New clues about a hydrogen fuel catalyst

... out of a tank, but getting hydrogen out of a molecule requires a catalyst. Now, researchers reveal new ... catalyst chemically reacts with ammonia borane, a molecule that stores hydrogen densely, to release the ... hydrogen as part of a larger molecule. The molecule that contains hydrogen atoms, in this case ...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

... EVP-0962 is a proprietary small molecule that belongs to a new generation of potential ... and confirms that EVP-0962 is an ideal molecule to test the AB-hypothesis in our upcoming human ... dedicated to discovering and developing small molecule therapeutics for disorders of the central nervous ...

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

... release of a comprehensive global report on Small molecule Kinase Inhibitors market. World market for small molecule kinase inhibitor drugs is projected to reach ... among others. The report titled "Small molecule Kinase Inhibitors: A Global Strategic Business ...

ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week

... Traficet-EN is an orally-available small molecule drug that controls the inappropriate immune ... Traficet-EN is an orally-available small molecule drug which is administered in capsule form and ... chemoattractant receptors with different small molecule compounds. ChemoCentryx's lead compound, ...

DNA gripped in nanopores

... of the DNA. The researchers drove a single DNA molecule through a nanopore in order to analyze the forces ... DNA was linked. In this way they pulled the DNA molecule through a nanopore. The various dimensions of the ... basis for highly promising developments in single molecule techniques based on nanopores. For example, such ...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... it has identified an orally bioavailable small molecule antagonist of the C5a receptor, CCX168, as a ... for clinical development. The acceptance of the molecule as a development candidate triggered a $5.0 ... a highly potent and specific C5a receptor small molecule antagonist, and unlike other compounds that have ...

Telik Reports Preclinical Results at AACR Annual Meeting

... additional data for a novel class of small molecule drug candidates showing strong and equipotent ... focused on discovering and developing small molecule drugs to treat cancer and inflammatory diseases. ... the rapid and efficient discovery of small molecule drug candidates. TELIK, the Telik logo, ...

Scientists moving closer to 'artificial noses'

... that resonate in characteristic fashion. If a molecule docks onto one of the strings, then it becomes ... onto them. More specifically: only one kind of molecule can dock onto each string. When a molecule docks onto a string, the string becomes heavier ...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

... candidate for oncology. An optimal bispecific molecule was identified that demonstrated highly potent ... Class II molecule. Target binding by the SCORPION molecule has an affinity similar to Trubion's Small ... Results showed the CD79BxDR SCORPION molecule elicited strong Antibody-Dependent Cellular ...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... About AT-406 AT-406 is an orally-active, small molecule drug designed to promote programmed cell death ... Mcl-1 or Bcl-2). They showed that Ascenta's small molecule pan-Bcl-2 inhibitor, AT-101, had preferential ... lead agent, AT-101, is an orally-active small molecule pan Bcl-2 inhibitor (Bcl-2, Bcl-xL, and Mcl-1) ...

Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs

... Therapeutics, a company developing novel small molecule drugs targeting large underserved medical ... pharmaceutical company developing novel, small molecule drugs targeting large, underserved medical ... and nocturia: VA106483 is a novel small molecule drug candidate in Phase II trials to treat ...

Accera, Inc. Launches Neuera Pharmaceuticals, Inc.

... discovery and development of proprietary small molecule drugs for acute and chronic neurological ... the newly formed company, and the current small molecule pipeline at Accera including the preclinical ... engaged in the discovery and development of small molecule drugs for the treatment of neurodegenerative ...

Fitting pieces for biosensors

... select the best binding partners for the target molecule from a huge pool of 10 million x 100 million ... Once suitable binders (aptamers) for a target molecule have been found by the SELEX process and their ... and refers to the fact that a fluorescence molecule is added to the nucleic acids during the SELEX ...

Nuevolution Announces Progress in Its Collaboration With Merck & Co. Inc.

... drug discovery technology to identify novel small molecule leads against several drug targets. By ... multi-million member proprietary library of small molecule drug candidates. In addition, this development ... of millions of chemically diverse drug-like small molecule compounds and the efficient screening of these, ...

Publication of Shire plc's Annual Report 2008

... PLICERA is an orally-administered, small molecule pharmacological chaperone that is being developed ... AMIGAL is an orally-administered, small molecule pharmacological chaperone being developed for the ... HGT-3510 is an orally-administered, small molecule pharmacological chaperone being developed for the ...

New organic material may speed Internet access

... Biaggio's group is working with a small organic molecule called DDMEBT that possesses one of the strongest ... when compared to its relatively small size. The molecule can condense from the vapor phase into a bulk ... "Between high optical nonlinearity in a molecule and ability to actually fabricate a bulk plastic ...

Researchers discover a potential on-off switch for nanoelectronics

... to understand how the intrinsic properties of a molecule or junction are actually connected to its ... gold electrodes and bipyridinea benzene-like ring molecule containing nitrogen. The experimental data ... it bonds at an angle. As the gap increases, the molecule jumps to a vertical configuration, causing the ...

Quanterix Corporation Announces the Addition of Dr. Robert Corn to its Scientific Advisory Board

... Leader in single molecule detection to expand prominent Scientific Advisory ... -- Quanterix Corporation, the leader in single molecule detection, announced today that Robert ... Quanterix is developing a revolutionary Single molecule Array (SiMoA(TM)) technology that allows the ...

Gold nanostar shape of the future

... from a laser, is shined on a sample, the target molecule vibrates and scatters back in its own unique ... Raman response is extremely weak. When the target molecule is coupled with a metal nanoparticle or ... SERS. Vo-Dinh said that since each SERS label molecule has its own unique optical fingerprint, ...

Ultrafast lasers give CU-Boulder researchers a snapshot of electrons in action

... scientists have found a new way to peer into a molecule that allows them to see how its electrons rearrange as the molecule changes shape. Understanding how electrons ... how bonds are formed or broken between atoms in a molecule during chemical reactions. But only extremely ...

Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium

... NKTR-102 leverages Nektar's innovative small molecule PEGylation platform and is currently in Phase 2 ... which was invented by Nektar using its small molecule PEGylation technology platform. NKTR-102 is the ... that leverages Nektar's innovative small molecule PEGylation chemistry. Using a ...

Killer pulses help characterize special surfaces

... the electric field is strong enough, it rips a molecule apart, "killing" it. "If a molecule is in a very hot spot on the substrate, where the ... a weak pulse to kill it," Dlott said. "If the molecule is in a very cold spot, then it takes a really ...

ApoA-I Data Presented at European Society of Cardiology Congress

... presentation titled "RVX-208 a novel small molecule that increases apolipoprotein A-I enters into ... pushed to the forefront the importance of a small molecule in the form of an oral tablet that significantly ... in animals and humans. RVX-208, a novel small molecule drug that facilitates endogenous ...

SuperGen Reports 2008 Second Quarter Financial Results

... presentation entitled, "A potent small molecule PIM kinase inhibitor with activity in cell ... that allowed for the creation of small molecule PIM kinase inhibitors. SGI-1776 was ... In a poster presentation entitled "A potent small molecule PIM kinase inhibitor with in vivo oral ...

Lorus Therapeutics Reports Fourth Quarter Results for Fiscal Year 2008

... studies for Lorus' lead anticancer small molecule drug LOR-253. The toxicology studies, currently ... in activity within our LOR-2040 and Small molecule development programs, in particular, due to ... bladder cancer, and the advancement of our small molecule program into GLP-toxicology studies. For the ...

U.S. Genomics Awarded $9.1 Million Contract for Development of Advanced Biosensor by the U.S. Department of Homeland Security

... the detection of airborne pathogens using single molecule DNA mapping technology. "The award of the Phase ... validates the potential of U.S. Genomics' single molecule based DNA mapping technology for use as a ... Inc. U.S. Genomics is pioneering single molecule biology technologies for biodefense and ...

Quantum computing breakthrough arises from unknown molecule

... WEST LAFAYETTE, Ind. - The odd behavior of a molecule in an experimental silicon computer chip has led ... describe how they have created a new, hybrid molecule in which its quantum state can be intentionally ... state is what can be controlled in this new molecule simply by altering the voltage of the transistor. ...

Tethered molecules act as light-driven reversible nanoswitches

... uses a change in the shape of an azobenzene molecule in response to light to provide two different states. The azobenzene molecule consists of a bridge of two nitrogen atoms ... two benzene rings can be on the same side of the molecule (cis configuration) or on opposite sides (trans ...

Oncothyreon initiates Phase 1 trial of PX-866 cancer compound

... with advanced solid tumors. PX-866 is a small molecule compound designed to inhibit the activity ... programs underway for our promising small molecule inhibitors," said Robert L. Kirkman, ... cancer, and a Phase 1 trial of PX-478, a small molecule inhibitor of hypoxia inducible factor-1 alpha, in ...

Aegera Therapeutics collaboration with Human Genome Sciences leads to the initiation of a Phase 1 clinical trial with lead IAP inhibitor HGS1029 and receipt of first milestone payment

... rapid and successful development of this potent molecule across a broad range of cancer indications. ... - AEG41174 is a novel, non-ATP competitive, small molecule tyrosine kinase inhibitor targeting ... - AEG33773 is a novel, orally bioavailable small molecule developed to treat painful diabetic neuropathy ...

Pacific Biosciences Acquires Single Molecule Sequencing Technology from LI-COR Biosciences

... related to the SMRT(TM), single molecule real time, sequencing method. Developed by ... property developed under LI-COR's single molecule sequencing program, including a number of issued ... has acquired our early developments in single molecule DNA sequencing and will now shepherd ...

Real-time observation of the DNA-repair mechanism

... a single DNA molecule. To observe this, a DNA molecule is stretched between a magnetic bead and a glass ... researchers to pull and rotate a single DNA molecule in a controlled fashion. As the position of the bead changes when the DNA molecule is repaired, researchers are able to observe the ...

Oncothyreon files investigational new drug application for PX-866 oncology compound

... Food and Drug Administration for PX-866, a small molecule phosphatidylinositol-3-kinase ... the continued advancement of Oncothyreon's small molecule oncology pipeline," said Robert L. Kirkman, M.D., ... conducting a Phase 2 trial of PX-12, a small molecule inhibitor of thioredoxin-1, in patients with ...

BioNanomatrix Announces Appointment of Paul R. Selvin to Its Scientific Advisory Board

... - Noted Biophysicist Brings Expertise in Single molecule Fluorescence and Nanoscale ... Dr. Selvin's research focus includes single molecule detection and nanoscale fluorescent measurement. ... of fluorescence techniques and his work in single molecule detection and ultra-sensitive instrumentation. ....

Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS

... principle of a new approach for directing small molecule inhibitors to disease causing RAFT targets in ... a cellular assay, was coupled to a sterol anchor molecule and a potent inhibition of Beta-secretase ... its technology to generate multiple small molecule drug candidates, with its lead program in Phase ...

Sirion Therapeutics Preclinical Studies: Two New Potential Advances in Treatment of Retinal Diseases to be Presented at ARVO

... with a variety of ophthalmic diseases. Small molecule Non-retinoid Modulator In "Development of ... and screened oral, small molecule non-retinoid modulators (NRMs) for reducing the ... laboratory dedicated to the development of small molecule therapeutics to treat human retinal diseases. The ...

Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research

... relevant assays; identification of small molecule drug leads after testing as few as 200 ... hopping; and can speed the optimization of small molecule drugs. Telik, Inc. of Palo Alto, CA, is a ... developing and commercializing novel small molecule drugs to treat serious diseases. The company's ...

Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain

... for AEG33773, a novel, orally bioavailable small molecule in development for the treatment of painful ... - AEG41174 is a novel, non-ATP competitive, small molecule tyrosine kinase inhibitor targeting ... studies; - AEG40826 (HGS1029) is a small molecule IAP inhibitor that has shown promising ...

Mercury Therapeutics, Inc: Lead Series of Indirect AMPK Activators Licensed to Makoto Life Sciences

... Mercury and to apply Makoto's expertise in small molecule target identification to drug discovery in ... by leveraging our AMPK small molecule discovery platform to identify both direct and ... company focusing on the development of small molecule candidates against a number of selected protein ...

Telik Announces Revised Date for Year-End Financial Release, Conference Call and Webcast

... developing and commercializing novel small molecule drugs to treat serious diseases. The company's ... are TELCYTA(R), a tumor-activated small molecule product candidate in clinical development for the ... the rapid and efficient discovery of small molecule drug candidates. ...