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Necrosis in Biological Technology

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

... conventional therapy. Cimzia is the only PEGylated anti-TNF alpha (Tumor necrosis Factor alpha). "These are important findings as Cimzia(R) shows an ... (certolizumab pegol) Cimzia(R) is the only PEGylated anti-TNF (Tumor necrosis Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively ...

New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease

... with CIMZIA(R) (certolizumab pegol) - the only PEGylated anti-TNFa (Tumor necrosis Factor alpha). Additionally, the data showed that fistulas in most of ... pegol) CIMZIA(R) is the only PEGylated anti-TNFa (Tumour necrosis Factor alpha). CIMZIA(R) has a high affinity for human TNF-alpha, ...

Centocor, Inc. and Schering-Plough Submit Application Requesting Approval of Golimumab in Europe for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... and Phase 3 development programs are unprecedented among anti-tumor necrosis factor (TNF)- alpha therapies, as they mark the first time that an MAA has ... Inc. and Schering-Plough Corporation's next-generation human anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, is currently in the most ...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

... from a marine fungus. NPI-2358 has a dual effect on tumors: it selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis without affecting normal vasculature, and it has a direct apoptotic effect on tumor cells. In preclinical models of cancer, including lung, breast, ...

Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA

... characteristic and reproducible findings of signal void on post-contrast subtraction images ("black hole") correlates with an area of coagulation necrosis at the cryoablation site and a surrounding uniform thin rim enhancement ("cryohalo") corresponds to a zone of inflammation at the cryoablation ....

Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis

... at the American College of Rheumatology (ACR) Annual Scientific Meeting. The first trial was in patients who were previously treated with anti-tumor necrosis factor (TNF) agents and the second study was in patients who were active despite ongoing treatment with methotrexate. "In addition to reducing ...

Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research

... Dr. Paul Janssen Research Center in Beerse, Belgium tomorrow. Feldmann and Maini received the $100,000 prize for their role in the discovery of tumor necrosis factor-alpha (TNF-alpha) as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. "Thanks to their ...

ZyGEM and DIAGNOTEC Collaborate on Diagnostics for Detecting a Devastating Virus Attacking Salmon

... and DIAGNOTEC S.A. today announced they have entered into an agreement to produce molecular diagnostics for the detection of infectious pancreatic necrosis virus (IPNV), a deadly pathogen that attacks salmon and other fish species. The collaboration is harnessing ZyGEM's advanced enzymatic nucleic acid ...

Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis

... Annual Congress of Rheumatology. Golimumab is currently in the most comprehensive initial Phase 3 development program to date for an anti-tumor necrosis factor (TNF)-alpha biologic therapy with ongoing studies for the treatment of RA, psoriatic arthritis and ankylosing spondylitis. In the study, ...

Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Arana Therapeutics Ltd.

... as well as bone, lung, and colorectal cancer, melanoma, leukemia, and solid tumors. ART621, the Company's most advanced candidate, is a Tumor necrosis Factor alpha (TNF alpha)-blocker for rheumatoid arthritis (RA), psoriasis, and Crohn's disease. In March 2008, the Company commenced Phase II ...

Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data

... mechanisms of action. NPI-2358 has a dual effect on tumors: It selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis without affecting normal vasculature, and it has a direct apoptotic effect on tumors cells. NPI-2358 in combination with chemotherapeutic agents in ...

FDA Agrees to Review Cimzia(R) File for the Treatment of Rheumatoid Arthritis

... active rheumatoid arthritis (RA). Cimzia(R) is an investigational agent. If approved, Cimzia(R) will be the first and only PEGylated anti-TNF (Tumor necrosis Factor) biologic therapy available for the treatment of rheumatoid arthritis. "As a new anti-TNF, we believe that Cimzia(R) would provide ...

Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis

... (AS) and Crohn.s disease in the United States and Europe. HUMIRA resembles antibodies normally found in the body. It works by blocking tumor necrosis factor alpha (TNF-alpha), a protein that, when produced in excess, plays a central role in the inflammatory responses of many immune-mediated ...

ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis

... malignancies. Atacicept contains the soluble TACI receptor that binds to the cytokines BLyS and APRIL. These cytokines are members of the tumor necrosis factor family that promote B-cell survival and autoantibody production associated with certain autoimmune diseases such as SLE. Current data ...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

... influence on cell growth, cell differentiation, contractility and protein expression pattern. They trigger the release of tumor necrosis factor (TNF), Interleukins-1,6 and 8 and the production of Platelet-activating factors, Prostaglandin E 2 , Thromboxane A 2 7 ...

Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44)

... Proteins. In practical terms, possible uses of the SPECTRAmax GEMINI-XS with fluorescent proteins include discrimination of cellular apoptosis or necrosis (apoptosis induced decrease in fluorescence 6 ), determination of bacterial survival rates 7 or measurement of homologous DNA recombination repair ...

Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system

... in response to stresses such as heat shock, ultraviolet light, bacterial lipopolysaccharide (LPS) and to pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFa) and interleukin 6 (IL-6). MAPKAP-k2, a direct substrate of p38 MAPK , resides in both the nucleus and cytoplasm in non-stimulated ...

The Bio-Rad Silver Stain, Rev E

... activities, Proc Natl Acad Sci USA 82, 42504253 (1985) 38. Kull FC Jr et al., Cellular receptor for 125 l-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity Proc Natl Acad Sci USA 82, 57565760 (1985) ...

Is RNA Amplification Necessary for Microarrays?

... differential gene expression data using amplified RNA in a well established in vitro model of cytokine [tumor necrosis factor (TNF-α)]-stimulated human aortic endothelial cells (HAEC). 100 ng of total RNA, isolated from ...

Assessing Gene Function with siRNA Libraries

... changes in cell proliferation do not correlate with aberrant mitotic index warrant follow-up analysis of necrosis and apoptosis as likely causes. With this in mind, Cenix has recently developed a multiplex assay ...

Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged proteins

... culture volumes and yields see Table 1. CAT: 6xHis-tagged chloramphenicol acetyl-transferase; TNF- alpha: 6xHis-tagged tumor necrosis factor- alpha; 46: 6xHis-tagged 46 kDa protein; 38: 6xHistagged 38 kDa protein; GFP: 6xHis-tagged green fluorescent ...

Critical factors for successful microarray and real-time PCR analyses

... Probe RT-PCR Kit and primers and probes specific for the transforming growth factor (TGF- ) gene or the tumor necrosis factor alpha(TNF- alpha) gene. Analyses were carried out in triplicate on the ABI PRISM 7700 Sequence Detection System. ...

cMaster RTplusPCR System for increased sensitivity and product length in RT-PCR

... Targets for Two Step RT-PCR amplification: Alpha Tubulin mRNA (mouse and human), 500 bp fragment Tumor necrosis Factor Receptor (TNFR1) mRNA (mouse and human), 1.3 kb fragment Human Tuberous Sclerosis Factor (hTSF) mRNA, 5.3 kb fragment Mouse ...
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