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Fragment in Biological Technology

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

... - for high-sensitivity protein quantitation and fragment screening, respectively - for use on the ... using streptavidin biosensors. The new fragment screening assay methodology extends the company's ... kinetic characterization and screening of fragment libraries that include compounds in the 150 to ...

Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

... of ESBATech's proprietary single-chain antibody fragment therapeutics addresses and overcomes many of the ... of all 1.5 million naturally occurring antibody fragment frameworks resulted in highly-stable, ... humanized scFv non-aggregating antibody fragment being evaluated in treating a number of ...

ESBATech's Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops

... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that it ... retina, and choroid. ESBATech's lead antibody fragment ESBA105 is a TNFa antagonist that is scheduled to ... size. The primary advantage of human antibody fragment is their ability to penetrate tissues much better ...

ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications

... Sept. 8 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that the company has successfully completed ... dose escalation study in Switzerland. ESBA105 is a single-chain antibody fragment directed against TNF-alpha, and it is being developed initially for ...

Nuevolution Announces Worldwide Technology Cross-Licensing Agreement With GSK

... The company has developed Chemetics(R), a unique, patent protected hybrid of proven wet chemistry and molecular biology which represents the ultimate fragment based lead discovery technology. Chemetics(R) enables rapid synthesis and DNA-tagging of hundreds of millions of chemically diverse drug-like small ...

ForteBio Launches Two Revolutionary High-Throughput, Label-Free Instruments: The Octet(R) RED384 and the Octet QK384

... products, announced today that it has launched two next-generation instruments: the Octet RED384 for protein, peptide, small molecule and fragment screening; and the Octet QK384 for protein and antibody assays. The new instruments will debut this week at the 2009 American Association of ...

Odyssey Thera Announces Collaboration With Mitsubishi Tanabe Pharma Corporation, and Issuance of Core Patent in Japan

... from a number of Mitsubishi Tanabe preclinical programs. Odyssey also announced the issuance of Japanese patent number JP 4262778, entitled "Protein fragment complementation assays for the detection of biological or drug interactions." "We look forward to applying our patented human cell analysis ...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

... proteins that regulate certain types of inflammatory responses by the immune system. Fragments of these proteins, such as chemoattractant complement fragment C5a, work to recruit immune system cells including neutrophils and lymphocytes to the site of inflammation. The C5a receptor is highly expressed on ...

Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals

... our internal drug candidates," said Adam Mezo, Ph.D., Director of Chemistry at Syntonix. About Zenobia Zenobia provides a commercial fragment library and access to their structural biology, crystallography and fragment-based lead discovery expertise through partnerships, consulting and ...

Nuevolution Announces Progress in Its Collaboration With Merck & Co. Inc.

... The company has developed Chemetics(R), a unique, patent protected hybrid of proven wet chemistry and molecular biology which represents the ultimate fragment based drug discovery technology. Chemetics(R) enables rapid synthesis and DNA-tagging of hundreds of millions of chemically diverse drug-like small ...

Heptares Secures GBP21 Million in Series A Fund Raising to Accelerate Development of Pipeline of Small Molecules Against High-Value GPCR Drug Targets

... apply contemporary drug discovery approaches, such as crystallisation and structure-based design, biophysical analysis of ligand interactions, and fragment screening to stabilised GPCRs. This unique approach is expected to radically improve the chances of finding drugs to previously intractable targets ...

Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure

... Intrinsic Bioprobes. BNP is synthesized as a 108 amino acid propeptide and proteolytically processed to release an inactive 76 amino acid N-terminal fragment and bioactive mature BNP 1-32 into the bloodstream. "This is the first assay capable of detecting and quantifying BNP 1-32 alone. Furthermore, the ...

Caliper Life Sciences and DiscoveRx Announce Availability of PathHunter eXpress Reagents for GPCR Assays

... in Fremont, California, with an additional office in Birmingham, England. The Company pioneered the use of Beta-Galactosidase enzyme fragment complementation in biochemical and cell based assays for discovery research, and holds extensive intellectual property in this area. DiscoveRx is ...

Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008

... HER2. Patients are vaccinated 3 times, at 3 week intervals, with the MVA-BN(R) viral vector which has been engineered to express the extracellular fragment of human HER2. By July 2008 enrolment in the studies was completed. No drug-related severe adverse events have been reported thus far. The vaccine ...

U.S. Genomics Awarded $9.1 Million Contract for Development of Advanced Biosensor by the U.S. Department of Homeland Security

... positive rates. Using a universal reagent set that can detect and identify pathogens, the technology produces a genetic signature unique to each DNA fragment in the sample, and also identifies the organism from which the DNA originates. Unlike other detection technologies, U.S. Genomics' detection platform ...

SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393

... and development programs forward," said Mike Grey, CEO of SGX Pharmaceuticals. About SGX393 SGX393 was discovered by SGX utilizing FAST(TM), its fragment based approach to drug discovery. SGX393 initially fell within the purview of the Company's collaboration with the Novartis Institute for Biomedical ...

Nuevolution Announces Research and Development Collaboration with Merck & Co. Inc.

... The company has developed Chemetics(R), a unique, patent protected hybrid of proven wet chemistry and molecular biology which represents the ultimate fragment based drug discovery technology. Chemetics(R) enables rapid synthesis and DNA-tagging of hundreds of millions of chemically diverse drug-like small ...

New molecular imaging techniques may lead to advances in disease treatment

... as reporter probes. Cell culture and animal studies demonstrated intense and highly specific uptake of the probes in cells expressing the antibody fragment on the cell surface. These data indicate that antibody-based reporter genes represent a promising new platform for the development of new reporter ...

Northwestern chemist investigates lost reds in Homer painting

... to identify those used in Homer's painting as well as in a variety of textiles, such as a 16th century carpet from Istanbul and a rare textile fragment from Peru, dated from 800 to 1350 A.D. "Our research provides an entirely new window onto the analysis of artworks," said Van Duyne. "There's a ...

Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals

... The company has developed Chemetics(R), a unique, patent protected hybrid of proven wet chemistry and molecular biology which represents the ultimate fragment based drug discovery technology. Chemetics(R) enables rapid synthesis and DNA-tagging of hundreds of millions of chemically diverse drug-like small ...

Caliper Life Sciences and DiscoveRx Collaborate to Offer Solutions for Cell-Based GPCR Profiling and Lead Optimization

... in Fremont, California, with an additional office in Birmingham, England. The company pioneered the use of Beta-Galactosidase enzyme fragment complementation in biochemical and cell based assays for discovery research, and holds extensive intellectual property in this area. DiscoveRx is ...

New Fragment-based Drug Discovery Platform Announced Between IOTA Pharmaceuticals Ltd, Cambridge (UK), and Beactica AB, Uppsala (Sweden)

... lead discovery and optimization platform. The IOTA-Beactica platform couples comprehensive, site-directed FBDD libraries to state-of-the-art fragment and lead screening using surface plasmon resonance (SPR) biosensor technology, enabling the rapid progression of new discovery programs from concept ...

Genetic Engineering & Biotechnology News reports on growing use of cell-based assays

... protein-protein interactions. DiscoveRx created a new family of cell-based assays for the detection of protein-protein interactions using an enzyme fragment complementation assay. This system uses an enzyme acceptor, an inactive alpha-galactosidase enzyme that binds to its enzyme donor forming an active ...

Viventia Biotech to Explore Strategic Alternatives - Reports Positive Pivotal Phase III Interim Efficacy Data

... unlike the relatively high toxicity associated with other forms of intravesical therapy, including BCG. VB6-845 VB6-845 is a humanized antibody fragment targeting EpCAM fused with the Company's proprietary deimmunized form of the cytotoxic protein Bouganin, and is designed for systemic use against ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

... infarction: commonly known as a heart attack; is a disease state that occurs when the blood supply to a part of the heart is interrupted. Peptide: a fragment of a protein comprised of two or more amino acids. Phase IIa: clinical trial that examines a new drug candidate's safety and exploratory efficacy ...

Court bars patent protection for certain gene fragments

... useful. At issue was whether certain gene fragment sequences were useful. Most notably whether the ... contentious hurdle to overcome, but for gene fragment patent applications the standard has now been ... describing a set of five ESTs that encodes a fragment or entire maize protein. Neither the genes that ...

LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures

... Mass Zoom (LMZ)) which can be used to enhance fragment ion resolution for low mass fragment ions, e.g. diagnostic ions used for relative ... technology. Using the 114 and 117 reagents, the fragment ion resolution obtained in MS/MS mode is suffi ...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

... parent drug (bottom right) reveals a large common fragment ion at m/z 303. This supports the conclusion that ... by the observation that the mass 165 MS 2 fragment of verapamil is unshifted in the demethylated ... The same logic applied to the mass 260 MS 2 fragment eliminates sites 1 and 2. This leaves site 3 as ...

Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System

... cut-off, to provide a broad range of informative fragment ions. Furthermore, the coupling of highly ... for sample and control comparison as well as fragment comparison. ... precursor ion scan of 169, the dominant low mass fragment for the chlorinated ring portion of the molecule ...

Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems

... Introduction Amplified fragment length polymorphism (AFLP) analysis is a genetic ... such as high resolution, especially for large fragment sizes, which should result in more accurate ... operation for sample loading, data collection, fragment size-calling, and accurate marker scoring in both ...

Homogeneous, chemiluminescent kinase assay kits for assessing the functional activity of a broad range of serine-threonine and tyrosine kinases

... and tyrosine kinases. Based on enzyme fragment complementation and the subsequent hydrolysis of ... are competitive binding assays utilizing enzyme fragment complementation (EFC) for the sensitive and ... complementation of the enzyme donor (ED) fragment and the enzyme acceptor ...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

... a unique base pair sequence in a fragment of the16S rDNA of L. monocytogenes amplified by ... fragments. The G+C content of the fragment determines the denaturant concentration at which domains of the fragment will melt. A ...

Analysis of Bacterial Assemblage Genetic Diversity in Environmental Samples Using the DCode System

... Pittsburgh, PA) and contained 1x Stoffel fragment buffer (Perkin Elmer, Branchburg, NJ), ... template DNA, and 10 units of Stoffel fragment Taq polymerase (Perkin Elmer). ... of PCR primers that amplify a smaller DNA fragment and use of a GC clamp is recommended ...

The Gradient Feature: Use in Optimization of Allelic Discrimination Assays, Rev B

... was performed for the amplification of a fragment of the coagulation factor V gene (van ... for the amplification of a 220 bp fragment of the coagulation factor V gene. The ... PCR primers were designed to synthesize a 99 bp fragment of the coagulation factor V gene. The ...

Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A

... out using the GSPs that amplified a 128 bp fragment of the macula-enriched transcript of ... the mix A-based reactions, the 128 bp fragment was not amplified at all, whereas the products ... amplification curves for the 100 bp fragment crossed threshold fluorescence at 25.4 ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... Gentra). For the oyster, a ~400 bp fragment of the mitochondrial 16S RNA subunit ... clamp. For the tautog, a ≈380 bp fragment of the mitochondrial cytochrome b ... sequence data for the entire fragment except for a short stretch immediately ...

Separation of 16S rRNA PCR Products From a Model Community Using Temporal Temperature Gradient Gel Electrophoresis, Rev A

... chain reaction (PCR*), restriction fragment length analysis and/or DNA sequencing to ... consortia. Additionally, restriction fragment length analysis requires fragment pattern matches against a large database ...

A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis

... a linear gradient of denaturant. As the fragment migrates through the denaturant ... of a double stranded DNA fragment can be predicted a priori, allowing one to ... under which all alterations within that fragment should theoretically be resolved. The ...

RNA & cDNA Purification Using RNAClean

... consuming, less efficient over a wide range of fragment sizes and not easily automated. This ... of RNA ladders containing a wide range of fragment sizes (0.16 - 9.5kb) using LiCl or ... to application. We produced a 1.9kb RNA fragment through in vitro transcription and ...
Other Contents
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
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(Date:12/26/2014)... Parker & Sons, Inc. a ... heating, cooling and plumbing contractor services throughout Arizona ... in 2014 with regard to air-conditioning systems. Residential ... known for its incredibly hot summers. Working with ... and details of a wide variety of systems ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast and ... landscape, unmet needs, current pipeline and commercial opportunities in ... which is typically used for treating colorectal cancer. It ... gastric cancer and pancreatic cancer. TS-1 is composed of ... approved in 1999 in Japan for the treatment of ...
(Date:12/25/2014)... The short film “Color of Honor” by young director/producer ... true 9/11 hero, Welles Remy Crowther. It has been chosen ... of Nuremberg International Short Film Festival and the 8th International ... and director Luciana Lagana plays the mother of the ... Gregory Graham - Graham plays a heroic policeman ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping tips ... the models at LunaDress.co.uk come with big discounts, up to 80 ... can turn out to be a most exciting memory and can ... bring surprise to a wedding. On the updated fashion blog, ladies ... for a big day . , Going out with friends to ...
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