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Metabolite in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... exposure to IDX184 and the resulting nucleoside metabolite (NM). IDX184 is fully active against HCV ... (PK/PD) relationship between nucleoside metabolite concentrations in serum and viral load reductions in this study. Trough serum nucleoside metabolite levels were low, ranging from 2-8 ng/mL, and ...

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

... that XenoTech (Lenexa, KS) has begun offering new metabolite profiling services made possible in part by its ... The Synapt HDMS System is the centerpiece of its metabolite profiling efforts and allows XenoTech to offer ... for XenoTech. Its unique system of in vitro metabolite profiling can alleviate the need for expensive ...

Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium

... Active metabolite concentrations of NKTR-102 significantly more ... The observed plasma half life of the active metabolite (SN38) of NKTR-102 was 50 days; this is ... dosing.(1) Increased SN38 levels, the active metabolite of irinotecan responsible for its ...

Ausio Pharmaceuticals to Present at Bio(R) 2009

... Ausio has developed AUS-131, a pharmaceutical formulation of the soy metabolite S-equol. AUS-131 is expected to provide soy health benefits by ... About AUS-131 AUS-131 is pure, synthetic S-equol, a potent metabolite of the soy isoflavone, daidzein, which is produced in only a subset of ...

Tethys Bioscience Announces Acquisition of Lipomics Technologies

... Addition of metabolite technology uniquely positions company as it expands its ... terms were not disclosed. The acquisition brings together Lipomics' metabolite profiling technology with Tethys' proven expertise in the use of protein ...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

... Electrochemical detection in line with mass spectrometry streamlines the metabolite analysis, synthesis, and evaluation process. In order to determine the ... are identified, scale-up can be done for clinical trials to evaluate metabolite toxicity in humans." Dr. Acworth continued, "We are honored to be ...

Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology

... were conducted. Based on these studies, RDEA594 was identified as a major metabolite of RDEA806 in both humans and animals. RDEA594 exhibits a ... has potential for treating gout patients with hyperuricemia. RDEA594 is a metabolite of RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI) in ...

Anadys Pharmaceuticals Commences Phase I Clinical Trial of ANA773 in Cancer Patients

... in October 2007 showed that activation of TLR7 by the biologically active metabolite of ANA773 initiates a cascade of immune stimulatory events that has the ... 2007, data presented at the AACR meeting showed that ANA773 and its active metabolite stimulate secretion of interferon alpha and other cytokines as well as ...

Codexis Launches Codex(TM) MicroCyp Platform to Produce Drug Metabolites and Novel Lead Compounds

... from the California Institute of Technology (see Codexis Licenses New Drug metabolite Profiling and Lead Diversification Technology from California Institute ... and General Manager, Codexis Pharma Services. "Conventional methods for metabolite identification and production and lead diversification are difficult and ...

Tandem Labs' New England Facility Doubles Discovery Support Capacity - Increasing Foothold in New England

... rapid turnaround non- GLP discovery PK/PD services in addition to metabolite identification and biomarker services. Combined with other advanced mass ... is a drug metabolism technology that increases the productivity of drug metabolite identification and quantification. MarkerScan(TM) is a biomarker discovery ...

Scientists discover how cancer may take hold

... different colors of the jellyfish green fluorescent protein (GFP). When a metabolite binds to the biosensor, it changes the shape of the sensors backbone, ... a specific wavelength of light activates one tag, it fluoresces. When the metabolite causes the tags to move close together, the other tag will also ...

Codexis Licenses New Drug Metabolite Profiling and Lead Diversification Technology From the California Institute of Technology

... services at BioCatalytics, acquired by Codexis in July." "Current metabolite identification and synthesis methods are based on classical chemistry ... of drug metabolites. These new tools could add considerable value in metabolite profiling as well as lead diversification in drug discovery." Drug ...

Supelco(R) and MIP Technologies Launch New SPE Product for the Selective Extraction of NSAIDs From Environmental Water

... diclofenac and naproxen are non-steroidal anti-inflammatory drugs that have analgesic and antipyretic activities. Clofibric acid is an active metabolite of clofibrate, etofibrate and etofyllinclofibrate. These compounds are used as blood lipid regulators. Because of the pharmacological activity of the ...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

... Blood 109: 4557 - 4563, 2007). "While these trials were not designed to look at pulmonary endpoints, these observations suggest that a metabolite of oral BDP may be having a beneficial anti-inflammatory effect in the lungs of hematopoietic cell transplant recipients," stated Jason W. Chien, MD, ...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

... activity of elacytarabine is thought to be mediated through increased cellular uptake, decreased deactivation and prolonged exposure to the active metabolite ara-C triphosphate (ara-CTP) within the cell. In the Phase II trial, Elacytarabine was given as a single agent to patients with late stage AML ...

Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer

... G2 System provides researchers with intuitive operation, application flexibility, and a totally new level of performance for biopharmaceutical, metabolite identification, metabonomics, proteomics, biomarker studies, and food and environmental applications. Waters introduced the SYNAPT G2 System at the ...

Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution

... Solidus, with Research Labs in both New York and California, currently offers an in vitro toxicity screening service that determines compound and metabolite toxicity using a novel platform that supports arrays of miniaturized 3D cell cultures and metabolizing enzymes. Solidus has opted for Amphora's ...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

... ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED NUCLEOTIDE HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE NUCLEOSIDE metabolite IN HCV-INFECTED CHIMPANZEES - Abstract #583; Oral presentation; Parallel session entitled: Hepatitis C Virus Drug Development II; Session date: ...

Corgenix to Exhibit AspirinWorks(R) Test at ACC.09

... only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine the effect of aspirin in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane A2, the target of aspirin therapy. "The phenomenon of aspirin effect has been validated in numerous randomized, controlled ...

Waters Corporation Continues to Meet Today's Challenges for Improved Laboratory Operations with New Products at Pittcon 2009

... and applications-specific UP LC/MS and UPLC/MS/MS system solutions for food safety, amino acid, intact protein, oligonucleotide, peptide, metabolite profiling, bioanalysis, impurity profiling, ADME screening, and proteomics analyses. UPLC for At-Line Process Analysis Designed with the ...

Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

... study. The 675 mg and 1,350 mg twice daily doses of controlled release nitazoxanide produced trough plasma concentrations of tizoxanide, the active metabolite of nitazoxanide, that were approximately 3x and 12x the trough concentrations observed in historical studies using a standard nitazoxanide 500 mg ...

First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer

... an extended half-life and sustained delivery of the active metabolite. The Phase 1 data also show the significantly longer half-life of the active metabolite of NKTR-102 (50 days) relative to its half-life with standard irinotecan (30 to 50 hours). About Nektar Nektar Therapeutics is a ...

Cyprotex Purchases Applied Biosystems Sciex QTRAP(R) 5500 LC-MS/MS

... and will enable us to offer a comprehensive bioanalytical method development and validation service as well as an enhanced and highly sensitive metabolite profiling and identification service. The instrument will increase the likelihood of detecting poorly sensitive molecules which are problematic in ...

Corgenix to Exhibit AspirinWorks(R) Test, Discuss New CHARISMA Trial Results at AHA 2008 Meeting

... only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine the effect of aspirin in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane A2, the target of aspirin therapy. "The American Heart Association conference is an ideal forum in which to discuss the findings on ...

Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer

... neurological, psychiatric and pain disorders. Its lead compound, ganaxolone, is a synthetic analog of the neurosteroid allopregnanolone (3a,5a-P), a metabolite of progesterone. It is currently being investigated in a Phase IIb clinical trial as a potential treatment of epilepsy in children (infantile spasms) ...

Instrumentation Laboratory Announces Contract for Multi-Parameter Testing Products with Broadlane

... and service, including IL's flagship products, the new GEM(R) Premier(TM) 4000 and the GEM Premier 3000 analyzers for blood gas, electrolyte and metabolite testing, new GEMweb(R) Plus information management system for the GEM analyzers, GEM PCL Plus, a portable coagulation analyzer and GEM OPL, a ...

Fontus Pharmaceuticals Acquires Nephrology and Endocrinology Drug from Roche Laboratories Inc.

... and pseudohypoparathyroidism. About ROCALTROL(R) (calcitriol) ROCALTROL, available as capsules and as an oral solution, is the most potent metabolite of vitamin D available and is active in regulating the absorption of calcium from the gastrointestinal tract and its utilization in the body. The ...

Anadys Pharmaceuticals Reports First Quarter 2008 Financial Results and Highlights

... based on work done with the Moores Cancer Center at the University of California San Diego, reported the pro-apoptotic effect of the active metabolite of ANA773 on human chronic lymphocytic leukemia (CLL) cells ex vivo, and the enhancement of the apoptotic effect when added to either ...

FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder

... (sleepiness), decreased appetite, anxiety, and specific male sexual function disorders. About PRISTIQ PRISTIQ delivers the major active metabolite of EFFEXOR XR(R) (venlafaxine HCl) in its active state without going through the CYP2D6 metabolic pathway. This could be beneficial when PRISTIQ is ...

HealthTrust Expands Contract With Instrumentation Laboratory for Critical Care Portfolio to Include Consorta

... and service, including IL's flagship products, the new GEM(R) Premier(TM) 4000 and the GEM Premier 3000 analyzers for blood gas, electrolyte and metabolite testing. Additionally, the GEM Premier 4000 includes integrated CO-Oximetry and GEMweb(R) Plus, unique information management software for complete ...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

... based MAPKinase Inhibitors using Accurate MS(n) and Isotopic Pattern Data Poster M291 -- Analysis of the Intraspecies Variation of Secondary metabolite Production by Myxococcus xanthus using ESI-TOF-MS and PCA Poster M327 Bioinformatics -- Support Vector Classification of Proteomic Profile ...

Hyperion Therapeutics, Inc. Announces Senior Management Team and $15M Financing Event

... The most common adverse reactions associated with BUPHENYL were amenorrhea dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these ...

Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer

... and quantitating acepromazine (ACE) and its major metabolite 2-(1-hydroxyethyl) promazine sulfoxide (HEPS) in ... MS/MS analysis of acepromazine (ACE), its major metabolite 2-(1-hydroxyethyl) promazine sulfoxide (HEPS) and ... be detected in the horse at this time whereas its metabolite HEPS could be quantitated and its concentration ...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

... Words Metabolism Study Structure Elucidation metabolite ID Mass Frontier Mark R. Kagan, ... including those present at very low levels. The metabolite ID and Mass Frontier software packages have been ... requirements. Overview metabolite ID and Mass Frontier have been designed to work ...

Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System

... In this application note, several different metabolite identification approaches are evaluated for their ... Overview A common strategy for metabolite analysis consists of using two mass spectrometry ... instruments in a sequential manner with the metabolite identification information from the triple ...

Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

... the use of the new Q TRAP LC/MS/MS system with metabolite ID software for Phase I and Phase II metabolite identification and discusses its unique ... about a potential drugs biotransformation and metabolite characterization. To obtain maximum ...

Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS

... ion. The single MS spectrum (Figure 2.) of CAP metabolite and its product ion spectrum (Figure 3.) stated that the metabolite is glucuronidation of CAP. Figure 4. Single MS ... at t = 4.31 minutes. During the runs, one major metabolite -glucuronide of CAP was identified as well as CAP ...

In-Vitro Metabolism Studies Using Data-Dependent LC/MSn

... Beecham Pharmaceuticals metabolite Characterization The data presented here ... order product ion spectra afford data that allow metabolite identification with greater specificity. ... Strategy An effective strategy for metabolite characterization is to 1) obtain MS n ...

DHEA Boosts Growth Rate of Human Neural Stem Cells

... but the problem with DHEA in rats is that it is not a major metabolite in that animal so its effects may not be the same as those seen in ... of whether DHEA itself is having this effect, or if there's another metabolite of the hormone involved, still exists." One of the intriguing aspects ...
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