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Conjugation in Biological Technology

SoluLinK Introduces New One-Shot ChromaLink(TM) Biotin Antibody Labeling Kit with Built-in Biotin Quantification.

... needs in detection with effective and proven conjugation technology, supplied in a complete, easy-to-use ... SoluLinK is the leader in the development of conjugation reagents, easy-to-use complete kits, and conjugation services for the life science research, ...

SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres

... -- SoluLinK, Inc., a leader in next-generation conjugation products and kits, is proud to announce ... efforts in leveraging SoluLinK's next-generation conjugation technology into formats that enable ... manufacturing and marketing of advanced conjugation reagents (HydraLink(TM)) biotinylation ...

SoluLinK Introduces ChromaLink(TM) Biotin Labeling Kit to Biotinylate and Measure With One Reagent

... --- SoluLinK, Inc., a leader in biomolecular conjugation products and kits, announced the introduction ... SoluLinK's continuous and ongoing innovation of conjugation chemistry has provided significant contributions ... has established a strong leadership position in conjugation and continues to actively build, maintain, ...

SAFC Supports Potent API Conjugate Manufacturing With New St. Louis Production Suite

... HPAPIs per batch. SAFC President, Frank Wicks, commented, "High potency conjugation is an exciting new technology that demands a very special combination of specific skills. Adding HPAPI conjugation capacity enables SAFC to further vertically integrate our contract ...

Nektar Therapeutics to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference in New York City

... About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday, August 4, 2009, After Close of U.S.-Based Financial Markets

... About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

... and download the following poster presentations from Celsis' experts: The Effects of Cryopreservation on P450 Oxidation and Phase II conjugation Activity A High Throughput Screening Assay for Hepatotoxicity Using Cryopreserved Hepatocytes Comparison of Fresh and Cryo Cynomolgus ...

Nektar Therapeutics Promotes Lorianne Masuoka, M.D. to Chief Medical Officer

... About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Sangart, Inc. Completes Series F Funding Round

... The MP4 molecule is the basis for Sangart's oxygen therapeutic product platform. The MP4 molecule is created using unique polyethylene glycol conjugation with human hemoglobin and was specifically designed to the optimal molecular size, viscosity, oxygen affinity and diffusion potential to target ...

Nektar Therapeutics' President and CEO, Howard W. Robin, to Present at the 29th Annual Cowen and Company Healthcare Conference in Boston

... About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Nektar to Announce Year-End 2008 Financial Results on Wednesday, February 25, 2009 After Close of U.S.-Based Financial Markets

... About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Nektar Announces Retirement of Irwin Lerner from Board of Directors

... Nektar." About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer

... 50 hours). About Nektar Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its advanced polymer conjugation technology platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading ...

Sangart, Inc. Announces Key Executive Appointments and Company Restructuring

... Hemospan(R) Sangart's lead product candidate, Hemospan(R) is an oxygen therapeutic product that is created using unique polyethylene glycol conjugation with human hemoglobin. Hemospan(R) was specifically designed to the optimal molecular size, viscosity, oxygen affinity and diffusion potential to ...

ConjuChem and Novozymes Enter Long-Term Supply Agreement for Recombumin(R) use in PC-DAC(TM):Exendin-4

... "Recombumin(R) is an important part of our current technology and Novozymes Biopharma has been an integral partner in the development of our peptide conjugation platform. These two Agreements further solidify our relationship and are validation of the promise of our technology." Peter Rosholm, Vice ...

Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.

... In particular, he and his colleagues demonstrated that a wide variety of bacteria can promiscuously exchange genetic material and they proved that conjugation could account for dissemination of genes between phylogenetically remote bacterial genera. Because of his long-term interest in horizontal gene ...

Major Adult Vaccine Clinical Trial for Pneumonia Prevention Begins

... pneumonia and invasive pneumococcal disease." The investigational 13-valent vaccine being evaluated in this trial in adults uses Wyeth-pioneered conjugation technology, and is based on the science of PREVENAR(TM) (Pneumococcal Saccharide Conjugated Vaccine, Adsorbed). PREVENAR is indicated for active ...

PharmAthene Completes Pharmacokinetic Studies of Protexia(R); Program on Target for IND Filing in 2008

... circulating serum half-life and increase stability of recombinant proteins. The data from these studies confirm that the specific PEG chosen for conjugation to rBChE will significantly improve the half-life of the protein in vivo. The PK studies demonstrated that Protexia(R) had a half life ...

Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System

... samples. Methods Viral Disruption for conjugation To develop a method for viral conjugation, we began with our ... beads were run on the Bio-Plex system. Optimizing conjugation by Virus/Plasma Titration After determining that we could ...

Immunoassay of Theophylline by fluorescence polarisation

... The label should have at least one reactive functional group, such as isothiocyanate, acid chloride, or diazonium salt, to ease its conjugation to the ligand. The label should not alter the specificity of the ligand for its antibody by shielding the reactive sites ...

Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method

... metabolism within the body, which introduces a hydrophilic site on the metabolized drug enabling either easy elimination of the drug or further conjugation by Phase II enzymes, such as UDPGTs, sulfotransferases or amino acid-conjugation (among others) 2 . Recently there has been increased interest in ...

Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS

... limit of quantitation is around the parts per billion (ppb) level. In vitro half life has been calculated. Chloramphenicol is mainly metabolized by conjugation with glucuronic acid, which is in a good agreement with USP in vivo data. This technique could be applied widely in drug discovery, such as ...

The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies

... the images using the Granularity Analysis Module.

conjugation of CypHer5E NHS ester to anti-EGFR antibody 1. ... supplied with CypHer5E NHS ester (PAI5401) or the CypHer User Manual. For conjugation of CypHer5E NHS ester to anti-EGFR antibody we recommend a 20 M excess of ...

The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR

... nm excitation and 450BP65 emission for Hoechst.

conjugation of CypHer 5 Mono NHS Ester to anti-EGFR antibody 1. ... supplied with CypHer5 Mono NHS Ester and/or the CypHer User Manual. For conjugation of CypHer5 Mono NHS Ester to anti-EGFR antibody, we recommend a 40 molar ...

Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies

... isotyping kit is a rapid method for determining the isotypes of mouse monoclonal antibodies. This kit uses a colloidal-gold conjugation technique to label rabbit anti-mouse l and k light chain antibodies as indicating reagents, and rabbit anti-mouse isotyping ...
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