SNPs Powerful Tools for Association Studies
... of diversity, is measured by an index called heterozygosity
that is based on both the number and proportion of individual alleles. heterozygosity
ranges from 0 to 1, where 0 is no variation and 1 ... generally agree that markers should have a heterozygosity
of 0.7 or greater. For instance, STR marker ...
Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA)
... with sequence-specific
oligonucleotides. Biochem. Biophys. Res. Commun. 142 :710-6
2. Bianchi A., et al., (1991) Detection of loss of heterozygosity
in formalin-fixed paraffinembedded
tumor specimens by the polymerase chain reaction. Am. J. Pathol. 1991 Feb;
138 (2): ...
Detection of Mutant K-ras in a Kindred With Hereditary Pancreatic Cancer by DGGE
... is believed to involve the K-ras oncogene, DCC, p16, APC, bcl-2 and p53
tumor suppressor genes; screening for mutations or loss of heterozygosity
in these genes may provide better diagnostic tests that are more sensitive
and specific. 1 The study of families in which ...
SeeSNP Propietary Analysis Advantages
... controlled manner to account for such artifacts.
The core component of PolyPhred that calculates the likelihood
by evaluating multicomponent signals is well
tested, easily automated, and highly reliable. The input quality
files can be ...
Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon
Allelic Discrimination Kits
... allele, FAM
fluorescence indicates homozygosity for the mutant allele, and both TET
and FAM fluorescence together indicates heterozygosity
Screening is performed with PCR mixtures that consist of a DNA template,