Navigation Links
Conserved in Biological Technology

Growing old together: Yeast, worms and people may age by similar mechanisms

... This report describes the identification of conserved aging-related genes in simple model organisms ... Previous studies have implicated a number of conserved genes in model organisms as regulators of aging, ... the degree to which aging-related genes are conserved across the genome among distantly related ....

First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide

... chairman, Dr. Samuel Bogoch, found that some of these regions have been conserved for decades. In H1N1 last year the company detected the highest ... that H1N1 would strike this year, has been used to manufacture synthetic conserved Replikin vaccines against both these influenza strains, Replikins H5N1 ...

Beyond associations: Colorectal cancer culprit found

... colorectal cancer, and found that it resides in a DNA sequence that is conserved in many other species so well conserved that they were able to use xenopus frogs as a model organism to test the ...

Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data

... which they named Replikins, which are shared across flu strains, conserved over time, associated with the last three pandemics of 1918, 1957 and ... 2. Ekeirt, D.C. et al. "Antibody Recognition of a Highly conserved Influenza Virus Epitope." Science DOI: 10.1126-science.1171491, Science ...

Symbiotic microbes induce profound genetic changes in their hosts

... genetic changes in a tiny squid, including a set of evolutionarily conserved genes that may hold the secrets to developing a mutually beneficial ... numbers of environmental bacteria These genes might be considered the core conserved responses of animals to interactions with bacteria" along tissue surfaces ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI's efforts to fight this virus are focused on using conserved epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

... in their prime more severely. In addition, LEAPS conjugates may be used to potentially overcome the virus' mutations by focusing on more conserved and common epitopes critical for critical viral function. The L.E.A.P.S. technology is a novel T-cell modulation platform technology that ...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

... to become some or all of the major specialized cell types of the particular tissue or organ in which it is found. The discovery of a number of conserved mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell ...

Avian Adenovirus Genotyping Diagnostic Service

... is the major capsid protein of the non-enveloped virion on which type, group and subgroup specific determinants are located. The hexon consists of conserved regions (pedestals), which are located inside the virion, and variable loops which protrude from the surface containing the type-specific ...

H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide

... regions in virus genes that have been linked with past epidemics. The company's chairman, Dr. Samuel Bogoch, found that the regions have been conserved for decades. In H1N1 last year the company detected the highest concentrations of these specific regions ever seen, except for those from the 1918 ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

... specific antibody production in animal models. In CEL-SCI's L.E.A.P.S. swine flu vaccine the TCBLs will be coupled to two different and known highly conserved peptide protective epitopes from two different essential proteins common to all influenza A virus strains. L.E.A.P.S. technology is a novel ...

Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting

... team of expert scientists was able to demonstrate one of the main tenets of systems biology -- that the networks that regulate cellular processes are conserved across tumor and tissue types, even when the transcriptional responses of these tissues are markedly different." About Genstruct Founded in ...

Life sticks: UC San Diego bioengineer's sticky insights published in journal Science

... When pressure builds up, acini can hold more and more volume until they need to push the milk proteins down the duct. "This kind of structure is conserved in a variety of dissimilar systems that respond to forces in a manner similar," said Engler. The long bones of the human skeleton are another ...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

... an innovative and proprietary approach to evaluate the human genome and proteome from a physiologic perspective, we were able to identify a highly conserved bioactive gene product that triggers islet neogenesis. Restoring functional islets as a therapeutic approach is fundamental to curing the underlying ...

Use it or lose it? Researchers investigate the dispensability of our DNA

... relationships; however, protein-coding genes account for only a small fraction the genome, and there are many other DNA sequences that are conserved across species. What are these sequences doing, and do we really need them at all? In a study published online today in Genome Research ( ...

In vivo visualization of alternative splicing

... profiles of alternative splicing in living organisms. We are coming to realize that the molecular mechanisms of alternative splicing are highly conserved throughout metazoan evolution, explains Dr. Kuroyanagi. ...

New target for anti-flu drug development

... been published in the August 15, 2007 issue of the journal Cell Cycle. The potential drug target is the flu protein M2, long known to be highly conserved between avian and human strains of the virus. Scientists at Cure Lab found that this M2 protein may single-handedly kill human cells. This effect ...

UW-Madison scientists find a key to cell division

... this mutli-organismal approach. The fact that the process is highly conserved across two very different species shows how ancient and conserved the process of cell division is." The team analyzed 160 key proteins - ...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

... polymerase chain reaction (PCR)* using primers that anneal to conserved sequences, yielded multiple copies of gene fragments that, when ... number of cells required for successful amplification of the conserved region of their 16S rRNA gene using PfuTurbo polymerase. A ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... chain reaction* using universal primers targeting highly conserved regions. 1 Mitochondrial genes are popular candidates because ... variation than coding regions. Introns may be amplified using conserved primers targeted to flanking exon sequence, a strategy termed ...

Getting Started with MicroRNA Research

... more than 90% of the miRNAs are completely conserved among species, suggesting that these molecules are ... targets. MicroRNAs (miRNAs) are highly conserved regulatory molecules expressed in eukaryotic cells. Data ...

FERMENTATION BASICS

... source is being actively incorporated into biomass trough anabolism during growth, about 40-50 % of the available enthalpy in the substrate is conserved in the biomass, the rest being given off as heat. When the carbon source is being catabolized to provide energy for cell maintenance, all the ...

The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System

... (1). Chemokines are classified into four families (CXC, CC, C, and CXC3) based on the number and sequential relationship of the first two of four conserved cysteine residues. They induce their biological effect by binding to chemokine receptors that belong to the superfamily of G protein-coupled ...

Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A

... of a homologue to cysteine protease ER 60, Exp Parasitol 86, 17 (1997) Gillingham AK and Munro S, The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin, EMBO Rep 1, 524529 (2000) Grevelding ...

Detection of Genetically Modified Soybean in Processed Foods Using Real-Time Quantitative PCR with SYBR Green I Dye on the DNA Engine Opticon 2 System

... D.A., Frazier, R.B., Hironaka, C.M., Levine, E.B., Shah, D.M., Fraley, R.T. and Kishore, G.M. Site-directed mutagenesis of a conserved region of the 5-enolpyruvylshikimate-3-phosphate synthase active site. Journal of Biological Chemistry 266(33):22364-22369 ...

Total RNA from Whole Blood for Expression Profiling

... spanned a much smaller range (0.64- to 1.62-fold), highlighting hundreds of genesapproximately 10% of the arraythat were well conserved in RNA later , but not with the market leader's protocol. The converse, however, was not true: deviations from 1.0 in the RNA later ...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... putative let-7 complementary sites with features of validated C. elegans LCSs. Many of the LCSs are conserved in rodents, amphibians, and fish, suggesting functional relevance. The presence of putative LCSs in human ...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

... of many of the miRNAs are homologous between species, suggesting that miRNAs represent an evolutionally conserved and critical regulatory pathway [11]. The best understood miRNA, lin-4, was identified ...

Setting up a kinase profiler with IMAP

... the peptide 5FAM-LKKLRRRLSDANF-NH 2 (ID G3H4). This peptide was chosen as the AMPK profiling substrate because its assay both conserved enzyme and maintained a robust signal. As AMPK is maximally active in the presence of AMP, AMP was added to the enzyme ...

HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex Virus DNA

... Fig.1 Detecting Both HSV-1 and HSV-2 DNA The HSVision module primers are derived from a 109 base-pair region of the gB gene that is highly conserved in HSV-1 and HSV-2 genomes. 8 Because PCR reactions are often susceptible to a variety of inhibitors in biological specimens, an IAC is included ...

The GeneZoo or the GeneJungle?

... unique gene-identification tag has been demonstrated as an effective gene-specific marker. Because the 3 UTRs are not as conserved as the coding sequences, this makes it easier to distinguish between individual genes and paralogous gene family members that may ...
Other Contents
(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
(Date:9/29/2014)... story from 2009, "human activities in this area of the ... oil is increasingly grown for use as a cooking oil ... It has become the most widely produced edible oil in ... surpass that of soybean oil. , The environmental effects of ... to grow the crop, and the preferred method is fire. ...
(Date:9/29/2014)... DETROIT In order to support the world,s ... chemicals, polymers and more, new and more efficient ... team of researchers, including several from Wayne State ... of a new grant from the National Science ... Guided Design of Multicomponent Materials for Electrocatalytic Cascade ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Wayne State research aims to develop new, more efficient catalytic materials 2
(Date:9/30/2014)... September 30, 2014 Dynamic health ... hampered growth in the Bread Production industry over ... consumers to moderate their consumption of a variety ... premium varieties shrunk the market for white loaf ... proactively responded by introducing more nutritious products to ...
(Date:9/30/2014)... A University of Maryland-led research team has been ... National Institutes of Health (NIH) to develop new ... further our understanding of how large networks of ... information. This knowledge will help researchers identify the ... drive behavior, like decision-making and speaking, and alterations ...
(Date:9/30/2014)... September 30, 2014 The American ... to help diabetics curb their sweet tooth, but the ... this September, suggests that zero-calorie sweeteners may actually ... diabetes. , The Weizmann Institute of Science in ... artificial sweeteners to mice, the mice developed glucose intolerance. ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set ... Nashville, Tennessee. RMS welcomes the launch of an entirely ... of a new treatment center for the Lung Institute. ... Institute to Nashville, the hope is to bring awareness ... diagnosed and undiagnosed. With Nashville being a hub for ...
(Date:9/30/2014)... -- Medicare should cover low-dose computed tomography lung cancer ... a coalition of more than 60 patient and medical ... Cancer Alliance, the Society of Thoracic Surgeons, the American ... American Society of Clinical Oncology, made its point in ... Medicare & Medicaid Services (CMS). Such screening reduces ...
Breaking Medicine News(10 mins):Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:Artificial Sweeteners May be Linked to Greater Diabetes Risk 2Health News:Regenerative Medicine Solutions Expanding 2Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2
Other TagsOther Tags