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Mitochondrial in Biological Technology

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

... Genetic Test Provides Early Diagnosis of mitochondrial Diseases LOS ANGELES, June 9 /PRNewswire/ -- ... an innovative test for early diagnosis of mitochondrial diseases, a group of disorders that can result in ... blindness, deafness, and diabetes. The MEDomics mitochondrial genome test, MitoDx(TM), uses the revolutionary ...

New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers

... Bioscience, Inc. to organize an advanced XF mitochondrial workshop and will share their years of experience ... learning experience with the world's leaders in mitochondrial physiology." "The workshop will help ... Buck Institute for Age Research specializing in mitochondrial dysfunction. He is also a visiting Professor in ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... products for mutation detection in cancer and mitochondrial diseases," said Eric Kaldjian, CSO at ... It could also have application in analysis of mitochondrial DNA heteroplasmies." "We are delighted to ... resistance and relapse as well as expanding our mitochondrial DNA toolbox." Technical Information ...

Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update

... that Dimebon potentially stabilizes and improves mitochondrial function in a way that prevents neuron death and ... , which quantified the impact of Dimebon on mitochondrial function. Responses were seen on mitochondrial function at low concentrations of Dimebon across ...

'Museomics' yields new insights into extinct Tasmanian tiger

... an international team of scientists has sequenced mitochondrial and nuclear DNA from the hair of the male ... 70 years later. In addition to using the mitochondrial genome sequence to study the phylogeny of the ... about even bigger projects. "The large amount of mitochondrial and nuclear DNA gained in our study demonstrates ...

Medivation Presents New Data on Dimebon's Novel Mechanism of Action

... it promoted neurite outgrowth and it preserved mitochondrial function after brain cells were challenged with ... beta amyloid, Dimebon was shown to stabilize mitochondrial function, a vital element of neuron function and ... progression of Alzheimer's disease by preserving mitochondrial function. This potential novel mechanism may help ...

Biological electron transfer captured in real time

... most of the maternally inherited so-called mitochondrial diseases are caused by dysfunction of Complex I. ... which in eukaryotes takes place in the inner mitochondrial membrane, and in the cell membrane of ... charged protons across the membrane, so that the mitochondrial membrane (or the cell membrane in bacteria) ...

Transgenomic, Inc. Reports Fourth Quarter and Fiscal Year 2008 Results

... with the Clayton Foundation for Medical Research for their patent on mitochondrial DNA damage and our license with Power3 Medical for their proteomic assay ... disease. The Clayton Medical license has allowed us to develop a mitochondrial damage assay which we hope will serve as a very important assessment tool ...

Seahorse Bioscience, Inc. Acquires BioProcessors Corp.

... use instruments. Its XF series instruments measure energy consumption and mitochondrial function in cells in a 24 or 96 well microplate with precision and ... use these tools to advance their research in understanding the role of mitochondrial function in obesity, diabetes, ageing, cancer, cardiovascular function and ...

MyHeritage And Family Tree DNA Partner To Help People Trace Family History Using DNA

... Y-DNA25 - a Y-chromosome test for males (US$129) mtDNA - a mitochondrial DNA test for males and females (US$129) Y-DNA25 + mtDNA - a combined Y-chromosome and mitochondrial DNA test for males (US$219) Bennett Greenspan, President and CEO of ...

Edison Pharmaceuticals Receives Commendation From the City of San Jose

... remarkable job by focusing its R&D efforts on discovering a treatment for mitochondrial diseases -- that impair energy metabolism, and for which there exist no ... mitochondria. The Company's initial focus is on inherited diseases of the mitochondrial respiratory chain. The company is leveraging insights derived from those ...

Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences

... Cortes-Hernandez, M.D., Ph.D. Laboratory of Jodi M. Nunnari, Ph.D. University of California, Davis mitochondrial division and cell death For full biographies and information regarding the fellows' research subjects, please ...

Medivation Completes Enrollment in Confirmatory, Pivotal Phase 3 'CONNECTION' Trial of Dimebon in Patients With Alzheimer's Disease

... disease and Huntington disease explored thus far, dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial function in a way that prevents neuron death and dysfunction. The dimebon mechanism is thought to be distinct from that of currently available ...

Ambry Genetics Announces the Addition of Array CGH Services Through Partnership With Baylor College of Medicine

... chromosomal abnormalities that are associated with over 270 genetic syndromes can be easily identified via analysis of each 105K whole genome and mitochondrial array. The partnership with Baylor College of Medicine equips Ambry with an extensive library as a reference, as well as expert support for ...

Medivation Announces Upcoming Scientific Presentations at Medical Conferences

... In preclinical models of AD and HD explored thus far, Dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial function in a way that prevents neuron death and dysfunction. The Dimebon mechanism is thought to be distinct from currently available AD ...

Transgenomic Awarded Clinical Laboratory Certification in California

... California it can begin offering its services in the state. Transgenomic expects to begin marketing their Molecular Laboratory services, including mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases, to physicians in California immediately. Transgenomic also boasts a ...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

... activity against AML cells. The main mechanism of this action was shown to be the triggering of caspase-dependent apoptosis by activation of the mitochondrial pathway. The combination of ONCONASE or R-Amph with doxorubicin in AML exhibited significant synergistic cytotoxicity, and offers insights into the ...

Update: Georgia and North Carolina Teens Honored for Research in Biochemistry and Genetics in Nation's Premier High School Science Competition

... the structure of mitochondria influences the cellular levels of two proteins, Bax and Bak. His project is titled Inhibition of Bax/Bak activation by mitochondrial fusion: a novel mechanism to block programmed cell death. "The long term goals of Mr. Meixiong's research are to fully comprehend the complex ...

Transgenomic to Present at Rodman & Renshaw 10th Annual Healthcare Conference

... include the Transgenomic Clinical Reference Laboratory, which provides reference laboratory services specializing in molecular diagnostics including mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases. Transgenomic Genomic Research Services is a CRO for pharmacogenomic, ...

Medivation Reports Second Quarter 2008 Financial Results and Provides Corporate Update

... Presented new preclinical data at a podium presentation on Dimebon's novel mechanism of action, showing that Dimebon improves mitochondrial function in the setting of cellular stress with very high potency. Mitochondria, which generate energy for cells and play ...

Transgenomic Reports Second Quarter 2008 Results

... include the Transgenomic Clinical Reference Laboratory, which provides reference laboratory services specializing in molecular diagnostics including mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases. Transgenomic Genomic Research Services is a CRO for pharmacogenomic, ...

Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi

... protection and primer extension, and expression array assays. With the Plant/Fungi DNA Isolation Kit total DNA is isolated including genomic DNA, mitochondrial DNA and chloroplast DNA. The purified DNA can be used in a number of downstream applications including Real-Time PCR, Southern blotting and ...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... include the Transgenomic Clinical Reference Laboratory, which provides reference laboratory services specializing in molecular diagnostics including mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases. Transgenomic Genomic Research Services is a CRO for pharmacogenomic, ...

Bionovo Reports First Quarter 2008 Financial Results

... -- BN107 and BN108 -- at the American Association of Cancer Research (AACR) conference in April. BN107 induces apoptosis through the mitochondrial pathway, and induces cell death only in estrogen receptor negative breast cancer cells. BN108 induces cancer cell death by rapid ...

Bionovo to Present Recent Findings of BN107 and BN108, Its Anticancer Agents, at the American Association of Cancer Research

... Research at Bionovo, the ability of BN107 to induce death cancer cell death is distinct from that of BN108. BN107 induces apoptosis through the mitochondrial pathway. BN107 induces death only in estrogen receptor negative breast cancer cells. BN108 induces cancer cell death by rapid inactivation of both ...

DNA Testing Systems Inks Agreement with DNAPrint Genomics

... want to keep it that way." In addition to biogeographical DNA tests, the company also sells traditional paternity, Y chromosome (male) and mitochondrial (female-passed DNA) tests. For more information, visit DNA Testing at http://www.dnaconsultants.com or call toll free 1-877-473-5155. Donald ...

Winnick Family Clinical Research Center Celebrates 6th Anniversary

... researchers at Cedars-Sinai Medical Center. These researchers are active in areas ranging from women's health and the genetics of common diseases to mitochondrial genetics, insulin resistance and AIDS. The Winnick Family Foundation, founded by business visionary Gary Winnick, funds the Winnick Family Clinical ...

Transgenomic, Inc. Forms Scientific Advisory Board

... Newly formed Advisory Board to advise on cancer screening methods and mitochondrial DNA-based disease detection OMAHA, Neb., Jan. 17 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) today announced that it ...

Stemagen First to Create Cloned Human Embryos From Adult Cells

... demonstrating the presence of the skin cell donor DNA in the blastocyst, while one was further confirmed to be a clone by an additional mitochondrial DNA (mtDNA) analysis which revealed the presence of oocyte donor mtDNA without any oocyte donor nuclear DNA. For technical reasons, the genetic ...

REPLI-g Mitochondrial DNA Kit

... reliable whole genome amplification from human mitochondrial DNA in total DNA samples The REPLI-g mitochondrial DNA Kit provides specific and uniform whole ... DNA samples. The simple procedure enriches for mitochondrial DNA with minimal contamination from ...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

... images and quantitate changes in nuclear and mitochondrial status. Primary rat hepatocytes are exposed to ... 1B) attributable to nuclear DNA condensation. mitochondrial changes are monitored using MitoTtracker Deep Red ... channel for nuclear measurements; red channel for mitochondrial measurements).

During ...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... than with 1 gold particles. Yeast mitochondrial transformants, which arise at a very ... ade2-101 ura3-52 kar1-1) lacking mitochondrial DNA [rho o ] was used for assaying nuclear and mitochondrial transformation. Cells were bombarded ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... primers targeting highly conserved regions. 1 mitochondrial genes are popular candidates because ... to locate and score both nuclear and mitochondrial DNA polymorphisms in a variety of ... For the oyster, a ~400 bp fragment of the mitochondrial 16S RNA subunit was amplified using a ...

Fully automated DNA purification and efficient multiplex PCR for analysis of microsatellite loci

... provides walkaway automated purification of genomic and mitochondrial DNA from blood using QIAGEN certified ready-to-run QIAamp ... tubes and were stored at 28C until preparation. Genomic and mitochondrial DNA was purified from 200 l whole blood using the QIAamp DNA ...

Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS

... Results Figure 1 shows the progress of the synthesis of the 21 mer peptide fragment from the targetting sequence of the precursor of mitochondrial aspartate aminotransferase, ALLQSRLLLSAPRRAAATARA. A deprotection time of 1hour was used for these experiments. Had there been an issue with the ...

Optimization of Biolistic Transformation Using the Helium-Driven PDS-1000/He System

... plants, EMBO J., 6 , 3901-3907 (1987). Johnston, S. A., Anziano, P. Q., Shark, K., Sanford, J. C. and Butow, R. A., mitochondrial transformation in yeast by bombardment with microprojectiles, Science, 240 , 1538-1541 (1988). Kempthorne, O., The Design and ...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

... diversity in a primitive teleost, Immunological Rev., 166 , In Press, (1998). 6. Norman, J. A., Moritz, C. and Limpus, C. J., mitochondrial DNA control region polymorphisms: genetic markers for ecological studies of marine turtles, Mol. Ecol., 3 , 363373 (1994). ...

Measuring multiple apoptosis parameters with the Agilent 2100 bioanalyzer

... a distinct set of morphological events involving plasma membrane blebbing and asymmetry loss, reduction of cell volume, loss of mitochondrial membrane potential, nuclear condensation, fragmentation of DNA at nucleosomal intervals and other cytoplasmatic changes. ...

QIAamp DNA Blood BioRobot MDx Kit

... For automated purification of genomic and mitochondrial DNA from whole blood* Format: 96-well plates (for 3296 samples in increments ...
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