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Mutations in Biological Technology

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

... measurement of KRAS, BRAF, EGFR and other key mutations for predicting patient response to targeted ... researchers and clinicians to measure the key mutations DxS Scorpion probes target directly from blood." "Combining the ability to pull high-quality mutations from a simple blood draw with the unparalleled ...

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

... NextGen sequencing technology to detect all mutations in any of the 37 mitochondrial DNA genes. The ... and accurate risk counseling. Disease from mutations in mitochondrial DNA is now thought to be common ... processes, including growth, and metabolism. mutations in mitochondrial genes may decrease energy ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... variation of the standard PCR technology enriches mutations in samples where normal DNA predominates. ... demonstrated its effectiveness in enriching for mutations in cancer-related genes in samples where DNA ... solution to high sensitivity detection of somatic mutations that are key to cancer biology." Cold-PCR ...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

... Transgenomic. "Scanning to identify presence of mutations limits the amount of DNA sequencing required, ... some samples incorrectly scored as homozygous mutations by DNA sequencing were shown by Surveyor Nuclease ... due to the size of the genes and the variety of mutations involved. Transgenomic CEO Craig Tuttle ...

Unraveling the genetic picture of lung cancer

... seeking possible cancer genes elucidated the mutations and the genetic pathways activated in the most ... any previous study, allowed scientists to find mutations associated with sub-types of the lung cancer ... approach enabled the BCM researchers to identify mutations with unprecedented sensitivity. As a result, ...

Large-scale genetic study sheds new light on lung cancer

... in the disease, and described patterns of genetic mutations among different subgroups of lung cancer ... Next, they sequenced the DNA to look for mutations in 623 genes with known or potential ... are: Neurofibromatosis 1 (NF1). mutations in this gene have previously been shown to cause ...

/R E P E A T -- Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours/

... disease. Patients must have demonstrated mutations in K-RAS or EGFR, or EGFR gene amplification ... disease. A large number of mutations, including mutations in EGFR, Her2 or K-RAS along the RAS pathway lead ... therapies have shown that patients with mutations or overexpression of EGFR, which are ...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours

... disease. Patients must have demonstrated mutations in K-RAS or EGFR, or EGFR gene amplification ... disease. A large number of mutations, including mutations in EGFR, Her2 or K-RAS along the RAS pathway lead ... therapies have shown that patients with mutations or overexpression of EGFR, which are ...

PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet

... lung, pancreas, liver, and other organs. Nonsense mutations are single-point alterations in the genetic code ... genetic defect responsible for CF. Nonsense mutations are responsible for approximately 10 percent of ... fibrosis worldwide. However, in Israel, nonsense mutations are responsible for the majority of CF cases. ...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... test genome. SEAL is designed to recognize point mutations and small insertion/deletions at 100 to 1000 ... on our prediction that SEAL should identify point mutations and small insertion/deletions at 100 to 1000 ... and protocols for the detection of mutations in DNA. All of these kits are based on the use of ...

Roche Signs Exclusive Distribution Deal with DxS for K-RAS and EGFR Cancer Mutation Tests

... Tests identify genetic mutations that can affect patient response to ... certified companion diagnostic for tumor-specific mutations in patients with colorectal cancer. In addition, ... are frequently found in many cancer types. These mutations are common in colorectal cancer, pancreatic ...

PTC124 Featured at Third Annual Congress of Myology

... a specific type of genetic alteration -- nonsense mutations -- PTC124 bypasses the defect and leads to the ... in a significant percentage of patients. Nonsense mutations inactivate gene function and are known to cause ... disorders due to nonsense mutations. Nonsense mutations are single-point alterations in the genetic code ...

MIT explains spread of 1918 flu

... Mass.--MIT researchers have explained why two mutations in the H1N1 avian flu virus were critical for ... that the 1918 influenza strain developed two mutations in a surface molecule called hemagglutinin (HA), ... in the human upper respiratory tract. Two mutations dramatically change the HA binding affinity to ...

International team identifies 480 genes that control human cell division

... three genes responsible for repairing genetic mutations that occur as DNA is duplicated in the cell. ... in cancer cells raises the possibility that some mutations associated with cancer may not cause cancer. Some of the mutations may be caused by the non-cycling genes, rather ...

Amicus Therapeutics Announces Positive Results From Phase 2 Clinical Trials of Amigal(TM) for Fabry Disease

... The 26 patients had 21 different missense genetic mutations that cause Fabry disease. The ... has a meaningful effect on a range of genetic mutations in Fabry disease and thus has the potential to ... storage disorder caused by inherited genetic mutations in the GLA gene, which result in deficient ...

JCI table of contents: Dec. 3, 2007

... because UV light from the sun can cause genetic mutations that enable cells in the skin to grow in an ... College of Physicians and Surgeons, New York. mutations in the p53 gene that result in the production of ... including those that are associated with genetic mutations that result in chronic signaling through the cell ...

Individual differences caused by shuffled chunks of DNA in the human genome

... suggesting that it is due less to single point mutations than to the presence of structural changes that ... differences has traditionally been on point mutations or SNPs changes in single bases in individual ... Life Sciences. Previous work, based on point mutations estimated that there is a 0.1 percent difference ...

Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer

... observed in patients with and without activating mutations in the epidermal growth factor receptor (EGFR), a target of XL647. Activating mutations in EGFR have been associated with improved ... -- All 6 patients with EGFR-activating mutations demonstrated clinical benefit (5 PR, 1 SD). ...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

... inhibitors. Furthermore, ANA598 retains full activity in vitro against mutations conferring resistance to protease inhibitors, nucleoside polymerase ... protease and nucleoside polymerase inhibitors retain full activity against mutations conferring resistance to ANA598. ANA598 has received Fast Track ...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

... highly sensitive and specific mass spec-based detection of low frequency mutations that are typically undetected using conventional techniques. ... enables detection of the most common molecular biomarker classes - somatic mutations via the OncoCarta mutation panel, SNPs, CNVs, methylation patterns, ...

OMT announces a breakthrough in the development of a novel human antibody platform

... of Science . The creation of rats with permanent, heritable genetic mutations is a critical milestone in the development of OMT's novel human monoclonal ... BioSciences, Inc. to knockout a gene encoding rat immunoglobulin. The mutations in rat immunoglobulin caused no off-target effects in other genes, and ...

Novel gene found for dilated cardiomyopathy

... failure in some children and adults with dilated cardiomyopathy (DCM). mutations in the ANKRD1 gene may cause DCM, which is the most common cause of ... Children's. "This clarifies the mechanisms by which these inherited mutations cause disease in a subset of DCM patients." DCM is a condition in which ...

Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease

... have long indicated that Parkinson's is a genetic disorder when certain mutations are inherited. However, specific genetic factors relevant to the general ... called dardarin, derived from the Basque word dardara, meaning tremor. mutations in LRRK2 are a common cause of familial Parkinson's disease. This ...

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

... Anderson Cancer Center identified three novel (previously undescribed) mutations along the BCR-ABL tyrosine kinase that may constitute a new class of mutations that "confer significant drug resistance" to imatinib therapy by ...

Beyond associations: Colorectal cancer culprit found

... difficult, owing to the genetic heterogeneity of cancer cells. Numerous mutations can be found in a cancer cell, but the key to developing new treatments ... is to identify the variants that cause the disease hidden amongst many mutations that are simply bystanders. Recently, researchers have been aided in this ...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

... modifier genes that control the severity of VWD. The lab has also defined mutations in ADAMTS13, an enzyme that processes von Willebrand factor, as the cause ... combined deficiency of factors V and VIII by the Ginsburg lab identified mutations in two genes that define a novel pathway for the transport of a select ...

Transgenomic, Inc. Reports Fourth Quarter and Fiscal Year 2008 Results

... products to surpass typical sequencing in finding these key cancer gene mutations is well known. However, we believe that clinical use of the WAVE and ... kits based on our experience in clinical trial assessments of these gene mutations that we are providing through our Pharmacogenomics Services Lab." ...

Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain

... Greater than ninety nine percent of H5N1 samples studied did not exhibit mutations that confer oseltamivir resistance.(3) According to Benjamin Schwartz, MD, CDC National Vaccine Program Office, "the mutations that have made the H1N1 virus resistant are unlikely to occur in a ...

Researchers develop new model for cystic fibrosis

... including the intestines, pancreas, and lung. Mice with CF-causing mutations have helped researchers learn more about this disease, however, differences in physiology and biology mean that mice with CF mutations do not develop many of the typical symptoms that affect humans with CF. ...

Pigs bred with cystic fibrosis provide model to mimic human disease

... perform analysis during the transit to determine which piglets have the mutations "So far, all the mutations in the pigs have exactly mimicked the problems in humans born with CF," ...

Exosome Diagnostics Appoints Johan Skog, Ph.D., as Director of Genetics Research

... of our development program to capture diagnostic quantities of genetic mutations in blood," said James McCullough, chairman & chief executive officer. "His expertise as the inventor of the technology of isolating genetic mutations from circulating exosomes for use as diagnostic and prognostic tools will ...

33rd ESMO Congress in Stockholm, 12-16 September 2008

... 12:45 CEST) Lung cancer patients whose tumours carry specific genetic mutations can achieve significantly longer survival when treated with targeted ... to examine the benefits of customising lung cancer treatment based on mutations in the epidermal growth factor receptor (EGFR) gene. Phase II trial of ...

JCI online early table of contents: March 6, 2008

... might model cystic fibrosis Cystic fibrosis (CF) is caused by mutations in the gene responsible for making the protein CFTR. Progress toward ... syndrome (SDS) is an inherited disorder, caused by genetic mutations in the SBDS gene and characterized by, among other things, bone marrow ...

Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements

... for nearly two years -- Responses in patients with different Fabry mutations were consistent with the results of in vitro testing, thus confirming ... vivo response study designed to test the responsiveness of various Pompe mutations to AT2220. "The data from these Phase 2 trials of Amigal and Plicera are ...

National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment

... patients within all stages of CLL. Studies show that CLL patients with mutations in their IgVH gene have a longer median survival (293 months) than CLL patients without these mutations (117 months). Approximately 50 to 70 percent of patients with CLL have ...

Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis

... in version 4.6, which allows researchers to quickly and easily find DNA mutations and Single Nucleotide Polymorphisms (SNPs) in their sequences. SNPs are ... your experimental data to a genomic DNA reference when looking for mutations or other changes. This feature alone reinforces Sequencher as one of the ...

PTC Therapeutics Announces Encouraging Additional Phase 2 Results of PTC124 in Cystic Fibrosis

... CF is caused by a nonsense mutation and it is estimated that nonsense mutations are the cause of CF in approximately 10% of patients in the United States. ... for the treatment of genetic disorders due to nonsense mutations. Nonsense mutations are single-point alterations in the genetic code that prematurely halt the ...

New target for anti-flu drug development

... the ion channel is blocked. The researchers have shown that these specific mutations they introduced in the protein significantly reduces its ability to kill ... view of the pharmaceutical industry and feasibility studies, introducing mutations into a protein, which mimic an effect of a future drug, is a way to ...

SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights

... researchers to rapidly profile genetic changes associated with tumor initiation and progression. The company expects to add more oncogenes and mutations to the OncoCarta panel in the near future. Diagnostics Business Commercial Launch Plans - The company is on track to launch three ...

Junying Yu, Leading Stem Cell Researcher, Joins Cellular Dynamics International

... vector, concerns have arisen over the potential risks associated with the insertion of foreign DNA into the cell's genome. For example, insertion mutations could affect the biology of the cell or potentially lead to tumorigenesis. Dr. Yu, who comes to CDI from an associate scientist position ...
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