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Metabolize in Biological Technology

Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing

... vary due to each person's ability to process or metabolize thiopurines. Most people have no problem ... percent of patients have almost no ability to metabolize these drugs. Failure to metabolize thiopurines can result in myelosuppression ...

Center for Molecular Medicine Only Regional Provider of Test Suggested in FDA Alert on Prescribing Codeine to Nursing Mothers

... order a CYP2D6 genotyping test to determine how the patient will metabolize codeine in advance of its prescription. The FDA noted that when codeine ... available at the CMM, tell a physician how rapidly a specific patient will metabolize codeine based on a patient's genetic makeup. "The CMM was created to ...

Kuvan Receives Priority Review Status From Health Canada

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA). ...

Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World

... (probiotics) that possess a high affinity for various nitrogenous waste products. When the kidneys are unable to filter toxins normally, the microbes metabolize the renal waste products and use them as nutrients for growth. As the microbes grow and replicate, they create colonies capable of utilizing even ...

Kibow Biotech, Inc. Launches Breakthrough Probiotic Dietary Supplement for Kidney Health in USA and Canada

... and specifically selected beneficial microbes (probiotics) that possess a high affinity for various nitrogenous waste products. The microbes metabolize the waste products and use them as nutrients for growth. As the microbes grow and replicate, they create colonies capable of utilizing even more ...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA). ...

Video: Accera Launches Axona(TM), First Medical Food Therapy to Help Manage Mild-to-Moderate Alzheimer's Disease

... Alzheimer's disease is a progressive and fatal neurological disease characterized by a substantial decrease in the brain's ability to metabolize glucose, which is the brain's primary source of energy. Known as hypometabolism, this defect may contribute to both the clinical and pathological ...

Kuvan Receives Positive Opinion From CHMP for European Approval

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential treatment option for approximately 30 percent to 50 percent of the estimated ...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

... This can be very useful in new FDA-mandated drug safety testing to evaluate active/toxic human drug metabolites. Studies have shown that drugs can metabolize differently in humans than in other animals, resulting in potentially toxic levels of drug metabolites that can't be identified by animal studies ...

New yeast trick for eating favorite food: Details in Nature paper

... the glucose network actively shuts down the galactose network by degrading messenger RNA that would otherwise go on to form the enzymes needed to metabolize galactose. "To find something new in the well-known galactose network after predicting it is extremely exciting," said Matthew Bennett, the first ...

Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential treatment option for approximately 30 percent to 50 percent of the estimated ...

European Regulatory Agency Supports OPAXIO(TM) Brand Name for Cell Therapeutics' Lung Cancer Drug

... allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may ...

Synvista Therapeutics to Present at the 10th Annual BIO CEO & Investor Conference

... pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical ...

Kaiser Permanente Study Shows Newer, Stronger Evidence That Caffeine During Pregnancy Increases Miscarriage Risk

... can harm a fetus have been suspected for some time. Caffeine crosses through the placenta to the fetus, but can be difficult for the fetus to metabolize because of the under-developed metabolic system. Caffeine also may influence cell development and decrease placental blood flow, which may lead to an ...

Synvista Therapeutics to Develop Topical Formulation of ALT-2074 for the Treatment of Psoriasis

... pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical ...

Biochip mimics the body to reveal toxicity of industrial compounds

... by the liver. Because of differences in the type and amount of their drug-metabolizing enzymes, most of which are in the liver, individuals can metabolize a drug or other chemical compound differently. What is harmless to one person may be toxic to another. By arranging the ratio of enzymes on the ...

Synvista Therapeutics to be Featured on Wallst.net

... pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical ...

Synvista Therapeutics to Present at the BIO InvestorForum 2007

... pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical ...

Cell Therapeutics, Inc. (CTI) Receives SPA Approval from FDA and Launches Gender-Specific Phase III Trial for Advanced Non-Small Cell Lung Cancer

... allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that XYOTAX metabolism by lung cancer cells may ...

Exclusive Rights to Kuvan(TM) Data Licensed to Asubio Pharma in Japan

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Clinical data suggest that treatment with Kuvan results in significant reductions in blood Phe levels in BH4-responsive patients. It also may ...

Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System

... individual differences in the ability to metabolize specific drugs. Based on these ... as poor metabolizers (PMs) who cannot metabolize CYP2D6-dependent drugs, extensive metabolizers (EMs) who metabolize CYP2D6 substrates normally, intermediate ...

Marshfield Clinic charges ahead in genetic research

... plan to turn it around in the next year and study it prospectively, where we take the genotypes we have found to be associated with the inability to metabolize coumadin and genotype at the point of diagnosis and prescribe prospectivelythe right drug in the right dose at the right time. Caldwell said ...

FDA programs encourage and expedite drug development and approval

... Under the law, this can include a medically plausible subset of persons with a disease that affects a large number of people, such as those who metabolize a type of drug differently than the larger population. Drugs and biologics designated as orphan products are eligible for four major economic ...

Milwaukee area biotech ZyStor seeks more funding

... needed to break down glycogen, and at St. Louis University for the treatment of Fabry Disease, which is caused by the lack of the enzyme needed to metabolize lipids. "There's no question that if the animal studies are successful, they will raise the money easily," said Daniel Broderick, managing ...

Father of life patents downplays historic role

... you," Chakrabarty said. "I knew nothing about cancer." Patenting life The first life form patent also was a bacterium, one that was able to metabolize hydrocarbons in crude oil, but it didn't happen without a fight. In a case that has parallels to today's debate over embryonic stem cell research, ...

ZyStor seeks to raise $15M for clinical trials

... are underway, including a study at St. Louis University for the treatment of Fabry Disease , which is caused by the lack of the enzyme needed to metabolize lipids. Double dipping Daniel Broderick, managing partner at Mason Wells, has said the success of the animal studies are considered critical ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... that make structures involved in cellular movement. mitochondria Animal-cell organelles that reproduce using their own DNA. They metabolize nutrients to provide the cell with energy and are believed to have once been symbiotic bacteria. Chloroplasts are their plant-cell ...

Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method

... to CYP testing is the discovery that polymorphisms in the genetic sequences expressing these enzymes leads to populations of people whose ability to metabolize certain classes of drugs may be attenuated in comparison to other races/populations 5 . In this application note LC-ESI-MS/MS is used to ...
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