Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver
... include data on IDX184, a once-daily, oral nucleotide
polymerase inhibitor prodrug currently being ... an optimal combination therapy."
Prodrug Polymerase Inhibitor
IDX184 is a liver-targeted, oral nucleotide
prodrug designed to enhance the formation of its ...
Pharmasset Reports Fiscal First Quarter 2009 Financial Results
... 30, 2009, Pharmasset filed an IND for PSI-7851, a nucleotide
inhibitor of HCV, with the FDA and expects to ... filing an IND for PSI-7851, our second generation nucleotide
for HCV and, strengthening our balance sheet by ... phase 1 studies with its second generation nucleotide
inhibitor for HCV, PSI-7851 in the first quarter ...
Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
... not limited to
assessment of known common single nucleotide
polymorphisms (SNPs). It thus
bridges the current ... recognition of both the
sequence of the variant nucleotide
and the sequence context of the
mutation. The ... of mismatches arising
from the presence of single nucleotide
polymorphisms (SNPs) or from small
insertions or ...
Pharmasset Reports Fiscal Second Quarter 2009 Financial Results
... healthy volunteer in the phase 1 trial with PSI-7851, a second generation nucleotide
inhibitor of HCV.
"Our HCV pipeline continues to make ... collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide
analog, which recently began Phase 1 clinical studies and Racivir, for the ...
SeqWright to Invest in LaserGen's Novel Lightning Terminators(TM)
... while lowering cost. These benefits are achieved through LaserGen's nucleotide
chemistry by attaching a special terminating group directly to the base, ... cleavage, however, Lightning Terminators(TM) restore the incorporated nucleotide
back to its natural state. This distinguishes the LaserGen chemistry from ...
Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)
... as follows:
ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED nucleotide
HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE ... 16:00 - 18:00
IDX184, A LIVER-TARGETED nucleotide
HCV POLYMERASE INHIBITOR: RESULTS OF A FIRST-IN-MAN SAFETY AND ...
Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug
... drug for a kidney target, ISIS-SGLT2Rx is also unique due to its 12 nucleotide
length rather than the more typical 18 - 21 nucleotide
sequences that comprise Isis' other drugs, an attribute that reduces the ...
Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
... non-variant DNA, but is not limited to
assessment of known common single nucleotide
polymorphisms (SNPs). It thus
bridges the current technology gap between ... reference sample, allowing recognition of both the sequence of the
and the sequence context of the mutation. The library can
be sequenced ...
Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis
... allows researchers to quickly
and easily find DNA mutations and Single nucleotide
Polymorphisms (SNPs) in
their sequences. SNPs are single nucleotide
changes in the DNA associated
with diversity and certain diseases. ...
Pharmasset to Present at Canaccord Adams Conference
... being conducted through a strategic collaboration with Roche. Our other clinical stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide
analog which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV, which has completed a Phase 2 clinical trial.
SEQUENOM Announces Launch of MassARRAY Compact 96 System
... changes to assays and biomarkers throughout the validation process.
MassARRAY technology supports key genomic applications, including single nucleotide
polymorphism (SNP) genotyping, quantitative gene expression, and copy number variation (CNV) analysis, providing a multi-faceted view of a ...
Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results
... that it had successfully completed a proof-of-concept study of its lead HCV antiviral development program, IDX184, a novel once-daily liver-targeted nucleotide
prodrug. This double-blind, placebo-controlled, monotherapy, dose-escalation study in HCV genotype-1-infected patients evaluated the safety and ...
Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market
... of specificity is uncommon in natural proteins and is an inherent property of the I-CreI enzyme, which can recognize and modify a distinctive 22 nucleotide
DNA 'address' in the genome of certain algae.
"Precision successfully adapted this natural DNA editing system for use in biotechnology by ...
Beyond associations: Colorectal cancer culprit found
... in this search by the genome-wide association study (GWAS), a technique that scans the genome for known common genetic variants, also known as single nucleotide
polymorphisms, or "SNPs," that are more prevalent in patients with a specific disease. However, a SNP associated with a disease is not necessarily ...
Frost & Sullivan Lauds BioTrove for Providing Research-Enabling Life Sciences and Drug Discovery Technologies
... to assist research efforts with the company's innovative technologies. These research endeavors ranged from lead compound discovery to single nucleotide
polymorphism (SNP) genotyping on the OpenArray(R) system to investigating novel therapeutic targets with the RF-MS system. Researchers often ...
California Grants SeqWright License to Operate as a Clinical Laboratory
... today that it has been granted a California clinical laboratory license. This license enables SeqWright to utilize its DNA sequencing and Single nucleotide
Polymorphism (SNP) Genotyping expertise in order to provide genetic tests to California residents and represents a significant step forward in the ...
Discovery of a new retinal gene involved in childhood blindness
... detailed screen are then subjected to a second DNA chip, this one to identify significant stretches of homozygosity in SNP markers. SNPs are single nucleotide
repeats, which are natural variations in the human genome. These homozygous regions may contain new genes and are carefully probed based on ...
Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results
... million in development, regulatory and sales milestones.
During 2008, Idenix completed a phase I, healthy volunteer study of IDX184, its lead nucleotide
polymerase inhibitor for the treatment of hepatitis C, and advanced the drug candidate into proof-of-concept testing in treatment-naive HCV-infected ...
Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance
possible in DCIS that is adjacent to invasive ductal carcinoma of the
- Results indicating that multiple single nucleotide
the genes that encode ER were not associated with the level of ER
expression in breast cancer. This suggests that ...
23andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases
... for genome-wide association studies and has the unique capability to include custom markers. This feature enabled 23andMe to select SNPs (single nucleotide
polymorphisms), or variants that provide coverage of genes associated with drug response, information that is proving to be critical for the ...
Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum
... underlying serum-microRNA platform is extremely sensitive, and
has demonstrated detection sensitivity on the order of a single molecule,
specificity, and up to 700 fold test-to-control increase of
certain serum microRNA biomarkers." said Dr. Ayelet Chajut, EVP R&D Molecular
World's First Low Radiocarbon Food May Reduce Risks of Cancer and Birth Defects, and Possibly Even Slow the Aging Process
... to 99% of the radiocarbon in the most
critical food components. They will also be growing algae to produce
affordable low radiocarbon amino acid and nucleotide
that can be used in infant formula, baby foods, and child and maternal dietary
All ordinary food, ...
Idenix Pharmaceuticals Reports Second Quarter and Six Month Financial Results
... amended to also evaluate
a 100 mg/day dose.
-- Idenix has submitted an investigational new drug (IND) application
for IDX184, a once-daily, oral nucleotide
prodrug candidate for the
treatment of chronic hepatitis C, to the United States Food and Drug
Administration (FDA) and has initiated a phase I ...
DNA Study Unlocks Mystery to Diverse Traits in Dogs
... Kennels in Gilroy, California and Mars' Waltham Center for Pet
Nutrition in the United Kingdom, studied simple genetic markers known as
Polymorphisms, or SNPs, to find places in the dog genome
that correlate with breed traits. Because many traits are "stereotyped" --
or fixed within ...
Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets
... Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti
J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano
G, Levine AJ. A Single nucleotide
Polymorphism in the MDM2 Promoter
Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumour
Formation in Humans. Cell; 2004; 119: 591-602.
Honey bee invaders exploit the genetic resources of their predecessors
The researchers were looking for tiny variations in the sequences of nucleotides that make up all genes. Certain versions of these single nucleotide
polymorphisms (SNPs, or snips) are more common to African honey bees, while others occur more frequently in honey bees in western Europe, eastern ...
Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study
... is the
complete DNA sequence present in every cell of an organism.
"The location of naturally occurring variations in human DNA, known as
Polymorphisms (SNPs), serve as signposts or markers in
the genome. Associating these SNP markers with diseases in different
individuals provides ...
Anadys Pharmaceuticals Reports Third Quarter 2007 Financial Results and Operational Highlights
... for the treatment of certain cancers. Included within this restructuring were the decisions to discontinue further development of ANA380, a nucleotide
analog for the treatment of hepatitis B virus (HBV) infection, halt all work on early discovery projects, and effect an immediate reduction ...
Consortium publishes Phase II map of human genetic variation
... treat and prevent disease.
The second-generation haplotype map, or Phase II HapMap, contains more than 3.1 million genetic variants, called single nucleotide
polymorphisms (SNPs) three times more than the approximately 1 million SNPs contained in the initial version. The more SNPs that are on the map, the ...
454 sequencing uncovers significant genetic variation
... appears online (ahead of print) today in the journal Science.
Previous studies of human genomic variation tended to look at changes called single nucleotide
polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural ...
454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation
... appears online (ahead of print) today in the journal Science. Previous studies of human genomic variation tended to look at changes
called single nucleotide
polymorphism, variations that involve just one
nucleotide, commonly referred to as SNP. However, the study published today
suggests that structural ...
SNPs Powerful Tools for Association Studies
... studies. This analysis will clarify why single nucleotide
polymorphisms (SNPs) are powerful tools for ... from each other.
In this case, the nucleotide
change that results in a RFLP is also the ... change (i.e., an A-to-T change in the number two nucleotide
of the sixth exon in the - globin chain of the ...
Isolation and Characterization of Anti-Viral Nucleoside Compounds from the Chinese Herb Taraxacum Mongolicum
Characterization of nucleotide
and nucleoside analogs from Taraxacum mongolicum, ... ingredients in the herb were characterized using nucleotide
and nucleoside standards with product and ... of drugs with anti-HSV-1 properties, including nucleotide
and nucleoside analogs. LC/MS/MS conditions were ...
Real-Time PCR/Melt-Curve Analysis: SNP Detection With FRET, Rev A
... powerful tool for the identification of single nucleotide
(SNPs). The frequency of ... 6-FAM-labeled probe, with the polymorphic nucleotide
placed in the middle,
hybridizes next ... Reverse: 5'-CACAGGGCAGGTCT-3'
The third nucleotide
position from the 3' end of the reverse primer ...
Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System
... the wild-type G nucleotide
and the variant A nucleotide
at position 1934 (*4 allele) of the CYP2D6 gene. ...
CYP2D6 gene contains numerous Single nucleotide
Polymorphisms (SNPs) that
alter enzyme ... Accession #M33388), where
a variant A nucleotide
replaces the wild-type G nucleotide. Our assay ...
Comparison of PCR Kleen Spin Columns to Traditional Methods for Purification of PCR Products Prior to Sequencing, Rev A
is the most critical factor in nucleotide
sequencing. The presence of
... and compared the
sequences obtained from these samples with the ... Following sequencing PCR, the resulting nucleotide
sequences were analyzed
on an ABI ...
Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System
... a rapid and sensitive method for the detection of nucleotide
sequence variation which can be used ... the 28 identified A1 sequences, with a
sequence variation between them of 116 nt plus
... all fish analyzed. This rapid rate of analysis of nucleotide
variation makes it possible ...
RNA Interference and Gene Silencing: History and Overview
... PTGS indicate that these 21-23
dsRNAs mediate PTGS. Introduction of siRNAs can ... embryo lysates was processed to 21-23
species. They also found that the homologous ... and
that cleavage occurred at 21-23 nucleotide
intervals (26 ).
Your Data: Silencing of a Pro-apoptotic Transcription Factor Using Synthetic siRNA... been shown to be
mediated by 2123 nucleotide RNA fragments, termed short
... ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.
Cell. 101(1) : 2533. ... is mediated by 21- and 22-
nucleotide RNAs. Genes Dev. 15(2) : 188200.