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Familial in Biological Technology

Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen

... clearance under the Hart-Scott-Rodino Antitrust Improvements Act. About familial Hypercholesterolemia (FH) FH patients have high blood concentrations of ... risk of premature cardiovascular diseases (CVD) and CVD-related death. familial hypercholesterolemia can be present in two forms: homozygous (hoFH), where ...

Genzyme Launches Cholestagel(R) in Europe

... the efficacy of Cholestagel as an add-on therapy in patients with familial hypercholesterolemia (FH) -- an inherited disorder that causes ... results are expected in Q3 2008. "Patients with genetic conditions like familial hypercholesterolemia are at particularly high risk of early coronary heart ...

Axial Biotech Enters Partnership with the University of Utah to Utilize the Utah Population Database to Develop Personalized Diagnostic Tests for Spine Disorders

... records that provides a rich source of information for genetic, epidemiological, demographic and public health studies which can be used to identify familial clusters of disease including spinal disorders. The UPDB combined with Axial's proprietary GenDB Genealogical Database will help Axial researchers ...

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... in patients with Parkinson's disease accumulate a protein called alpha-synuclein. Moreover, genetic abnormalities in alpha-synuclein cause a rare familial form of the disease. Dr. Lindquist and her team previously showed that when yeast cells are engineered to produce large amounts of human ...

Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease

... 2 (LRRK2) , which encodes a protein called dardarin, derived from the Basque word dardara, meaning tremor. Mutations in LRRK2 are a common cause of familial Parkinson's disease. This study published in the Annals of Human Genetics describes a combination of four gene variants found in a third of ...

Stem Cell Sciences Enters into Services Agreement with Huntingdon's Disease Research Group, CHDI Foundation Inc.

... For further information on the company please visit: http://www.stemcellsciences.com . About Huntington's Disease Huntington's disease is a familial disease caused by a mutation in the huntingtin gene. Each child of a parent with a mutation in the huntingtin gene has a 50-50 chance of inheriting ...

Isis Reports Financial Results and Highlights for Third Quarter of 2008

... patients and high-risk high cholesterol patients -- Report top line data on mipomersen from a Phase 2 liver imaging study in heterozygous familial Hypercholesterolemia (FH) patients -- Provide an update on mipomersen from an ongoing open-label extension study in patients with FH -- Report ...

Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.

... experience in their respective areas of research so fundamental to our success. We continue to make great progress with our development programs for familial polyposis, human papilloma virus, and inflammatory bowel disease, and their input will be paramount as we advance our pipeline of RNAi drug ...

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

... in the brain, leading to Huntington's symptoms ranging from jerky and random movements to impaired thinking and perception. Huntington's disease is a familial disease, passed from parent to child through a mutation in the normal gene. Symptoms of Huntington's disease typically emerge between the ages of 30 ...

Cequent Pharmaceuticals Meets Novartis Option Fund Milestone; Continues to Next Phase to Validate Inflammatory Bowel Disease Targets in Vivo

... target to be the subject of the Option agreement. We believe our success with this work, along with progress in our other development programs for familial Polyposis (FAP) and Human Papilloma Virus (HPV), demonstrate the potential of our tkRNAi technology to become an important tool to better understand, ...

Isis Reports Financial Results and Highlights for Second Quarter of 2008

... performance." Upcoming Key Milestones -- Initiate three trials in addition to the Phase 3 study in patients with heterozygous familial Hypercholesterolemia (FH) announced this week, studying mipomersen in apheresis-eligible patients and high-risk high cholesterol patients ...

Exelixis Reaches Agreement with FDA on Special Protocol Assessment for XL184 Phase 3 Trial

... mutation in RET in their germline DNA. Activating mutations in RET are also present in the tumor DNA of up to 50% of sporadic MTC patients with no familial history of thyroid cancer. MTC may metastasize to lymph nodes or other organs before it is ever diagnosed. Additionally, MTC does not take up ...

Genzyme Reports Strong First-Quarter Growth

... and severely ill patient population. Mipomersen is currently being studied in a Phase 3 clinical trial involving patients with homozygous familial hypercholesterolemia. This press release contains forward-looking statements regarding Genzyme's financial outlook and business plans and ...

Lustgarten Foundation Announces $1.25 Million Commitment to Pancreatic Cancer Biomarker Development Project

... -- In December 2007, Dr. Teri Brentnall of the University of Washington announced the discovery of a gene, which, when mutated, may cause familial pancreatic cancer. The finding has promising implications for better understanding the sporadic instances of pancreatic cancer that occur in ...

Pharmion and MethylGene Announce Orphan Drug Designation Granted by the European Medicines Agency (EMEA) for MGCD0103 for the Treatment of Hodgkin's Lymphoma

... cause of the disease, but epigenetic alterations including histone acetylation, have been identified. In addition, the Epstein-Barr virus, HIV and familial history are known risk factors. The disease is slightly more prevalent in men than women, and the median age of diagnosis is 38. About MethylGene ...

BioLife Solutions' CryoStor(TM) Adopted by Tissue Regeneration Therapeutics for Preservation Protocol for New, Non-Embryonic Source of Stem Cells

... to CReATe Cord Blood Bank in Toronto, who market HUCPVCs as Peristem(TM). In June 2007, TRT licensed exclusive USA rights for HUCPVC technology for familial banking to Stem Cell Authority, Akron OH. TRT's preclinical and clinical development program is designed to define patient benefits for auto-immune ...

SNPs Powerful Tools for Association Studies

... STRs at a 5 cM to 10 cM density can be sufficient when genotyping familial samples, where limited recombination eventsone every 50 cM on averageoccur ... Hall, J.M., Lee, M.K., Newman, B., et al. 1990. Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 250, 1684- 1689. ...

Human cloning plans get blessing from British government

... a Kings College release said. They will then remove the genetic information from an unfertilized egg and replace it with the nucleus of a cell from a familial MND patient. Eggs that have successfully received the nucleus containing the MND-causing gene defect will be encouraged to grow up to the 200-cell ...

National Bio and Agro Defense fits Wisconsin

... Because Wisconsin's agricultural roots run deep, many researchers and scientists here are closely connected to the land through cultural and familial ties. The state also is home to architectural, engineering, and construction firms that are among the nation's best in designing and building secure, ...

Craigslist exec strives to keep the Internet neutral

... . The committee contends that the ads, which pertain to housing, are discriminatory on the basis of race, sex, national origin, religion, color, and familial status. The ads prompted a lawsuit that recently was dismissed in U.S. District Court in Chicago, which ruled that the Communications Decency ...

Detection of Apolipoprotein Gene Variants by DGGE Using the DCode System

... lipoprotein (HDL) levels. Three mutations in the LDL receptor binding domain of the apoB gene that cause the disorder familial ligand-defective apoB (FDB) 5, 6, 7 were detected by DGGE (Figure 3, lanes 3, 4 and 5). In addition, a rare missense mutation ...

Mutation detection for the K- rasand P16 genes

... the K-ras gene codon 12 region can lead to cancer, for example of the colon, pancreas, liver, spleen, stomach or lungs. The CDKN2A/P16 gene is a familial melanoma gene. Routine PCR and DNA sequencing methods can identify exactly which point mutation is present in patient tissue samples. Freshly ...
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