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Concentration in Biological Technology

Halozyme Therapeutics Begins Phase 2 Clinical Trial of Insulin With rHuPH20 in Type 1 Diabetic Patients

... be the area under the curve for plasma insulin concentration from zero to 60 minutes after ... additional PK data, as well as blood glucose concentration at various time points. Safety data such as ... insulin absorption and a shorter time to peak concentration when compared to Humalog alone. Results ( ...

Highest Replikin Concentrations and Cyclical Behavior Related to Human Mortality Are Found in Malaria Trypanosomes

... between 1986 and 2007. The quantitative replikin concentration (Replikin Count(TM) = number of replikins per 100 ... mortality. Cyclic increases in replikin concentration in the genome can be a mechanism of expansion of ... into a territory. In other examples, the replikin concentration of West Nile Virus was earlier found to increase ...

ANX-530 Demonstrates Equivalent Pharmacokinetics to Navelbine(R) in a Registrational Bioequivalence Clinical Study

... in the body over time. Cmax is the maximum concentration of the drug measured in the blood at any given ... 80-125% Cmax: Maximum plasma concentration AUClast: Area under the plasma concentration time curve from time zero to the last ...

Baxter to Launch GARDian(TM), a Groundbreaking Initiative That Helps Provide Continued Access to GAMMAGARD for Current Patients

... should be administered at the minimum concentration available and the minimum rate of infusion ... should be administered at the minimum concentration available and the minimum rate of infusion ... should be administered at the minimum concentration available and the minimum rate of infusion ...

Five Questions About Protopic (tacrolimus) Ointment

... Protopic is available in two concentrations: 0.1% and 0.03%. Either concentration can be used in adults, while only the 0.03% concentration is indicated for children between the ages of 2 and 15. Protopic should ...

Tobira Therapeutics Inc. Announces Phase I Data Demonstrating Pharmacokinetic Properties of TAK-652 for the Treatment of HIV

... relatively good oral bioavailability (as shown by the plasma TBR-652 concentration data) and has a long plasma half-life of TBR-652 (approximate mean of 35 ... TBR-652 plasma concentrations were well above the predicted target plasma concentration (2ng/mL) with or without food. In both studies TBR-652 was safe and well ...

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... show that in patients dosed in the first two cohorts of the study, the concentration of Cotara in brain tumors was on average more than 300-fold higher than in ... the University of Alabama at Birmingham , and his colleagues assessed the concentration of Cotara in GBM patients' tumors and in their healthy brain tissue, as ...

AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support

... Statins act on low density lipoprotein cholesterol (LDLc) and reduce its concentration in the blood. This type of treatment can reduce the likelihood of severe ... decreasing the cholesterol transfer from HDL to LDL, thus increasing the concentration of the beneficial HDL. This vaccine approach with its long-lasting effects ...

Microtest Laboratories is an Industry Leader in ICH Stability Testing

... sterility, endotoxins, and particulates. Microtest also checks that the concentration of active ingredients is within specifications, and watch for evidence that real-time or accelerated aging has affected drug concentration or purity. Moreover, Microtest is one of a few labs that offer ...

SemBioSys Genetics Inc. Announces Clinical Results with Plant-Produced Insulin

... insulin for eight hours post-injection (AUC(insulin0to8hrs)); 2) maximum concentration of insulin (Cmax(insulin)); 3) total glucose infused over eight hours ... to Humulin(R) S with respect to total insulin exposure, maximum concentration of insulin and total glucose infused. The only anomalous result from this ...

NeurogesX to Present at 11th Annual BIO CEO & Investor Conference

... product portfolio is led by its product candidate QutenzaTM, a dermal high concentration capsaicin patch designed to manage pain associated with peripheral ... NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain ...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

... Drs. Bogoch called them "Replikins," and they are strictly defined by the concentration of lysine and histidine residues and the spacing between them. To ... What Replikins have found is that there's a strong correlation between the concentration of replikins and the lethality of an influenza virus outbreak. This allows ...

Paperwork: Buckypapers clarify electrical, optical behavior of nanotubes

... for conductive films is the so-called percolation thresholdessentially the concentration at which random two- or three-dimensional networks of nanotubes first ... follows the percolation theory for ideal two-dimensional sheets, with concentration threshold for conductivity getting lower as the tubes get longer. A sheet ...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

... destroys mutated proteins which were originally designed to regulate the concentration of salt in the epithelial cells of the lungs and other organs. In patients ... marker is missing, the protein evades destruction and can regulate the concentration of water and salt secretion in the lung despite its minor structural ...

U.S. Government Accepts $192 Million of sanofi pasteur H5N1 Bulk Vaccine Antigen for Pandemic Stockpile

... for its bulk pandemic vaccine. The dose calculation is based on antigen concentration of seasonal influenza vaccine, which contains 15 mcg per dose. When the dose calculation is based on concentration of sanofi pasteur's licensed pandemic vaccine, which contains 90 mcg per ...

FluForecast(R) Replikin Count(TM) Predicts That the H5N1 Cycle Which Began in 1996 Is Now Over

... A key gene, the Replikin Peak Gene, was found to contain the highest concentration of replikins in the virus genome. In H5N1 reservoirs in chickens, the ... the replikins, specific small peptide constituents of virus proteins whose concentration has been shown to be related quantitatively to rapid replication and ...

Alexza Announces Partnership With Endo for AZ-003 (Staccato(R) fentanyl) in North America

... AZ-003 PK was equivalent to the IV fentanyl PK, with similar peak plasma concentration (Cmax), time to maximum plasma concentration (Tmax), and area under the curve concentration (AUC). These data suggest ...

Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers

... proof-of-concept that human monoclonal antibodies (hmAbs) can decrease the concentration of soluble ligands in tumors, suggesting that targeting ligands of growth ... the ligand between the blood and the tumor resulting in a decreased ligand concentration in the tumor. "These data are important because targeting the ligands of ...

Fluid theory confirmed by Foton

... decade. All liquids experience minute fluctuations in temperature or concentration as a result of the different velocities of individual molecules. These ... has also shown that the amplitude of the fluctuations in temperature and concentration greatly increased. It is a rare event when a space mission is able to ...

Scientists discover how cancer may take hold

... enzyme (dubbed IDO) forms molecules called kynurenines. This reduces the concentration of tryptophan in the local tissues and starves T-cells for tryptophan. A ... fork. This system allows the scientists to visually track the location and concentration of certain biochemicals. Our FRET technology with the novel tryptophan ...

NeurogesX Reports Second Quarter 2009 Results

... November 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

ThermoGenesis Announces Expanded Collaboration With Celling Technologies

... In a separate press release today, ThermoGenesis announced the launch of its Res-Q System, an automated cell processing medical device for the concentration of bone marrow-derived stem cells at the point of care. Celling will be the distributor for the Res-Q System in orthopedic applications. ...

Angiotech Pharmaceuticals, Inc. announces financial results for the second quarter ended June 30, 2009

... or slower relative growth, particularly our sales of components to third party medical device manufacturers, which may be impacted by customer concentration and the business issues that certain of our large customers may face, as well as to a more limited extent by economic and credit market conditions. ...

NeurogesX Announces New PDUFA Date for Qutenza(TM) New Drug Application

... November 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

NeurogesX to Hold Conference Call to Discuss Second Quarter 2009 Financial Results

... August 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test

... For more information, please visit www.fenwalinc.com . (i.) Benjamin R. and Wagner S. The residual risk of sepsis: modeling the effect of concentration on bacterial detection in 2-bottle culture systems and estimation of false-negative culture rates. Transfusion 2007; 47:1381-1389. ...

NeurogesX Added to Russell 3000 Index

... of August 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

Innocoll Announces Provisional Findings From Its Three Phase 2 Clinical Trials Investigating CollaRx(R) GENTAMICIN TOPICAL for the Treatment and Prevention of Diabetic Foot Infections

... aminoglycoside antibiotic with a concentration-dependent mechanism of action, for local action at the wound site. This technology achieves a high concentration of drug at the target tissue, while maintaining low systemic levels well below the toxicity threshold. The product concept and technology is featured ...

Lethality of H1N1 Influenza Virus Increasing According to Latest Analysis of Virus Peptide Genomic Data

... and predictive tools are based on the company's discovery of a new group of peptides related to rapid replication called Replikins, whose increase in concentration in virus or other organism proteins (Replikin Count(TM) = number of replikins per 100 amino acids) is associated with rapid replication. ...

NeurogesX Provides U.S. Regulatory Update for Qutenza(TM)

... of August 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

NeurogesX to Present at Needham Life Sciences Conference

... of August 16, 2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is ...

Genomatica Produces Pure BDO From Natural Sugars

... to show that its organisms can directly produce BDO in a fermentation broth from sugars; next, to show that the yield and rate of BDO production and concentration can reach levels consistent with commercial goals; and finally, to show that BDO can be purified from the fermentation broth using a cost-effective ...

Laboratory Test May Predict Effectiveness of ERBITUX(R) for Individual Colorectal Cancer Patients

... assay was also performed on 54 cultures of primary human colorectal cancer. Cell lines and specimens were treated with a serial dose of 10 concentration of cetuximab for 72 hours, stained with a nuclear dye, and remaining post-treatment live cells were counted. Two of the examined cell lines showed ...

Serial Monitoring With ImmuKnow(R) is Useful in the Risk Assessment of Kidney Transplant Recipients

... immune function that assesses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly ...

Plexus Awarded Development Contract With QIAGEN

... risks include customer delays, start-up costs, our potential inability to execute and lack of a track record of order volume and timing; the risks of concentration of work for certain customers; the weakness of the global economy and the continuing instability of the global financial markets and banking system, ...

ZyGEM Corp. Signs Agreement to Incorporate Its Breakthrough DNA Extraction Technology Into Rubicon's Research and Diagnostic Products

... including qPCR, microarrays, and next-generation sequencing. Rubicon kits amplify small clinical samples into large amounts of pure DNA with uniform concentration and molecular weight that increase the sensitivity, specificity, and reproducibility of analysis in research and diagnostic applications, including ...

Prospect Therapeutics, Inc.'s GCS-100 Inhibited Blood Vessel Formation in a Variety of Cancer Models

... Prospect's lead product candidate, GCS-100, is a carbohydrate molecule designed to inhibit the activity of Galectin-3, a protein found in high concentration in a broad range of human cancers and whose over-expression is associated with poor prognosis in cancer patients. About Joseph F. Finn, Jr., ....

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... agents, such as beta-adrenergic receptor agonists or inhibitors of phosphodiesterase activity, increase cardiac cell contractility by increasing the concentration of intracellular calcium, which further activates the cardiac sarcomere. This effect on calcium levels, however, also has been linked to potentially ...

MIT reels in RNA surprise with microbial ocean catch

... able to track the dynamics of small RNA expression in situ provides insight into how microbes respond to environmental changes such as nutrient concentration and physical properties like light and pressure," said Shi. "A very interesting question to follow up in the lab is how much fitness advantage a ...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

... and predictive tools are based on the company's discovery of a new group of peptides related to rapid replication called Replikins, whose increase in concentration in virus or other organism proteins (Replikin Count™ = number of replikins per 100 amino acids) is associated with rapid replication. # # # ...
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(Date:8/27/2014)... associated with outcomes after the repair of peripheral ... mechanism of injury, nerve injured, injury location, defect ... repair materials. However, despite numerous studies of outcomes ... is no agreement regarding the independent predictors of ... the predictors has not been quantified. A study ...
(Date:8/27/2014)... a dreaded bacterium that can be found in both ... 28 persons in Denmark have been infected with ... have died. , The bacterium is notoriously difficult to ... adapt to changes in its surroundings, says Associate Professor ... from the Department of Biochemistry and Molecular Biology, she ...
(Date:8/26/2014)... University in St. Louis have developed algorithms to identify ... tearing or breaking. The technology, which needs to be ... may help pinpoint minor strains and tiny injuries in ... The research is available online Aug. 27 in the ... publishes research at the nexus of the physical and ...
Breaking Biology News(10 mins):Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3
(Date:8/28/2014)... Now in its 4th year, Step for Hope ... two brain aneurysm survivors. The ongoing mission of Step for ... help increase early detection and to help support individuals and ... hope that you will be able to join this remarkable ... Step for Hope Run/ Walk on Saturday, September 6, 2014. ...
(Date:8/28/2014)... FL (PRWEB) August 28, 2014 The ... that produces deep, resonant, meditative sounds that can be ... talent is needed to use it – just taking ... always sounds soothing. , Here are some examples ... ,     Close your eyes, relax, and maintain good ...
(Date:8/28/2014)... 2014 On September 1st, the National ... campaign. The goal is to help families and ... and effectively and without exposures to risky pesticides. ... “Children’s exposures to pesticides should be limited as ... Head lice are often trivialized in the media, which ...
(Date:8/27/2014)... 2014 Author and orthopedic surgeon William ... on the thrilling adventures of sharp and witty ... is gearing up for a new marketing push in ... novellas , “Prescription: Murder” follows the adventures of ... dodging assassination attempts and thwarting criminals. In the first ...
(Date:8/27/2014)... Spine Guide has built a reputation for itself ... health. Now, the e-health site will offer new surgical ... pain symptoms. Spine Guide specializes in three types of ... surgery. , Some of the most common back pain ... radiating down the leg, inability to stand up straight, ...
Breaking Medicine News(10 mins):Health News:Step for Hope and Raise Brain Aneurysm Awareness 2Health News:Ever Thought of Meditating With a Harmonica; Harmonica Techs, Inventors of the Pulmonica® Pulmonary Harmonica®, Present Tips on How to Relax with Soothing Sounds 2Health News:Head Lice Can Be a Public Health Opportunity 2Health News:Head Lice Can Be a Public Health Opportunity 3Health News:Head Lice Can Be a Public Health Opportunity 4Health News:William H. Simon Launches New Marketing Campaign for Book 2Health News:Spine Guide Offering New Overview of Surgical Options For Back Pain 2
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