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Nonsense in Biological Technology

PTC Therapeutics Receives $2.6 Million in Government Grants

... ongoing pivotal trial of ataluren (PTC124(TM)) in nonsense mutation Duchenne and Becker muscular dystrophy ... developed as a new approach for the treatment of nonsense mutation genetic disorders. nonsense mutations create a premature stop signal in the ...

PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet

... of the lung, pancreas, liver, and other organs. nonsense mutations are single-point alterations in ... the underlying genetic defect responsible for CF. nonsense mutations are responsible for approximately ... the PTC124 mechanism of action in overcoming nonsense mutations as the basis for treating genetic ...

Genzyme Corporation and PTC Therapeutics Announce Collaboration on Small Molecule for Genetic Diseases

... the treatment of genetic disorders due to nonsense mutations. Under the terms of the agreement, ... patients, approximately 13 percent of which have nonsense mutations. Of the more than 30,000 U.S. patients with CF, about 10 percent have nonsense mutations. There is a significant unmet medical ...

PTC124 Featured at Third Annual Congress of Myology

... a specific type of genetic alteration -- nonsense mutations -- PTC124 bypasses the defect and leads ... disease in a significant percentage of patients. nonsense mutations inactivate gene function and are known ... preclinical models of genetic diseases harboring nonsense mutations, PTC124 was shown to regulate ...

PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis

... patients with cystic fibrosis (CF) due to a nonsense mutation. These pediatric results and additional ... to determine if a patient's CF is caused by a nonsense mutation and it is estimated that nonsense ... of genetic disorders due to nonsense mutations. nonsense mutations are single-point alterations in the ...

New Scientific Worldview 'Biocentrism' Featured in The Huffington Post - #1 Weblog in the World

... for understanding the world. "Biocentrism unlocks the cage we have unwittingly confined ourselves. A new paradigm is usually dismissed as nonsense from within the existing paradigm. But allowing the observer into the equation opens new approaches to understanding everything from the tiny world ...

Protein Truncation Tests Using the DCode System

... for a mutation in this region. Sequence analysis identified a nonsense mutation at 5971 nt substituting a G to T (5971G>T[c1990]). ... in a truncated protein, as well as for substitutions creating a nonsense mutation. PTT will also reveal large in-frame insertions or ...

Detection of Mutations in the CYP21 Gene Using the DCode System

... 5. Lajic, S., and Wedell, A., An intron 1 splice mutation and a nonsense mutation (W23X) in CYP21 causing severe congenital adrenal ... 98 (2):1824 (1996). 6. Levo, A., and Partanen, J., Novel nonsense mutation (W302X) in the steroid 21-hydroxylase gene of a ...

Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep Technology

... more efficiently on a per scan basis by lowering the number of nonsense full-scan MS/MS spectra. This reduction in the amount of MS/MS ... content of the Data-Dependent experiment by reducing the number of nonsense spectra collected, a consequence of chemical noise triggering an ...

IBM Develops Wireless Security Service

... address and identity Man in the middle - hacker assumes the access point ID and can eavesdrop Denial of service - flooding the access point with nonsense traffic in order to clog it Improperly configured access points - an unlocked, open door to the network The new service's architecture includes ...

Rice Centromere, Supposedly Quiet Genetic Domain, Surprises

... from other organisms, it is of a manageable size. Most centromeres are composed of vast stretches of what was once called "junk DNA," seemingly nonsense genetic sequences with no apparent coding function. "They're humongous," Jiang explains. The DNA within centromeres is "highly repetitive, and it ...

RNAi: The Controls You Need

... for larger version Scrambled (Negative) siRNA Control Comparing cells transfected with a nonsense or scrambled sequence siRNA control to nontransfected cells can reveal changes caused by siRNA delivery. ...
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(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
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