collected, along with any phenotypic information provided, in clinical trials, to understand potential causes of these diseases. 23andMe will coordinate genome-wide association studies ...

University of Glasgow Becomes a Member of GeneGo's MetaMiner Stem Cell Partnership Program

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Pacific Northwest National Laboratories Becomes a GeneGo Center of Excellence

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

The Burnham Institute for Medical Research Becomes a GeneGo Center of Excellence Using MetaCore for Stem Cell Research and Neurology

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research

... companies, hospitals and universities to conduct research into cardiovascular disease, cancer, and developmental biology including genetic research, phenotypic study and drug development. Only VisualSonics platforms combine high-resolution, real-time in vivo imaging with ease-of-use, portability and no ...

GeneGo Is Awarded NCI Grant for Development of Systems Biology Database and Tools for Nutrition in Cancer in Collaboration with the FDA

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics, metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

MD Anderson Becomes a GeneGo Center of Excellence Using MetaCore for Oncology Research

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics, metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

New yeast trick for eating favorite food: Details in Nature paper

... and the formation of functional proteins. This "post-transcriptional" regulation provides cells with an additional level of control over phenotypic expression. The UCSD team demonstrated that the glucose network actively shuts down the galactose network by degrading messenger RNA that would ...

New Aptivus(R) (tipranavir) Oral Solution Approved for Treatment-Experienced Pediatric and Adolescent HIV Patients

... not recommended. -- The use of other active agents with APTIVUS/r is associated with a greater likelihood of treatment response. -- Genotypic or phenotypic testing and/or treatment history should guide the use of APTIVUS/r. The number of baseline primary protease inhibitor mutations affects the virologic ...

VTT Technical Research Centre of Finland Licenses MetaCore from GeneGo for Cancer Research and Diagnostics

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics, metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Advanced Analytical Unveils New Instrument for Rapid Microbial Identification at BIO 2008

... could be available within hours of testing." Unlike biochemical-based identification systems which can take days and rely on the viability and phenotypic characteristics of the microorganism, the DNA PROfiler(TM) system from AATI, will provide accurate and rapid species level identification of ...

Researchers Document Rapid, Dramatic 'Reverse Evolution' in the Threespine Stickleback Fish

... than someone who has the same genes but may not have had as good of a diet growing up," Peichel said. "Our findings challenge the primary role of phenotypic plasticity in rapid evolutionary change." The gene that controls for plating is called Eda, which comes in two forms: one causes low plating and ...

Oxford Finance Corporation and Comerica Bank Provide $15 Million Loan Facility to VisualSonics Inc.

... researchers at the world's most prestigious pharmaceutical and biotechnology companies, hospitals and research centers to conduct genetic research, phenotypic study and drug development. Micro-ultrasound is one of the fastest growing preclinical imaging modalities. This enabling technology is facilitating ...

Monogram Biosciences and Avexa Announce Exclusive Collaboration to Support New HIV Drug Discovery and Development Efforts

... accuracy and reliability that are necessary for studies that are intended to be submitted to the FDA and other regulatory agencies." "Monogram's phenotypic resistance tests to optimize background therapy helped contribute to successful clinical trials for both new HIV drugs approved by the FDA in 2007," ...

Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success

... is necessary to correlate any induced phenotypic change with the extent of knockdown ... protein levels to correlate phenotypic changes--monitored by enzymatic assay, cell based ... An example in which the phenotypic effects of an siRNA were correlated ...

Are siRNA Pools Smart?

... Quantitative, phenotypic assays were used to determine how well single ... siRNAs were carried out using nine different phenotypic assays including protein ... and false negatives. The phenotypic differences between single siRNAs and pooled ...

SNPs Powerful Tools for Association Studies

... well as genomewide). Recombination that creates haplotypes coinciding with phenotypic changes is called informative recombination ; such events are the key to ... conditions are present. The best way to measure penetrance is phenotypic concordance in monozygotic twins. Phenotype Visible or ...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

... with morphological parameters to provide a detailed description of the phenotypic effects of siRNAs in cellular screens.

In this study we ... Conclusions Perturbation of sensitive and dynamic phenotypic cellular assays via siRNA provides a powerful tool for functional analysis ...

Recommendations for Successful siRNA Library Screens

... found to block caspase 3 activation (a marker for apoptosis) in a phenotypic screen. As predicted by mRNA studies, there was essentially no ... siRNA screen analysis was repeated using nine different phenotypic assays including cell proliferation, cell morphology, and ...

Getting Started with MicroRNA Research

... study standard genes: analysis of measurements from phenotypic responses or reporter assays. MicroRNA activity can ... Functional studies require quantitative, phenotypic assays (e.g., protein level, activity, or ...

High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells

... plates reduces the variability of quantitative phenotypic results and improves the resolution of screening ... further improving the likelihood that significant phenotypic differences will be observed. ...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

... non-dividing cells, overcoming low transfection and integration difficulties when using these cell lines. pLKO.1 allows for long-term knockdown and phenotypic observation and transduction of difficult or sensitive cell lines. Figure 2. Screening Tumor ...

Identification of Disease Causing Mutations in Phenylketonuria by Denaturing Gradient Gel Electrophoresis Using the DCode System

... variety of mutations described in this gene results in a broad range of plasma phenylalanine concentrations associated with phenotypic differences ranging from the severest form of PKU to the mildest hyperphenylalaninaemia. PKU is autosomal recessively inherited, carriers ...

Setting up Successful siRNA Library Screens

... for cellular functions. The diversity of cell functions that can be characterized using siRNA libraries is limited only by the range of phenotypic assays that can be developed. With siRNA libraries, you will be able to identify critical human genes faster and easier than ...

RNAi: The Controls You Need

... to the same target and with comparable gene silencing efficacy (i.e. mRNA reduction) should induce similar phenotypic effects. Any changes induced by one siRNA and not the other(s) could be attributed to off-target effects. One of ...

RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs

... molecule (12). In each of the screening applications, the keys to the experiments have been robust phenotypic assays and high quality RNAi libraries. siRNAs as Therapeutics: The Next Frontier ...