Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery
... factor receptor)
gene rearrangements; adult patients with aggressive systemic mastocytosis
(ASM) without the D816V c-KIT mutation or with c-KIT mutational
unknown; adult patients with hypereosinophilic syndrome (HES) and/or
chronic eosinophilic leukemia (CEL) who have the FIP1L1- PDGFR alpha ...
Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
... the well-characterized bacterial lacI gene as a mutational
gene. The lacI gene, part of ... number of mutants have been sequenced, a mutational
Mutational spectra are ... the mutants revealed a unique difference in mutational
spectrum from the liver was ...
Randomize Gene Sequences with New PCR Mutagenesis Kit
... PCR mutagenesis kit produces a unique
with minimal bias, and its mutational
spectrum is distinct from that of
Taq ... in studies employing lacZ
as the mutational
target gene. A 650-bp DNA fragment containing a ...
A Positive Selection Assay for Mutation Analysis in Big Blue
... now offers an alternative way to perform mutational
the Big Blue transgenic rodent ... studying
tissue-specific mutant frequencies and mutational
1 ... l LIZ
shuttle vector, functions as a mutational
test sequence. Rescued shuttle
Organize Your Data from the Big Blue Mutation Assay
... The report compares mutant
frequencies from two treatment groups. mutational
events are assessed using the Mutational
Spectrum Report, which tabulates mutational
spectra based on the
occurrence of each mutation type. Specialized ...
Cytosolic expression of Green Fluorescent Protein (GFP) and its derivatives
in the yeast Saccharomyces cerevisiae: Detection in vivo using
the Varian Cary Eclipse
... Gerdes and Kaether 2 ). Since then, a rapidly increasing variety of
applications for GFP and its derivatives have been developed. mutational
of the chromophore and surrounding amino acids have produced new GFPs with altered
excitation and emission spectra. ...
Detection of Mutations in the CYP21 Gene Using the DCode System
Hum. Mutat., 5 , 12630 (1995).
3. Wedell, A., Thilen, A., Ritzen, E. M., Stengler, B., and Luthman,
spectrum of the steroid 21-hydroxylase gene in Sweden:
implications for genetic diagnosis and association with disease manifestation,
Transfection Reagent Selector Kit Handbook
cells has become a powerful tool for the study and control of gene expression,
e.g. for biochemical characterization, mutational
analyses, or investigation
of the effects of regulatory elements or cell growth behavior. Two principally
different transfection ...
Mx4000 Multiplex Quantitative PCR System*,PPP
Real-time quantitative PCR (QPCR) allows researchers to quickly and easily
quantify nucleic acids for studying gene expression, mutational
disease state, and gene dosage. QPCR measures PCR product accumulation during
the exponential phase of the reaction using fluorescence ...
Map and Link Human Genetic Disorders with SSLP Analysis
... the rapid identification of
new disease genes. Recognition of the heterogeneity of genetic diseases, the
allelic nature of certain disorders, and mutational
heterogeneity in the cause
of genetic conditions may ultimately lead to understanding the relationship
between phenotype and gene.
Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase
... enhancing factor on the replication fidelity of
Pfu DNA polymerase was investigated using the lacI-based
PCR assay. The lacI mutational
target gene was amplified from varying
amounts of plasmid DNA and from a single-copy transgene in rodent genomic
DNA, and error ...