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Cyclic in Biological Technology

New drugs faster from natural compounds: A UC San Diego breakthrough

... San Diego. "Compound 879," for example, is a cyclic NRP discussed in the Nature Methods paper that ... from the mass spectrometers that break the cyclic peptides into smaller and smaller linear pieces. ... in order to determine the chemical structure of a cyclic NRP. This is called "De Novo sequencing of NRPs." ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

... approach are extremely small proteins, called cyclic peptides, which are capable of targeting the ... among proteins that occur at these surfaces. cyclic peptides have the ability to bind where ... University, Kritzer created a vast "library" of cyclic peptides containing various amino acid ...

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... the cells to make very small proteins called cyclic peptides. Two of the cyclic peptides had a protective effect on the yeast ... the cellular pathways that are affected by these cyclic peptides." The research emerged from the lab ...

Novel compound may treat acute diarrhea

... of ever-present cellular messenger molecules, cyclic guanosine monophosphate and cyclic adenosine monophosphate, caused by various ... of a group of intracellular messengers, cyclic nucleotides, that stimulate intestinal cells to ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... "Cyclic Natriuretic Peptide Constructs." Allowed claims cover a family of cyclic compounds that bind to natriuretic peptide receptor A (NPRA), including ... of once-daily administration." PL-3994 and the related family of cyclic compounds were discovered entirely in-house and are owned by Palatin. In ...

Rising H9N2 Influenza Replikin Count Has Doubled That of H5N1

... Replikin Count® annually in each of H9N2 and its sister strain H5N1. cyclic increases and decreases appear to be synchronous for H9N2 and H5N1, with ... the subsequent H5N1 Replikin Count increases and outbreaks (see Figure). cyclic increases and decreases appear to be synchronous for H9N2 and H5N1, with ...

Highest Replikin Concentrations and Cyclical Behavior Related to Human Mortality Are Found in Malaria Trypanosomes

... of infectivity, host morbidity and mortality. Timely repeated analyses of cyclic changes in an organism's replikin structure may be useful to bring current ... company is predicting further increases in count and malaria mortality. cyclic increases in replikin concentration in the genome can be a mechanism of ...

Job-related stress: NIST demonstrates fatigue effects in silicon

... backbone of the semiconductor industryis one the worlds most heavily studied materials, and it has long been believed to be immune to fatigue from cyclic stresses because of the nature of its crystal structure and chemical bonds. And indeed, conventional tests have validated this. Recent research into ...

Platinum-rich shell, platinum-poor core

... copper, and cobalt that is deposited onto carbon supports in the form of nanoparticles. The active catalytic phase is formed in situ: when a cyclic alternating current is applied to the electrode, the less precious metals, especially the copper, on the surface of the nanoparticles separate from ...

Tapeworm's Chemical Trick Could Make Drugs More Effective

... Oaks and Bass, known in scientific shorthand as cyclic GMP, is a member of a family of compounds known ... to quickly sweep food along. "Inside cells, cyclic GMP is a signal molecule," notes Oaks, a ... digesting material as it normally would." The cyclic GMP compound, Oaks adds, is cheap and easy to ...

cAMP DataFile: Homogenous Cyclic AMP detection using High Efficiency Fluorescence Polarization

... Introduction cyclic adenosine monophosphate (cAMP) is a second ... cyclase. Adenylyl cyclase converts ATP into cyclic AMP that in turn activates protein kinases. ... correlated to the intracellular concentration of cyclic AMP. The level ...

Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray Ion Trap Mass Spectrometry

... (type-I) whereas MetSO near the C-terminus affected CaM-dependent cyclic phosphodiesterase. 2,3 For a range of biochemical studies, the ... Modulator: The Role of Methionine Residues in the Activation of cyclic Nucleotide Phosphodiesterase. Biochemistry 17: 3924-3928; 1978. ...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

... fusion activator plasmid is shown in Figure 2 B. cyclic AMP-dependent protein kinase (PKA) is a known activator of the ... tandem repeats of one of the following enhancer elements: cyclic AMP response element (CRE), serum response element (SRE), ...

UW-Eau Claire chemistry faculty get $600,000 in NSF grants

... use modern instruments in student-centered, student-driven projects. A $190,000 grant for a project titled "RUI: Cavity Ringdown Spectroscopy of cyclic Enones in Triplet Excited States. By exposing molecules to the right color of light, it's possible to cause the molecules to undergo chemical ...

HTRF IP-One Assay Performed on the PHERAstar and RUBYstar Plate Readers

... of Gq coupled GPCRs result in a transient increase of intracellular Ca 2+ triggered by inositol (1,4,5) tri-phosphate (IP3). cyclic AMP and IP3 therefore represent two essential secondary messengers for monitoring the activity of most GPCRs. ...

Comparison of Performance between the AlphaQuest - HTS and the Fusion α Multilabel Reader for Detection of cAMP

... Membranes. Poster. The Society for Biomolecular Screening Annual Conference, Vancouver, CN. 2000. 3. Rawlins, P., et al. A Comparison of cyclic AMP Accumulation Assays for High Throughput Screening. Poster. The Society for Biomolecular Screening Annual Conference, Vancouver, CN. 2000. ...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

... combat these diseases. In many cells, binding of the neurotransmitter to its receptor alters the production of the second messenger adenosine 3', 5' cyclic monophosphate (cAMP), through the enzyme adenylyl cyclase. Intracellular changes in the level of cAMP can then initiate a cascade of other cellular ...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

... pharmaceutical agents.

Here, we describe an assay for screening at GPCRs based on enzyme fragment complementation (EFC) technology and cyclic adenosine 3’, 5’ monophosphate (cAMP) measurement. The data show the cAMP II HitHunter Chemiluminescence Assay has a sensitivity of ~ 1 ...

Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells

... Trends in Pharmacol. Sci., 22 , (5), 247–254, (2001).

2. PRICE, E. et al ., Direct, quantitative, intracellular measurement of cyclic AMP in cells: A LEADseeker assay utilizing Protein A Polystyrene SPA Imaging Beads. Poster presentation, Screening Europe Conference, London ...

Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system

... exploit the signal readouts from the sensor gene markers.

This application note describes the development of an NTR reporter assay for the cyclic adenosine monophosphate response element (CRE). CRE acts as a molecular docking site for two endogeneous transcription factors (cAMP binding protein, ...

Setting up a kinase profiler with IMAP

... of forskolininduced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino )ethyl] -5-isoquinolinesulfonamide (H-89), of PC12D ...

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

... extracellular stimuli on the activation of c-Jun N-terminal kinase (JNK), 2,3 mitogen-activated protein kinase (MAPK), 4,5 cyclic AMP-dependent protein (PKA) 6 and other signaling molecules leading to the activation of these kinases. The PathDetect ...

In Vivo Signal Transduction Pathway Reporting Systems

... of new genes, growth factors and drug candidates on the activation of c-Jun N-terminal kinase (JNK), mitogen-activated protein kinase (MAPK), cyclic AMP-dependent protein (PKA) and other signaling molecules leading to the activation of these kinases. When a fusion activator plasmid, reporter ...

Enzyme Immunoassay for Studying Intracellular Levels of cAMP

... is increased to the picomolar range with acetylated cAMP. cyclic adenosine monophosphate (cAMP) plays a key role as an ... agonists. REFERENCES Brooker, G., et al. (1979) Adv. cyclic Nucleotide Res. 10: 10. Barnes, S.J., and Conn, P.M. ...

Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements

... plasmids ( figure 1 ) of the PathDetect cis-reporting systems contain tandem repeats of one of the following enhancer elements: cyclic AMP response element (CRE), serum response element (SRE), nuclear factor k B (NF- k B), activator protein 1 (AP-1) or serum ...
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