Accera, Inc. Launches Neuera Pharmaceuticals, Inc.
... neurological conditions where the mechanism of defective
energy metabolism or hypometabolism is involved. ... a physiological hallmark of Alzheimer's disease. defective
metabolism of glucose has been shown to precede ... patients. Axona addresses the hypometabolism or defective
metabolism of glucose that occurs in those areas ...
Discovery of new cause of mental retardation simplifies search for treatments
... an over-production of a protein than to repair a defective
protein or to replace a missing protein.
... of a protein, or cause it to be produced in a defective
way, could lie at the basis of this disorder. The ... an over-production of a protein than to repair a defective
Consequences for detecting and ...
CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients
... 17,000 Americans have hemophilia. The disease is caused by
deficient or defective
blood coagulation proteins known as factor VIII or
IX. The most common ... deficient or
defective. Hemophilia B is characterized by deficient or defective
About CSL Behring
CSL Behring is a global leader in the ...
Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease
... In clinical trials, Axona has been shown to safely improve cognitive function and memory in AD patients. Axona addresses the hypometabolism or defective
metabolism of glucose that occurs in those areas of the brain that are involved in Alzheimer's disease. Accera engages in research, development and ...
Sorenson Molecular Genealogy Foundation to Protect Archived DNA Using Biomatrica's Room Temperature Storage
"I am all too familiar with losing precious biological materials since my wife has lost an enormous number of samples in defective
freezers, and I have seen decreased sample quality through repeated freeze/thaw cycles, even when stored at minus 80 degrees," said Rolf Muller, ....
Telik Reports Preclinical Results at AACR Annual Meeting
... apoptosis in human cancer cell lines, such as HCT116 (colon), HL60 (promyelocytic leukemia) and A549 (lung) - reflecting cell lines with intact or defective
p53-dependent post-mitotic checkpoints.
More than 80% inhibition of tumor growth was seen in an HL60 xenograft model following a once daily ...
GYNECARE PROLIFT+M(TM) Pelvic Floor Repair System Launched in US for Use in Pelvic Organ Prolapse Surgery
... of the pelvic floor in vaginal wall prolapse where surgical treatment is intended, either as mechanical support or as a bridging material for defective
fascia. The mesh is implanted using the tension-free vaginal mesh (TVM) technique, a procedure involving a small incision in the vaginal wall.
ThermoGenesis Says FDA Concurs with Plan for Previously Announced AXP(TM) Bagset Recall
... issues; the field action was a result of the potential for particulates to be released into the sterile, non-pyrogenic fluid path as a result of a defective
component provided by one of the suppliers to the Company. The Company indicated that it was providing customers a blood filter to be used, as ...
Mindset BioPharmaceuticals (USA) Inc Obtains Notice of Allowance for European Patent Related to Use of Insulin Sensitizers in Senile Dementia, Dementia and Memory Loss
... in the brain's of older people and especially those suffering from Senile Dementia or other forms of memory loss. There is growing evidence that this defective
brain glucose utilization results from resistance to the action of insulin. Insulin sensitizer drugs such as Rosiglitazone and Pioglitazone help ...
PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet
... 10 percent of patients in the United
States and Europe and over 50 percent of patients in Israel. There is
currently no available therapy to correct defective
CFTR production and
function. Instead, available treatments for CF are designed to alleviate
the symptoms of the disease. These treatments include ...
A first in integrated nanowire sensor circuitry
... did fail, the causes were due to defects in fabrication of the circuit connections (10 percent), failure in photosensor printing (5 percent), or defective
nanowires (5 percent). The relatively high yield of complex operational circuits proved the potential of the technology, with improvements readily ...
AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy
... in animal
models. This vector has been licensed to AMT.
Repair factor IX production and blood clotting
Hemophilia B is characterized by defective
blood clotting due to an
absence of functional clotting Factor IX. The gene with the information for
the Factor IX protein is mutated in Hemophilia ...
Weitz & Luxenberg Files Seroquel Diabetes Lawsuit Against AstraZeneca
... firms in America. The firm
has played leading roles in national and local litigations involving
asbestos/mesothelioma, DES, silicone breast implants, defective
and medical devices, and general negligence, among others. A forerunner in
the legal fight against environmental polluters, Weitz & ...
AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response
... debilitating disease).
Hemophilia B occurs in 1 in 30,000 males and results in severe internal
and external bleeding. The disease is caused by defective
due to an absence of clotting factor Factor IX. Gene therapy can be used to
introduce the gene that produces Factor IX and thereby ...
Raptor Pharmaceuticals Corp. Receives FDA Orphan Drug Designation for Cysteamine in Huntington's Disease
... defect that is believed to cause HD, a
progressive disease that often leads to death within 15 to 20 years after
diagnosis. HD is caused by a defective
gene resulting in the degeneration
of certain nerve cells in the brain. The disease is characterized by
uncontrollable movements and mood swings or ...
Illinois Pharmaceutical Manufacturer Sued for Injuries to Kentucky Resident
... and its wholly-owned subsidiary, Baxter
Healthcare Corporation, manufactured the drug with a contaminated API and
that Baxter failed to recall the defective
drug in a timely fashion. The
suit cites four causes of action against Baxter and Scientific Protein Labs
including Products Liability, Negligence, ...
Susan G. Komen for the Cure(R) Announces Largest Grants Slate Ever: $100 Million to Speed Delivery of Breast Cancer Discoveries, Cures
... the Cure grant was awarded to Insoo Bae, Ph.D., of Georgetown University to identify environmental agents that cause DNA damage to BRCA1 defective
breast cells, triggering the development of cancerous tumors. -- A Komen for the Cure grant is supporting the work of Amy Trenthan-Dietz, ...
CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies
... FS should not be used to treat people with VWD since it
does not contain the von Willebrand factor, the endogenous protein which is
absent or defective
in the VWD. For more information about von Willebrand
disease, please visit http://www.allaboutbleeding.com .
Adverse events related to the use of ...
CryoLife Announces Implant of First FDA-Cleared SynerGraft(R) Processed Human Pulmonary Heart Valve
... heart defects. In addition, the valve can be used
for pulmonary valve replacement during the Ross Procedure, an operation in
which a patient's defective
aortic valve is removed and replaced with his
own pulmonary valve. The CryoValve SG is then surgically implanted in place
of the removed native ...
Avicena's HD-02 to Proceed to NIH Sponsored Phase III Huntington's Disease Trial
and prolonged survival.
ABOUT HUNTINGTON'S DISEASE
Huntington's disease is a progressive neurodegenerative disease caused
by a defective
gene that is often inherited from parent to child. This
genetic defect causes a widespread deterioration of neurons in those parts
of the brain that ...
A New Era in Cell Biology: German Company Develops Groundbreaking Alternative to Stem Cell Therapy
... desired target cells, for example liver or muscle cells or cells in
pancreatic islets of Langerhans." The therapeutic possibilities lie in
or missing cells (regenerative medicine) or producing
cells that regulate the immune system. A significant advancement in the
treatment of autoimmune ...
CryoLife Receives FDA 510(k) Clearance for SynerGraft(R) Processed Human Pulmonary Heart Valves
... heart defects. In addition, the valve
can be used for pulmonary valve replacement during the Ross Procedure, an
operation in which a patient's defective
aortic valve is removed and
replaced with his own pulmonary valve. The CryoValve SG is then surgically
implanted in place of the removed native ...
Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen
diseases (CVD) and CVD-related death. Familial hypercholesterolemia can be
present in two forms: homozygous (hoFH), where the same defective
inherited from both parents, or heterozygous (heFH), where the defective
gene is inherited from only one parent so that some function is ...
Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections
... disease in Caucasians and is caused by a mutation in the
CFTR-gene (cystic fibrosis transmembrane conductance regulator) on
chromosome 7. The defective
gene leads to viscous secretions and impaired
mucociliary clearance. The most devastating clinical consequence of CF and
cause of morbidity and ...
Shareholder Class Action Filed Against LCA-Vision, Inc. by the Law Firm of Schiffrin Barroway Topaz & Kessler, LLP
... stores had significantly
declined; (2) that overall growth was solely coming from new store
openings; (3) that the Company was operating under defective
about its marketing budget and deferred revenue; (4) that the Company
lacked adequate internal and financial controls; and (5) that, as a ...
RNA Interference and Gene Silencing: History and Overview
... normally in somatic cells, but
in germline cells where ego-1 is primarily ... Arabidopsis mutants of AGO1 , which are defective
cosuppression, also exhibit defects ... with mutated rde-2 or mut-7 genes exhibit defective
RNAi, but interestingly, they also ...
Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN
siRNA and TransMessenger Transfection Reagent*
Suppression of MAP2 Leads to defective
(arrowed) exhibits severely defective
... Figure "Suppression
of MAP2 Leads to defective
Neuronal Development" ).
Researchers report major advance in gene therapy technique
... continued to attract many of the worlds brightest scientists. They are tantalized by the enormous potential that replacing missing genes or disabling defective
ones offers for curing diseases of many kinds.
One group, consisting of researchers from the University of Wisconsin Medical School , the ...
Part 6 Project Performance Get on the path to continuous improvement
... requirements. Sigma refers to the Greek symbol σ, which represents the amount of variation in a process. The lower the variation, the fewer defective
parts are produced and the fewer repair calls you need to make. The ultimate goal is to eliminate defects and errors and their associated costs.
Research on fruit flies opens up possibilities for human treatments
... reach of treatments for treating genetic disorders. By targeting a combination of proteins and genetic pathways, it may be possible to locate the defective
genes and stop the disease at each stage.
While the fruit flies are far simpler than humans, Yin said this research may help reveal a common ...
How's the State of the State? It depends on what numbers are crunched
... states largest business group is still smarting, as well, over Doyles vetoes of four bills that would have made it harder to sue makers of allegedly defective
products. One bill would have shielded manufacturers from lawsuits if plaintiffs could not pinpoint the exact maker of a harmful product, a stance a ...
Four ways lawmakers could help Wisconsins high-growth economy
... 2005 Supreme Court ruling that enables litigants to bring suit against a group of defendants in lieu of identifying the specific manufacturer of a defective
product or a product that causes injury.
Because of the scope of the ruling, component manufacturers are at risk of pass-through litigation that ...
Legislature adopts one tech bill, leaves two others twisting
... ruling. Critics contend it permits litigants to bring lawsuits against a group of defendants in lieu of identifying the specific manufacturer of a defective
product that causes an injury. As a result, they believe it subjects manufacturers involved in the production of components, including those in ...
UW links with Israeli school to locate genes
Geiger said the Genetic Center in northern Israel is using it to study a rare genetic disease that distorts women's palms. By studying the defective
gene and its relation to a secondary gene, researchers have a better chance to keep other family members healthy.
The Superlink team has been ...
Stem cell and regenerative medicine center to aid education and commerce
... faculty members engaged to varying degrees in stem cell research and in regenerative medicine, which is developing technologies to repair or replace defective
tissues and organs.
In addition to regenerative medicine and an interdisciplinary stem cell post-doctoral training program, the center will ...
Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods
... ASM News 1991; 57: 175-82.
2. Profos Endotoxin Compendium
3. Profos Endotoxin Compendium
4. Poltorak, A. et al. (1998) defective
LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science
5. Shimazu, R. et al. (1999) ...
Verifying Multichannel Pipettor Performance with Standard Dispense Solutions in the SpectraMax Plus (MaxLine Application Note #28)
... AND SUMMARY
Most pipettors, given enough use, will eventually require repair, and therefore should be checked regularly to avoid having a defective
pipettor in service. In the days when the typical laboratory had only a few single-channel, hand-held pipettors, the traditional gravimetric method ...
Characterizing galvanizing baths
Automobile-parts production can be paralyzed by a defective
electron-galvanizing (EV) bath line. Because a sensitive and accurate analysis of EV solutions is fundamental to productivity, quality, and ...
Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system
... 36 , 59–74 (1977).
2. Krougliak, V. and Graham, F.L., Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6 , 1575–86 (1995).
3. Kozarsky, K.F. and Wilson, J.M., Gene therapy: adenovirus ...