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Downstream in Biological Technology

Genomatica Produces Pure BDO From Natural Sugars

... With downstream processing techniques proven cost-effective, Genomatica looks to develop ... The purification achievement proves the feasibility of critical downstream process engineering elements of Genomatica's manufacturing method for ...

SAFC Biosciences(TM) Completes Conversion of Lenexa Media Milling Facility to Animal Component Free

... a leading provider of cell culture materials and services for upstream and downstream processes in the biopharmaceutical industry and a business segment within ... of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated ...

High-quality DNA/RNA from Microorganisms in Environmental Samples

... high quality, inhibitor-free DNA and/or RNA that can be used in various downstream applications such as PCR. The Soil DNA Isolation Kit allows for the ... The purified DNA is of the highest quality and is fully compatible with downstream PCR applications, as humic substances and other PCR inhibitors are ...

Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi

... DNA and chloroplast DNA. The purified DNA can be used in a number of downstream applications including Real-Time PCR, Southern blotting and sequencing. ... The procedure yields sufficient fungal DNA to be used in a number of downstream applications including Real-Time PCR, sequencing, Southern blotting and ...

Device That Clears Debris From Artery Aids Blood Flow in PCI

... and blood clot can break loose during angioplasty and stenting, traveling downstream to occlude the tiny vessels, or microcirculation, that supply blood deep ... have been developed that either aspirate or filter out debris that travels downstream during PCI. The TAPAS study was designed to test the effectiveness of the ...

TSH Testing Raises Awareness of Importance of Thyroid Health

... between nuclear reactors and thyroid disease near NYC was made at Croton on Hudson, during this year's Clearwater Festival. The festival is held just downstream from Indian Point, the oldest operating nuclear reactor in the U.S. In keeping with Clearwater's commitment to a clean environment, it stepped up by ...

SAFC Biosciences(R) Defines Hydrolysate Components That Enhance Chinese Hamster Ovary (CHO) Cell Line Protein Production

... ) About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, along with ...

Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies

... Virtx tailors upstream functions, such as content authoring and reviewing to meet electronic requirements and standards, while automating downstream functions such as assembly, publishing, delivery and archiving. Key capabilities include: Out-of-the-box compliance with ...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... of the GPCR from the ligand binding, signaling, and dimerization angles without compromising the functional integrity of the receptor or downstream signaling." An important aspect of Tag-lite(TM) technology is a SNAP or CLIP tag, which is essentially a suicide enzyme with a capability of one ...

Nanosys Licenses Nanowire Technology to QuantuMDx Group for Next Generation Diagnostic and Sequencing Technologies

... use of nanowires for DNA sequencing and detecting biomarkers associated with disease. In exchange, Nanosys has received an upfront license fee and downstream royalty payments. No other financial details of the deal were disclosed. While Nanosys owns an extensive IP portfolio around multiple aspects ...

ZyGEM Releases Application Note Showing its DNA Extraction Kits Rapidly Produce High Yields of Quality DNA

... prep GEM(TM) kits enable high-throughput DNA extraction of 384 samples in less than 30 minutes. They contain reagents that have been optimized for downstream PCR-based applications including quantitative PCR, genotyping using STRs or SNPs, RFLP analyses, etc. prep GEM(TM) kits are proven on a range of ...

Solutia Reports First Quarter 2009 Results

... volume declines were magnified by inventory destocking actions. Inventory levels for the most part now appear to be better aligned with the weaker downstream demand environment. The Company expects a relatively soft demand environment with some seasonal growth in the coming quarters and has taken ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... This enzyme expression converts AF to metabolites that are covalently bound to DNA. This results in phosphorylation of p53 with induction of the p53 downstream target p21Waf1/Cip1 and apotosis. About Tigris Pharmaceuticals, Inc. Tigris Pharmaceuticals, Inc. is a privately held biopharmaceutical ...

Inimex Pharmaceuticals begins First Clinical Study of an Innate Defense Regulator

... IMX942 is a small, proprietary, fully synthetic peptide that binds to an intracellular adaptor protein and modifies the signaling network downstream of TLR, TNF, and IL-1 receptors. IMX942 has no direct anti-bacterial activity but can control the outcome of infections caused by a broad spectrum of ...

GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2

... Web Services interface, and standardized flat-file import/export capabilities, GenConnect can be seamlessly integrated with any upstream or downstream informatics packages and databases. The latest example of this is the integration of GenConnect 3.2 to GenoLogics' Biomedical Informatics product ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

... (EpoR) Was Expressed at Low to Undetectable Levels in Tumor Cell Lines: Expression Was Not Regulated by Hypoxia and No Epo-Induced downstream Signaling Was Detectable Overview: EpoR, mRNA and protein expression were surveyed in 67 tumor-derived cell lines from ovary, breast, ...

SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines

... . About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, along with ...

Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session

... of acute myocardial infarction (AMI). 160,000 AMIs are severe enough to cause ventricular remodeling leading to further tissue damage over time and downstream adverse events including premature death, recurrent myocardial infarction, congestive heart failure, significant arrhythmias and acute coronary ...

ZyGEM Corp. and VWR International Europe BVBA Sign Agreement to Distribute Breakthrough DNA Extraction Technology in Europe

... prep GEM(TM) kits enable high-throughput DNA extraction of 384 samples in less than 30 minutes. They contain reagents that have been optimized for downstream PCR-based applications including quantitative PCR, genotyping using STRs or SNPs, RFLP analyses, etc. prep GEM(TM) kits are proven on a range of ...

Covance Increases Early Clinical Footprint in Europe with Acquisition of Swiss-Based Early Clinical Development Site

... clinical studies. Covance's early clinical development offerings are well-positioned to provide our clients with the knowledge critical to enhancing downstream success rates." Swiss Pharma Contract is an experienced, high-quality provider of clinical research services to the pharmaceutical, ...

Odyssey Thera Granted U.S. Patent for Novel GPCR Assay Strategy

... in this patent are the only available strategy for capturing GPCR activities, including responses of hetero-dimeric GPCR complexes and diverse downstream effector proteins, in living human cells. These powerful new tools are essential in our search for more effective therapies for cancer and other ...

Maximize Data Analysis with METTLER TOLEDO FBRM

... II - Correlating FBRM® Directly to Process Efficiency and Product Quality - Tuesday, February 10 How can FBRM® be correlated to predict downstream process efficiency or product quality? How can FBRM® be correlated to an offline particle measurement such as laser diffraction, sieving, or ...

GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research

... the PI3-kinase pathway. Company scientists say they are studying the pathway because there are a number of feedback loops that emanate from m-TOR and downstream kinases that circle back to the top of the pathway and turn on AKT, an enzyme that drives tumor survival signals. Investigators at the ...

Therapure Biopharma Inc. Announces Manufacturing Agreement with Biomedical Frontiers Incorporated -- Contract will Support Phase II Trials for Thalassemia Treatment

... Hemosol Corporation, a specialist in therapies derived from hemoglobin, a blood protein. Therapure Biopharma applies scientific, manufacturing, and downstream purification expertise with an intimate understanding of advanced biology, complex proteins, and regulatory processes to develop effective and ...

Frost & Sullivan Awards Baxter's BioPharma Solutions Business the 2008 North American Customer Service Leadership of the Year Award

... continuous engagement and flow of information with clients. "In addition to providing contract manufacturing services, BPS also offers upstream and downstream services, such as formulation services, development services and packaging," continues Subramanian. "As a one-stop shop, sponsors are able to take a ...

LI-COR Introduces Three IRDye(R) Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Protease Substrates

... are a family of intracellular cysteine proteases that are vital in the process of apoptosis (programmed cell death). Caspase-3 functions as the most downstream executioner in the caspase-apoptosis signaling cascade. Activation of Caspase-3 by upstream initiator caspases (Caspases 2, 8, 9) results in the ...

Potentia Pharmaceuticals Appoints Johanna M. Seddon, M.D. and Janet Stoltz Sunness, M.D. to Scientific Advisory Board

... the complement activation cascade. As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular ...

Potentia Pharmaceuticals' Drug Candidate for Age-Related Macular Degeneration Shows Positive Safety Profile in Phase I Clinical Trial

... the complement activation cascade. As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular ...

Potentia Pharmaceuticals to Present ASaP Phase I Clinical Trial Data for POT-4 at the American Academy of Ophthalmology Annual Meeting

... the complement activation cascade. As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular ...

Sensorin Raises Equity Financing to Launch Novel Industrial Sensing Venture

... president and CEO. "Sensorin's system represents a compelling solution for bioprocessing, including fixed and disposable fermentation systems and downstream processing." "Improved pH control has the potential to significantly increase biopharmaceutical yields," commented Frank Jackson, former Vice ...

Arobella Medical CEO is Issued U.S. Patent for Ultrasound Wound Therapy Technology

... and protecting granulation tissue, improving circulation through vasodilation and angiogenesis, and preparing the wound bed for more effective use of downstream therapies such as grafts and flaps. "This patent, which is the first of many that are currently pending, will help protect the next generation of ...

Oncolytics Biotech Inc. Completes Initial Scale Up of Manufacturing Process for REOLYSIN(R) to Commercial Scale

... completed initial scale up of its manufacturing process for REOLYSIN(R) to commercial scale. The scale up of primary production and downstream processing development was undertaken by the National Research Council Biotechnology Research Institute (NRC-BRI) located in Montreal, Canada. "Our ...

GenVault Corporation Launches GenTegra(TM) DNA

... GenTegra DNA is provided in ready to use aliquots, and purified DNA dried within GenTegra DNA is simply and fully resolubilized with water for direct downstream molecular analysis. "GenVault's goal is to provide solutions that enable efficiency in biosample management for genomic-based medicine and ....

Monitor Granule Growth in Process with the FBRM C35

... changes to minimize batch failures, improve yield, and troubleshoot scale-up or technology transfer; Identify batch endpoint - Ensure consistent downstream particle flow, tableting, and dissolution; Ensure consistent measurements - A patented scraper keeps the probe window clean allowing the C35 to ...

Nomad Bioscience: New Plant Biotechnology Company Founded to Focus on Biomaterials and Biopharmaceuticals

... NOMAD's proprietary technologies further improve the upstream part of the manufacturing process, but most importantly, they provide for novel downstream solutions that together with the in-licensed upstream components should result in a superior fully integrated manufacturing process for most of ...

Microchip Biotechnologies, Inc. Awarded Contract Under US Army Commercialization Pilot Program

... Sample Preparation Module that will automatically purify DNA from pathogen targets contained in complex matrices to provide samples for various downstream DoD-sponsored analytical platforms. The USPM will enable front-end sample preparation with high specificity for rapid detection, identification, and ...

Therapure Biopharma Inc. opens for business with first client contracts

... manufacturing organization (CMO)," said Thomas G. Wellner, President and Chief Executive Officer. "The Company's scientific, manufacturing, and downstream purification expertise, combined with an intimate understanding of advanced biology, complex proteins, and the regulatory requirements for biological ...

Cyntellect to Collaborate With the Burnham Institute for Medical Research

... and Associate Director, Del E. Webb Neuroscience, Aging and Stem Cell Research Center. "We also believe LEAP can be a transforming technology in the downstream use of stem cells and their progeny as it has clear potential as a sample preparation system for adherent cell types derived from stem cell ...

Bluestar Silicones Presents Adhesive Gels for Wound Care at Medical Grade Polymers Conference

... Bluestar Silicones, which has manufacturing operations in all regions of the world, combines upstream silicon metal operations and capacity with downstream silicone market and applications expertise. As one of the world's leading fully integrated global silicones manufacturers with more than 50 years of ...

Silence Obtains Important Patent Protection for Lead Internal Development Compound, Atu027

... cancers involving the PI3-kinase pathway. Other claims are related to the use of protein kinase N beta for screening purposes and its use as a downstream target of the PI3-kinase pathway. Atu027 is a proprietary AtuRNAi molecule currently in development for solid cancer indications, including ...
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