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Hypothesis in Biological Technology

University of Southern California Receives Cancer Diagnosis System for Detecting Esophageal Dysplasia

... in identifying dysplasia or cancer in the esophagus will be evaluated. The hypothesis that the sensitivity of a WavSTAT-assisted endoscopic examination improves that of standard endoscopy alone will be tested. If this hypothesis is correct, the physician should be able to take fewer physical biopsies, ...

Researchers enlist DNA to bring carbon nanotubes' promise closer to reality

... get a variant called the beta-barrel." While the researchers do not have absolute proof, they say circumstantial evidence strongly supports their hypothesis that the DNA is forming this well-organized structure and that it recognizes a specific CNT in the same way that biological molecules recognize each ...

ROCK STARS OF SCIENCE: Prana's Co-Founding Scientist, Rudy Tanzi Teams up with Star-Powered Cast in GQ Photoshoot

... for Alzheimer's disease research: The Metropolitan Life Foundation Award and The Potamkin Prize. Dr. Tanzi is also a co-founder of the "Metal hypothesis of Alzheimer's disease," the premise behind Prana's novel therapeutics for treating the disease. Also featured in the magazine is Professor ...

Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA

... pressure and an improvement in renal function. The Company believes that the current preclinical and clinical data supports the pharmacological hypothesis at doses that have been safely tolerated by patients, and provides CD-NP with the potential for favorable differentiation from other acute heart ...

Sandia researchers construct carbon nanotube device that can detect colors of the rainbow

... chemistry. He and Wong laid the groundwork with their theoretical research, with Wong completing the first-principles calculations that supported the hypothesis of how the chromophores were arranged on the nanotubes and how the chromophore isomerizations affected electronic properties of the devices. To ...

Chromosome breakpoints contribute to genetic variation

... was completely counterintuitive. I thought we would have these breakpoints in gene deserts," Lewin said. "We had to rethink the whole evolutionary hypothesis about what was going on in breakpoints." In the new study, Denis Larkin, a senior scientist on Lewin's team, compared the chromosomes of nine ...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... synergistic anti-tumor activity in multiple myeloma (AACR Annual Meeting 2008, #4181). The synergy of these combinations confirms Investigators' hypothesis that rapamycin is active only on mTORC1 and inhibition of mTORC2 by either Erlotinib or Perifosine is necessary to achieve complete shutdown of mTOR ...

Nile Therapeutics Announces Focus on CD-NP for Acute Heart Failure and Termination of 2NTX-99 Program

... designed to assess safety and efficacy of early administration of CD-NP in this patient population and may provide additional evidence to support the hypothesis that CD-NP enhances renal function. Such results would build upon the recently completed Phase Ib study in which CD-NP demonstrated diuretic effects ...

Star Scientific Announces Successful Completion of Product Satisfaction Study - Results Show Potential for Development and Manufacturing of New Pharmaceutical Product for Smoking and Smokeless Tobacco Cessation

... results published in 2007 in the journal Tobacco Control . These results are important because they confirm the "proof of concept" hypothesis that is the basis of Rock Creek's focus on developing and manufacturing a low-cost, botanical-based NRT product to compete with NRT products now on ...

Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure

... need for the treatment of patients with acute heart failure." "We are very pleased with the results of this Phase 1b study which support the hypothesis that the administration of CD-NP in heart failure patients results in diuresis and enhanced renal function with minimal blood pressure effects," said ...

Update: Georgia and North Carolina Teens Honored for Research in Biochemistry and Genetics in Nation's Premier High School Science Competition

... Georgia Institute of Technology . "Mr. Meixiong used three different and technically challenging approaches and drew responses consistent with his hypothesis in each case, ultimately creating a shift in the way we think about controlling cell death for diseases such as Parkinson's, Muscular Dystrophy and ...

Duska Therapeutics Provides Program Update and Reports Third Quarter 2008 Financial Results

... conducted scientific studies that establish a critical regulatory role of NO signal transduction. Dr. Stamler's research supports the hypothesis that dysregulated NO signaling contributes to human diseases including heart failure, arrhythmia, respiratory diseases, and cancer. ...

CorMatrix Announces Pre-Clinical Data Suggesting Next Generation ECM Technology(TM) Can Improve Cardiac Function

... data today demonstrating that an injection of an emulsified version of their ECM Technology(TM) improved cardiac function. The study tested the hypothesis that an injection of ECM emulsion into infarcted myocardium would promote wound healing and angiogenesis by naturally recruiting c-kit positive ....

RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease

... 1 and 7. A 12-14 percent increase in plasma A-beta40 levels was observed at the highest dose of RVX-208 after 7 days of dosing. Based on the study hypothesis these results trended towards significance versus placebo, even with the minimal number of study subjects. Emerging evidence from large ...

GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C

... for infectious diseases. It is designed to integrate and better coordinate the progression of infectious diseases medicines from therapeutic hypothesis to clinical proof of concept. While drawing from the broader resources of GSK's R&D organization, the ID CEDD bridges the conventional gap between ...

Calvert Research and Auburn University Announce Joint Venture

... Bookbinder, west coast regional director, is coordinating the research on behalf of Calvert Research LLC. The study will center on the hypothesis that targeting siRNA-containing pharmaceutical nanocarriers, such as liposomes, with breast tumor-specific phage proteins may significantly enhance ...

Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant

... scientific studies that establish a ubiquitous role for nitric oxide in the regulation of protein function. Dr. Stamler's research supports the hypothesis that dysregulated nitric oxide signaling commonly contributes to human disease including heart failure, arrhythmia, respiratory diseases, and ...

Monogram and Dana-Farber Cancer Institute Initiate Evaluation of HERmark(TM) Breast Cancer Assay in Metastatic Breast Cancer

... IHC and/or FISH, tested centrally," said Michael Bates, M.D., Monogram's Vice President of Clinical Research. "The aim of this study is to test the hypothesis that HERmark selects patients for Herceptin treatment in the metastatic setting better than other currently available assays, as well as to test ...

CEO's Letter to Shareholders of Imaging Diagnostic Systems, Inc.

... sites throughout the United States. These sites are currently gathering cancer cases and non-cancer cases required to support the intended use hypothesis for the PMA application. Once the data required has been obtained it will be tested by independent radiologists, analyzed by our bio-statisticians ...

Microscopic 'clutch' puts flagellum in neutral

... parts are no longer in contact. In this case, the flagellum would still have freedom of motion, listless as it might be. To determine which hypothesis was correct, the scientists decided it best to let the tail wag the dog. They attached the tail end of the flagellum to a glass slide and examined ...

GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections

... for infectious diseases. It is designed to integrate and better coordinate the progression of infectious diseases medicines from therapeutic hypothesis to clinical proof of concept. While drawing from the broader resources of GlaxoSmithKline's R&D organization, the ID CEDD bridges the conventional ...

Coalition for Pulmonary Fibrosis and American Thoracic Society Continue Research Partnership Through 2010

... currently in year two of her research entitled "VEGF: Marker or mediator of lung injury in pulmonary fibrosis?" Her research is currently testing the hypothesis that locally elevated levels of vascular endothelial growth factor (VEGF) in the lungs of patients with autoimmune pulmonary fibrosis contribute to ...

Genstruct and Sirtris Pharmaceuticals Win Bio-IT World's Best Practices Award

... the molecular MOA of Sirt1 activating compounds. In blinded analysis, Genstruct's causal network modeling (CNM) approach concluded that the strongest hypothesis for the results seen in the Sirtris Type 2 diabetes study was caloric restriction (CR) -- showing that Sirtris' SIRT1 activators are mimicking the ...

Experts prove the geochemical origin of part of the CO2 emissions in semiarid climates

... It proves that CO2 production is not only related to vegetation, but also to geochemical emissions which increase in dry seasons. The hypothesis formulated in this work -says Serrano- is that the emissions are a consequence of a ventilation phenomenon of the carbonated systems macro-pores, ...

International team of scientists discover clue to delay of life on Earth

... studying Earths ancient oceans, atmosphere and biology we can test how well we understand the modern environment, according to Anbar. Our molybdenum hypothesis was inspired by the theory that biology in the oceans today is often starved for a different metal iron and that the lack of iron in parts of the ...

Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France

... within 14 days of oral consumption. In Paris, Dr. Hesslink presented research from radio tracer label data and ligand binding assays supporting the hypothesis that Celadrin(R) interacts with membrane receptors involved with the inflammatory cascade. To support this hypothesis, Dr. Hesslink presented ...

Researchers engineer new polymers to change their stiffness and strength when exposed to liquids

... brain signals recorded by such microelectrodes usually degrades within a few months after implantation, making chronic applications challenging. One hypothesis for this failure is that the high stiffness of these electrodes, which is required for their insertion, causes damage to the surrounding, very soft ...

Ortho Biotech Statement On JAMA Publication Regarding Erythropoiesis-Stimulating Agents

... questions that will be addressed through further research and risk minimization activities. EPO Receptors The data remain inconclusive on the hypothesis that the expression of erythropoietin receptors on tumor cells can lead to shortened survival in cancer patients. The company has proposed ...

The Michael J. Fox Foundation Awards $2 Million to Shed Light on Role of LRRK2 and Alpha-Synuclein Genes in Parkinson's Disease

... effects on aggregation and toxicity to dopamine neurons. A third investigator, Deniz Kirik, MD, PhD, of Lund University in Sweden, will test the hypothesis that the toxicity of alpha-synuclein may be enhanced by interaction with dopamine itself, which might help further explain the selective ...

National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment

... Institute. The multi-center study will include 1,700 newly diagnosed patients with chronic lymphocytic leukemia (CLL) and is designed to test the hypothesis that early treatment of patients with certain negative risk factors leads to longer survival. Genzyme will perform the IgVH mutation analysis for the ...

Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9

... that the previously reported ability of IRS 954 to block IFN-alpha translates into reduced symptoms in an animal model of lupus. The data support our hypothesis that blocking both TLR7 and TLR9 in B cells and in human plasmacytoid dendritic cells is a promising new approach for the treatment of lupus. The ...

MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation

... of active-to-total GLP- 1 of approximately 67% whereas ratios of 20 - 33% have been reported following intravenous administration of GLP-1. "Our hypothesis at present is that delivery of active GLP-1 to the arterial circulation via the lung avoids much of the degradation by dipeptidyl peptidase-4 that ...

Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers

... the premature forms of IGF-II, is most extensively characterized and was evaluated in an in vivo MCF-7 cell-based mouse xenograph model to test the hypothesis that high levels of soluble ligand-specific antibody in the blood could shift the quasi-equilibrium distribution of the ligand between the blood and ...

GlaxoSmithKline and Anacor Pharmaceuticals Form Alliance to Develop Systemic Antivirals and Antibiotics Based on Boron Chemistry

... for infectious diseases. It is designed to integrate and better coordinate the progression of infectious diseases medicines from therapeutic hypothesis to clinical proof of concept. While drawing from the broader resources of GlaxoSmithKline's R&D organization, the ID CEDD bridges the conventional ...

Gladstone scientists uncover potential mechanism of memory loss in Alzheimer's disease

... may also have non-convulsive seizures that could easily escape detection by standard clinical exams. The investigators are eager to test this hypothesis in a planned follow-up study of human subjects. "Our results have important therapeutic implications, because the prevention and reversal of ...

Structural Determination of Flavonoids Using MSn

... on the m/z 433 ion and the spectrum is illustrated in Figure 5. The hypothesis that the m/z 271 originated from the m/z 433 ion has been ... a spectrum which is similar to the MS/MS spectrum of apiginin. This hypothesis is tested via the MS 4 experiment of the m/z 271 ion. The ...

Medical College discovery leads to new stents

... dynamic modeling, LaDisa investigated specific factors of stent geometry that contribute to, or minimize, the likelihood of restenosis. We tested the hypothesis that differences in the geometric design of an implanted stent -- differences in number, width and thickness of the linkages that compose a stent -- ...

PDAs add new dimension to distance learning

... information and interviews that they needed to share with the others to get the whole picture. As the game progressed they had to come up with a hypothesis for the cause of death. The results of the program were better than expected - each of the students, even the typically uncommunicative ones, got ...

NimbleGen microarrays speed genetic findings

... people of European descent and seems to occur preferentially among children of individuals who carry the inversion. The research was based on the hypothesis that the genome contains "hotspots" that are prone to instability and flanked on each side by large, repetitive regions of DNA, termed "segmental ...
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(Date:8/29/2014)... climatic shifts over the last 120,000 years may ... team of researchers led by City College of ... new biodiversity metric called "phylogeographic endemism." , It ... within species is restricted in geographical space. , ... 14 other researchers from institutions in Brazil, Australia ...
(Date:8/29/2014)... nucleus, chromosomal DNA is tightly bound to structural ... chromatin. Until about two decades ago, histones were ... material around which the glamorous DNA strands were ... appreciation for how DNA/histone interactions govern gene expression. ... studying the sequence of the genome from cancer ...
(Date:8/28/2014)... a handful of bacterial culprits that may drive inflammatory ... colitis, using patients, own intestinal immune responses as a ... the journal Cell . , Trillions of bacteria ... critical role in the development and progression of IBD. ... bacterial species affect a person,s susceptibility to IBD and ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Yale study identifies possible bacterial drivers of IBD 2
(Date:8/29/2014)... FRIDAY, Aug. 29, 2014 (HealthDay News) -- Selling cigarettes ... or illegal tobacco and doesn,t harm sales in small ... problems were predicted by the tobacco industry when it ... in the world to introduce plain packaging for tobacco ... Ireland, New Zealand and the U.K. Researchers surveyed ...
(Date:8/29/2014)... August 29, 2014 Honey Gifts, premium ... company will now be selling purse-sized adult toys and ... way that they can be carried in a woman’s ... the purse-sized range at Honey Gifts is also leak-free ... life and rechargeable batteries are common characteristics of Honey ...
(Date:8/29/2014)... Barbara, CA (PRWEB) August 29, 2014 ... in Santa Barbara in the Santa Barbara News-Press Readers’ ... Evolutions won the Readers’ Choice poll as Best Medical ... 20, 2014 reads the following about Evolutions Medical Spa ... spa, but it is recognized as a top-notch, cutting-edge ...
(Date:8/29/2014)... COLUMBUS, Ohio (PRWEB) August 29, 2014 ... vice president of operations & business development. , Rees ... the vice president of business development. , A wholly ... (OPRS), Senior Independence provides older adults with options, including ... teams, in-home care (e.g., meal preparation) and therapeutic adult ...
(Date:8/29/2014)... Last week, the Fed reported an increase in ... rose to 0.4% while manufacturing output progressed to 1.0%. ... boost since February this year. Capacity use has increased by ... – an increase that could be attributed to the boost ... which is a measure of slack across the industries. , ...
Breaking Medicine News(10 mins):Health News:Study Counters Critics of Plainer Cigarette Packaging 2Health News:Honey Gifts Now Provides Purse Sized Adult Toys in Vancouver 2Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 2Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 3Health News:Senior Independence Promotes Rees to Vice President of Operations & Business Development 2Health News:LeaseQ Announces That Recent Industrial Production Report Spells Good Things For The Equipment Leasing Industry 2Health News:LeaseQ Announces That Recent Industrial Production Report Spells Good Things For The Equipment Leasing Industry 3
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