PTC Therapeutics Receives $2.6 Million in Government Grants
... ongoing pivotal trial of ataluren (PTC124(TM)) in nonsense
mutation Duchenne and Becker muscular dystrophy ... developed as a new approach for the treatment of nonsense
mutation genetic disorders. nonsense
mutations create a premature stop signal in the ...
PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet
... of the lung, pancreas, liver, and
other organs. nonsense
mutations are single-point alterations in ... the underlying genetic defect
responsible for CF. nonsense
mutations are responsible for approximately ... the PTC124 mechanism of action in overcoming nonsense
mutations as the
basis for treating genetic ...
Genzyme Corporation and PTC Therapeutics Announce Collaboration on Small Molecule for Genetic Diseases
... the treatment of genetic disorders due to nonsense
Under the terms of the agreement, ... patients,
approximately 13 percent of which have nonsense
mutations. Of the more than
30,000 U.S. patients with CF, about 10 percent have nonsense
There is a significant unmet medical ...
PTC124 Featured at Third Annual Congress of Myology
... a specific type of
genetic alteration -- nonsense
mutations -- PTC124 bypasses the defect and
leads ... disease in a significant percentage of
mutations inactivate gene function and are known ... preclinical models of genetic diseases harboring nonsense
PTC124 was shown to regulate ...
PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis
... patients with cystic
fibrosis (CF) due to a nonsense
mutation. These pediatric results and
additional ... to determine
if a patient's CF is caused by a nonsense
mutation and it is estimated that
nonsense ... of genetic disorders due to nonsense
mutations are single-point alterations in the ...
New Scientific Worldview 'Biocentrism' Featured in The Huffington Post - #1 Weblog in the World
... for understanding the world.
"Biocentrism unlocks the cage we have unwittingly confined ourselves. A new paradigm is usually dismissed as nonsense
from within the existing paradigm. But allowing the observer into the equation opens new approaches to understanding everything from the tiny world ...
Protein Truncation Tests Using the DCode System
for a mutation in this region. Sequence analysis identified a nonsense
mutation at 5971 nt substituting a G to T (5971G>T[c1990]).
... in a truncated protein,
as well as for substitutions creating a nonsense
mutation. PTT will also
reveal large in-frame insertions or ...
Detection of Mutations in the CYP21 Gene Using the DCode System
5. Lajic, S., and Wedell, A., An intron 1 splice mutation and a nonsense
mutation (W23X) in CYP21 causing severe congenital adrenal ... 98 (2):1824 (1996).
6. Levo, A., and Partanen, J., Novel nonsense
mutation (W302X) in the
steroid 21-hydroxylase gene of a ...
Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep
... more efficiently
on a per scan basis by lowering the number of nonsense
spectra. This reduction in the amount of MS/MS ... content of the Data-Dependent experiment by reducing the number of nonsense
spectra collected, a consequence of chemical noise triggering an ...
IBM Develops Wireless Security Service
... address and identity
Man in the middle - hacker assumes the access point ID and can eavesdrop
Denial of service - flooding the access point with nonsense
traffic in order to clog it
Improperly configured access points - an unlocked, open door to the network
The new service's architecture includes ...
Rice Centromere, Supposedly Quiet Genetic Domain, Surprises
... from other organisms, it is of a manageable size. Most centromeres are composed of vast stretches of what was once called "junk DNA," seemingly nonsense
genetic sequences with no apparent coding function.
"They're humongous," Jiang explains. The DNA within centromeres is "highly repetitive, and it ...
RNAi: The Controls You Need
... for larger version
Scrambled (Negative) siRNA Control
Comparing cells transfected with a nonsense
or scrambled sequence siRNA control to nontransfected cells
can reveal changes caused by siRNA delivery. ...