Nanotech particles affect brain development in mice

... of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in ... while pregnant showed alteration in gene expression related to neurological dysfunction. Ken ... researchers were able to demonstrate changes in expression of hundreds of genes. According to Takeda, ...

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

... of VEGF, while sparing the physiological VEGF expression necessary to maintain the growth and function of ... PTC299 through PTC's proprietary GEMS (Gene expression Modulation by Small-Molecules) technology by ... inhibitors, while sparing the physiological VEGF expression necessary to maintain the growth and function of ...

OMT announces a breakthrough in the development of a novel human antibody platform

... paper. "Inactivation of endogenous rat antibody expression is essential for human antibody expression in genetically engineered animals. To solve this ... to the inactivation of endogenous antibody expression described in the "Science" article. Previously, ...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

... "Molecular signatures defined by large-scale gene expression profiling are at the forefront in developing new ... fingerprinting methods, including mRNA and miRNA expression profiling. Both of these high-throughput methods ... minimizing experimental variation. HybSelect and expression profiling can easily be performed in the ...

Data on WaferGen's SmartChip(TM) System to be Presented at 3rd Annual Rediscovering Biomarkers Conference

... will present differential gene expression data between matched normal lung ... system is currently the focus of ongoing gene expression research collaborations with scientific teams at ... and validate therapeutically-relevant gene expression biomarkers in areas including chronic obstructive ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

... of New Sequence Data into Biochips for Gene expression Profiling and Sequence Capture for ... of genes and SNPs of interest using Gene expression Profiling, SNP-Detection, ncRNA analysis as well ... This array allows the performance of a microarray expression profiling as well as a targeted Next-Generation ...

DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches

... this patent has been proven to increase protein expression yields by up to 50 times greater than competing ... algorithm enables the company to offer expression yields up to 50 times greater than competing ... within their native host. Optimizing a gene for expression by designing the most effective coding sequence ...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

... activity in breast cancer patients with high expression of EpCAM ORLANDO, Fla., June 1 ... [version 1.0] was 38% in patients with high expression of EpCAM (n=8), the target of adecatumumab, compared to 9% in patients with low EpCAM expression (n=11). Patients treated with higher doses of ...

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

... F. Brands, J. Engel, J. Pinski, investigates the expression of Luteinizing Hormone Releasing Hormone (LHRH) ... indications, the new results show continued expression of LHRH receptors in prostate cancer specimens ... male patients." Results LHRH receptor expression was demonstrated in more than 95% of 130 prostate ...

MIT reels in RNA surprise with microbial ocean catch

... while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of ... of RNA that act as switches to regulate gene expression in these single-celled creatures. Before now, ... will allow us to get an even deeper view of gene expression and microbial response to environmental changes. ...

GenomeQuest, Inc. Announces Digital Gene Expression Solution Within Its Sequence Data Management Platform

... announced that it has released a Digital Gene expression Workflow designed to enable researchers working ... next-generation sequencing data. The Digital Gene expression Workflow is the second such workflow to be ... by the exploratory nature of our Digital Gene expression workflow, which enables them to interact directly ...

Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation

... of Pathology ) meeting demonstrated that the expression of FOXA1, now known to be an estrogen receptor ... cancer patients, researchers found that FOXA1 expression identified the same low risk, ER-positive, ... Chief Medical Officer. "Recent gene expression profiling studies have classified breast cancer ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... (AMG 479) on cell proliferation and expression of key targets involved in IGF-1R ... Undetectable Levels in Tumor Cell Lines: expression Was Not Regulated by Hypoxia and No ... Overview: EpoR, mRNA and protein expression were surveyed in 67 tumor-derived cell ...

WaferGen Announces Signing of Private Financing

... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is being ... as the first whole genome, high throughput gene expression real-time PCR platform. This innovative system, ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

Jivan Focuses on Solutions for Transcriptome Sequencing

... amplification, and software for analyzing mRNA expression from RNA-Seq, multiplexed PCR and microarrays. ... oligonucleotide design capabilities, and expression analysis software give us a tremendous advantage ... has developed a database for analysis of mRNA expression from transcriptome sequencing. It enables ...

Groundbreaking Research Begins for Pancreatic and Lung Cancers

... mechanisms. Using microarray technology, gene expression patterns in pancreatic tumor tissue are compared ... genes in a single experiment. Differences in the expression of genes encoding cellular proteins are of ... others acquire resistance. By comparing the gene expression patterns in tumors that have become resistant to ...

WaferGen Biosystems, ImmuneRegen BioSciences and University of Texas Southwestern Medical Center to Collaborate on Novel Wound Healing Research

... particularly in validating relevant gene expression biomarkers and assessing their impact on patient ... PCR System in order to identify and validate gene expression biomarkers related to wound healing. ... as the first whole genome, high-throughput gene expression real-time PCR platform. This innovative system, ...

DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors

... challenge utilizing pET vectors for bacterial expression has been the cost and uncertainty associated with ... a new family of vectors for bacterial protein expression using either T7 or T5 promoters. Cloning into ... and provides the freedom of working with expression vectors that are not constrained by intellectual ...

WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference

... in evaluating differential gene expression between normal lung and tumor tissue samples. ... system is currently the focus of ongoing gene expression research collaborations with scientific teams at ... and validate therapeutically-relevant gene expression biomarkers in areas including chronic obstructive ...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

... 1) miExpress(TM) vector based precursor miRNA expression clones; 2) miTarget(TM) miRNA target sequence (3' UTR) expression clones; and 3) All-in-One(TM) miRNA RT-qPCR ... vector system, miExpress(TM) precursor miRNA expression clone collections cover all known miRNAs for ...

Data on WaferGen's SmartChip(TM) System Presented at 16th International Molecular Medicine Tri-Conference

... platform's performance in conducting novel gene expression research. The next phase of the alpha testing ... as the first whole genome, high-throughput gene expression real-time PCR platform. This innovative system, ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

Data on WaferGen's SmartChip Real-Time PCR System(TM) to be Presented at 16th International Molecular Medicine Tri-Conference

... SmartChip System for Real-Time Gene expression Analysis" Time: From 9:40 a.m. (PST) on ... platform's performance in conducting novel gene expression research. About WaferGen WaferGen ... as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) ...

Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement

... of lentiviral gene delivery technologies, and expression Therapeutics, a biotechnology company ... a deficiency of factor VIII protein. Lentigen and expression Therapeutics will develop two types of treatments ... technology in two important areas: protein expression and cell therapy. Factor VIII is a difficult ...

Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance

... -- Oncotype DX remains the only multi-gene expression assay to be recommended by both the ... were not associated with the level of ER expression in breast cancer. This suggests that differences in ER expression between individual tumors are likely a result of ...

WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program

... the platform has shown the ability to capture the expression of genes that have not been able to be seen using ... as the first whole genome, high-throughput gene expression real-time PCR platform. This innovative system, ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

New technique allows simultaneous tracking of gene expression and movement

... analyses of correlations between behavior, gene expression and aging. John Tower led a team of ... video tracking system allows tissue-specific GFP expression to be visualized, then quantified and correlated ... methods allow specific temporal patterns of gene expression to be correlated with temporal patterns of animal ...

WaferGen Announces Third Quarter 2008 Financial Results

... $3 million grant to conduct novel gene expression research in the area of lung disease ... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

WaferGen to Present at the Rodman & Renshaw 10th Annual Healthcare Conference

... which is currently being developed for the gene expression and genotyping markets, and the SmartSlide(TM) ... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

NIH Awards Approximately $3M Grant for Research Involving WaferGen's SmartChip(TM) Real-Time PCR System at the University of Pittsburgh

... $3 million grant to conduct novel gene expression research in the area of lung disease involving ... M.D., and Frank Sciurba, M.D., will apply gene expression profiling to lung samples from patients with ... is to identify and validate disease relevant gene expression signatures and microenvironments, while also ...

WaferGen to Present at the Seventh Annual BIO Investor Forum

... which is currently being developed for the gene expression and genotyping markets, and the SmartSlide(TM) ... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

... for changes in the hundreds of genes whose expression in the brain is altered in the mouse model of ... identified genes in three brain regions whose expression was altered in the Huntington's mice and ... inhibitor. Treatment partially normalized the expression level of approximately 90% of these genes with ...

Expression Genetics' EGEN-001 Named One of 10 Most Promising Oncology Products by Windhover

... HUNTSVILLE, Ala., Sept. 5 /PRNewswire/ -- expression Genetics, Inc. (EGEN) announced today that the ... president and chief executive officer of expression Genetics. "With its unique profile, proprietary ... strategic partnering. As a selected company, expression Genetics has been invited to present data on ...

Vascular Biogenics Ltd. Presented With the Frost & Sullivan 2008 European Gene Expression Targeting Platform Technology Innovation Award

... technology permitting the limitation of gene expression to endothelial cells undergoing angiogenesis," ... where angiogenesis occurs." The innovative gene expression targeting platform technology essentially facilitates control of gene expression to the zones where angiogenesis is taking place ...

Agendia and Ferrer Announce Exclusive Agreement for Sales of Cancer Diagnostic Services in Four Major European Markets

... cancer tumor recurrence, and CupPrint*, a gene expression profiling service which offers a fast and ... to expand the commercialization of these gene expression profiling tools in these four European ... The Netherlands, is a world leader in gene expression analysis-based diagnostics with three products on ...

Agendia's MammaPrint(R) Receives Prestigious Award From Dutch Innovation Platform

... -- Agendia BV, a world leader in gene expression analysis-based diagnostics, is pleased ... The MammaPrint test measures the level of expression of each of these genes in a sample of a woman's ... The Netherlands, is a world leader in gene expression analysis-based diagnostics with three products on ...

Dow AgroSciences, Sangamo BioSciences Announce the Achievement of Key Milestones in Plant Agriculture Collaboration

... the second milestone, the control of the expression of a native gene in canola, a major food oil crop ... factors (ZFP TFs) that can control gene expression and consequently, cell function. Sangamo has ... factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

Agent in red wine found to keep hearts young

... of the profile of caloric restriction at the gene expression level," says Tomas Prolla, a UW-Madison professor ... muscle and brain by looking for changes in gene expression in those tissues. As animals age, gene expression in the different tissues of the body changes as ...

Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting

... HER2 total protein and HER2 homodimer expression and their relationship to clinical outcomes. ... substantially increase our knowledge of how the expression of these HER-family proteins are represented in ... that accurately quantifies HER2 total protein expression and HER2 homodimerization in patients with ...

Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores

... by Oncotype DX can deliver quantitative gene expression levels for assessing estrogen receptor (ER) and ... a specific score across a continuous range of expression which allows physicians to factor the ... scores provides added certainty in confirming expression levels of these important genes in predicting how ...

MammaPrint(R) Breast Cancer Test Provides Valuable Insight for Personalized Treatment Decisions

... The MammaPrint(R) test measures the level of expression of each of these genes in a sample of a woman's ... The Netherlands, is a world leader in gene expression analysis-based diagnostics with three products on ... of diagnostic tests using tumor gene expression profiling. Agendia was the first company to ...