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Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights

... ANA773 is an oral prodrug of a small molecule inducer of endogenous interferons that acts via the ... a Phase I Healthy Volunteer with ANA773, an Oral inducer of Endogenous Interferons that Acts Via TLR7, for ... polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 ...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

... 2009. ANA773 ANA773 is the Company's oral inducer of endogenous interferons that acts via the toll like receptor 7 (TLR7) ... has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, ...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

... be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may ... may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. ...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement Statements ...

Anadys Pharmaceuticals to Report Second Quarter 2009 Financial Results

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement ...

Anadys Pharmaceuticals, Inc. Announces Strategic Restructuring to Focus Operations on Continuing the Advancement of ANA598

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement ...

Anadys Pharmaceuticals to Report First Quarter 2009 Financial Results

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Anadys Pharmaceuticals to Present at Future Leaders in the Biotech Industry

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at AASLD 2008

... is a good candidate for combination therapies with STAT-C agents in the absence of interferon or ribavirin. -- "Nitazoxanide (NTZ) is an inducer of eIF2a and PKR phosphorylation," Elazar et al., Tuesday, November 4, 8:00 AM - 12:30 PM PST (Poster #1881) This poster presentation by ...

Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation

... and may be the only novel oral anticoagulant available for patients with severe renal disease. And because betrixaban is neither an inhibitor nor an inducer of cytochrome P450 enzymes, it minimizes the risk of drug-drug interactions often seen with other Factor Xa inhibitors in development and with ...

Romark Laboratories Announces Presentation of New Nitazoxanide Data at 59th Annual AASLD Meeting and 50th Anniversary IASL Meeting in San Francisco

... Without the Development of Resistance," Korba, et al. Sunday Nov. 2, 5:30 PM PST (Oral Session #115) -- "Nitazoxanide (NTZ) is an inducer of eIF2a and PKR phosphorylation," Elazar et al., Tuesday, November 4, 8:00 AM - 12:30 PM PST (Poster #1881) STEALTH C-3 Fully Enrolled ...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

... of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, ...

Method to deliver molecules within embryonic stem cells improves differentiation

... mixed with retinoic acid-loaded microspheres, and cells treated with soluble retinoic acid. Retinoic acid was chosen initially because it is a potent inducer of embryonic stem cell differentiation. After ten days, approximately 90 percent of the embryoid bodies mixed with retinoic acid-loaded ...

EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound

... discovered through EpiCept's Anti-cancer Screening Apoptosis Program (ASAP). EPC2407, a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of cancer patients with advanced, solid tumors and lymphomas, is currently in Phase I clinical development by EpiCept. In July ...

Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells

... drawbacks: pleiotropic effects caused by the inducer or the transcriptional activator, prohibitively ... or poor penetrance and/or clearance of the inducer in some tissues. Stratagene has recently ... to comparable levels over a 100-fold range of inducer concentration. To more accurately ...

DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging

... acquisition and analysis methods allowing quantification of foci development both over time and with increasing concentrations of H 2 O 2 , a known inducer of DNA damage. Methods Cell Culture HT1080 cells (ATCC, CCL-121, human fibrosarcoma derived cell line) were grown ...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

... alkaloid, a strong inhibitor of protein kinases, thought to work through JNK1, caspase proteases, AP-1, and NFκβ. It is an apoptotic inducer causing nuclear condensation (1, 2). Diclofenac is a non-steroidal anti-inflammatory compound that has been associated with liver damage and covalent ...

Mammalian and Bacterial Expression in One Vector

... of IPTG (lane 3), but expression of the fusion protein increased dramatically when cells were grown in the presence of the inducer (lane 2). Purification of CBP-Tagged Protein ...

pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins

... expression cassette by endogenuos transcription factors, is extremely unlikely. In addition, it has been found that in the absence of inducer the heterodimer remains bound at the promoter in a complex with corepressors and histone deacetylase, and is, thus, tightly repressed until ...
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