New clues about a hydrogen fuel catalyst
... out of a tank, but getting hydrogen out of a molecule
requires a catalyst. Now, researchers reveal new ... catalyst chemically reacts with ammonia borane, a molecule
that stores hydrogen densely, to release the ... hydrogen as part of a larger molecule. The molecule
that contains hydrogen atoms, in this case ...
EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator
EVP-0962 is a proprietary small molecule
that belongs to a new generation of potential ... and confirms that EVP-0962 is an ideal molecule
to test the AB-hypothesis in our upcoming human ... dedicated to discovering and developing small molecule
therapeutics for disorders of the central nervous ...
Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.
... release of a comprehensive global report on Small molecule
Kinase Inhibitors market. World market for small molecule
kinase inhibitor drugs is projected to reach ... among others.
The report titled "Small molecule
Kinase Inhibitors: A Global Strategic Business ...
ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week
... Traficet-EN is an orally-available small molecule
drug that controls the inappropriate immune ...
Traficet-EN is an orally-available small molecule
drug which is administered in capsule form and ... chemoattractant receptors with different small molecule
compounds. ChemoCentryx's lead compound, ...
DNA gripped in nanopores
... of the DNA. The researchers drove a single DNA molecule
through a nanopore in order to analyze the forces ... DNA was linked. In this way they pulled the DNA molecule
through a nanopore. The various dimensions of the ... basis for highly promising developments in single molecule
techniques based on nanopores. For example, such ...
ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist
... it has identified an orally bioavailable small molecule
antagonist of the C5a receptor, CCX168, as a ... for clinical development. The acceptance of the molecule
as a development candidate triggered a $5.0 ... a highly potent and specific C5a receptor small molecule
antagonist, and unlike other compounds that have ...
Telik Reports Preclinical Results at AACR Annual Meeting
... additional data for a novel class of small molecule
drug candidates showing strong and equipotent ... focused on discovering and developing small molecule
drugs to treat cancer and inflammatory diseases. ... the rapid and efficient discovery of small molecule
TELIK, the Telik logo, ...
Scientists moving closer to 'artificial noses'
... that resonate in characteristic fashion. If a molecule
docks onto one of the strings, then it becomes ... onto them. More specifically: only one kind of molecule
can dock onto each string. When a molecule
docks onto a string, the string becomes heavier ...
Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting
... candidate for oncology. An optimal bispecific molecule
was identified that demonstrated highly potent ... Class II molecule. Target binding by the SCORPION molecule
has an affinity similar to Trubion's Small ... Results showed the CD79BxDR SCORPION molecule
elicited strong Antibody-Dependent Cellular ...
Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models
... About AT-406
AT-406 is an orally-active, small molecule
drug designed to promote programmed cell death ... Mcl-1 or Bcl-2). They showed that Ascenta's small molecule
pan-Bcl-2 inhibitor, AT-101, had preferential ... lead agent, AT-101, is an orally-active small molecule
pan Bcl-2 inhibitor (Bcl-2, Bcl-xL, and Mcl-1) ...
Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs
... Therapeutics, a
company developing novel small molecule
drugs targeting large underserved
medical ... pharmaceutical company developing
novel, small molecule
drugs targeting large, underserved medical ... and nocturia:
VA106483 is a novel small molecule
drug candidate in Phase II trials to
Accera, Inc. Launches Neuera Pharmaceuticals, Inc.
... discovery and development of proprietary small molecule
drugs for acute and chronic neurological ... the newly formed company, and the current small molecule
pipeline at Accera including the preclinical ... engaged in the discovery and development of small molecule
drugs for the treatment of neurodegenerative ...
Fitting pieces for biosensors
... select the best binding partners for the target molecule
from a huge pool of 10 million x 100 million ... Once suitable binders (aptamers) for a target molecule
have been found by the SELEX process and their ... and refers to the fact that a fluorescence molecule
is added to the nucleic acids during the SELEX ...
Nuevolution Announces Progress in Its Collaboration With Merck & Co. Inc.
... drug discovery technology to identify novel small molecule
leads against several drug targets.
By ... multi-million member proprietary library of small molecule
drug candidates. In addition, this development ... of millions of chemically diverse drug-like small molecule
compounds and the efficient screening of these, ...
Publication of Shire plc's Annual Report 2008
PLICERA is an orally-administered, small molecule
chaperone that is being developed ...
AMIGAL is an orally-administered, small molecule
chaperone being developed for the ...
HGT-3510 is an orally-administered, small molecule
chaperone being developed for the ...
New organic material may speed Internet access
... Biaggio's group is working with a small organic molecule
called DDMEBT that possesses one of the strongest ... when compared to its relatively small size. The molecule
can condense from the vapor phase into a bulk ...
"Between high optical nonlinearity in a molecule
and ability to actually fabricate a bulk plastic ...
Researchers discover a potential on-off switch for nanoelectronics
... to understand how the intrinsic properties of a molecule
or junction are actually connected to its ... gold electrodes and bipyridinea benzene-like ring molecule
containing nitrogen. The experimental data ... it bonds at an angle. As the gap increases, the molecule
jumps to a vertical configuration, causing the ...
Quanterix Corporation Announces the Addition of Dr. Robert Corn to its Scientific Advisory Board
... Leader in single molecule
detection to expand prominent Scientific Advisory ... -- Quanterix Corporation, the
leader in single molecule
detection, announced today that Robert ... Quanterix is developing a revolutionary Single molecule
(SiMoA(TM)) technology that allows the ...
Gold nanostar shape of the future
... from a laser, is shined on a sample, the target molecule
vibrates and scatters back in its own unique ... Raman response is extremely weak. When the target molecule
is coupled with a metal nanoparticle or ... SERS. Vo-Dinh said that since each SERS label molecule
has its own unique optical fingerprint, ...
Ultrafast lasers give CU-Boulder researchers a snapshot of electrons in action
... scientists have found a new way to peer into a molecule
that allows them to see how its electrons rearrange as the molecule
Understanding how electrons ... how bonds are formed or broken between atoms in a molecule
during chemical reactions. But only extremely ...
Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium
... NKTR-102 leverages Nektar's innovative small molecule
platform and is currently in Phase 2 ... which
was invented by Nektar using its small molecule
platform. NKTR-102 is the ... that leverages Nektar's
innovative small molecule
PEGylation chemistry. Using a ...
Killer pulses help characterize special surfaces
... the electric field is strong enough, it rips a molecule
apart, "killing" it.
"If a molecule
is in a very hot spot on the substrate, where the ... a weak pulse to kill it," Dlott said. "If the molecule
is in a very cold spot, then it takes a really ...
ApoA-I Data Presented at European Society of Cardiology Congress
... presentation titled "RVX-208 a novel small molecule
apolipoprotein A-I enters into ... pushed to the
forefront the importance of a small molecule
in the form of an oral tablet
that significantly ... in animals and humans.
RVX-208, a novel small molecule
drug that facilitates endogenous ...
SuperGen Reports 2008 Second Quarter Financial Results
... presentation entitled, "A potent small molecule
PIM kinase inhibitor with activity in cell ... that allowed for the creation of small molecule
PIM kinase inhibitors. SGI-1776 was ... In a poster presentation entitled "A potent small molecule
PIM kinase inhibitor with in vivo oral ...
Lorus Therapeutics Reports Fourth Quarter Results for Fiscal Year 2008
... studies for Lorus' lead anticancer small molecule
drug LOR-253. The toxicology studies, currently ... in activity within our
LOR-2040 and Small molecule
development programs, in particular, due to ... bladder cancer, and the
advancement of our small molecule
program into GLP-toxicology studies.
For the ...
U.S. Genomics Awarded $9.1 Million Contract for Development of Advanced Biosensor by the U.S. Department of Homeland Security
... the detection of airborne
pathogens using single molecule
DNA mapping technology.
"The award of the Phase ... validates the
potential of U.S. Genomics' single molecule
based DNA mapping technology
for use as a ... Inc.
U.S. Genomics is pioneering single molecule
biology technologies for
biodefense and ...
Quantum computing breakthrough arises from unknown molecule
... WEST LAFAYETTE, Ind. - The odd behavior of a molecule
in an experimental silicon computer chip has led ... describe how they have created a new, hybrid molecule
in which its quantum state can be intentionally ... state is what can be controlled in this new molecule
simply by altering the voltage of the transistor. ...
Tethered molecules act as light-driven reversible nanoswitches
... uses a change in the shape of an azobenzene molecule
in response to light to provide two different states. The azobenzene molecule
consists of a bridge of two nitrogen atoms ... two benzene rings can be on the same side of the molecule
(cis configuration) or on opposite sides (trans ...
Oncothyreon initiates Phase 1 trial of PX-866 cancer compound
... with advanced solid tumors. PX-866 is
a small molecule
compound designed to inhibit the activity ... programs underway for our
promising small molecule
inhibitors," said Robert L. Kirkman, ... cancer, and a
Phase 1 trial of PX-478, a small molecule
inhibitor of hypoxia inducible
factor-1 alpha, in ...
Aegera Therapeutics collaboration with Human Genome Sciences leads to the initiation of a Phase 1 clinical trial with lead IAP inhibitor HGS1029 and receipt of first milestone payment
... rapid and successful development of
this potent molecule
across a broad range of cancer indications. ... - AEG41174 is a novel, non-ATP competitive, small molecule
tyrosine kinase inhibitor targeting ... - AEG33773 is a novel, orally bioavailable small molecule
developed to treat painful diabetic neuropathy ...
Pacific Biosciences Acquires Single Molecule Sequencing Technology from LI-COR Biosciences
... related to the SMRT(TM), single molecule
real time, sequencing
method. Developed by ... property developed under LI-COR's single molecule
program, including a number of issued ... has acquired our early
developments in single molecule
DNA sequencing and will now shepherd ...
Real-time observation of the DNA-repair mechanism
... a single DNA molecule.
To observe this, a DNA molecule
is stretched between a magnetic bead and a glass ... researchers to pull and rotate a single DNA molecule
in a controlled fashion. As the position of the bead changes when the DNA molecule
is repaired, researchers are able to observe the ...
Oncothyreon files investigational new drug application for PX-866 oncology compound
... Food and Drug Administration for
PX-866, a small molecule
phosphatidylinositol-3-kinase ... the continued advancement of
Oncothyreon's small molecule
oncology pipeline," said Robert L. Kirkman,
M.D., ... conducting a Phase 2 trial of PX-12, a
inhibitor of thioredoxin-1, in patients with ...
BioNanomatrix Announces Appointment of Paul R. Selvin to Its Scientific Advisory Board
... - Noted Biophysicist Brings Expertise in Single molecule
Fluorescence and Nanoscale ... Dr. Selvin's research focus includes single molecule
nanoscale fluorescent measurement. ... of fluorescence techniques and his work
in single molecule
detection and ultra-sensitive instrumentation. ....
Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS
... principle of a new approach for directing
inhibitors to disease causing RAFT targets in ... a cellular assay, was
coupled to a sterol anchor molecule
and a potent inhibition of
Beta-secretase ... its
technology to generate multiple small molecule
drug candidates, with its
lead program in Phase ...
Sirion Therapeutics Preclinical Studies: Two New Potential Advances in Treatment of Retinal Diseases to be Presented at ARVO
... with a
variety of ophthalmic diseases.
In "Development of ... and screened oral, small molecule
(NRMs) for reducing the ... laboratory dedicated to the development of
therapeutics to treat human retinal diseases. The ...
Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research
... relevant assays; identification of small molecule
drug leads after testing as few as 200 ... hopping; and can speed the optimization of small molecule
Telik, Inc. of Palo Alto, CA, is a ... developing and commercializing novel small molecule
treat serious diseases. The company's ...
Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain
... for AEG33773, a
novel, orally bioavailable small molecule
in development for the treatment
of painful ... - AEG41174 is a novel, non-ATP competitive, small molecule
tyrosine kinase inhibitor targeting ... studies; - AEG40826 (HGS1029) is a small molecule
IAP inhibitor that has shown promising ...
Mercury Therapeutics, Inc: Lead Series of Indirect AMPK Activators Licensed to Makoto Life Sciences
... Mercury and to apply
Makoto's expertise in small molecule
target identification to drug
discovery in ... by leveraging our AMPK small molecule
discovery platform to
identify both direct and ... company focusing on the
development of small molecule
candidates against a number of selected
Telik Announces Revised Date for Year-End Financial Release, Conference Call and Webcast
... developing and commercializing novel small molecule
treat serious diseases. The company's ... are TELCYTA(R), a tumor-activated small molecule
candidate in clinical development for the ... the rapid and efficient discovery of