Enzyme in Biological Technology

DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity

... Custom enzyme Design Technology to Bring More Options to Global ... and are currently inaccessible using traditional enzyme engineering approaches. Arzeda was founded by ... and further develop its computational enzyme design technology. Arzeda's team includes the ...

Kuvan Receives Priority Review Status From Health Canada

... (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with ... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for ... in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe ...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... SNAP or CLIP tag, which is essentially a suicide enzyme with a capability of one successful reaction ... expressed on the cell surface. "Given that enzyme substrate reactions have the highest order of ... only when the substrates come in contact with the enzyme active site," observes Dr. Basu. "Hence, ...

The Journal of Cardiac Failure Publishes Results From Celladon Corporation's First-in-Human Phase 1/2 Clinical Trial in Advanced Heart Failure

... Safety and Biological Effects of SERCA2a enzyme Replacement Using Gene Transfer SAN DIEGO, ... MYDICAR(R) (AAV1/SERCA2a), a genetically targeted enzyme replacement therapy for advanced heart failure, ... attempt to rescue a failing heart by replacing an enzyme known to play a critical role in normal cardiac ...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

... (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with ... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for ... in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe ...

Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting

... to maintain elevated levels of the target enzyme (a-Gal A), as measured in white blood cells, and ... gene, which result in deficient activity of the enzyme alpha-galactosidase A (a-Gal A). Deficient a-Gal ... A, which facilitates proper trafficking of the enzyme to the lysosomes, where it is needed to break ...

Publication of Shire plc's Annual Report 2008

... Gaucher disease Velaglucerase alfa is an enzyme replacement therapy being developed for the ... Shire has an ongoing enzyme replacement therapy program for the treatment of ... disorder that results from a deficiency in the enzyme arylsulfatase-A ('ASA'). In June 2008 Shire ...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

... lab has also defined mutations in ADAMTS13, an enzyme that processes von Willebrand factor, as the ... Salvesen's research focuses on the central role enzyme pathways play in the life and death of cells. ... molecular interactions that occur within these enzyme pathways. This knowledge is used to engineer ...

BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA

... deserve. BioMarin has successfully advanced two enzyme replacement therapies from IND filing to FDA ... has developed and manufactures two FDA-approved enzyme replacement therapies, one for the treatment of ... conditions caused by the underlying enzyme deficiency. The incidence estimates for MPS ...

Commonwealth Biotechnologies Presents Data at Forensic Sciences Meeting Confirming Benefits of ZyGEM's DNA Extraction Technology

... forensicGEM(TM) family of kits uses a proprietary enzyme to extract DNA from samples using a single ... forensicGEM(TM) approach uses ZyGEM's proprietary enzyme and a single closed-tube system to simplify ... lower cost. The AAFS poster, "Use of a Novel enzyme to Prepare Samples for Forensic Analysis," was ...

Enobia Completes Target Enrollment in Clinical Trial for Infantile Hypophosphatasia

... of hypophosphatasia. Enobia is investigating enzyme Replacement Therapy (ERT) with ENB-0040 for the ... About ENB-0040 ENB-0040 is a subcutaneous enzyme replacement therapy of tissue non-specific ... there is no currently approved drug therapy. enzyme Replacement Therapy for the treatment of ...

Genencor Launches Accellerase(R) 1500, Next Step Toward Scale-Up of Cellulosic Ethanol

... the next generation of its cellulosic ethanol enzyme product. Genencor introduced the product at the ... in the industry. Now, by launching this improved enzyme product, we reach another important technical ... ethanol industry, which includes its dedicated enzyme business, and its joint venture DuPont Danisco ...

Naglazyme Approved by Brazil's National Health Surveillance Agency

... genetic disease caused by a deficiency of the enzyme N-acetylgalactosamine 4-sulfatase. This enzyme deficiency leads to the accumulation of certain ... Naglazyme Naglazyme is the first and only enzyme replacement therapy indicated for the treatment ...

Verenium Announces First Commercial Cellulosic Ethanol Project

... Next-generation cellulosic ethanol uses advanced enzyme science to reduce the cost of ethanol production ... end-to-end capabilities in pre-treatment, novel enzyme development, fermentation, engineering, and ... biomass-derived sugars. Verenium's Specialty enzyme business harnesses the power of enzymes to create ...

Data to Be Presented at 58th Annual Meeting of The American Society of Human Genetics

... dihydrochloride), Naglazyme(R) (galsulfase) and enzyme replacement therapies for MPS IVA ... keratan sulfate?" 752/W - "Intrathecal (IT) enzyme replacement therapy (ERT) for symptomatic spinal ... 805/F - "An improved alpha-glucosidase enzyme for Pompe disease" About Kuvan Kuvan ...

Scientists use light to control proteins

... a light-sensing protein from an oat plant into an enzyme -- a type of protein that catalyzes biochemical ... had to consider was the proper location on the enzyme into which the light-sensing protein from the oat ... they attached the light-sensing domain to the enzyme at a particular site. The switch did not operate ...

Nu Skin Scientists Correlate the Appearance of Aging With arNOX Free Radical Generator

... Study Subjects with Decreased enzyme Activity Appear Years Younger PROVO, Utah, Oct. ... while women with decreased activity levels of the enzyme appeared to be seven years younger than their ... be launched later this month. Because the arNOX enzyme is present throughout the body, not just in the ...

Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice

... "We are extremely pleased to see evidence that enzyme replacement therapy with ENB-0040 may help repair ... domain, and an anionic peptide used to target the enzyme to bone at the upcoming IBC 2008 Bioprocessing ... and a patented anionic peptide used to target the enzyme to bone. Preclinical studies of ENB-0040 in the ...

Halozyme Therapeutics Reports 2008 Second Quarter Financial Results

... proprietary recombinant human hyaluronidase enzyme (rHuPH20) with Humulin R(R) (regular insulin ... treatment of mitomycin plus the rHuPH20 enzyme was well tolerated and appears safe. The study ... animal efficacy data for pegylated-rHuPH20 enzyme (PEGPH20) at the American Association for ...

Shire Delivers Strong Quarter: Driven by $243m of New Product Sales (+164% YOY Growth). Revenue Guidance Upgrade.

... 3 clinical program for velaglucerase alfa, an enzyme replacement therapy being developed for the ... tolerated at all doses and increased target enzyme activity levels in a majority of patients. ... was granted by the FDA for HGT-1410, an enzyme replacement therapy being developed for the ...

CBDM.T, The Market and Business Intelligence Company Reviews The Enzyme Market

... market and business intelligence company, the enzyme market is significant and estimated at €3.4 ... The market and business intelligence company, the enzyme market is significant and estimated at € ... with an annual growth of about 6.5 to 10%. enzyme products such as Insulin were the first biotech ...

Amicus Therapeutics Announces First Quarter 2008 Financial Results

... In addition, Amigal increased the level of the enzyme deficient in Fabry patients in 24 of 26 study ... 2 study in Gaucher patients who switched from enzyme replacement therapy (ERT) with imiglucerase to ... well tolerated at all doses and increased target enzyme activity levels in a majority of patients. In the ...

Verenium Reports Financial Results for the First Quarter 2008

... Specialty enzyme business delivers record growth; biofuels ... maintained healthy gross margins in our specialty enzyme business through our continued focus on achieving ... also experienced solid sales growth for its other enzyme products, including Fuelzyme(R)- LF, the ...

Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS

... describes how Beta-secretase, the rate-limiting enzyme in the production of Alzheimer's disease ... inhibition to the sub-compartment where the enzyme is active, the approach has potential to be used ... soluble ss-secretase but failed to block the enzyme in a cellular assay, was coupled to a sterol ...

Genetic Engineering & Biotechnology News reports on growing use of cell-based assays

... of protein-protein interactions using an enzyme fragment complementation assay. This system uses an enzyme acceptor, an inactive alpha-galactosidase enzyme that binds to ...

Genetic Engineering & Biotechnology News Reports on Growing Use of Cell-Based Assays

... of protein-protein interactions using an enzyme fragment complementation assay. This system uses an enzyme acceptor, an inactive alpha-galactosidase enzyme that binds to ...

Naglazyme Approved by Japanese Ministry of Health

... genetic disease caused by a deficiency of the enzyme N- acetylgalactosamine 4-sulfatase. This enzyme deficiency leads to the accumulation of certain ... About Naglazyme Naglazyme is the first and only enzyme replacement therapy indicated for the treatment ...

Amicus Therapeutics Presents Positive Data from Phase 2 Clinical Trial of Plicera(TM) for Gaucher Disease

... well tolerated at all doses and increased target enzyme activity levels in a majority of patients. ... of treatment, including effects on GCase (the enzyme deficient in individuals with Gaucher disease) ... N370S and L444P mutations. Patients were on enzyme replacement therapy (ERT) with imiglucerase for ...

Halozyme Therapeutics Presents Favorable New Safety and Pharmacokinetic Data on rHuPH20 Enzyme Produced Via New Manufacturing Process at European Federation for Pharmaceutical Sciences

... process for its recombinant human PH20 enzyme (rHuPH20). The data from three studies were ... in any toxicology parameters and no systemic enzyme accumulation was observed. -- A 3-month interim ... recombinant form of the naturally occurring human enzyme being investigated for its ability to break down ...

Genetic pathway critical to disease, aging found

... essential for the health of a cell. A key enzyme in the new pathway, dubbed Star-PAP by its ... is translated into protein." The Star-PAP enzyme regulates the production of a relatively small ... in the study. New drugs that modulate the enzyme and control its activity could potentially blunt ...

New approach may render disease-causing staph harmless

... designed to lower cholesterol blocks a key enzyme in that pathway, weakening the organisms defenses ... pharmacy, showed that knocking out a gene for an enzyme in the chemical pathway that produced the Staph ... fungal and parasitic diseases. He noted that an enzyme in the human pathway, squalene synthase, was ...

Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements

... reported -- Amigal increased the level of the enzyme deficient in Fabry patients in 24 of 26 study ... events have been reported -- The level of the enzyme deficient in people with Gaucher disease ... pharmacological chaperone targeting the enzyme deficient in people living with Pompe disease. ...

BioMarin and Genzyme Restructure Aldurazyme 50/50 Joint Venture

... disease caused by a deficiency of the enzyme alpha L-iduronidase that affects an estimated ... in the United States. Patients who lack this enzyme accumulate a carbohydrate called ... cause of MPS I by replacing the missing enzyme through a weekly infusion. More information about ...

Amicus Therapeutics Announces Positive Results From Phase 2 Clinical Trials of Amigal(TM) for Fabry Disease

... treatment, including effects on a-GAL (the target enzyme deficient in Fabry patients) and levels of ... in patients with both low levels of residual enzyme activity ( higher baseline levels (greater ... gene, which result in deficient activity of the enzyme alpha-galactosidase A (a-GAL). Deficient a-GAL ...

Tethered to chip, energy supply that drives sperm could power 'nanobot'

... targeting domain of hexokinase, the first enzyme of glycolysis, with a tag that binds to a special gold surface. Even when tethered, the enzyme remained functional. Next they tagged the second enzyme in the pathway, glucose-6-phosphate isomerase. ...

Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy

... for future research into the role each gene and enzyme might play in degrading the structural ... end-to-end capabilities in pre-treatment, novel enzyme development, fermentation, engineering, and ... sugars. Verenium's Specialty enzyme business harnesses the power of enzymes to create ...

Genencor Launches First Ever Commercial Enzyme Product for Cellulosic Ethanol

... the first ever commercially available biomass enzyme developed specifically for second generation ... will fill a large unmet need for reliable biomass enzyme supply to pilot and demonstration plant ... product. The remaining nutrients from enzyme production are available to the yeast in ...

Shire's ELAPRASE(R) (idursulfase) Approved in Japan for the Treatment of Hunter Syndrome

... Labour and Welfare has approved ELAPRASE, a human enzyme replacement therapy for the treatment of Hunter ... that results from a deficiency in the lysosomal enzyme iduronate-2-sulfatase. Without this enzyme, ... Therapies, Inc. (HGT) is the first and only enzyme replacement therapy approved for people ...

Using catalysts to stamp nanopatterns without ink

... Toones team chose as a catalyst the biological enzyme exonuclease I, derived from the bacterium E. ... visible under a microscope. Wherever the enzyme met the DNA, the end of the DNA chain and its ... attachment chemistry, we can easily wash the old enzyme off, put on a new one and keep going, Clark said. ...

Verenium Advances Its Development Work With Cargill on a New Food-Related Product

... Verenium and Cargill, Verenium is applying its enzyme discovery and optimization technologies to ... project highlights the potential of Verenium's enzyme discovery and development platforms to provide ... end-to-end capabilities in pre-treatment, novel enzyme development, fermentation, engineering, and ...