Growing old together: Yeast, worms and people may age by similar mechanisms
... This report describes the identification of conserved
aging-related genes in simple model organisms ... Previous studies have implicated a number of conserved
genes in model organisms as regulators of aging, ... the degree to which aging-related genes are conserved
across the genome among distantly related ....
First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide
... chairman, Dr. Samuel Bogoch, found that some of these regions have been conserved
for decades. In H1N1 last year the company detected the highest ... that H1N1 would strike this year, has been used to manufacture synthetic conserved
Replikin vaccines against both these influenza strains, Replikins H5N1 ...
Beyond associations: Colorectal cancer culprit found
... colorectal cancer, and found that it resides in a DNA sequence that is conserved
in many other species so well conserved
that they were able to use xenopus frogs as a model organism to test the ...
Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data
... which they named Replikins, which are shared across flu strains, conserved
over time, associated with the last three pandemics of 1918, 1957 and ...
2. Ekeirt, D.C. et al. "Antibody Recognition of a Highly conserved
Influenza Virus Epitope." Science DOI: 10.1126-science.1171491, Science ...
Symbiotic microbes induce profound genetic changes in their hosts
... genetic changes in a tiny squid, including a set of evolutionarily conserved
genes that may hold the secrets to developing a mutually beneficial ... numbers of environmental bacteria These genes might be considered the core conserved
responses of animals to interactions with bacteria" along tissue surfaces ...
CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses
... more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI's efforts to fight this virus are focused on using conserved
epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective ...
CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology
... in their prime more severely.
In addition, LEAPS conjugates may be used to potentially overcome the virus' mutations by focusing on more conserved
and common epitopes critical for critical viral function.
The L.E.A.P.S. technology is a novel T-cell modulation platform technology that ...
Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital
... to become some or all of the major specialized cell types of the particular tissue or organ in which it is found. The discovery of a number of conserved
mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell ...
Avian Adenovirus Genotyping Diagnostic Service
... is the major capsid protein of the non-enveloped virion on which type, group and subgroup specific determinants are located. The hexon consists of conserved
regions (pedestals), which are located inside the virion, and variable loops which protrude from the surface containing the type-specific ...
H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide
... regions in virus genes that have been linked with past epidemics. The company's chairman, Dr. Samuel Bogoch, found that the regions have been conserved
for decades. In H1N1 last year the company detected the highest concentrations of these specific regions ever seen, except for those from the 1918 ...
CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies
... specific antibody production in animal models. In CEL-SCI's L.E.A.P.S. swine flu vaccine the TCBLs will be coupled to two different and known highly conserved
peptide protective epitopes from two different essential proteins common to all influenza A virus strains.
L.E.A.P.S. technology is a novel ...
Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting
... team of expert scientists was able to demonstrate one of the main tenets of systems biology -- that the networks that regulate cellular processes are conserved
across tumor and tissue types, even when the transcriptional responses of these tissues are markedly different."
Founded in ...
Life sticks: UC San Diego bioengineer's sticky insights published in journal Science
... When pressure builds up, acini can hold more and more volume until they need to push the milk proteins down the duct.
"This kind of structure is conserved
in a variety of dissimilar systems that respond to forces in a manner similar," said Engler. The long bones of the human skeleton are another ...
Novel Diabetes Drug Discovery Has Potential to Reverse Disease
... an innovative and proprietary approach to evaluate the human genome and proteome from a physiologic perspective, we were able to identify a highly conserved
bioactive gene product that triggers islet neogenesis. Restoring functional islets as a therapeutic approach is fundamental to curing the underlying ...
Use it or lose it? Researchers investigate the dispensability of our DNA
... relationships; however, protein-coding genes account for only a small fraction the genome, and there are many other DNA sequences that are conserved
across species. What are these sequences doing, and do we really need them at all? In a study published online today in Genome Research ( ...
In vivo visualization of alternative splicing
... profiles of alternative splicing in living organisms. We are coming to realize that the molecular mechanisms of alternative splicing are highly conserved
throughout metazoan evolution, explains Dr. Kuroyanagi.
New target for anti-flu drug development
... been published in the August 15, 2007 issue of the journal Cell Cycle.
The potential drug target is the flu protein M2, long known to be highly conserved
between avian and human strains of the virus. Scientists at Cure Lab found that this M2 protein may single-handedly kill human cells.
This effect ...
UW-Madison scientists find a key to cell division
... this mutli-organismal approach. The fact that the process is highly conserved
across two very different species shows how ancient and conserved
the process of cell division is."
The team analyzed 160 key proteins - ...
Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes
... polymerase chain reaction (PCR)*
using primers that anneal to conserved
sequences, yielded multiple copies
of gene fragments that, when ... number of cells required for successful
amplification of the conserved
region of their 16S rRNA gene using PfuTurbo
polymerase. A ...
Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms
... chain reaction* using universal
primers targeting highly conserved
regions. 1 Mitochondrial genes are
popular candidates because ... variation
than coding regions. Introns may be amplified using conserved
targeted to flanking exon sequence, a strategy termed ...
Getting Started with MicroRNA Research
than 90% of the miRNAs are completely conserved
suggesting that these molecules are ... targets.
MicroRNAs (miRNAs) are highly conserved
expressed in eukaryotic cells. Data ...
... source is being actively incorporated into
biomass trough anabolism during growth, about 40-50 % of the available enthalpy in the
substrate is conserved
in the biomass, the rest being given off as heat. When the carbon
source is being catabolized to provide energy for cell maintenance, all the ...
The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System
... (1). Chemokines are classified into four families (CXC, CC, C, and CXC3) based on the number and sequential relationship of the first two of four conserved
cysteine residues. They induce their biological effect by binding to chemokine receptors that belong to the superfamily of G protein-coupled ...
Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A
of a homologue to cysteine protease ER 60, Exp Parasitol 86, 17 (1997)
Gillingham AK and Munro S, The PACT domain, a conserved
motif in the coiled-coil proteins AKAP450 and pericentrin, EMBO Rep 1,
Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System
... D.A., Frazier,
R.B., Hironaka, C.M., Levine, E.B., Shah, D.M., Fraley, R.T. and Kishore,
G.M. Site-directed mutagenesis of a conserved
region of the 5-enolpyruvylshikimate-3-phosphate
synthase active site. Journal of Biological Chemistry 266(33):22364-22369
Total RNA from Whole Blood for Expression Profiling
... spanned a much smaller range (0.64- to 1.62-fold),
highlighting hundreds of genesapproximately 10% of the arraythat were
in RNA later , but not with the market leader's protocol.
The converse, however, was not true: deviations from 1.0 in the RNA later
The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis
... putative let-7 complementary sites with features of
validated C. elegans LCSs. Many of the LCSs are
in rodents, amphibians, and fish, suggesting
functional relevance. The presence of putative LCSs in human
MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers
many of the miRNAs are homologous between species, suggesting
that miRNAs represent an evolutionally conserved
regulatory pathway .
The best understood miRNA, lin-4, was identified
Setting up a kinase profiler with IMAP
... the peptide
5FAM-LKKLRRRLSDANF-NH 2 (ID G3H4). This peptide was chosen as the
AMPK profiling substrate because its assay both conserved
enzyme and maintained
a robust signal. As AMPK is maximally active in the presence of AMP, AMP
was added to the enzyme ...
HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex
Detecting Both HSV-1 and HSV-2 DNA
The HSVision module primers are derived from a 109 base-pair region of the gB
gene that is highly conserved
in HSV-1 and HSV-2 genomes. 8 Because
PCR reactions are often susceptible to a variety of inhibitors in biological
specimens, an IAC is included ...
The GeneZoo or the GeneJungle?
gene-identification tag has been demonstrated as an effective
gene-specific marker. Because the 3 UTRs are
not as conserved
as the coding sequences, this makes it easier to
distinguish between individual genes and paralogous gene family members
that may ...