Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients
... conventional therapy. Cimzia is the only PEGylated anti-TNF alpha (Tumor necrosis
"These are important findings as Cimzia(R) shows an ... (certolizumab pegol)
Cimzia(R) is the only PEGylated anti-TNF (Tumor necrosis
Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively ...
New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease
... with CIMZIA(R) (certolizumab pegol) - the only PEGylated anti-TNFa (Tumor necrosis
Factor alpha). Additionally, the data showed that fistulas in most of ... pegol)
CIMZIA(R) is the only PEGylated anti-TNFa (Tumour necrosis
Factor alpha). CIMZIA(R) has a high affinity for human TNF-alpha, ...
Centocor, Inc. and Schering-Plough Submit Application Requesting Approval of Golimumab in Europe for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
... and Phase 3 development programs are unprecedented among
factor (TNF)- alpha therapies, as they mark the first
time that an MAA has ... Inc. and Schering-Plough Corporation's
next-generation human anti-tumor necrosis
factor (TNF)-alpha monoclonal
antibody, is currently in the most ...
Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer
... from a marine fungus. NPI-2358 has a dual effect on tumors: it selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis
without affecting normal vasculature, and it has a direct apoptotic effect on tumor cells. In preclinical models of cancer, including lung, breast, ...
Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA
... characteristic and reproducible
findings of signal void on post-contrast subtraction images ("black hole")
correlates with an area of coagulation necrosis
at the cryoablation site and a
surrounding uniform thin rim enhancement ("cryohalo") corresponds to a zone of
inflammation at the cryoablation ....
Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis
... at the American College
of Rheumatology (ACR) Annual Scientific Meeting. The first trial was in
patients who were previously treated with anti-tumor necrosis
agents and the second study was in patients who were active despite ongoing
treatment with methotrexate.
"In addition to reducing ...
Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research
... Dr. Paul Janssen Research Center in Beerse, Belgium
tomorrow. Feldmann and Maini received the $100,000 prize for their role in
the discovery of tumor necrosis
factor-alpha (TNF-alpha) as an effective
therapeutic target for rheumatoid arthritis and other chronic inflammatory
"Thanks to their ...
ZyGEM and DIAGNOTEC Collaborate on Diagnostics for Detecting a Devastating Virus Attacking Salmon
... and DIAGNOTEC S.A. today announced they
have entered into an agreement to produce molecular diagnostics for the
detection of infectious pancreatic necrosis
virus (IPNV), a deadly pathogen
that attacks salmon and other fish species. The collaboration is harnessing
ZyGEM's advanced enzymatic nucleic acid ...
Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis
... Annual Congress of Rheumatology. Golimumab is currently in the most comprehensive initial Phase 3 development program to date for an anti-tumor necrosis
factor (TNF)-alpha biologic therapy with ongoing studies for the treatment of RA, psoriatic arthritis and ankylosing spondylitis.
In the study, ...
Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Arana Therapeutics Ltd.
... as well as bone, lung, and colorectal cancer,
melanoma, leukemia, and solid tumors. ART621, the Company's most advanced
candidate, is a Tumor necrosis
Factor alpha (TNF alpha)-blocker for
rheumatoid arthritis (RA), psoriasis, and Crohn's disease. In March 2008,
the Company commenced Phase II ...
Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data
... mechanisms of action. NPI-2358 has a dual effect on tumors: It
selectively attacks existing tumor blood vessels leading to hemorrhagic
without affecting normal vasculature, and it has a direct
apoptotic effect on tumors cells. NPI-2358 in combination with
chemotherapeutic agents in ...
FDA Agrees to Review Cimzia(R) File for the Treatment of Rheumatoid Arthritis
... active rheumatoid arthritis (RA).
Cimzia(R) is an investigational agent. If approved, Cimzia(R) will be the
first and only PEGylated anti-TNF (Tumor necrosis
Factor) biologic therapy
available for the treatment of rheumatoid arthritis.
"As a new anti-TNF, we believe that Cimzia(R) would provide ...
Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis
... (AS) and Crohn.s disease in the United States and
Europe. HUMIRA resembles antibodies normally found in the body. It works by
blocking tumor necrosis
factor alpha (TNF-alpha), a protein that, when
produced in excess, plays a central role in the inflammatory responses of
many immune-mediated ...
ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis
... malignancies. Atacicept
contains the soluble TACI receptor that binds to the cytokines BLyS and
APRIL. These cytokines are members of the tumor necrosis
factor family that
promote B-cell survival and autoantibody production associated with certain
autoimmune diseases such as SLE. Current data ...
Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods
influence on cell growth, cell differentiation, contractility and protein
expression pattern. They trigger the release of tumor necrosis
(TNF), Interleukins-1,6 and 8 and the production of Platelet-activating
factors, Prostaglandin E 2 , Thromboxane A 2 7 ...
Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44)
... Proteins. In practical terms, possible uses of the SPECTRAmax GEMINI-XS with fluorescent proteins include discrimination of cellular apoptosis or necrosis
(apoptosis induced decrease in fluorescence 6 ), determination of bacterial survival rates 7 or measurement of homologous DNA recombination repair ...
Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system
... in response to stresses such as heat shock, ultraviolet light, bacterial lipopolysaccharide (LPS) and to pro-inflammatory cytokines, such as tumor necrosis
factor alpha (TNFa) and interleukin 6 (IL-6). MAPKAP-k2, a direct substrate of p38 MAPK , resides in both the nucleus and cytoplasm in non-stimulated ...
The Bio-Rad Silver Stain, Rev E
... activities, Proc Natl Acad Sci
USA 82, 42504253 (1985)
38. Kull FC Jr et al., Cellular receptor for 125 l-labeled tumor necrosis
factor: specific binding, affinity labeling, and relationship to sensitivity
Proc Natl Acad Sci USA 82, 57565760 (1985)
Is RNA Amplification Necessary for Microarrays?
... differential gene expression data using amplified RNA in a
well established in vitro model of cytokine [tumor necrosis
factor (TNF-α)]-stimulated human aortic endothelial cells
(HAEC). 100 ng of total RNA, isolated from ...
Assessing Gene Function with siRNA Libraries
... changes in cell
proliferation do not correlate with aberrant mitotic index
warrant follow-up analysis of necrosis
and apoptosis as likely
causes. With this in mind, Cenix has recently developed a
multiplex assay ...
Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged
... culture volumes and yields see Table 1. CAT: 6xHis-tagged chloramphenicol
acetyl-transferase; TNF- alpha: 6xHis-tagged tumor necrosis
alpha; 46: 6xHis-tagged 46 kDa protein; 38: 6xHistagged 38 kDa protein;
GFP: 6xHis-tagged green fluorescent ...
Critical factors for successful microarray and real-time PCR analyses
RT-PCR Kit and primers and probes specific for the transforming growth
factor (TGF- ) gene or the tumor necrosis
alpha) gene. Analyses were carried out in triplicate on the ABI PRISM
7700 Sequence Detection System. ...
cMaster RTplusPCR System for increased sensitivity and product length
Targets for Two Step RT-PCR amplification:
Alpha Tubulin mRNA (mouse and human), 500 bp fragment
Factor Receptor (TNFR1) mRNA (mouse and human), 1.3 kb fragment
Human Tuberous Sclerosis Factor (hTSF) mRNA, 5.3 kb fragment